The relationship between matrix metalloproteinases (MMP-3, -8, -9) in serum and peripheral lymphocytes (CD8+, CD56+) in Down syndrome children with gingivitis

Background and Objective Altered immune response may be a major contributor to periodontal disease in Down syndrome. This study investigated the relationship between peripheral lymphocytes and matrix metalloproteinases (MMPs) in serum in Down syndrome children with gingivitis. Material and Methods C...

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Vydané v:	Journal of periodontal research Ročník 49; číslo 6; s. 742 - 750
Hlavní autori:	Tsilingaridis, G., Yucel-Lindberg, T., Concha Quezada, H., Modéer, T.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Blackwell Publishing Ltd 01.12.2014
Predmet:	Adolescent CD56 Antigen - analysis CD8 Antigens - analysis CD8-Positive T-Lymphocytes - immunology Child crevicular fluid Cross-Sectional Studies Down syndrome Down Syndrome - blood Down Syndrome - enzymology Down Syndrome - immunology Female Gingival Crevicular Fluid - enzymology Gingival Crevicular Fluid - immunology Gingivitis - blood Gingivitis - enzymology Gingivitis - immunology Humans Killer Cells, Natural - immunology Lipopolysaccharides - pharmacology Male Matrix Metalloproteinase 3 - blood Matrix Metalloproteinase 8 - blood Matrix Metalloproteinase 9 - blood matrix metalloproteinases Pilot Projects Porphyromonas gingivalis serum T cells Tissue Inhibitor of Metalloproteinase-1 - blood Tissue Inhibitor of Metalloproteinase-2 - blood Tissue Inhibitor of Metalloproteinase-3 - blood Young Adult crevicular fluid Down syndrome T cells serum matrix metalloproteinases
ISSN:	0022-3484, 1600-0765, 1600-0765
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Abstract	Background and Objective Altered immune response may be a major contributor to periodontal disease in Down syndrome. This study investigated the relationship between peripheral lymphocytes and matrix metalloproteinases (MMPs) in serum in Down syndrome children with gingivitis. Material and Methods Children with Down syndrome (n = 10) and healthy controls (n = 10) were clinically and radiographically examined during dental treatment under general anaesthesia. Peripheral blood and gingival crevicular fluid were collected from each subject and concentrations were determined: serum MMP‐2, ‐3, ‐8 and ‐9; serum tissue inhibitors of metalloproteinases (TIMP) ‐1, ‐2 and ‐3; and gingival crevicular fluid. Leukocytes were isolated from peripheral blood and the relative amounts (%) of the various cell phenotypes were analysed using flow cytometry. In addition, peripheral blood cells were treated with Porphyromonas gingivalis lipopolysaccharide and levels of MMPs and TIMPs measured. Results Concentrations of MMP‐3, MMP‐8 and TIMP‐1 in serum were significantly higher (p < 0.05) in the Down syndrome group compared to the controls. When peripheral blood leukocytes were cultured in the presence or absence of P. gingivalis lipopolysaccharide, MMP‐8 levels were significantly (p < 0.05) higher in the Down syndrome group compared to controls. Children with Down syndrome exhibited significant positive correlations between CD8+ T cells and MMP‐8 (r = 0.630; p = 0.050), between CD8+ T cells and MMP‐9 (r = 0.648; p = 0.043), and between CD56+ NK cells and MMP‐3 (r = 0.828; p = 0.003) compared to controls. Conclusions The positive relationship of serum MMP‐3, ‐8 and ‐9 with immune cells in children with Down syndrome may facilitate migration of CD8+ T cells and CD56+ NK cells into the periodontal tissue, which may contribute to the increased degradation of periodontal tissue in individuals with Down syndrome.
