A biomimetic injectable chitosan/alginate hydrogel biocopmosites encapsulating selenium- folic acid nanoparticles for regeneration of spinal cord injury: An in vitro study

Spinal cord injury (SCI) poses significant challenges to regenerative medicine due to its limited self-repair capabilities. In this study, we engineered a biomimetic injectable hydrogel using modified chitosan and alginate biopolymers encapsulating selenium-folic acid nanoparticles (Se-FA NPs) to fa...

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Veröffentlicht in:International journal of biological macromolecules Jg. 288; S. 138682
Hauptverfasser: Farzan, Mahan, Soleimannejad, Mostafa, Shariat, Saeedeh, Heidari Sureshjani, Mina, Gholipour, Abolfazl, Ashrafi Dehkordi, Korosh, Alerasoul Dehkordi, Seyed Mohammad Reza, Farzan, Mahour
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.02.2025
Schlagworte:
alginates
Alginates - chemistry
animal injuries
Animals
bioactive properties
biocompatibility
biocomposites
Biomimetic Materials - chemistry
Biomimetic Materials - pharmacology
biomimetics
biopolymers
cell growth
Cell Proliferation - drug effects
Cell Survival - drug effects
cell viability
chitosan
Chitosan - chemistry
Electrospinning
Folic acid
Folic Acid - chemistry
Folic Acid - pharmacology
gene expression
Humans
Hydrogel
hydrogels
Hydrogels - chemistry
Hydrogels - pharmacology
medicine
nanofibers
nanoparticles
Nanoparticles - chemistry
Oxidized alginate
Selenium - chemistry
Selenium - pharmacology
Selenium nanoparticles
spinal cord
Spinal Cord Injuries - drug therapy
Spinal Cord Injuries - therapy
Spinal cord injury
Spinal Cord Regeneration - drug effects
therapeutics
tissue repair
Oxidized alginate
Electrospinning
Hydrogel
Spinal cord injury
Selenium nanoparticles
Folic acid
ISSN:0141-8130, 1879-0003, 1879-0003
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Zusammenfassung:Spinal cord injury (SCI) poses significant challenges to regenerative medicine due to its limited self-repair capabilities. In this study, we engineered a biomimetic injectable hydrogel using modified chitosan and alginate biopolymers encapsulating selenium-folic acid nanoparticles (Se-FA NPs) to facilitate SCI regeneration. The hydrogel exhibited a unique porous structure attributed to the incorporation of nanofiber fragments, enhancing its biocompatibility and bioactivity. Through a series of in vitro evaluations, including cell viability assays, proliferation studies, gene expression analysis, we assessed the hydrogel's cytocompatibility and its potential for supporting neural cell growth. Our results demonstrate the promising efficacy of the hydrogel in providing a conducive microenvironment for neural tissue regeneration. Moreover, the sustained release of Se-FA NPs from the hydrogel system offers neuroprotective, antioxidative, and anti-inflammatory benefits crucial for SCI therapy. Overall, our biomimetic hydrogel biocomposites hold great potential as a therapeutic strategy for promoting spinal cord regeneration, highlighting their significance in advancing the field of regenerative medicine. [Display omitted]
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2024.138682