Gold nanoparticles–conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt–mediated pathway in breast cancer cell lines (MCF‐7 and MDA‐MB‐231)

Epidermal growth factor plays a major role in breast cancer cell proliferation, survival, and metastasis. Quercetin, a bioactive flavonoid, is shown to exhibit anticarcinogenic effects against various cancers including breast cancer. Hence, the present study was designed to evaluate the effects of g...

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Vydáno v:	Cell biochemistry and function Ročník 35; číslo 4; s. 217 - 231
Hlavní autoři:	Balakrishnan, Solaimuthu, Mukherjee, Sudip, Das, Sourav, Bhat, Firdous Ahmad, Raja Singh, Paulraj, Patra, Chitta Ranjan, Arunakaran, Jagadeesan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Wiley Subscription Services, Inc 01.06.2017
Témata:	1-Phosphatidylinositol 3-kinase AKT protein Annexin V Apoptosis Apoptosis - drug effects Assaying BAX protein Bcl-2 protein Biocompatibility Biomedical materials Biotechnology Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Caspase Caspase-3 Cell death Cell growth Cell proliferation Cell survival Condensation Crystal structure Cytotoxicity Drug delivery Drug delivery systems Drug Delivery Systems - methods EGFR Epidermal growth factor Epidermal growth factor receptors Female Glycogen Synthase Kinase 3 beta - metabolism Gold Gold - chemistry gold nanoparticles and quercetin Humans Immunoblotting Immunocytochemistry MAP Kinase Signaling System - drug effects MCF-7 Cells Metal Nanoparticles Metastases Nanoparticles Phosphatidylinositol 3-Kinases - metabolism Proteins Proto-Oncogene Proteins c-akt - metabolism Quercetin - chemistry Quercetin - pharmacology Signal transduction Signaling Staining Surgical implants Survival Therapy TOR Serine-Threonine Kinases - metabolism Tumor cell lines gold nanoparticles and quercetin apoptosis breast cancer drug delivery EGFR
ISSN:	0263-6484, 1099-0844, 1099-0844
On-line přístup:	Získat plný text
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