AbstractList	Altered immune response may be a major contributor to periodontal disease in Down syndrome. This study investigated the relationship between peripheral lymphocytes and matrix metalloproteinases (MMPs) in serum in Down syndrome children with gingivitis.BACKGROUND AND OBJECTIVEAltered immune response may be a major contributor to periodontal disease in Down syndrome. This study investigated the relationship between peripheral lymphocytes and matrix metalloproteinases (MMPs) in serum in Down syndrome children with gingivitis.Children with Down syndrome (n = 10) and healthy controls (n = 10) were clinically and radiographically examined during dental treatment under general anaesthesia. Peripheral blood and gingival crevicular fluid were collected from each subject and concentrations were determined: serum MMP-2, -3, -8 and -9; serum tissue inhibitors of metalloproteinases (TIMP) -1, -2 and -3; and gingival crevicular fluid. Leukocytes were isolated from peripheral blood and the relative amounts (%) of the various cell phenotypes were analysed using flow cytometry. In addition, peripheral blood cells were treated with Porphyromonas gingivalis lipopolysaccharide and levels of MMPs and TIMPs measured.MATERIAL AND METHODSChildren with Down syndrome (n = 10) and healthy controls (n = 10) were clinically and radiographically examined during dental treatment under general anaesthesia. Peripheral blood and gingival crevicular fluid were collected from each subject and concentrations were determined: serum MMP-2, -3, -8 and -9; serum tissue inhibitors of metalloproteinases (TIMP) -1, -2 and -3; and gingival crevicular fluid. Leukocytes were isolated from peripheral blood and the relative amounts (%) of the various cell phenotypes were analysed using flow cytometry. In addition, peripheral blood cells were treated with Porphyromonas gingivalis lipopolysaccharide and levels of MMPs and TIMPs measured.Concentrations of MMP-3, MMP-8 and TIMP-1 in serum were significantly higher (p < 0.05) in the Down syndrome group compared to the controls. When peripheral blood leukocytes were cultured in the presence or absence of P. gingivalis lipopolysaccharide, MMP-8 levels were significantly (p < 0.05) higher in the Down syndrome group compared to controls. Children with Down syndrome exhibited significant positive correlations between CD8(+) T cells and MMP-8 (r = 0.630; p = 0.050), between CD8(+) T cells and MMP-9 (r = 0.648; p = 0.043), and between CD56(+) NK cells and MMP-3 (r = 0.828; p = 0.003) compared to controls.RESULTSConcentrations of MMP-3, MMP-8 and TIMP-1 in serum were significantly higher (p < 0.05) in the Down syndrome group compared to the controls. When peripheral blood leukocytes were cultured in the presence or absence of P. gingivalis lipopolysaccharide, MMP-8 levels were significantly (p < 0.05) higher in the Down syndrome group compared to controls. Children with Down syndrome exhibited significant positive correlations between CD8(+) T cells and MMP-8 (r = 0.630; p = 0.050), between CD8(+) T cells and MMP-9 (r = 0.648; p = 0.043), and between CD56(+) NK cells and MMP-3 (r = 0.828; p = 0.003) compared to controls.The positive relationship of serum MMP-3, -8 and -9 with immune cells in children with Down syndrome may facilitate migration of CD8(+) T cells and CD56(+) NK cells into the periodontal tissue, which may contribute to the increased degradation of periodontal tissue in individuals with Down syndrome.CONCLUSIONSThe positive relationship of serum MMP-3, -8 and -9 with immune cells in children with Down syndrome may facilitate migration of CD8(+) T cells and CD56(+) NK cells into the periodontal tissue, which may contribute to the increased degradation of periodontal tissue in individuals with Down syndrome. Background and Objective Altered immune response may be a major contributor to periodontal disease in Down syndrome. This study investigated the relationship between peripheral lymphocytes and matrix metalloproteinases (MMPs) in serum in Down syndrome children with gingivitis. Material and Methods Children with Down syndrome (n = 10) and healthy controls (n = 10) were clinically and radiographically examined during dental treatment under general anaesthesia. Peripheral blood and gingival crevicular fluid were collected from each subject and concentrations were determined: serum MMP‐2, ‐3, ‐8 and ‐9; serum tissue inhibitors of metalloproteinases (TIMP) ‐1, ‐2 and ‐3; and gingival crevicular fluid. Leukocytes were isolated from peripheral blood and the relative amounts (%) of the various cell phenotypes were analysed using flow cytometry. In addition, peripheral blood cells were treated with Porphyromonas