Long non‐coding RNAs as potential biomarkers in the prognosis and diagnosis of lung cancer: A review and target analysis

Long non‐coding RNAs (lncRNA) have been emerged as a novel class of molecular regulators in cancer. They are dysregulated in many types of cancer; however, there is not enough knowledge available on their expression and functional profiles. Lung cancer is the leading cause of the cancer deaths world...

Full description

Saved in:
Bibliographic Details
Published in:IUBMB life Vol. 73; no. 2; pp. 307 - 327
Main Authors: Aftabi, Younes, Ansarin, Khalil, Shanehbandi, Dariush, Khalili, Majid, Seyedrezazadeh, Ensiyeh, Rahbarnia, Leila, Asadi, Milad, Amiri‐Sadeghan, Amir, Zafari, Venus, Eyvazi, Shirin, Bakhtiyari, Nasim, Zarredar, Habib
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01.02.2021
Wiley Subscription Services, Inc
Subjects:
Biomarkers
Biomarkers, Tumor - genetics
Diagnosis
Epigenetics
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Humans
Invasiveness
lncRNAs
Lung cancer
Lung Neoplasms - diagnosis
Lung Neoplasms - therapy
Medical prognosis
molecular biomarkers
Non-coding RNA
Prognosis
RNA, Long Noncoding - genetics
Tumors
lncRNAs
lung cancer
diagnosis
molecular biomarkers
prognosis
ISSN:1521-6543, 1521-6551, 1521-6551
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Long non‐coding RNAs (lncRNA) have been emerged as a novel class of molecular regulators in cancer. They are dysregulated in many types of cancer; however, there is not enough knowledge available on their expression and functional profiles. Lung cancer is the leading cause of the cancer deaths worldwide. Generally, lncRNAs may be associated with lung tumor pathogenesis and they may act as biomarkers for the cancer prognosis and diagnosis. Compared to other invasive prognostic and diagnostic methods, detection of lncRNAs might be a user‐friendly and noninvasive method. In this review article, we selected 27 tumor‐associated lncRNAs by literature reviewing to further discussing in detail for using as diagnostic and prognostic biomarkers in lung cancer. Also, in an in silico target analysis, the “Experimentally supported functional regulation” approach of the LncTarD web tool was used to identifying the target genes and regulatory mechanisms of the selected lncRNAs. The reports on diagnostic and prognostic potential of all selected lncRNAs were discussed. However, the target genes and regulatory mechanisms of the 22 lncRNAs were identified by in silico analysis and we found the pathways that are controlled by each target group of lncRNAs. They use epigenetic mechanisms, ceRNA mechanisms, protein interaction and sponge mechanism. Also, 10, 23, 5, and 28 target genes for each of these mechanisms were identified, respectively. Finally, each group of target genes controls 50, 12, 7, and 2 molecular pathways, respectively. In conclusion, LncRNAs could be used as biomarkers in lung cancer due to their roles in control of several signaling pathways related to lung tumors. Also, it seems that lncRNAs, which use epigenetic mechanisms for modulating a large number of pathways, could be considered as important subjects for lung cancer‐related diagnostic and prognostic biomarkers.
AbstractList Long non‐coding RNAs (lncRNA) have been emerged as a novel class of molecular regulators in cancer. They are dysregulated in many types of cancer; however, there is not enough knowledge available on their expression and functional profiles. Lung cancer is the leading cause of the cancer deaths worldwide. Generally, lncRNAs may be associated with lung tumor pathogenesis and they may act as biomarkers for the cancer prognosis and diagnosis. Compared to other invasive prognostic and diagnostic methods, detection of lncRNAs might be a user‐friendly and noninvasive method. In this review article, we selected 27 tumor‐associated lncRNAs by literature reviewing to further discussing in detail for using as diagnostic and prognostic biomarkers in lung cancer. Also, in an in silico target analysis, the “Experimentally supported functional regulation” approach of the LncTarD web tool was used to identifying the target genes and regulatory mechanisms of the selected lncRNAs. The reports on diagnostic and prognostic potential of all selected lncRNAs were discussed. However, the target genes and regulatory mechanisms of the 22 lncRNAs were identified by in silico analysis and we found the pathways that are controlled by each target group of lncRNAs. They use epigenetic mechanisms, ceRNA mechanisms, protein interaction and sponge mechanism. Also, 10, 23, 5, and 28 target genes for each of these mechanisms were identified, respectively. Finally, each group of target genes controls 50, 12, 7, and 2 molecular pathways, respectively. In conclusion, LncRNAs could be used as biomarkers in lung cancer due to their roles in control of several signaling pathways related to lung tumors. Also, it seems that lncRNAs, which use epigenetic mechanisms for modulating a large number of pathways, could be considered as important subjects for lung cancer‐related diagnostic and prognostic biomarkers.
Long non-coding RNAs (lncRNA) have been emerged as a novel class of molecular regulators in cancer. They are dysregulated in many types of cancer; however, there is not enough knowledge available on their expression and functional profiles. Lung cancer is the leading cause of the cancer deaths worldwide. Generally, lncRNAs may be associated with lung tumor pathogenesis and they may act as biomarkers for the cancer prognosis and diagnosis. Compared to other invasive prognostic and diagnostic methods, detection of lncRNAs might be a user-friendly and noninvasive method. In this review article, we selected 27 tumor-associated lncRNAs by literature reviewing to further discussing in detail for using as diagnostic and prognostic biomarkers in lung cancer. Also, in an in silico target analysis, the "Experimentally supported functional regulation" approach of the LncTarD web tool was used to identifying the target genes and regulatory mechanisms of the selected lncRNAs. The reports on diagnostic and prognostic potential of all selected lncRNAs were discussed. However, the target genes and regulatory mechanisms of the 22 lncRNAs were identified by in silico analysis and we found the pathways that are controlled by each target group of lncRNAs. They use epigenetic mechanisms, ceRNA mechanisms, protein interaction and sponge mechanism. Also, 10, 23, 5, and 28 target genes for each of these mechanisms were identified, respectively. Finally, each group of target genes controls 50, 12, 7, and 2 molecular pathways, respectively. In conclusion, LncRNAs could be used as biomarkers in lung cancer due to their roles in control of several signaling pathways related to lung tumors. Also, it seems that lncRNAs, which use epigenetic mechanisms for modulating a large number of pathways, could be considered as important subjects for lung cancer-related diagnostic and prognostic biomarkers.Long non-coding RNAs (lncRNA) have been emerged as a novel class of molecular regulators in cancer. They are dysregulated in many types of cancer; however, there is not enough knowledge available on their expression and functional profiles. Lung cancer is the leading cause of the cancer deaths worldwide. Generally, lncRNAs may be associated with lung tumor pathogenesis and they may act as biomarkers for the cancer prognosis and diagnosis. Compared to other invasive prognostic and diagnostic methods, detection of lncRNAs might be a user-friendly and noninvasive method. In this review article, we selected 27 tumor-associated lncRNAs by literature reviewing to further discussing in detail for using as diagnostic and prognostic biomarkers in lung cancer. Also, in an in silico target analysis, the "Experimentally supported functional regulation" approach of the LncTarD web tool was used to identifying the target genes and regulatory mechanisms of the selected lncRNAs. The reports on diagnostic and prognostic potential of all selected lncRNAs were discussed. However, the target genes and regulatory mechanisms of the 22 lncRNAs were identified by in silico analysis and we found the pathways that are controlled by each target group of lncRNAs. They use epigenetic mechanisms, ceRNA mechanisms, protein interaction and sponge mechanism. Also, 10, 23, 5, and 28 target genes for each of these mechanisms were identified, respectively. Finally, each group of target genes controls 50, 12, 7, and 2 molecular pathways, respectively. In conclusion, LncRNAs could be used as biomarkers in lung cancer due to their roles in control of several signaling pathways related to lung tumors. Also, it seems that lncRNAs, which use epigenetic mechanisms for modulating a large number of pathways, could be considered as important subjects for lung cancer-related diagnostic and prognostic biomarkers.
Long non‐coding RNAs (lncRNA) have been emerged as a novel class of molecular regulators in cancer. They are dysregulated in many types of cancer; however, there is not enough knowledge available on their expression and functional profiles. Lung cancer is the leading cause of the cancer deaths worldwide. Generally, lncRNAs may be associated with lung tumor pathogenesis and they may act as biomarkers for the cancer prognosis and diagnosis. Compared to other invasive prognostic and diagnostic methods, detection of lncRNAs might be a user‐friendly and noninvasive method. In this review article, we selected 27 tumor‐associated lncRNAs by literature reviewing to further discussing in detail for using as diagnostic and prognostic biomarkers in lung cancer. Also, in an in silico target analysis, the “Experimentally supported functional regulation” approach of the LncTarD web tool was used to identifying the target genes and regulatory mechanisms of the selected lncRNAs. The reports on diagnostic and prognostic potential of all selected lncRNAs were discussed. However, the target genes and regulatory mechanisms of the 22 lncRNAs were identified by in silico analysis and we found the pathways that are controlled by each target group of lncRNAs. They use epigenetic mechanisms, ceRNA mechanisms, protein interaction and sponge mechanism. Also, 10, 23, 5, and 28 target genes for each of these mechanisms were identified, respectively. Finally, each group of target genes controls 50, 12, 7, and 2 molecular pathways, respectively. In conclusion, LncRNAs could be used as biomarkers in lung cancer due to their roles in control of several signaling pathways related to lung tumors. Also, it seems that lncRNAs, which use epigenetic mechanisms for modulating a large number of pathways, could be considered as important subjects for lung cancer‐related diagnostic and prognostic biomarkers.
