Vanillin and vanillic acid modulate antioxidant defense system via amelioration of metabolic complications linked to Fe2+-induced brain tissues damage

The therapeutic effect of phenolics on neurodegenerative diseases has been attributed to their potent antioxidant properties. In the present study, the neuroprotective activities of vanillin and vanillic acid were investigated in Fe 2+ - induced oxidative toxicity in brain tissues by investigating t...

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Vydané v:Metabolic brain disease Ročník 35; číslo 5; s. 727 - 738
Hlavní autori: Salau, Veronica F., Erukainure, Ochuko L., Ibeji, Collins U., Olasehinde, Tosin A., Koorbanally, Neil A., Islam, Md. Shahidul
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: New York Springer US 01.06.2020
Springer Nature B.V
Predmet:
Acetylcholinesterase
Acids
Activation
Adenosine triphosphatase
Antioxidants
Biochemistry
Biomedical and Life Sciences
Biomedicine
Blood-brain barrier
Brain damage
Brain injury
Catalase
Cell lines
Cholinergics
Complications
Cytotoxicity
Depletion
Glutathione
Hippocampus
Histidine
Iron
Malondialdehyde
Metabolic Diseases
Metabolic pathways
Metabolism
Metabolites
Neurodegenerative diseases
Neurology
Neuroprotection
Neurosciences
Nitric oxide
Nucleotides
Oncology
Original Article
Pentose
Pentose phosphate pathway
Phenols
Restoration
Tissues
Toxicity
Vanillic acid
Vanillin
Vanillic acid
Vanillin
Antioxidant
Neurodegeneration
Phenolics
ISSN:0885-7490, 1573-7365, 1573-7365
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Shrnutí:The therapeutic effect of phenolics on neurodegenerative diseases has been attributed to their potent antioxidant properties. In the present study, the neuroprotective activities of vanillin and vanillic acid were investigated in Fe 2+ - induced oxidative toxicity in brain tissues by investigating their therapeutic effects on oxidative imbalance, cholinergic and nucleotide-hydrolyzing enzymes activities, dysregulated metabolic pathways. Their cytotoxicity was investigated in hippocampal neuronal cell lines (HT22). The reduced glutathione level, SOD and catalase activities were ameliorated in tissues treated with the phenolics, with concomitant depletion of malondialdehyde and nitric oxide levels. They inhibited acetylcholinesterase and butyrylcholinesterase activities, while concomitantly elevated ATPase activity. Treatment with vanillin led to restoration of oxidative-depleted metabolites and reactivation of the pentose phosphate and purine metabolism pathways, with concomitant activation of pathways for histidine and selenoamino metabolisms. While vanillic acid restored and reactivated oxidative-depleted metabolites and pathways but did not activate any additional pathway. Both phenolics portrayed good binding affinity for catalase, with vanillic acid having the higher binding energy of −7.0 kcal/mol. Both phenolics were not cytotoxic on HT22 cells, and their toxicity class were predicted to be 4. Only vanillin was predicted to be permeable across the blood brain barrier (BBB). These results insinuate that vanillin and vanillic acid confer a neuroprotective effect on oxidative brain damage, when vanillin being the most potent.
Bibliografia:ObjectType-Article-1
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ISSN:0885-7490
1573-7365
1573-7365
DOI:10.1007/s11011-020-00545-y