gingivalis lipopolysaccharide and levels of MMPs and TIMPs measured. Results Concentrations of MMP‐3, MMP‐8 and TIMP‐1 in serum were significantly higher (p < 0.05) in the Down syndrome group compared to the controls. When peripheral blood leukocytes were cultured in the presence or absence of P. gingivalis lipopolysaccharide, MMP‐8 levels were significantly (p < 0.05) higher in the Down syndrome group compared to controls. Children with Down syndrome exhibited significant positive correlations between CD8+ T cells and MMP‐8 (r = 0.630; p = 0.050), between CD8+ T cells and MMP‐9 (r = 0.648; p = 0.043), and between CD56+ NK cells and MMP‐3 (r = 0.828; p = 0.003) compared to controls. Conclusions The positive relationship of serum MMP‐3, ‐8 and ‐9 with immune cells in children with Down syndrome may facilitate migration of CD8+ T cells and CD56+ NK cells into the periodontal tissue, which may contribute to the increased degradation of periodontal tissue in individuals with Down syndrome. Altered immune response may be a major contributor to periodontal disease in Down syndrome. This study investigated the relationship between peripheral lymphocytes and matrix metalloproteinases (MMPs) in serum in Down syndrome children with gingivitis. Children with Down syndrome (n = 10) and healthy controls (n = 10) were clinically and radiographically examined during dental treatment under general anaesthesia. Peripheral blood and gingival crevicular fluid were collected from each subject and concentrations were determined: serum MMP-2, -3, -8 and -9; serum tissue inhibitors of metalloproteinases (TIMP) -1, -2 and -3; and gingival crevicular fluid. Leukocytes were isolated from peripheral blood and the relative amounts (%) of the various cell phenotypes were analysed using flow cytometry. In addition, peripheral blood cells were treated with Porphyromonas gingivalis lipopolysaccharide and levels of MMPs and TIMPs measured. Concentrations of MMP-3, MMP-8 and TIMP-1 in serum were significantly higher (p<0.05) in the Down syndrome group compared to the controls. When peripheral blood leukocytes were cultured in the presence or absence of P. gingivalis lipopolysaccharide, MMP-8 levels were significantly (p<0.05) higher in the Down syndrome group compared to controls. Children with Down syndrome exhibited significant positive correlations between CD8+ T cells and MMP-8 (r = 0.630; p=0.050), between CD8+ T cells and MMP-9 (r = 0.648; p=0.043), and between CD56+NK cells and MMP-3 (r = 0.828; p =0.003) compared to controls. The positive relationship of serum MMP-3, -8 and -9 with immune cells in children with Down syndrome may facilitate migration of CD8+ T cells and CD56+NK cells into the periodontal tissue, which may contribute to the increased degradation of periodontal tissue in individuals with Down syndrome. Altered immune response may be a major contributor to periodontal disease in Down syndrome. This study investigated the relationship between peripheral lymphocytes and matrix metalloproteinases (MMPs) in serum in Down syndrome children with gingivitis. Children with Down syndrome (n = 10) and healthy controls (n = 10) were clinically and radiographically examined during dental treatment under general anaesthesia. Peripheral blood and gingival crevicular fluid were collected from each subject and concentrations were determined: serum MMP-2, -3, -8 and -9; serum tissue inhibitors of metalloproteinases (TIMP) -1, -2 and -3; and gingival crevicular fluid. Leukocytes were isolated from peripheral blood and the relative amounts (%) of the various cell phenotypes were analysed using flow cytometry. In addition, peripheral blood cells were treated with Porphyromonas gingivalis lipopolysaccharide and levels of MMPs and TIMPs measured. Concentrations of MMP-3, MMP-8 and TIMP-1 in serum were significantly higher (p < 0.05) in the Down syndrome group compared to the controls. When peripheral blood leukocytes were cultured in the presence or absence of P. gingivalis lipopolysaccharide, MMP-8 levels were significantly (p < 0.05) higher in the Down syndrome group compared to controls. Children with Down syndrome exhibited significant positive correlations between CD8(+) T cells and MMP-8 (r = 0.630; p = 0.050), between CD8(+) T cells and MMP-9 (r = 0.648; p = 0.043), and between CD56(+) NK cells and MMP-3 (r = 0.828; p = 0.003) compared to controls. The positive relationship of serum MMP-3, -8 and -9 with immune cells in children with Down syndrome may facilitate migration of CD8(+) T cells and CD56(+) NK cells into the periodontal tissue, which may contribute to the increased degradation of periodontal tissue in individuals with Down syndrome.