Author Zafari, Venus
Ansarin, Khalil
Seyedrezazadeh, Ensiyeh
Bakhtiyari, Nasim
Rahbarnia, Leila
Asadi, Milad
Zarredar, Habib
Shanehbandi, Dariush
Eyvazi, Shirin
Aftabi, Younes
Khalili, Majid
Amiri‐Sadeghan, Amir
Author_xml – sequence: 1
  givenname: Younes
  surname: Aftabi
  fullname: Aftabi, Younes
  organization: Tabriz University of Medical Science
– sequence: 2
  givenname: Khalil
  surname: Ansarin
  fullname: Ansarin, Khalil
  organization: Tabriz University of Medical Science
– sequence: 3
  givenname: Dariush
  surname: Shanehbandi
  fullname: Shanehbandi, Dariush
  organization: Tabriz University of Medical Sciences
– sequence: 4
  givenname: Majid
  surname: Khalili
  fullname: Khalili, Majid
  organization: Tabriz University of Medical Science
– sequence: 5
  givenname: Ensiyeh
  surname: Seyedrezazadeh
  fullname: Seyedrezazadeh, Ensiyeh
  organization: Tabriz University of Medical Science
– sequence: 6
  givenname: Leila
  surname: Rahbarnia
  fullname: Rahbarnia, Leila
  organization: Tabriz University of Medical Sciences
– sequence: 7
  givenname: Milad
  surname: Asadi
  fullname: Asadi, Milad
  organization: Tabriz University of Medical Sciences
– sequence: 8
  givenname: Amir
  surname: Amiri‐Sadeghan
  fullname: Amiri‐Sadeghan, Amir
  organization: Tabriz University of Medical Science
– sequence: 9
  givenname: Venus
  surname: Zafari
  fullname: Zafari, Venus
  organization: Tabriz University of Medical Science
– sequence: 10
  givenname: Shirin
  surname: Eyvazi
  fullname: Eyvazi, Shirin
  organization: Tabriz University of Medical Science
– sequence: 11
  givenname: Nasim
  surname: Bakhtiyari
  fullname: Bakhtiyari, Nasim
  organization: Tabriz University of Medical Science
– sequence: 12
  givenname: Habib
  orcidid: 0000-0002-7217-7521
  surname: Zarredar
  fullname: Zarredar, Habib
  email: habib_zarredar@yahoo.com
  organization: Tabriz University of Medical Science
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33369006$$D View this record in MEDLINE/PubMed
BookMark eNp10d1KHDEUB_BQlPrRgk9QAr3xZtZkkplJerdKW4VFodTrkMmcWWNnk22SUbZXfQSf0Sdp1l0tSJub5MAvhz_nHKAd5x0gdETJhBJSntixnZSckTdon1YlLeqqojsvb8720EGMtySfhsi3aI8xVktC6n30a-bdHOd2j78fjO9sLr5dTiPWES99ApesHnBr_UKHHxAitg6nG8DL4OfOR5uh63Bn9bbyPR7G3MNoZyB8wlMc4M7C_RNLOswh5aceVhm_Q7u9HiK8396H6PrL5-9n58Xs6uvF2XRWGMYlKahgpjKmBNO1ALWoSt5WtKY949QII1hjWi573pkWODRa5KKWreRNKXpRG3aIjjd9c-ifI8SkFjYaGAbtwI9RlbxhnEghSaYfX9FbP4acd60Ez1FKWWf1YavGdgGdWgabx7NSz1PNYLIBJvgYA_TK2KST9S4FbQdFiVqvTeW1qfXa_kZ8-fDc8x-02NB7O8Dqv05dXJ8--T-_jKaq
CitedBy_id crossref_primary_10_4103_abr_abr_185_22
crossref_primary_10_1038_s41419_021_04228_z
crossref_primary_10_1007_s12013_022_01121_0
crossref_primary_10_1111_imm_13581
crossref_primary_10_1016_j_jep_2023_117547
crossref_primary_10_3389_fgene_2021_779455
crossref_primary_10_1080_02648725_2023_2196489
crossref_primary_10_1080_15257770_2024_2439904
crossref_primary_10_3389_fgene_2022_1010089
crossref_primary_10_1016_j_ygeno_2023_110570
crossref_primary_10_1016_j_microc_2022_107248
crossref_primary_10_1155_2021_2448782
crossref_primary_10_5812_gct_117415
crossref_primary_10_1007_s10495_023_01840_6
crossref_primary_10_1007_s12033_022_00531_y
crossref_primary_10_1016_j_prp_2022_154053
crossref_primary_10_1016_j_biopha_2022_112963
crossref_primary_10_1007_s12029_021_00667_1
crossref_primary_10_1016_j_sajb_2022_01_006
crossref_primary_10_1038_s41598_021_04664_z
crossref_primary_10_1002_mco2_401
crossref_primary_10_1186_s13287_021_02250_8
crossref_primary_10_4049_jimmunol_2100743
crossref_primary_10_1177_15330338211038488
Cites_doi 10.1631/jzus.B1900312
10.1111/cbdd.12967
10.1038/srep11516
10.1186/1471-2407-13-464
10.1016/j.biopha.2018.12.024
10.1007/s13277-015-3460-9
10.1007/s13277-015-4023-9
10.2147/OTT.S167633
10.1111/1440-1681.12780
10.18632/oncotarget.19738
10.1089/cbr.2019.3120
10.1016/j.cca.2017.10.027
10.1007/s10549-015-3632-8
10.1016/j.bbrc.2017.12.114
10.1089/dna.2018.4462
10.1007/s00018-019-03135-z
10.18632/oncotarget.7077
10.2174/1871520619666190301125203
10.1007/s00268-010-0951-0
10.1111/jcmm.12431
10.1097/MD.0000000000004608
10.1016/j.oraloncology.2016.12.017
10.1111/1759-7714.13371
10.1177/1533034617723754
10.3727/096504017X14850182723737
10.1371/journal.pone.0077293
10.1177/1947601911431081
10.1159/000445591
10.1134/S0006297907110016
10.1016/j.cell.2009.02.006
10.1080/09168451.2019.1694404
10.3389/fendo.2020.00457
10.1097/JTO.0000000000000470
10.1007/s13277-015-4521-9
10.1007/s00018-019-03305-z
10.1093/nar/gkx600
10.3390/cells6020012
10.1159/000480209
10.1016/j.omtn.2019.06.003
10.1038/onc.2012.28
10.2147/CMAR.S207801
10.1007/s13277-015-4261-x
10.1186/s12935-018-0537-8
10.1111/1759-7714.12767
10.1038/sj.onc.1206928
10.3322/caac.21492
10.1038/nrg.2015.10
10.1042/BSR20181599
10.1186/s12885-020-6530-3
10.1186/s13045-014-0090-4
10.1016/j.lungcan.2014.05.011
10.1111/cas.13879
10.1016/j.biopha.2015.07.003
10.1016/j.biopha.2017.12.031
10.1016/j.biopha.2020.110239
10.1038/aps.2016.133
10.1038/mt.2016.71
10.1038/cr.2014.35
10.1177/1010428317697568
10.1016/j.yexmp.2017.10.002
10.1080/15476286.2015.1122164
10.1158/0008-5472.CAN-12-2850
10.1186/s13000-015-0247-7
10.1186/s12943-018-0836-7
10.1016/j.ymthe.2018.02.024
10.1158/1535-7163.MCT-15-0707
10.1038/bjc.2013.698
10.1158/1538-7445.AM2016-1598
10.1038/nature13311
10.3892/ijo.2017.3925
10.1159/000374038
10.1038/cddis.2017.328
10.1016/j.bbrc.2017.06.055
10.1007/s13277-015-3860-x
10.1016/j.cellsig.2013.02.006
10.1016/j.biopha.2018.05.123
10.1155/2017/7439698
10.3892/mmr.2017.7081
10.1016/j.bbrc.2016.08.030
10.1002/jcb.25960
10.1038/cdd.2013.110
10.18632/oncotarget.10108
10.1016/j.canlet.2018.01.036
10.1038/cddis.2015.203
10.1186/s12967-016-1100-9
10.3389/fgene.2018.00471
10.1016/j.febslet.2008.05.012
10.1038/377552a0
10.1002/mc.22120
10.1016/j.taap.2015.04.003
10.18632/oncotarget.13980
10.1093/carcin/bgu055
10.1158/1535-7163.MCT-14-0492
10.18632/oncotarget.1902
10.1186/1756-0500-6-518
10.1186/s12890-019-0991-7
10.1080/07357907.2017.1416393
10.1159/000475637
10.1002/jcp.28209
10.1038/onc.2008.373
10.1038/srep31093
10.2174/1871520618666180808125459
10.1016/S0092-8674(88)91065-3
10.18632/oncotarget.11518
10.1080/15384047.2018.1529110
10.1155/2019/2476175
10.1002/jcb.27782
10.1016/j.cell.2007.05.022
10.1016/j.biopha.2017.07.120
10.3389/fendo.2018.00405
10.2147/OTT.S157551
10.1038/ng.710
10.1016/j.bbadis.2013.05.005
10.1136/jim-2019-001080
10.1158/1538-7445.AM2017-1895
10.3727/096504017X15009792179602
10.1016/j.canlet.2015.11.024
10.1111/cas.14039
10.1016/j.bbrc.2013.05.101
10.2147/OTT.S235336
ContentType Journal Article
Copyright 2020 International Union of Biochemistry and Molecular Biology
2020 International Union of Biochemistry and Molecular Biology.
2021 International Union of Biochemistry and Molecular Biology
Copyright_xml – notice: 2020 International Union of Biochemistry and Molecular Biology
– notice: 2020 International Union of Biochemistry and Molecular Biology.
