Syrian hamster embryo (SHE) assay (pH 6.7) coupled with infrared spectroscopy and chemometrics towards toxicological assessment

The Syrian hamster embryo (SHE) assay (pH 6.7) is an in vitro candidate to replace in vivo carcinogenicity tests. However, the conventional method of visual scoring of foci (non-transformed vs. transformed colonies) can be time-consuming and is open to subjectivity. Infrared (IR) spectroscopy has th...

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Veröffentlicht in:	Analyst (London) Jg. 135; H. 12; S. 3266
Hauptverfasser:	Trevisan, Júlio, Angelov, Plamen P, Patel, Imran I, Najand, Ghazal M, Cheung, Karen T, Llabjani, Valon, Pollock, Hubert M, Bruce, Shannon W, Pant, Kamala, Carmichael, Paul L, Scott, Andrew D, Martin, Francis L
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.12.2010
Schlagworte:	Animals Biological Assay - instrumentation Biological Assay - methods Cell Transformation, Neoplastic - drug effects Cricetinae Discriminant Analysis Embryo, Mammalian - cytology Embryo, Mammalian - drug effects Mesocricetus - embryology Organic Chemicals - pharmacology Principal Component Analysis Spectroscopy, Fourier Transform Infrared - instrumentation Spectroscopy, Fourier Transform Infrared - methods
ISSN:	1364-5528, 1364-5528
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