Author	Concha Quezada, H. Yucel-Lindberg, T. Modéer, T. Tsilingaridis, G.
Author_xml	– sequence: 1 givenname: G. surname: Tsilingaridis fullname: Tsilingaridis, G. email: georgios.tsilingaridis@ki.se organization: Division of Paediatric Dentistry, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden – sequence: 2 givenname: T. surname: Yucel-Lindberg fullname: Yucel-Lindberg, T. organization: Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Sweden, Huddinge – sequence: 3 givenname: H. surname: Concha Quezada fullname: Concha Quezada, H. organization: Center for Infectious Medicine, Department of Medicine, Karolinska University Hospital, Huddinge, Sweden – sequence: 4 givenname: T. surname: Modéer fullname: Modéer, T. organization: Division of Paediatric Dentistry, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24372339$$D View this record in MEDLINE/PubMed http://kipublications.ki.se/Default.aspx?queryparsed=id:130160255$$DView record from Swedish Publication Index (Karolinska Institutet)
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Leppert D, Hauser SL, Kishiyama JL, An S, Zeng L, Goetzl EJ. Stimulation of matrix metalloproteinase-dependent migration of T cells by eicosanoids. FASEB J 1995;9:1473-1481. Restaino CG, Chaparro A, Valenzuela MA et al. Stimulatory response of neutrophils from periodontitis patients with periodontal pathogens. Oral Dis 2007;13:474-481. Xia M, Leppert D, Hauser SL et al. Stimulus specificity of matrix metalloproteinase dependence of human T cell migration through a model basement membrane. J Immunol 1996;156:160-167. Modeer T, Barr M, Dahllof G. Periodontal disease in children with Down's syndrome. Scand J Dent Res 1990;98:228-234. Murphy M, Lempert MJ, Epstein LB. Decreased level of T cell receptor expression by Down syndrome (trisomy 21) thymocytes. Am J Med Genet Suppl 1990;7:234-237. de Hingh YC, van der Vossen PW, Gemen EF et al. Intrinsic abnormalities of lymphocyte counts in children with Down syndrome. J Pediatr 2005;147:744-747. Reynolds JJ, Meikle MC. Mechanisms of connective tissue matrix destruction in periodontitis. Periodontol 2000 1997;14:144-157. Reeves AF, Rees JM, Schiff M, Hujoel P. Total body weight and waist circumference associated with chronic periodontitis among adolescents in the United States. Arch Pediatr Adolesc Med 2006;160:894-899. Barnett ML, Press KP, Friedman D, Sonnenberg EM. The prevalence of periodontitis 2009; 45 1989; 41 1997; 158 1990; 98 2002; 110 2006; 38 1993; 20 2013; 167 2002; 115 2012; 16 1996; 35 1996; 103 1993; 6 1992; 7 1976; 34 2003; 92 1997; 55 2005; 147 1984; 55 1997; 14 2006; 69 2011; 64 2011; 63 2005; 32 2000; 164 2006; 160 2001; 55 2008; 112 2007; 65 1998; 10 1996; 67 1995; 9 2001; 72 2013; 