– notice: 2021 International Union of Biochemistry and Molecular Biology
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1002/iub.2430
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
CrossRef

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
Chemistry
EISSN 1521-6551
EndPage 327
ExternalDocumentID 33369006
10_1002_iub_2430
IUB2430
Genre reviewArticle
Research Support, Non-U.S. Gov't
Journal Article
Review
GrantInformation_xml – fundername: University of Tabriz
GroupedDBID ---
-~X
.55
.GJ
05W
0R~
1OC
24P
29J
31~
33P
36B
3O-
3SF
3WU
4.4
50Y
52U
53G
5GY
5RE
5VS
8-1
8UM
A00
AAESR
AAEVG
AAHHS
AAHQN
AAIHA
AAMNL
AANLZ
AAONW
AASGY
AAXRX
AAYCA
AAZKR
ABCUV
ABJNI
ACAHQ
ACCFJ
ACCZN
ACGEJ
ACGFO
ACGFS
ACPOU
ACPRK
ACXBN
ACXQS
ADBBV
ADEOM
ADIZJ
ADKYN
ADMGS
ADOZA
ADXAS
ADXPE
ADZMN
ADZOD
AEEZP
AEGXH
AEIGN
AEIMD
AENEX
AEQDE
AEUYR
AFBPY
AFFPM
AFGKR
AFPWT
AFWVQ
AFZJQ
AHBTC
AIAGR
AITYG
AIURR
AIWBW
AJBDE
AJXKR
ALMA_UNASSIGNED_HOLDINGS
ALUQN
ALVPJ
AMBMR
AMYDB
ATUGU
AUFTA
AZVAB
BFHJK
BHBCM
BMNLL
BMXJE
BNHUX
BOGZA
BRXPI
CAG
COF
CS3
DCZOG
DPXWK
DRFUL
DRSTM
DU5
EBS
EJD
EMOBN
ESX
F5P
G-S
GODZA
HF~
HGLYW
HZ~
LATKE
LEEKS
LH4
LITHE
LOXES
LUTES
LW6
LYRES
MEWTI
MRFUL
MRSTM
MSFUL
MSSTM
MXFUL
MXSTM
MY~
O66
O9-
OIG
OK1
OVD
P2W
P4E
QRW
R.K
ROL
RX1
SUPJJ
TEORI
V2E
WBKPD
WIH
WIK
WIN
WNSPC
WOHZO
WXSBR
WYISQ
WYJ
X7M
XV2
ZGI
ZXP
ZZTAW
~KM
~S-
AAMMB
AAYXX
AEFGJ
AEYWJ
AGHNM
AGXDD
AGYGG
AIDQK
AIDYY
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
ID FETCH-LOGICAL-c3490-183c5cc2ecdbee68524b5161f341c8c837cb49f4dcbe4e7a849f69b94728f86c3
IEDL.DBID WIN
ISICitedReferencesCount 34
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000601411500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1521-6543
1521-6551
IngestDate Sun Nov 09 09:07:46 EST 2025
Fri Jul 25 11:52:57 EDT 2025
Thu Apr 03 07:05:05 EDT 2025
Sat Nov 29 06:10:42 EST 2025
Tue Nov 18 20:54:52 EST 2025
Wed Jan 22 16:32:12 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords lncRNAs
lung cancer
diagnosis
molecular biomarkers
prognosis
Language English
License 2020 International Union of Biochemistry and Molecular Biology.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3490-183c5cc2ecdbee68524b5161f341c8c837cb49f4dcbe4e7a849f69b94728f86c3
Notes Funding information
University of Tabriz
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0002-7217-7521
PMID 33369006
PQID 2484183296
PQPubID 1026336
PageCount 21
ParticipantIDs proquest_miscellaneous_2473409890
proquest_journals_2484183296
pubmed_primary_33369006
crossref_citationtrail_10_1002_iub_2430
crossref_primary_10_1002_iub_2430
wiley_primary_10_1002_iub_2430_IUB2430
PublicationCentury 2000
PublicationDate February 2021
2021-02-00
20210201
PublicationDateYYYYMMDD 2021-02-01
PublicationDate_xml – month: 02
  year: 2021
  text: February 2021
PublicationDecade 2020
PublicationPlace Hoboken, USA
PublicationPlace_xml – name: Hoboken, USA
– name: England
– name: Oxford
PublicationTitle IUBMB life
PublicationTitleAlternate IUBMB Life
PublicationYear 2021
Publisher John Wiley & Sons, Inc
Wiley Subscription Services, Inc
Publisher_xml – name: John Wiley & Sons, Inc
– name: Wiley Subscription Services, Inc
References 2019; 2019
2015c; 285
2020a; 48
2019; 11
2015; 75
2019; 17
2019; 19
2014; 24
2020; 13
1995; 377
2007; 72
2020; 11
2020; 10
2017b; 90
2013; 8
2016; 37
2008; 582
2017b; 94
2018; 9
2019; 20
2017b; 475
2015a; 35
2017; 77
2018a; 36
2019; 23
2019; 25
2014; 18
2018a; 495
2016a; 15
2018; 38
2013a; 32
2011; 2
2017a; 2017
2018; 105
2017; 65
2015; 54
2019; 38
2018b; 26
2017a; 16
2020; 35
2018; 22
2016; 13
2018; 26
2017; 50
2016; 6
2018; 18
2018; 17
2016; 7
2010; 42
2013; 73
2014; 35
2020; 24
2018b; 11
2014a; 85
2020; 21
2016a; 38
2018; 11
2018c; 418
2018; 98
2018; 16
2016; 8
2016; 9
2016; 24
2018b; 18
2003; 22
2015; 35
2017; 6
2017b; 44
2017a; 8
2017; 8
2015; 36
2017; 41
2013; 25
2017; 3
2017; 45
2016; 76
2020; 129
2020; 56
2017a; 490
2017; 9
2020b; 43
2014b; 7
2019; 120
2014; 5
2013; 13
2017; 39
2017; 38
2020c; 20
2013; 436
2015a; 8
2019; 234
2020; 48
2016; 478
2017c; 16
2014; 7
2019; 110
2016a; 95
2014; 512
2015; 14
2015; 17
2007; 129
2015; 6
2015; 5
1988a; 54
2013; 1832
2017; 25
2019; 77
2018a; 24
2016b; 14
2019; 76
2017; 21
2013a; 6
2015; 10
2017c; 21
2011; 35
2014; 110
2009; 136
2018; 68
2009; 28
2013b; 20
2015; 154
2019
2017
2017a; 42
2020; 68
2017; 103
2018a; 9
2016; 371
e_1_2_9_75_1
e_1_2_9_98_1
e_1_2_9_52_1
Wang H‐M (e_1_2_9_135_1) 2015; 8
e_1_2_9_79_1
e_1_2_9_94_1
e_1_2_9_10_1
e_1_2_9_56_1
Jing H (e_1_2_9_89_1) 2018; 24
e_1_2_9_90_1
Zhuang Y (e_1_2_9_21_1) 2017; 9
Naemura M (e_1_2_9_114_1) 2018; 38
Cai Y (e_1_2_9_113_1) 2018; 22
e_1_2_9_71_1
e_1_2_9_126_1
e_1_2_9_122_1
Lin H (e_1_2_9_26_1) 2018; 16
e_1_2_9_14_1
e_1_2_9_141_1
e_1_2_9_37_1
e_1_2_9_18_1
Sun S (e_1_2_9_107_1) 2017; 21
e_1_2_9_41_1
e_1_2_9_64_1
e_1_2_9_87_1
e_1_2_9_22_1
e_1_2_9_45_1
e_1_2_9_68_1
e_1_2_9_83_1
e_1_2_9_6_1
e_1_2_9_119_1
e_1_2_9_60_1
e_1_2_9_2_1
e_1_2_9_138_1
e_1_2_9_111_1
e_1_2_9_115_1
e_1_2_9_49_1
Wu B (e_1_2_9_109_1) 2017; 21
e_1_2_9_130_1
Kang Y‐H (e_1_2_9_36_1) 2015; 35
Kumar M (e_1_2_9_103_1) 2016; 76
Khiavi MA (e_1_2_9_134_1) 2020; 10
e_1_2_9_30_1
e_1_2_9_53_1
e_1_2_9_99_1
e_1_2_9_11_1
e_1_2_9_34_1
e_1_2_9_57_1
e_1_2_9_95_1
e_1_2_9_76_1
e_1_2_9_91_1
e_1_2_9_102_1
e_1_2_9_129_1
Nakano Y (e_1_2_9_72_1) 2020; 56
Qu C (e_1_2_9_84_1) 2017; 21
e_1_2_9_106_1
e_1_2_9_15_1
e_1_2_9_140_1
e_1_2_9_19_1
Yang Y‐R (e_1_2_9_121_1) 2014; 7
e_1_2_9_42_1
e_1_2_9_88_1
e_1_2_9_61_1
Jansen BA (e_1_2_9_125_1) 2017; 77
e_1_2_9_46_1
e_1_2_9_23_1
e_1_2_9_65_1
e_1_2_9_80_1
e_1_2_9_5_1
e_1_2_9_137_1
e_1_2_9_118_1
e_1_2_9_133_1
e_1_2_9_9_1
e_1_2_9_27_1
e_1_2_9_69_1
e_1_2_9_110_1
Fan Y‐F (e_1_2_9_38_1) 2019; 25
e_1_2_9_31_1
e_1_2_9_50_1
e_1_2_9_73_1
e_1_2_9_35_1
e_1_2_9_77_1
e_1_2_9_96_1
e_1_2_9_12_1
e_1_2_9_54_1
e_1_2_9_92_1
Chen Q (e_1_2_9_67_1) 2019; 23
Zhao L (e_1_2_9_28_1) 2020; 43
e_1_2_9_101_1
e_1_2_9_128_1
e_1_2_9_105_1
e_1_2_9_124_1
e_1_2_9_39_1
e_1_2_9_16_1
e_1_2_9_58_1
e_1_2_9_143_1
Yue Q (e_1_2_9_74_1) 2018; 22
e_1_2_9_20_1
e_1_2_9_62_1
e_1_2_9_24_1
e_1_2_9_43_1
e_1_2_9_66_1
e_1_2_9_8_1
e_1_2_9_81_1
e_1_2_9_4_1
e_1_2_9_117_1
e_1_2_9_136_1
e_1_2_9_47_1
e_1_2_9_132_1
Lu Y (e_1_2_9_33_1) 2016; 9
e_1_2_9_51_1
e_1_2_9_78_1
e_1_2_9_13_1
e_1_2_9_32_1
e_1_2_9_55_1
e_1_2_9_97_1
e_1_2_9_93_1
e_1_2_9_70_1
e_1_2_9_127_1
e_1_2_9_100_1
e_1_2_9_123_1
e_1_2_9_104_1
e_1_2_9_17_1
e_1_2_9_59_1
e_1_2_9_142_1
Chen L (e_1_2_9_108_1) 2020; 24
e_1_2_9_63_1
e_1_2_9_40_1
Huang C (e_1_2_9_120_1) 2016; 8
e_1_2_9_44_1
e_1_2_9_86_1
e_1_2_9_7_1
e_1_2_9_82_1
e_1_2_9_3_1
Zhao H (e_1_2_9_144_1) 2020; 48
Zhou X (e_1_2_9_139_1) 2019; 11
e_1_2_9_112_1
e_1_2_9_116_1
Fu Z (e_1_2_9_85_1) 2017; 3
e_1_2_9_25_1
e_1_2_9_131_1
e_1_2_9_48_1
Rodchenkov I (e_1_2_9_145_1) 2020; 48
e_1_2_9_29_1
References_xml – volume: 2019
  start-page: 1
  year: 2019
  end-page: 13
  article-title: Low long noncoding RNA growth arrest‐specific transcript 5 expression in the exosomes of lung cancer cells promotes tumor angiogenesis
  publication-title: J Oncol
– volume: 21
  start-page: 504
  year: 2017
  end-page: 510
  article-title: Long non‐coding RNA NEAT1 acts as oncogene in NSCLC by regulating the Wnt signaling pathway
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 6
  start-page: 31093
  year: 2016
  article-title: Downregulation of the long noncoding RNA GAS5‐AS1 contributes to tumor metastasis in non‐small cell lung cancer
  publication-title: Sci Rep
– volume: 42
  start-page: 1113
  year: 2010
  article-title: Large intergenic non‐coding RNA‐RoR modulates reprogramming of human induced pluripotent stem cells
  publication-title: Nat Genet
– volume: 7
  start-page: 51784
  year: 2016
  article-title: Long non‐coding RNA NEAT1 promotes non‐small cell lung cancer progression through regulation of miR‐377‐3p‐E2F3 pathway
  publication-title: Oncotarget
– volume: 20
  start-page: 77
  year: 2020c
  article-title: Prognostic and clinicopathological significance of SNHG6 in human cancers: A meta‐analysis
  publication-title: BMC Cancer
– volume: 16
  start-page: 1060
  year: 2017c
  end-page: 1066
  article-title: Identification of circulating long noncoding RNA HOTAIR as a novel biomarker for diagnosis and monitoring of non–small cell lung cancer
  publication-title: Technol Cancer Res Treat
– volume: 38
  start-page: 371
  year: 2017
  end-page: 381
  article-title: The lncRNA XIST exhibits oncogenic properties via regulation of miR‐449a and Bcl‐2 in human non‐small cell lung cancer
  publication-title: Acta Pharmacol Sin
– volume: 2
  start-page: 829
  year: 2011
  end-page: 840
  article-title: Colorectal neoplasia differentially expressed (CRNDE), a novel gene with elevated expression in colorectal adenomas and adenocarcinomas
  publication-title: Genes Cancer
– volume: 37
  start-page: 3497
  year: 2016
  end-page: 3504
  article-title: The plasma lncRNA acting as fingerprint in non‐small‐cell lung cancer
  publication-title: Tumor Biol
– volume: 7
  start-page: 90
  year: 2014
  article-title: Functions of lncRNA HOTAIR in lung cancer
  publication-title: J Hematol Oncol
– volume: 1832
  start-page: 1613
  year: 2013
  end-page: 1623
  article-title: Long non‐coding RNA GAS5 regulates apoptosis in prostate cancer cell lines
  publication-title: Biochim Biophys Acta
– volume: 15
  start-page: 1082
  year: 2016a
  end-page: 1094
