Raman imaging of single living cells: probing effects of non-cytotoxic doses of an anti-cancer drug

Identifying cell response to a chemotherapy drug treatment, in particular at the single cell level, is an important issue in patient management. This study aims at evaluating the effect of gemcitabine on single living cells using micro-Raman imaging. We used as a model the non-small lung cancer cell...

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Vydané v:	Analyst (London) Ročník 136; číslo 13; s. 2718
Hlavní autori:	Draux, Florence, Gobinet, Cyril, Sulé-Suso, Josep, Manfait, Michel, Jeannesson, Pierre, Sockalingum, Ganesh D
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 07.07.2011
Predmet:	Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Cell Line, Tumor Cell Proliferation - drug effects Cell Survival Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Deoxycytidine - toxicity DNA - metabolism Dose-Response Relationship, Drug Drug Screening Assays, Antitumor - methods Humans Intracellular Space - drug effects Intracellular Space - metabolism Molecular Imaging - methods Principal Component Analysis Proteins - metabolism Quartz RNA - metabolism Single-Cell Analysis - methods Spectrum Analysis, Raman
ISSN:	1364-5528, 1364-5528
On-line prístup:	Zistit podrobnosti o prístupe
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