A multiscale absorption and transit model for oral delivery of hydroxychloroquine: Pharmacokinetic modeling and intestinal concentration prediction to assess toxicity and drug‐induced damage in healthy subjects

Hydroxychloroquine (HCQ) is commonly used in the treatment of malaria and rheumatic diseases. Recently it has also been identified as possible therapeutic option in combating COVID‐19. However, the use of HCQ is known to induce cytotoxicity. In 2020, we developed a multiscale absorption and transit...

Full description

Saved in:

Bibliographic Details
Published in:	International journal for numerical methods in biomedical engineering Vol. 36; no. 12; pp. e3403 - n/a
Main Authors:	Kannan, Ravishekar, Przekwas, Andrzej
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01.12.2020 Wiley Subscription Services, Inc
Subjects:	Absorption Administration, Oral Bioavailability CC50 Computer applications Computer Simulation COVID-19 COVID-19 - drug therapy COVID-19 - metabolism COVID-19 - pathology Cytotoxicity Damage Data integration Dissolution Duodenum gastrointestinal tract GIT HCQ Healthy Volunteers Humans Hydroxychloroquine Hydroxychloroquine - adverse effects Hydroxychloroquine - pharmacokinetics Hydroxychloroquine - therapeutic use Intestine Malaria MAT Medical treatment Metabolism Models, Biological multiscale multiscale absorption and transit Optimization Oral administration Pharmacokinetics Pharmacology quasi‐3D (Q3D) Rheumatic diseases SARS-CoV-2 Stomach Toolkits Toxicity Vector-borne diseases COVID-19 MAT GIT gastrointestinal tract CC50 multiscale absorption and transit HCQ quasi-3D (Q3D) multiscale cytotoxicity
ISSN:	2040-7939, 2040-7947, 2040-7947
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!