  article-title: Long noncoding RNA PVT1 promotes non–small cell lung Cancer cell proliferation through epigenetically regulating LATS2 expression
  publication-title: Mol Cancer Ther
– volume: 25
  start-page: 2745
  year: 2019
  article-title: lncRNA colorectal neoplasia differentially expressed (CRNDE) promotes proliferation and inhibits apoptosis in non‐small cell lung cancer cells by regulating the miR‐641/CDK6 axis
  publication-title: Med Sci Mon Int Med J Exp Clin Res
– volume: 37
  start-page: 1437
  year: 2016
  end-page: 1444
  article-title: The growth arrest‐specific transcript 5 (GAS5): A pivotal tumor suppressor long noncoding RNA in human cancers
  publication-title: Tumor Biol
– volume: 17
  start-page: 92
  year: 2018
  article-title: Long noncoding RNA AFAP1‐AS1 predicts a poor prognosis and regulates non–small cell lung cancer cell proliferation by epigenetically repressing p21 expression
  publication-title: Mol Cancer
– volume: 8
  start-page: e2997
  year: 2017
  end-page: e2997
  article-title: Long noncoding RNA CRNDE promotes colorectal cancer cell proliferation via epigenetically silencing DUSP5/CDKN1A expression
  publication-title: Cell Death Dis
– volume: 28
  start-page: 195
  year: 2009
  end-page: 208
  article-title: GAS5, a non‐protein‐coding RNA, controls apoptosis and is downregulated in breast cancer
  publication-title: Oncogene
– volume: 234
  start-page: 15619
  year: 2019
  end-page: 15626
  article-title: LINC00052 functions as a tumor suppressor through negatively modulating miR‐330‐3p in pancreatic cancer
  publication-title: J Cell Physiol
– volume: 8
  start-page: 11824
  year: 2015a
  article-title: Upregulated lncRNA‐UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma
  publication-title: Int J Clin Exp Med
– volume: 24
  start-page: 513
  year: 2014
  end-page: 531
  article-title: Human colorectal cancer‐specific CCAT1‐L lncRNA regulates long‐range chromatin interactions at the MYC locus
  publication-title: Cell Res
– volume: 436
  start-page: 319
  year: 2013
  end-page: 324
  article-title: Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease‐free survival in human non‐small cell lung cancer
  publication-title: Biochem Biophys Res Commun
– volume: 38
  start-page: 77
  year: 2018
  end-page: 81
  article-title: The long noncoding RNA OIP5‐AS1 is involved in the regulation of cell proliferation
  publication-title: Anticancer Res
– volume: 48
  start-page: D118
  year: 2020a
  end-page: D126
  article-title: LncTarD: A manually‐curated database of experimentally‐supported functional lncRNA–target regulations in human diseases
  publication-title: Nucleic Acids Res
– volume: 35
  start-page: 351
  year: 2020
  end-page: 361
  article-title: Long noncoding RNA SNHG6 promotes proliferation and inhibits apoptosis in non‐small cell lung cancer cells by regulating miR‐490‐3p/RSF1 axis
  publication-title: Cancer Biother Radiopharm
– volume: 24
  start-page: 4317
  year: 2018a
  end-page: 4323
  article-title: A novel long noncoding RNA (lncRNA), LL22NC03‐N64E9.1, promotes the proliferation of lung cancer cells and is a potential prognostic molecular biomarker for lung cancer
  publication-title: Med Sci Mon Int Med J Exp Clin Res
– volume: 45
  start-page: 9947
  year: 2017
  end-page: 9959
  article-title: Quantitative proteomics reveals that long non‐coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation
  publication-title: Nucleic Acids Res
– volume: 95
  start-page: e4608
  year: 2016a
  article-title: Circulating long noncoding RNA GAS5 is a novel biomarker for the diagnosis of nonsmall cell lung cancer
  publication-title: Medicine
– volume: 136
  start-page: 629
  year: 2009
  end-page: 641
  article-title: Evolution and functions of long noncoding RNAs
  publication-title: Cell
– volume: 18
  start-page: 38
  year: 2018
  article-title: The long non‐coding RNA AK001796 contributes to tumor growth via regulating expression of p53 in esophageal squamous cell carcinoma
  publication-title: Cancer Cell Int
– volume: 377
  start-page: 552
  year: 1995
  end-page: 557
  article-title: Radiation‐induced cell cycle arrest compromised by p21 deficiency
  publication-title: Nature
– volume: 68
  start-page: 394
  year: 2018
  end-page: 424
  article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
  publication-title: CA Cancer J Clin
– volume: 73
  start-page: 1180
  year: 2013
  end-page: 1189
  article-title: The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells
  publication-title: Cancer Res
– volume: 24
  start-page: 1199
  year: 2016
  end-page: 1215
  article-title: CRNDE promotes malignant progression of glioma by attenuating miR‐384/PIWIL4/STAT3 axis
  publication-title: Mol Ther
– volume: 9
  start-page: 939
  year: 2018a
  end-page: 949
  article-title: Long non‐coding RNA OIP5‐AS1 promotes proliferation of lung cancer cells and leads to poor prognosis by targeting miR‐378a‐3p
  publication-title: Thorac Cancer
– volume: 6
  start-page: 518
  year: 2013a
  article-title: Evaluation of long noncoding RNA MALAT1 as a candidate blood‐based biomarker for the diagnosis of non‐small cell lung cancer
  publication-title: BMC Res Notes
– start-page: 1
  year: 2019
  end-page: 13
  article-title: Up‐regulated Linc00472 suppresses development of lung cancer cell via inhibition of MiR‐196b‐5p
  publication-title: Biosci Biotechnol Biochem
– volume: 8
  start-page: 7867
  year: 2017a
  article-title: LncRNA16 is a potential biomarker for diagnosis of early‐stage lung cancer that promotes cell proliferation by regulating the cell cycle
  publication-title: Oncotarget
– volume: 48
  start-page: D489
  year: 2020
  end-page: D497
  article-title: Pathway commons 2019 update: Integration, analysis and exploration of pathway data
  publication-title: Nucleic Acids Res
– volume: 19
  start-page: 638
  year: 2019
  end-page: 644
  article-title: Synergistic effect of novel EGFR inhibitor AZD8931 and p38 alpha siRNA in lung adenocarcinoma cancer cells
  publication-title: Anticancer Agents Med Chem
– volume: 18
  start-page: 1991
  year: 2018b
  end-page: 2005
  article-title: Critical microRNAs in lung cancer: Recent advances and potential applications
  publication-title: Anti‐Cancer Agents Med Chem
– volume: 105
  start-page: 176
  year: 2018
  end-page: 181
  article-title: LncRNA NNT‐AS1 promotes the proliferation, and invasion of lung cancer cells via regulating miR‐129‐5p expression
  publication-title: Biomed Pharmacother
– volume: 98
  start-page: 102
  year: 2018
  end-page: 110
  article-title: Long non‐coding RNA OIP5‐AS1 functions as an oncogene in lung adenocarcinoma through targeting miR‐448/Bcl‐2
  publication-title: Biomed Pharmacother
– volume: 76
  start-page: 3363
  year: 2019
  end-page: 3381
  article-title: Targeted enzyme delivery systems in lysosomal disorders: An innovative form of therapy for mucopolysaccharidosis
  publication-title: Cell Mol Life Sci
– volume: 22
  start-page: 8031
  year: 2003
  end-page: 8041
  article-title: MALAT‐1, a novel noncoding RNA, and thymosin β 4 predict metastasis and survival in early‐stage non‐small cell lung cancer
  publication-title: Oncogene
– volume: 14
  start-page: 346
  year: 2016b
  article-title: LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2
  publication-title: J Transl Med
– volume: 21
  start-page: 3808
  year: 2017c
  end-page: 3812
  article-title: Long non‐coding RNA Loc344887 is a potential prognostic biomarker in non‐small cell lung cancer
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 2017
  start-page: 7439698
  year: 2017a
  article-title: Identification of circulating long noncoding RNA Linc00152 as a novel biomarker for diagnosis and monitoring of non‐small‐cell lung cancer
  publication-title: Dis Markers
– volume: 11
  start-page: 1180
  year: 2020
  end-page: 1190
  article-title: Long non‐coding RNA SNHG6 promotes the growth and invasion of non‐small cell lung cancer by downregulating miR‐101‐3p
  publication-title: Thoracic Cancer
– volume: 6
  start-page: e1858
  year: 2015
  end-page: e1858
  article-title: A novel lncRNA, LUADT1, promotes lung adenocarcinoma proliferation via the epigenetic suppression of p27
  publication-title: Cell Death Dis
– volume: 8
  start-page: 5025
  year: 2016
  end-page: 5034
  article-title: LncRNA PVT1 overexpression is a poor prognostic biomarker and regulates migration and invasion in small cell lung cancer
  publication-title: Am J Transl Res
– volume: 38
  start-page: 176
  year: 2019
  end-page: 183
  article-title: Long noncoding RNA LINC00460 promotes the gefitinib resistance of nonsmall cell lung cancer through epidermal growth factor receptor by sponging miR‐769‐5p
  publication-title: DNA Cell Biol
– volume: 42
  start-page: 2453
  year: 2017a
  end-page: 2466
  article-title: Knockdown of Lncrna PVT1 enhances radiosensitivity in non‐small cell lung cancer by sponging Mir‐195
  publication-title: Cell Physiol Biochem
– volume: 22
  start-page: 1003
  year: 2018
  end-page: 1010
  article-title: Effects of Linc00460 on cell migration and invasion through regulating epithelial‐mesenchymal transition (EMT) in non‐small cell lung cancer
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 110
  start-page: 825
  year: 2019
  end-page: 833
