Phenolic compounds as antidiabetic, anti‐inflammatory, and anticancer agents and improvement of their bioavailability by liposomes

Phenolic compounds, widespread in plants, are a necessary part of the human regimen due to their antioxidant and pro‐oxidative properties. Naturally, phenolics structurally range from a very simple phenolic molecule moiety to an intricate polymer. For decades, phenolic compounds have gained pronounc...

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Bibliographic Details
Published in:Cell biochemistry and function Vol. 39; no. 8; pp. 926 - 944
Main Authors: Tatipamula, Vinay Bharadwaj, Kukavica, Biljana
Format: Journal Article
Language:English
Published: England Wiley Subscription Services, Inc 01.12.2021
Subjects:
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Anticancer properties
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antioxidants
Antitumor agents
Bioavailability
Biological activity
Cancer
Chemical properties
Diabetes mellitus
Flavonoids
Formulations
Functional foods & nutraceuticals
Humans
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - pharmacology
Inflammation
Liposomes
Liposomes - chemistry
Molecular Structure
Oxidation
Phenolic acids
Phenols
Phenols - chemistry
Phenols - pharmacology
Polymers
pro‐oxidative properties
pro-oxidative properties
flavonoids
antioxidants
liposomes
phenolic acids
ISSN:0263-6484, 1099-0844, 1099-0844
Online Access:Get full text
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Summary:Phenolic compounds, widespread in plants, are a necessary part of the human regimen due to their antioxidant and pro‐oxidative properties. Naturally, phenolics structurally range from a very simple phenolic molecule moiety to an intricate polymer. For decades, phenolic compounds have gained pronounced attention because of their protective effects against degenerative disorders such as inflammation, diabetes and cancer. Physico‐chemical properties (eg, solubility) restricted their bioactivity and also limited their usage as nutraceutical ingredients. However, encapsulation technology like liposomal formulations has been developed for the delivery of phenolic compounds without affecting their original aesthetic and organoleptic property. Hence, this review outlines the antioxidant and pro‐oxidative properties of phenolic compounds and focuses on biological activity reports of flavonoids and phenolic acids as antidiabetic, anti‐inflammatory and anticancer agents. Also, the delivery applications of phenolic compounds as liposomes are discussed with few examples.
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ISSN:0263-6484
1099-0844
1099-0844
DOI:10.1002/cbf.3667