90‐day oral toxicity study in rats of a protein‐rich powder derived from Xanthobacter sp. SoF1

Xanthobacter sp. SoF1 (SoF1) is an autotrophic hydrogen‐oxidizing bacteria that produces protein‐rich biomass and has potential to be an alternative protein source that is more environmentally sustainable than animal and plant derived proteins. A protein‐rich powder derived from SoF1 was the test ma...

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Vydané v:Journal of applied toxicology Ročník 44; číslo 11; s. 1816 - 1830
Hlavní autori: Choi, Bean, Glávits, Róbert, Murbach, Timothy S., Endres, John R., Hirka, Gábor, Szakonyiné, Ilona Pasics
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Wiley Subscription Services, Inc 01.11.2024
Predmet:
Administration, Oral
Animals
Bacterial Proteins - toxicity
Dose-Response Relationship, Drug
Female
hydrogen oxidizing bacteria
Male
microbial protein
No-Observed-Adverse-Effect Level
NOAEL
Organs
Powders
Proteins
Rats
Rats, Wistar
safety
single cell protein
Toxicity
Toxicity testing
Whey protein
Xanthobacter
toxicity
Xanthobacter
safety
NOAEL
microbial protein
single cell protein
hydrogen oxidizing bacteria
ISSN:0260-437X, 1099-1263, 1099-1263
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Popis
Shrnutí:Xanthobacter sp. SoF1 (SoF1) is an autotrophic hydrogen‐oxidizing bacteria that produces protein‐rich biomass and has potential to be an alternative protein source that is more environmentally sustainable than animal and plant derived proteins. A protein‐rich powder derived from SoF1 was the test material in a 90‐day repeated‐dose oral toxicity study to explore major toxic effects, demonstrate target organs, and provide an estimate of a no‐observed‐adverse‐effect level (NOAEL). Daily doses of 0 (vehicle only), 375, 750, and 1500 mg/kg bw/day of the test material were administered by gavage to 10 Han:WIST rats/sex/group. An additional group was administered 1290 mg/kg bw/day whey protein concentrate as positive control. No treatment‐related adverse effects were observed, and no target organs were determined after 90/91 days of consecutive administration of the test item. A NOAEL of 1500 mg/kg bw/day was determined. A 90‐day repeated‐dose oral toxicity study was conducted to assess the subchronic toxicity of a microbial protein powder derived from Xanthobacter sp. SoF1. Daily doses of 0 (vehicle only), 375, 750, and 1500 mg/kg bw/day of the test material and 1290 mg/kg whey protein concentrate as a positive control were administered by gavage to 10 Han:WIST rats/sex/group. A no‐observed‐adverse‐effect‐level of 1500 mg/kg bw/day was determined.
Bibliografia:Funding information
The authors disclose that financial support for the research described herein was provided by Solar Foods Oy, Härkälenkki 11 Finland, 01730 Vantaa, Business ID: FI2872116‐8.
Ilona Pasics Szakonyiné is the senior author.
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ISSN:0260-437X
1099-1263
1099-1263
DOI:10.1002/jat.4663