  article-title: Long noncoding RNA CRNDE promotes non‐small cell lung cancer progression via sponging microRNA‐338‐3p
  publication-title: Biomed Pharmacother
– volume: 26
  start-page: 1287
  year: 2018
  end-page: 1298
  article-title: A positive feed‐forward loop between LncRNA‐CYTOR and Wnt/β‐catenin signaling promotes metastasis of colon cancer
  publication-title: Mol Ther
– volume: 25
  start-page: 1086
  year: 2013
  end-page: 1095
  article-title: Long non‐coding RNA ANRIL (CDKN2B‐AS) is induced by the ATM‐E2F1 signaling pathway
  publication-title: Cell Signal
– volume: 512
  start-page: 82
  year: 2014
  end-page: 86
  article-title: PVT1 dependence in cancer with MYC copy‐number increase
  publication-title: Nature
– volume: 21
  start-page: 4087
  year: 2017
  end-page: 4091
  article-title: Long non‐coding RNA ROR is a novel prognosis factor associated with non‐small‐cell lung cancer progression
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 94
  start-page: 644
  year: 2017b
  end-page: 651
  article-title: lncRNA LINC00152 knockdown had effects to suppress biological activity of lung cancer via EGFR/PI3K/AKT pathway
  publication-title: Biomed Pharmacother
– volume: 154
  start-page: 473
  year: 2015
  end-page: 482
  article-title: LINC00472 expression is regulated by promoter methylation and associated with disease‐free survival in patients with grade 2 breast cancer
  publication-title: Breast Cancer Res Treat
– volume: 490
  start-page: 406
  year: 2017a
  end-page: 414
  article-title: Serum long non coding RNA MALAT‐1 protected by exosomes is up‐regulated and promotes cell proliferation and migration in non‐small cell lung cancer
  publication-title: Biochem Biophys Res Commun
– volume: 10
  start-page: 10
  year: 2020
  article-title: PEGylated gold nanoparticles‐ribonuclease induced oxidative stress and apoptosis in colorectal cancer cells
  publication-title: Adv Pharm Bull
– volume: 17
  start-page: 563
  year: 2019
  end-page: 577
  article-title: LINC00472 acts as a tumor suppressor in NSCLC through KLLN‐mediated p53‐signaling pathway via microRNA‐149‐3p and MicroRNA‐4270
  publication-title: Mol Ther Nucleic Acids
– volume: 56
  start-page: 243
  year: 2020
  end-page: 257
  article-title: Clinical importance of long non‐coding RNA LINC00460 expression in EGFR‐mutant lung adenocarcinoma
  publication-title: Int J Oncol
– volume: 7
  start-page: 11696
  year: 2016
  article-title: Long non‐coding RNA LINC01133 represses KLF2, P21 and E‐cadherin transcription through binding with EZH2, LSD1 in non small cell lung cancer
  publication-title: Oncotarget
– volume: 5
  start-page: 2276
  year: 2014
  article-title: Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR‐99a/miR‐449a
  publication-title: Oncotarget
– volume: 120
  start-page: 5055
  year: 2019
  end-page: 5061
  article-title: Investigation of LINC00342 as a poor prognostic biomarker for human patients with non–small cell lung cancer
  publication-title: J Cell Biochem
– volume: 7
  start-page: 6929
  year: 2014b
  article-title: Increased expression of the lncRNA PVT1 promotes tumorigenesis in non‐small cell lung cancer
  publication-title: Int J Clin Exp Pathol
– volume: 37
  start-page: 4127
  year: 2016
  end-page: 4134
  article-title: Long non‐coding RNA PVT1 as a novel biomarker for diagnosis and prognosis of non‐small cell lung cancer
  publication-title: Tumor Biol
– volume: 11
  start-page: 6196
  year: 2019
  article-title: XIST promote the proliferation and migration of non‐small cell lung cancer cells via sponging miR‐16 and regulating CDK8 expression
  publication-title: Am J Transl Res
– volume: 129
  start-page: 1311
  year: 2007
  end-page: 1323
  article-title: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
  publication-title: Cell
– volume: 8
  start-page: e77293
  year: 2013
  article-title: The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21WAF1/CIP1 expression
  publication-title: PLoS One
– volume: 7
  start-page: 62474
  year: 2016
  article-title: Long noncoding RNA CCAT1 acts as an oncogene and promotes chemoresistance in docetaxel‐resistant lung adenocarcinoma cells
  publication-title: Oncotarget
– volume: 35
  start-page: 1751
  year: 2011
  end-page: 1756
  article-title: Expression and function of a large non‐coding RNA gene XIST in human cancer
  publication-title: World J Surg
– volume: 9
  start-page: 2997
  year: 2017
  end-page: 3005
  article-title: Down‐regulation of long non‐coding RNA AFAP1‐AS1 inhibits tumor cell growth and invasion in lung adenocarcinoma
  publication-title: Am J Transl Res
– volume: 14
  start-page: 268
  year: 2015
  end-page: 277
  article-title: Long noncoding RNA ANRIL promotes non–small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 expression
  publication-title: Mol Cancer Ther
– volume: 35
  start-page: 2360
  year: 2015a
  end-page: 2370
  article-title: Overexpression of long non‐coding RNA ZXF2 promotes lung adenocarcinoma progression through c‐Myc pathway
  publication-title: Cell Physiol Biochem
– volume: 475
  start-page: 152
  year: 2017b
  end-page: 156
  article-title: Circulating long non‐coding RNA AFAP1‐AS1 is a potential diagnostic biomarker for non‐small cell lung cancer
  publication-title: Clin Chim Acta
– volume: 11
  start-page: 2333
  year: 2018b
  end-page: 2344
  article-title: Combination of long noncoding RNA MALAT1 and carcinoembryonic antigen for the diagnosis of malignant pleural effusion caused by lung cancer
  publication-title: Onco Targets Ther
– volume: 582
  start-page: 1919
  year: 2008
  end-page: 1927
  article-title: UCA1, a non‐protein‐coding RNA up‐regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion
  publication-title: FEBS Lett
– volume: 18
  start-page: 2425
  year: 2014
  end-page: 2436
  article-title: Long non‐coding RNAs in non‐small cell lung cancer as biomarkers and therapeutic targets
  publication-title: J Cell Mol Med
– volume: 25
  start-page: 1305
  year: 2017
  end-page: 1316
  article-title: Long noncoding RNA GAS5 inhibits tumorigenesis and enhances radiosensitivity by suppressing miR‐135b expression in non‐small cell lung cancer
  publication-title: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
– volume: 8
  start-page: 59435
  year: 2017
  end-page: 59445
  article-title: A novel lncRNA, LL22NC03‐N64E9.1, represses KLF2 transcription through binding with EZH2 in colorectal cancer
  publication-title: Oncotarget
– volume: 11
  start-page: 457
  year: 2020
  article-title: Regulation of glucose and lipid metabolism by long non‐coding RNAs: Facts and research progress
  publication-title: Front Endocrinol
– volume: 9
  start-page: 3077
  year: 2016
  end-page: 3084
  article-title: Long noncoding RNA ANRIL could be transactivated by c‐Myc and promote tumor progression of non‐small‐cell lung cancer
  publication-title: Onco Targets Ther
– volume: 13
  start-page: 98
  year: 2016
  end-page: 108
  article-title: Long non‐coding RNA ANRIL regulates inflammatory responses as a novel component of NF‐κB pathway
  publication-title: RNA Biol
– volume: 478
  start-page: 811
  year: 2016
  end-page: 817
  article-title: Long noncoding RNA XIST acts as an oncogene in non‐small cell lung cancer by epigenetically repressing KLF2 expression
  publication-title: Biochem Biophys Res Commun
– volume: 418
  start-page: 185
  year: 2018c
  end-page: 195
  article-title: Long non‐coding RNA XIST promotes TGF‐β‐induced epithelial‐mesenchymal transition by regulating miR‐367/141‐ZEB2 axis in non‐small‐cell lung cancer
  publication-title: Cancer Lett
– volume: 75
  start-page: 8
  year: 2015
  end-page: 11
  article-title: The up‐regulation of long non‐coding RNA AFAP1‐AS1 is associated with the poor prognosis of NSCLC patients
  publication-title: Biomed Pharmacother
– volume: 44
  start-page: 895
  year: 2017b
  end-page: 902
  article-title: Highly expressed long non‐coding RNA CRNDE promotes cell proliferation through PI3K/AKT signalling in non‐small cell lung carcinoma
  publication-title: Clin Exp Pharmacol Physiol
– volume: 38
  start-page: 2389
  year: 2016a
  end-page: 2400
  article-title: Analysis of long non‐coding RNA expression profiles in non‐small cell lung cancer
  publication-title: Cell Physiol Biochem
– volume: 11
  start-page: 5383
  year: 2018
  article-title: Expression profiles of long noncoding RNAs in lung adenocarcinoma
  publication-title: Onco Targets Ther
– volume: 110
  start-page: 164
  year: 2014
  end-page: 171
  article-title: Amplification of PVT‐1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers
  publication-title: Br J Cancer
– volume: 10
  start-page: 14
  year: 2015
  article-title: Increased expression of the long non‐coding RNA ANRIL promotes lung cancer cell metastasis and correlates with poor prognosis
  publication-title: Diagn Pathol
– volume: 3
  start-page: 1
  year: 2017
  end-page: 10
  article-title: Endogenous miRNA sponge LincRNA‐ROR promotes proliferation, invasion and stem cell‐like phenotype of pancreatic cancer cells
  publication-title: Cell Death Dis
– volume: 68
  start-page: 52
  year: 2020
  end-page: 59
  article-title: lncRNA SLC16A1‐AS1 as a novel prognostic biomarker in non‐small cell lung cancer
  publication-title: J Invest Med