48 2010; 37 1959; 143 1987; 246 1986; 13 1986; 57 1992; 149 1993; 1177 2000; 71 1989; 24 2009; 27 2007; 13 2010; 45 1995; 84 2006; 85 1980; 4 1998; 1 2007; 86 2003; 61 1993; 157 1989; 16 1996; 156 1990; 7 e_1_2_5_27_1 e_1_2_5_25_1 e_1_2_5_48_1 e_1_2_5_46_1 e_1_2_5_21_1 e_1_2_5_44_1 Murphy M (e_1_2_5_19_1) 1992; 149 Colombo ML (e_1_2_5_22_1) 1989; 41 e_1_2_5_29_1 e_1_2_5_61_1 e_1_2_5_42_1 Nespoli L (e_1_2_5_31_1) 1993; 6 e_1_2_5_40_1 e_1_2_5_15_1 e_1_2_5_38_1 e_1_2_5_36_1 e_1_2_5_59_1 e_1_2_5_9_1 e_1_2_5_11_1 e_1_2_5_57_1 e_1_2_5_7_1 e_1_2_5_13_1 e_1_2_5_32_1 e_1_2_5_55_1 e_1_2_5_5_1 Karttunen R (e_1_2_5_23_1) 1984; 55 Xia M (e_1_2_5_37_1) 1996; 156 Barkin RM (e_1_2_5_17_1) 1980; 4 Weeks BS (e_1_2_5_53_1) 1998; 1 e_1_2_5_30_1 e_1_2_5_51_1 e_1_2_5_28_1 e_1_2_5_49_1 e_1_2_5_26_1 e_1_2_5_47_1 Barkin RM (e_1_2_5_16_1) 1980; 4 e_1_2_5_24_1 e_1_2_5_45_1 e_1_2_5_43_1 Modeer T (e_1_2_5_3_1) 1990; 98 e_1_2_5_60_1 Lejeune J (e_1_2_5_2_1) 1959; 143 e_1_2_5_41_1 e_1_2_5_14_1 e_1_2_5_39_1 e_1_2_5_58_1 e_1_2_5_8_1 Murphy M (e_1_2_5_20_1) 1990; 7 e_1_2_5_10_1 e_1_2_5_35_1 e_1_2_5_56_1 e_1_2_5_6_1 e_1_2_5_12_1 e_1_2_5_33_1 e_1_2_5_4_1 Page RC (e_1_2_5_54_1) 1976; 34 Johnatty RN (e_1_2_5_34_1) 1997; 158 Levin S (e_1_2_5_18_1) 1987; 246 e_1_2_5_52_1 e_1_2_5_50_1
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Snippet	Background and Objective Altered immune response may be a major contributor to periodontal disease in Down syndrome. This study investigated the relationship... Altered immune response may be a major contributor to periodontal disease in Down syndrome. This study investigated the relationship between peripheral...
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SubjectTerms	Adolescent CD56 Antigen - analysis CD8 Antigens - analysis CD8-Positive T-Lymphocytes - immunology Child crevicular fluid Cross-Sectional Studies Down syndrome Down Syndrome - blood Down Syndrome - enzymology Down Syndrome - immunology Female Gingival Crevicular Fluid - enzymology Gingival Crevicular Fluid - immunology Gingivitis - blood Gingivitis - enzymology Gingivitis - immunology Humans Killer Cells, Natural - immunology Lipopolysaccharides - pharmacology Male Matrix Metalloproteinase 3 - blood Matrix Metalloproteinase 8 - blood Matrix Metalloproteinase 9 - blood matrix metalloproteinases Pilot Projects Porphyromonas gingivalis serum T cells Tissue Inhibitor of Metalloproteinase-1 - blood Tissue Inhibitor of Metalloproteinase-2 - blood Tissue Inhibitor of Metalloproteinase-3 - blood Young Adult
Title	The relationship between matrix metalloproteinases (MMP-3, -8, -9) in serum and peripheral lymphocytes (CD8+, CD56+) in Down syndrome children with gingivitis
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