– volume: 9
  start-page: 405
  year: 2018
  end-page: 405
  article-title: ANRIL: A lncRNA at the CDKN2A/B locus with roles in cancer and metabolic disease
  publication-title: Front Endocrinol (Lausanne)
– volume: 36
  start-page: 7465
  year: 2015
  end-page: 7471
  article-title: A novel long noncoding RNA LINC01133 is upregulated in lung squamous cell cancer and predicts survival
  publication-title: Tumour Biol
– volume: 371
  start-page: 99
  year: 2016
  end-page: 106
  article-title: LncRNA‐UCA1 exerts oncogenic functions in non‐small cell lung cancer by targeting miR‐193a‐3p
  publication-title: Cancer Lett
– volume: 19
  start-page: 1
  year: 2019
  end-page: 6
  article-title: LncRNA LUADT1 sponges miR‐15a‐3p to upregulate Twist1 in small cell lung cancer
  publication-title: BMC Pulm Med
– volume: 6
  start-page: 12
  year: 2017
  article-title: Major tumor suppressor and oncogenic non‐coding RNAs: Clinical relevance in lung cancer
  publication-title: Cell
– volume: 77
  start-page: 1895
  year: 2017
  end-page: 1895
  article-title: Abstract 1895: A conserved E2F1‐activated gene regulatory network encompassing monocarboxylic acid transporter‐1, its co‐operating antisense lncRNA SLC16A1‐AS1 and their common downstream targets mediates bladder cancer invasiveness
  publication-title: Cancer Res
– volume: 35
  start-page: 1510
  year: 2014
  end-page: 1515
  article-title: HOTAIR long non‐coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients
  publication-title: Carcinogenesis
– volume: 72
  start-page: 1161
  year: 2007
  end-page: 1178
  article-title: Noncoding RNAs
  publication-title: Biochemistry (Moscow)
– volume: 37
  start-page: 729
  year: 2016
  end-page: 737
  article-title: AFAP1‐AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis
  publication-title: Tumor Biol
– volume: 26
  start-page: 537
  year: 2018b
  end-page: 546
  article-title: Long noncoding RNA urothelial carcinoma‐associated 1 promotes the proliferation and metastasis of human lung tumor cells by regulating MicroRNA‐144
  publication-title: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
– volume: 43
  start-page: 1045
  year: 2020b
  end-page: 1052
  article-title: Long non‐coding RNA CCAT1 enhances human non‐small cell lung cancer growth through downregulation of microRNA‐218
  publication-title: Oncol Rep
– volume: 20
  start-page: 1558
  year: 2013b
  end-page: 1568
  article-title: Negative regulation of lncRNA GAS5 by miR‐21
  publication-title: Cell Death Differ
– volume: 21
  start-page: 179
  year: 2020
  end-page: 191
  article-title: Role of LINC00152 in non‐small cell lung cancer
  publication-title: J Zhejiang Univ Sci B
– volume: 38
  year: 2018
  article-title: Long noncoding RNA CYTOR sponges miR‐195 to modulate proliferation, migration, invasion and radiosensitivity in nonsmall cell lung cancer cells
  publication-title: Biosci Rep
– volume: 495
  start-page: 2350
  year: 2018a
  end-page: 2355
  article-title: Long non‐coding RNA PVT1‐5 promotes cell proliferation by regulating miR‐126/SLC7A5 axis in lung cancer
  publication-title: Biochem Biophys Res Commun
– volume: 24
  start-page: 4810
  year: 2020
  end-page: 4821
  article-title: LncRNA NEAT1 regulated cell proliferation, invasion, migration and apoptosis by targeting has‐miR‐376b‐3p/SULF1 axis in non‐small cell lung cancer
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 54
  start-page: 787
  year: 1988a
  end-page: 793
  article-title: Genes specifically expressed at growth arrest of mammalian cells
  publication-title: Cell
– volume: 16
  start-page: 1809
  year: 2018
  end-page: 1814
  article-title: Overexpression of the long noncoding RNA CCAT1 promotes metastasis via epithelial‐to‐mesenchymal transition in lung adenocarcinoma
  publication-title: Oncol Lett
– volume: 50
  start-page: 1729
  year: 2017
  end-page: 1738
  article-title: Identification of circulating long non‐coding RNA GAS5 as a potential biomarker for non‐small cell lung cancer diagnosisnon‐small cell lung cancer, long non‐coding RNA, plasma, GAS5, biomarker
  publication-title: Int J Oncol
– volume: 39
  year: 2017
  article-title: Silencing long non‐coding RNA ROR improves sensitivity of non‐small‐cell lung cancer to cisplatin resistance by inhibiting PI3K/Akt/mTOR signaling pathway
  publication-title: Tumor Biol
– volume: 36
  start-page: 37
  year: 2018a
  end-page: 58
  article-title: Potential molecular targets in the treatment of lung cancer using siRNA technology
  publication-title: Cancer Invest
– volume: 9
  start-page: 471
  year: 2018
  article-title: Long non‐coding RNA NEAT1: A novel target for diagnosis and therapy in human tumors
  publication-title: Front Genet
– volume: 17
  start-page: 47
  year: 2015
  article-title: Unique features of long non‐coding RNA biogenesis and function
  publication-title: Nat Rev Genet
– volume: 10
  start-page: 645
  year: 2015
  end-page: 654
  article-title: Identification and validation of long noncoding RNA biomarkers in human non–small‐cell lung carcinomas
  publication-title: J Thorac Oncol
– volume: 76
  start-page: 1598
  year: 2016
  end-page: 1598
  article-title: Abstract 1598: LncRNA AK001796 as a therapeutic target in aggressive breast cancers
  publication-title: Cancer Res
– volume: 129
  start-page: 110239
  year: 2020
  article-title: SPI1‐induced upregulation of lncRNA SNHG6 promotes non‐small cell lung cancer via miR‐485‐3p/VPS45 axis
  publication-title: Biomed Pharmacother
– volume: 22
  start-page: 4879
  year: 2018
  end-page: 4887
  article-title: LncRNA NNT‐AS1 is a major mediator of cisplatin chemoresistance in non‐small cell lung cancer through MAPK/slug pathway
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 41
  start-page: 2221
  year: 2017
  end-page: 2229
  article-title: The long non‐coding RNA XIST controls non‐small cell lung cancer proliferation and invasion by modulating miR‐186‐5p
  publication-title: Cell Physiol Biochem
– year: 2017
  article-title: Interaction of lincRNA ROR and p53/miR‐145 correlates with lung cancer stem cell signatures
  publication-title: J Cell Biochem
– volume: 35
  start-page: 2795
  year: 2015
  end-page: 2803
  article-title: Down‐regulation of phospholipase D stimulates death of lung cancer cells involving up‐regulation of the long ncRNA ANRIL
  publication-title: Anticancer Res
– volume: 90
  start-page: 456
  year: 2017b
  end-page: 463
  article-title: The NmrA‐like family domain containing 1 pseudogene Loc344887 is amplified in gallbladder cancer and promotes epithelial–mesenchymal transition
  publication-title: Chem Biol Drug Des
– volume: 13
  start-page: 921
  year: 2020
  article-title: Long noncoding RNA SNHG6 functions as an oncogene in non‐small cell lung cancer via modulating ETS1 signaling
  publication-title: Onco Targets Ther
– volume: 20
  start-page: 368
  year: 2019
  end-page: 380
  article-title: Long non‐coding RNA LINC01133 silencing exerts antioncogenic effect in pancreatic cancer through the methylation of DKK1 promoter and the activation of Wnt signaling pathway
  publication-title: Cancer Biol Ther
– volume: 65
  start-page: 94
  year: 2017
  end-page: 101
  article-title: A three‐lncRNA signature derived from the Atlas of ncRNA in cancer (TANRIC) database predicts the survival of patients with head and neck squamous cell carcinoma
  publication-title: Oral Oncol
– volume: 32
  start-page: 61
  year: 2013a
  end-page: 69
  article-title: Loss of microRNA‐143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2‐p53 feedback loop
  publication-title: Oncogene
– volume: 23
  start-page: 7408
  year: 2019
  end-page: 7418
  article-title: LncRNA LINC00342 regulated cell growth and metastasis in non‐small cell lung cancer via targeting miR‐203a‐3p
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 54
  start-page: E1
  year: 2015
  end-page: E12
  article-title: A critical role for the long non‐coding RNA GAS5 in proliferation and apoptosis in non‐small‐cell lung cancer
  publication-title: Mol Carcinog
– volume: 11
  start-page: 7739
  year: 2019
  article-title: Long non‐coding RNA NNT‐AS1 functions as an oncogenic gene through modulating miR‐485/BCL9 in cholangiocarcinoma
  publication-title: Cancer Manag Res
– volume: 285
  start-page: 79
  year: 2015c
  end-page: 88
  article-title: A novel long noncoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer
  publication-title: Toxicol Appl Pharmacol
– volume: 13
  start-page: 464
  year: 2013
  article-title: The long non‐coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non‐small cell lung cancer
  publication-title: BMC Cancer
– volume: 16
  start-page: 4107
  year: 2017a
  end-page: 4112
  article-title: Long non‐coding RNA AK001796 contributes to cisplatin resistance of non‐small cell lung cancer
  publication-title: Mol Med Rep
– volume: 5
  start-page: 11516
  year: 2015
  article-title: Identification of the long non‐coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer
  publication-title: Sci Rep
– volume: 77
  start-page: 997
  year: 2019
  end-page: 1019
  article-title: Multifunctional nanomedicines for targeting epidermal growth factor receptor in colorectal cancer
  publication-title: Cell Mol Life Sci
– volume: 110
  start-page: 2211
  year: 2019
  end-page: 2225
  article-title: Long noncoding RNA Actin filament‐associated protein 1 antisense RNA 1 promotes malignant phenotype through binding with lysine‐specific demethylase 1 and repressing HMG box‐containing protein 1 in non‐small‐cell lung cancer
  publication-title: Cancer Sci
– volume: 110
  start-page: 289
  year: 2019
  end-page: 302
  article-title: Downregulation of long non‐coding RNA Opa interacting protein 5‐antisense RNA 1 inhibits breast cancer progression by targeting sex‐determining region Y‐box 2 by micro RNA‐129‐5p upregulation
  publication-title: Cancer Sci
– volume: 85
  start-page: 110
  year: 2014a
  end-page: 115
  article-title: Analysis of lncRNA expression profiles in non‐small cell lung cancers (NSCLC) and their clinical subtypes
  publication-title: Lung Cancer
– volume: 103
  start-page: 229
  year: 2017
  end-page: 236
  article-title: MicroRNA‐21 and long non‐coding RNA MALAT1 are overexpressed markers in medullary thyroid carcinoma
  publication-title: Exp Mol Pathol
– ident: e_1_2_9_43_1
  doi: 10.1631/jzus.B1900312
– ident: e_1_2_9_110_1
  doi: 10.1111/cbdd.12967
– ident: e_1_2_9_15_1
  doi: 10.1038/srep11516
– ident: e_1_2_9_63_1
  doi: 10.1186/1471-2407-13-464
– ident: e_1_2_9_39_1
  doi: 10.1016/j.biopha.2018.12.024
– ident: e_1_2_9_79_1
  doi: 10.1007/s13277-015-3460-9
– ident: e_1_2_9_104_1
  doi: 10.1007/s13277-015-4023-9
– ident: e_1_2_9_45_1
  doi: 10.2147/OTT.S167633
– ident: e_1_2_9_40_1
  doi: 10.1111/1440-1681.12780
– ident: e_1_2_9_88_1
  doi: 10.18632/oncotarget.19738
– ident: e_1_2_9_129_1
  doi: 10.1089/cbr.2019.3120
– ident: e_1_2_9_20_1
  doi: 10.1016/j.cca.2017.10.027
– ident: e_1_2_9_77_1
  doi: 10.1007/s10549-015-3632-8
– ident: e_1_2_9_5_1
  doi: 10.1016/j.bbrc.2017.12.114
– volume: 24
  start-page: 4810
  year: 2020
  ident: e_1_2_9_108_1
  article-title: LncRNA NEAT1 regulated cell proliferation, invasion, migration and apoptosis by targeting has‐miR‐376b‐3p/SULF1 axis in non‐small cell lung cancer
  publication-title: Eur Rev Med Pharmacol Sci
– ident: e_1_2_9_73_1
  doi: 10.1089/dna.2018.4462
– ident: e_1_2_9_90_1
  doi: 10.1007/s00018-019-03135-z
– volume: 11
  start-page: 6196
  year: 2019
  ident: e_1_2_9_139_1
  article-title: XIST promote the proliferation and migration of non‐small cell lung cancer cells via sponging miR‐16 and regulating CDK8 expression
  publication-title: Am J Transl Res
– ident: e_1_2_9_80_1
  doi: 10.18632/oncotarget.7077
– volume: 21
  start-page: 3808
  year: 2017
  ident: e_1_2_9_109_1
  article-title: Long non‐coding RNA Loc344887 is a potential prognostic biomarker in non‐small cell lung cancer
  publication-title: Eur Rev Med Pharmacol Sci
– ident: e_1_2_9_4_1
  doi: 10.2174/1871520619666190301125203
– ident: e_1_2_9_138_1
  doi: 10.1007/s00268-010-0951-0
– ident: e_1_2_9_16_1
  doi: 10.1111/jcmm.12431
– ident: e_1_2_9_52_1
  doi: 10.1097/MD.0000000000004608
– ident: e_1_2_9_71_1
  doi: 10.1016/j.oraloncology.2016.12.017
– ident: e_1_2_9_131_1
  doi: 10.1111/1759-7714.13371
– ident: e_1_2_9_62_1
  doi: 10.1177/1533034617723754
– ident: e_1_2_9_56_1
  doi: 10.3727/096504017X14850182723737
– volume: 25
  start-page: 2745
  year: 2019
  ident: e_1_2_9_38_1
  article-title: lncRNA colorectal neoplasia differentially expressed (CRNDE) promotes proliferation and inhibits apoptosis in non‐small cell lung cancer cells by regulating the miR‐641/CDK6 axis
  publication-title: Med Sci Mon Int Med J Exp Clin Res
– ident: e_1_2_9_66_1
  doi: 10.1371/journal.pone.0077293
– ident: e_1_2_9_37_1
  doi: 10.1177/1947601911431081
– ident: e_1_2_9_70_1
  doi: 10.1159/000445591
– ident: e_1_2_9_69_1
  doi: 10.1134/S0006297907110016
– ident: e_1_2_9_8_1
  doi: 10.1016/j.cell.2009.02.006
– volume: 56
  start-page: 243
  year: 2020
  ident: e_1_2_9_72_1
  article-title: Clinical importance of long non‐coding RNA LINC00460 expression in EGFR‐mutant lung adenocarcinoma
  publication-title: Int J Oncol
– ident: e_1_2_9_75_1
  doi: 10.1080/09168451.2019.1694404
– ident: e_1_2_9_10_1
  doi: 10.3389/fendo.2020.00457
– ident: e_1_2_9_14_1
  doi: 10.1097/JTO.0000000000000470
– ident: e_1_2_9_59_1
  doi: 10.1007/s13277-015-4521-9
– ident: e_1_2_9_13_1
  doi: 10.1007/s00018-019-03305-z
– ident: e_1_2_9_98_1
  doi: 10.1093/nar/gkx600
– ident: e_1_2_9_3_1
  doi: 10.3390/cells6020012
– ident: e_1_2_9_119_1
  doi: 10.1159/000480209
– ident: e_1_2_9_78_1
  doi: 10.1016/j.omtn.2019.06.003
– ident: e_1_2_9_83_1
  doi: 10.1038/onc.2012.28
– ident: e_1_2_9_111_1
  doi: 10.2147/CMAR.S207801
– volume: 10
  start-page: 10
  year: 2020
  ident: e_1_2_9_134_1
  article-title: PEGylated gold nanoparticles‐ribonuclease induced oxidative stress and apoptosis in colorectal cancer cells
  publication-title: Adv Pharm Bull
– ident: e_1_2_9_124_1
  doi: 10.1007/s13277-015-4261-x
– ident: e_1_2_9_102_1
  doi: 10.1186/s12935-018-0537-8
– ident: e_1_2_9_116_1
  doi: 10.1111/1759-7714.12767
– ident: e_1_2_9_94_1
  doi: 10.1038/sj.onc.1206928
– ident: e_1_2_9_2_1
  doi: 10.3322/caac.21492
– ident: e_1_2_9_9_1
  doi: 10.1038/nrg.2015.10
– volume: 9
  start-page: 2997
  year: 2017
  ident: e_1_2_9_21_1
  article-title: Down‐regulation of long non‐coding RNA AFAP1‐AS1 inhibits tumor cell growth and invasion in lung adenocarcinoma
  publication-title: Am J Transl Res
– ident: e_1_2_9_44_1
  doi: 10.1042/BSR20181599
– volume: 38
  start-page: 77
  year: 2018
  ident: e_1_2_9_114_1
  article-title: The long noncoding RNA OIP5‐AS1 is involved in the regulation of cell proliferation
  publication-title: Anticancer Res
– ident: e_1_2_9_128_1
  doi: 10.1186/s12885-020-6530-3
– ident: e_1_2_9_65_1
  doi: 10.1186/s13045-014-0090-4
– volume: 21
  start-page: 504
  year: 2017
  ident: e_1_2_9_107_1
  article-title: Long non‐coding RNA NEAT1 acts as oncogene in NSCLC by regulating the Wnt signaling pathway
  publication-title: Eur Rev Med Pharmacol Sci
– ident: e_1_2_9_11_1
  doi: 10.1016/j.lungcan.2014.05.011
– ident: e_1_2_9_117_1
  doi: 10.1111/cas.13879
– ident: e_1_2_9_19_1
  doi: 10.1016/j.biopha.2015.07.003
– ident: e_1_2_9_115_1
  doi: 10.1016/j.biopha.2017.12.031
– ident: e_1_2_9_132_1
  doi: 10.1016/j.biopha.2020.110239
– ident: e_1_2_9_143_1
  doi: 10.1038/aps.2016.133
– ident: e_1_2_9_42_1
  doi: 10.1038/mt.2016.71
– ident: e_1_2_9_25_1
  doi: 10.1038/cr.2014.35
– ident: e_1_2_9_86_1
  doi: 10.1177/1010428317697568
– ident: e_1_2_9_93_1
  doi: 10.1016/j.yexmp.2017.10.002
– volume: 43
  start-page: 1045
  year: 2020
  ident: e_1_2_9_28_1
  article-title: Long non‐coding RNA CCAT1 enhances human non‐small cell lung cancer growth through downregulation of microRNA‐218
  publication-title: Oncol Rep
– ident: e_1_2_9_34_1
  doi: 10.1080/15476286.2015.1122164
– ident: e_1_2_9_96_1
  doi: 10.1158/0008-5472.CAN-12-2850
– ident: e_1_2_9_31_1
  doi: 10.1186/s13000-015-0247-7
– ident: e_1_2_9_24_1
  doi: 10.1186/s12943-018-0836-7
– ident: e_1_2_9_47_1
  doi: 10.1016/j.ymthe.2018.02.024
– ident: e_1_2_9_122_1
  doi: 10.1158/1535-7163.MCT-15-0707
– ident: e_1_2_9_123_1
  doi: 10.1038/bjc.2013.698
– volume: 76
  start-page: 1598
  year: 2016
  ident: e_1_2_9_103_1
  article-title: Abstract 1598: LncRNA AK001796 as a therapeutic target in aggressive breast cancers
  publication-title: Cancer Res
  doi: 10.1158/1538-7445.AM2016-1598
– ident: e_1_2_9_118_1
  doi: 10.1038/nature13311
– ident: e_1_2_9_57_1
  doi: 10.3892/ijo.2017.3925
– ident: e_1_2_9_17_1
  doi: 10.1159/000374038
– ident: e_1_2_9_41_1
  doi: 10.1038/cddis.2017.328
– ident: e_1_2_9_95_1
  doi: 10.1016/j.bbrc.2017.06.055
– ident: e_1_2_9_18_1
  doi: 10.1007/s13277-015-3860-x
– volume: 48
  start-page: D118
  year: 2020
  ident: e_1_2_9_144_1
  article-title: LncTarD: A manually‐curated database of experimentally‐supported functional lncRNA–target regulations in human diseases
  publication-title: Nucleic Acids Res
– ident: e_1_2_9_29_1
  doi: 10.1016/j.cellsig.2013.02.006
– ident: e_1_2_9_112_1
  doi: 10.1016/j.biopha.2018.05.123
– ident: e_1_2_9_46_1
  doi: 10.1155/2017/7439698
– volume: 8
  start-page: 5025
  year: 2016
  ident: e_1_2_9_120_1
  article-title: LncRNA PVT1 overexpression is a poor prognostic biomarker and regulates migration and invasion in small cell lung cancer
  publication-title: Am J Transl Res
– ident: e_1_2_9_101_1
  doi: 10.3892/mmr.2017.7081
– ident: e_1_2_9_140_1
  doi: 10.1016/j.bbrc.2016.08.030
– ident: e_1_2_9_87_1
  doi: 10.1002/jcb.25960
– ident: e_1_2_9_53_1
  doi: 10.1038/cdd.2013.110
– volume: 23
  start-page: 7408
  year: 2019
  ident: e_1_2_9_67_1
  article-title: LncRNA LINC00342 regulated cell growth and metastasis in non‐small cell lung cancer via targeting miR‐203a‐3p
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 7
  start-page: 6929
  year: 2014
  ident: e_1_2_9_121_1
  article-title: Increased expression of the lncRNA PVT1 promotes tumorigenesis in non‐small cell lung cancer
  publication-title: Int J Clin Exp Pathol
– ident: e_1_2_9_106_1
  doi: 10.18632/oncotarget.10108
– ident: e_1_2_9_141_1
  doi: 10.1016/j.canlet.2018.01.036
– ident: e_1_2_9_91_1
  doi: 10.1038/cddis.2015.203
– ident: e_1_2_9_99_1
  doi: 10.1186/s12967-016-1100-9
– ident: e_1_2_9_105_1
  doi: 10.3389/fgene.2018.00471
– ident: e_1_2_9_133_1
  doi: 10.1016/j.febslet.2008.05.012
– ident: e_1_2_9_23_1
  doi: 10.1038/377552a0
– ident: e_1_2_9_54_1
  doi: 10.1002/mc.22120
– ident: e_1_2_9_100_1
  doi: 10.1016/j.taap.2015.04.003
– ident: e_1_2_9_127_1
  doi: 10.18632/oncotarget.13980
– ident: e_1_2_9_61_1
  doi: 10.1093/carcin/bgu055
– ident: e_1_2_9_30_1
  doi: 10.1158/1535-7163.MCT-14-0492
– ident: e_1_2_9_32_1
  doi: 10.18632/oncotarget.1902
– ident: e_1_2_9_12_1
  doi: 10.1186/1756-0500-6-518
– ident: e_1_2_9_92_1
  doi: 10.1186/s12890-019-0991-7
– ident: e_1_2_9_6_1
  doi: 10.1080/07357907.2017.1416393
– volume: 22
  start-page: 1003
  year: 2018
  ident: e_1_2_9_74_1
  article-title: Effects of Linc00460 on cell migration and invasion through regulating epithelial‐mesenchymal transition (EMT) in non‐small cell lung cancer
  publication-title: Eur Rev Med Pharmacol Sci
– ident: e_1_2_9_142_1
  doi: 10.1159/000475637
– ident: e_1_2_9_76_1
  doi: 10.1002/jcp.28209
– ident: e_1_2_9_50_1
  doi: 10.1038/onc.2008.373
– ident: e_1_2_9_55_1
  doi: 10.1038/srep31093
– ident: e_1_2_9_7_1
  doi: 10.2174/1871520618666180808125459
– volume: 3
  start-page: 1
  year: 2017
  ident: e_1_2_9_85_1
  article-title: Endogenous miRNA sponge LincRNA‐ROR promotes proliferation, invasion and stem cell‐like phenotype of pancreatic cancer cells
  publication-title: Cell Death Dis
– volume: 8
  start-page: 11824
  year: 2015
  ident: e_1_2_9_135_1
  article-title: Upregulated lncRNA‐UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma
  publication-title: Int J Clin Exp Med
– volume: 35
  start-page: 2795
  year: 2015
  ident: e_1_2_9_36_1
  article-title: Down‐regulation of phospholipase D stimulates death of lung cancer cells involving up‐regulation of the long ncRNA ANRIL
  publication-title: Anticancer Res
– ident: e_1_2_9_49_1
  doi: 10.1016/S0092-8674(88)91065-3
– volume: 24
  start-page: 4317
  year: 2018
  ident: e_1_2_9_89_1
  article-title: A novel long noncoding RNA (lncRNA), LL22NC03‐N64E9.1, promotes the proliferation of lung cancer cells and is a potential prognostic molecular biomarker for lung cancer
  publication-title: Med Sci Mon Int Med J Exp Clin Res
– volume: 16
  start-page: 1809
  year: 2018
  ident: e_1_2_9_26_1
  article-title: Overexpression of the long noncoding RNA CCAT1 promotes metastasis via epithelial‐to‐mesenchymal transition in lung adenocarcinoma
  publication-title: Oncol Lett
– ident: e_1_2_9_27_1
  doi: 10.18632/oncotarget.11518
– ident: e_1_2_9_81_1
  doi: 10.1080/15384047.2018.1529110
– ident: e_1_2_9_58_1
  doi: 10.1155/2019/2476175
– ident: e_1_2_9_68_1
  doi: 10.1002/jcb.27782
– ident: e_1_2_9_60_1
  doi: 10.1016/j.cell.2007.05.022
– volume: 22
  start-page: 4879
  year: 2018
  ident: e_1_2_9_113_1
  article-title: LncRNA NNT‐AS1 is a major mediator of cisplatin chemoresistance in non‐small cell lung cancer through MAPK/slug pathway
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 48
  start-page: D489
  year: 2020
  ident: e_1_2_9_145_1
  article-title: Pathway commons 2019 update: Integration, analysis and exploration of pathway data
  publication-title: Nucleic Acids Res
– ident: e_1_2_9_48_1
  doi: 10.1016/j.biopha.2017.07.120
– ident: e_1_2_9_35_1
  doi: 10.3389/fendo.2018.00405
– volume: 21
  start-page: 4087
  year: 2017
  ident: e_1_2_9_84_1
  article-title: Long non‐coding RNA ROR is a novel prognosis factor associated with non‐small‐cell lung cancer progression
  publication-title: Eur Rev Med Pharmacol Sci
– volume: 9
  start-page: 3077
  year: 2016
  ident: e_1_2_9_33_1
  article-title: Long noncoding RNA ANRIL could be transactivated by c‐Myc and promote tumor progression of non‐small‐cell lung cancer
  publication-title: Onco Targets Ther
– ident: e_1_2_9_97_1
  doi: 10.2147/OTT.S157551
– ident: e_1_2_9_82_1
  doi: 10.1038/ng.710
– ident: e_1_2_9_51_1
  doi: 10.1016/j.bbadis.2013.05.005
– ident: e_1_2_9_126_1
  doi: 10.1136/jim-2019-001080
– volume: 77
  start-page: 1895
  year: 2017
  ident: e_1_2_9_125_1
  article-title: Abstract 1895: A conserved E2F1‐activated gene regulatory network encompassing monocarboxylic acid transporter‐1, its co‐operating antisense lncRNA SLC16A1‐AS1 and their common downstream targets mediates bladder cancer invasiveness
  publication-title: Cancer Res
  doi: 10.1158/1538-7445.AM2017-1895
– ident: e_1_2_9_137_1
  doi: 10.3727/096504017X15009792179602
– ident: e_1_2_9_136_1
  doi: 10.1016/j.canlet.2015.11.024
– ident: e_1_2_9_22_1
  doi: 10.1111/cas.14039
– ident: e_1_2_9_64_1
  doi: 10.1016/j.bbrc.2013.05.101
– ident: e_1_2_9_130_1
  doi: 10.2147/OTT.S235336
SSID ssj0000709
Score 2.4693458
SecondaryResourceType review_article
Snippet Long non‐coding RNAs (lncRNA) have been emerged as a novel class of molecular regulators in cancer. They are dysregulated in many types of cancer; however,...
Long non-coding RNAs (lncRNA) have been emerged as a novel class of molecular regulators in cancer. They are dysregulated in many types of cancer; however,...
SourceID proquest
pubmed
crossref
wiley
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 307
SubjectTerms Biomarkers
Biomarkers, Tumor - genetics
Diagnosis
Epigenetics
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Humans
Invasiveness
lncRNAs
Lung cancer
Lung Neoplasms - diagnosis
Lung Neoplasms - therapy
Medical prognosis
molecular biomarkers
Non-coding RNA
Prognosis
RNA, Long Noncoding - genetics
Tumors
Title Long non‐coding RNAs as potential biomarkers in the prognosis and diagnosis of lung cancer: A review and target analysis
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fiub.2430
https://www.ncbi.nlm.nih.gov/pubmed/33369006
https://www.proquest.com/docview/2484183296
https://www.proquest.com/docview/2473409890
Volume 73
WOSCitedRecordID wos000601411500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVWIB
  databaseName: Wiley Online Library - Journals
  customDbUrl:
  eissn: 1521-6551
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000709
  issn: 1521-6543
  databaseCode: DRFUL
  dateStart: 19990101
  isFulltext: true
  titleUrlDefault: https://onlinelibrary.wiley.com
  providerName: Wiley-Blackwell
– providerCode: PRVWIB
  databaseName: Wiley Online Library Free Content
  customDbUrl:
  eissn: 1521-6551
  dateEnd: 20241207
  omitProxy: false
  ssIdentifier: ssj0000709
  issn: 1521-6543
  databaseCode: WIN
  dateStart: 19990101
  isFulltext: true
  titleUrlDefault: https://onlinelibrary.wiley.com
  providerName: Wiley-Blackwell
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFLZgIMELl41LYVRGQuMpbLWd2OatDComVRWaqOhbZJ84U6WRTE2LBE_8BH4jv4RznKTTBEhIPCVRTuzE9rnFnz8z9gLMkTVSuqTULktU6S2qlEiTNGTKey29cJEyf6pnM7NY2A8dqpLWwrT8ENsfbqQZ0V6TgjvfHF6Shi43_pVQktL1kRrR5gWfTmaXRlhHdAd5p4SWT_a8s0fisH_wqif6Lby8Gq1GdzO5-z8veo_d6YJMPm5HxX12LVS7bG9cYYL9-Ss_4BH2Gf-n77Jbx_2Wb3vs27SuznhVVz-__4CavBo_nY0b7hp-Ua8JV4Sl0oJ9wvSsGr6sOMaPnDBeVd0sUbAqeNGC9_CqLvk52hIONLJWr_mYtwtlolgLQcfTlhTlAZtP3n08fp90mzMkIJWl-WAJKYAIUPgQMpMK5VMMH0t0i2AA817wypaqAB9U0M7gRWa9VVqY0mQgH7Id_J7wmPHSpxmkqtAjT8ymzqdQQgEOsx3p7MgO2Mu-o3LomMtpA43zvOVcFjk2cU5NPGDPt5IXLVvHH2T2-77OO31t8IZRZNxshkVsb2Pr0_SJq0K9IRktMRs2Fot41I6RbSVSysyiARuwgzgU_lp7fjJ_Q8cn_yr4lN0WBKOJQPF9trNebcIzdhO-rJfNasiu64UZshtvTyfz6TCqwC_q0AiW
linkProvider Wiley-Blackwell
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NbtQwELaqglQu_LRQFgoYCZVTaBs7iV1OS0XVFUuEUCt6i-yJg1YqTrXZRYITj9Bn7JN0xt5sVQESEqckysRJbM-f_fkzY69A7WolhEmawuSJbKxGlUqzJHO5tLYQNjWBMn9clKU6PdWfVtjbfi1M5IdYDriRZgR7TQpOA9I716yhk7l9k0qB-fotiXEG7dvwZVRem-Ei4DvIPyW0gLJnnt1Nd_onb_qi3wLMm_FqcDiH9_7rU--zu4s4kw9jx3jAVpxfZxtDjzn2tx98mwfkZxhSX2drB_2ubxvs57j1X7lv_eWvC2jJsfHP5bDjpuPn7YygRVgqrdknWM-04xPPMYTkBPPybTdBQV_zOuL38Kpt-BmaEw7Uuab7fMjjWpkgFlHoeBp5UR6yk8P3xwdHyWJ_hgSE1DQlLCADSB3U1rlcZam0GUaQDXpGUICpL1ipG1mDddIVRuFFrq2WRaoalYN4xFbxf9xjxhub5ZDJutizRG5qbAYN1GAw4RFG7-kBe923VAUL8nLaQ-OsirTLaYVVXFEVD9jLpeR5JOz4g8xW39jVQmU7vKEk2TedYxHL21j7NINivGvnJFMITIiVxiI2YydZvkQIkWu0YQO2HfrCX99ejU7e0fHJvwq-YGtHxx_H1XhUfnjK7qSEqgm48S22OpvO3TN2G77PJt30edCAK9ilCiw
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFD6aOgR74bLBKAwwEhpPYVvsJDY8lY2KiaqaJirtLYpPnKnS5lRNiwRP_AR-437Jzsml0wRISDwlUU7sxPa5xZ8_A7xBvW-0lFlQJFkcqMIaUqkwCiIXK2sTacOspswfJeOxPjszJ2vwoVsL0_BDrH64sWbU9poV3M3yYu-GNXS6tO9CJSlfX1e8h0wP1o9Oh5PRjSFOaoQHe6iAl1B23LP74V737G1v9FuIeTtirV3O8MF_vexDuN9GmmLQDI1HsOb8JmwNPGXZl9_Frqixn_VP9U24d9jt-7YFP0alPxe-9Fc_f2HJrk2cjgeVyCoxKxcMLqJSedU-A3vmlZh6QUGkYKCXL6spCfpc5A2Cj67KQlyQQRHIw2v-XgxEs1qmFmtw6HTaMKM8hsnw09fDz0G7Q0OAUhmeFJYYIYYOc-tcrKNQ2YhiyIJ8I2qk5BetMoXK0TrlkkzTRWysUUmoCx2jfAI9-h73FERhoxgjlScHlulNMxthgTlmlPLIzByYPrzteirFlr6cd9G4SBvi5TClJk65ifvweiU5ayg7_iCz03V22iptRTe0YgtnYipidZtan-dQMu_KJcskklJibaiI7WaQrCqRUsaGrFgfduux8Nfa0-PJRz4--1fBV3D35GiYjo7HX57DRsiwmho4vgO9xXzpXsAd_LaYVvOXrQpcA4hzCtU
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Long+non%E2%80%90coding+RNAs+as+potential+biomarkers+in+the+prognosis+and+diagnosis+of+lung+cancer%3A+A+review+and+target+analysis&rft.jtitle=IUBMB+life&rft.au=Aftabi%2C+Younes&rft.au=Ansarin%2C+Khalil&rft.au=Shanehbandi%2C+Dariush&rft.au=Khalili%2C+Majid&rft.date=2021-02-01&rft.issn=1521-6543&rft.eissn=1521-6551&rft.volume=73&rft.issue=2&rft.spage=307&rft.epage=327&rft_id=info:doi/10.1002%2Fiub.2430&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_iub_2430
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1521-6543&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1521-6543&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1521-6543&client=summon