A systematic literature review of the association between global brain atrophy and the Expanded Disability Status Scale score in people with multiple sclerosis

Brain atrophy (BA) is a useful predictor of clinical outcomes in people with multiple sclerosis (PwMS). For this reason, MAGNIMS (Magnetic Resonance Imaging in Multiple Sclerosis), an expert consensus group, recommended that global brain volume loss (BVL) is included as a secondary outcome in therap...

Full description

Saved in:
Bibliographic Details
Published in:Therapeutic advances in neurological disorders Vol. 18; p. 17562864241303681
Main Authors: Zivadinov, Robert, Le, Hoa H., Keenan, Alexander, Stocks, Susan Jill
Format: Journal Article
Language:English
Published: England SAGE Publications 01.01.2025
SAGE Publishing
Subjects:
Systematic Review
brain atrophy
brain volume loss
disability
multiple sclerosis
ISSN:1756-2864, 1756-2856, 1756-2864
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Brain atrophy (BA) is a useful predictor of clinical outcomes in people with multiple sclerosis (PwMS). For this reason, MAGNIMS (Magnetic Resonance Imaging in Multiple Sclerosis), an expert consensus group, recommended that global brain volume loss (BVL) is included as a secondary outcome in therapeutic clinical trials. However, there has not been a recent review of the evidence of the association, or strength of association, between global BA and disability in PwMS. Our aim is to review articles from 2013 onward measuring the associations between percentage of brain volume loss (PBVL), normalized brain volumes (NBV) or normalized brain parenchymal volume (NBPV), and the Expanded Disability Status Scale (EDSS), or disability progression (DP) measured by EDSS in PwMS. Systematic review. We searched Medline, Embase, Cochrane Library, Cochrane Clinical Register of Controlled Trials, Cochrane Database of Systematic Reviews and Cumulative Index to Nursing and Allied Health Literature for observational studies, clinical trials and modelling studies measuring the association between global BVL, PBVL, NBV or NBPV, and EDSS score or DP in PwMS. We included people with clinically isolated syndrome and excluded studies with a population greater than 20% primary progressive multiple sclerosis patients. We found 58 studies were eligible for the review. Most longitudinal studies (19/23) observed a significant association between global BVL and change in EDSS score or DP. Similarly the majority of cross-sectional studies (26/29) observed an association between baseline BV measures and EDSS. Most studies investigating the association between baseline brain volume (BV) measures and follow-up EDSS, that is, asking if baseline BV is a predictor of DP, or future EDSS score, did not find an association (4/15 observed an association). Around a 1% (range 0.4%-1.3%) decrease in global BV per year was associated with DP, but caution in comparing studies is recommended due to variations in the definition of DP.
AbstractList Brain atrophy (BA) is a useful predictor of clinical outcomes in people with multiple sclerosis (PwMS). For this reason, MAGNIMS (Magnetic Resonance Imaging in Multiple Sclerosis), an expert consensus group, recommended that global brain volume loss (BVL) is included as a secondary outcome in therapeutic clinical trials. However, there has not been a recent review of the evidence of the association, or strength of association, between global BA and disability in PwMS.BackgroundBrain atrophy (BA) is a useful predictor of clinical outcomes in people with multiple sclerosis (PwMS). For this reason, MAGNIMS (Magnetic Resonance Imaging in Multiple Sclerosis), an expert consensus group, recommended that global brain volume loss (BVL) is included as a secondary outcome in therapeutic clinical trials. However, there has not been a recent review of the evidence of the association, or strength of association, between global BA and disability in PwMS.Our aim is to review articles from 2013 onward measuring the associations between percentage of brain volume loss (PBVL), normalized brain volumes (NBV) or normalized brain parenchymal volume (NBPV), and the Expanded Disability Status Scale (EDSS), or disability progression (DP) measured by EDSS in PwMS.ObjectivesOur aim is to review articles from 2013 onward measuring the associations between percentage of brain volume loss (PBVL), normalized brain volumes (NBV) or normalized brain parenchymal volume (NBPV), and the Expanded Disability Status Scale (EDSS), or disability progression (DP) measured by EDSS in PwMS.Systematic review.DesignSystematic review.We searched Medline, Embase, Cochrane Library, Cochrane Clinical Register of Controlled Trials, Cochrane Database of Systematic Reviews and Cumulative Index to Nursing and Allied Health Literature for observational studies, clinical trials and modelling studies measuring the association between global BVL, PBVL, NBV or NBPV, and EDSS score or DP in PwMS. We included people with clinically isolated syndrome and excluded studies with a population greater than 20% primary progressive multiple sclerosis patients.MethodsWe searched Medline, Embase, Cochrane Library, Cochrane Clinical Register of Controlled Trials, Cochrane Database of Systematic Reviews and Cumulative Index to Nursing and Allied Health Literature for observational studies, clinical trials and modelling studies measuring the association between global BVL, PBVL, NBV or NBPV, and EDSS score or DP in PwMS. We included people with clinically isolated syndrome and excluded studies with a population greater than 20% primary progressive multiple sclerosis patients.We found 58 studies were eligible for the review. Most longitudinal studies (19/23) observed a significant association between global BVL and change in EDSS score or DP. Similarly the majority of cross-sectional studies (26/29) observed an association between baseline BV measures and EDSS. Most studies investigating the association between baseline brain volume (BV) measures and follow-up EDSS, that is, asking if baseline BV is a predictor of DP, or future EDSS score, did not find an association (4/15 observed an association).ResultsWe found 58 studies were eligible for the review. Most longitudinal studies (19/23) observed a significant association between global BVL and change in EDSS score or DP. Similarly the majority of cross-sectional studies (26/29) observed an association between baseline BV measures and EDSS. Most studies investigating the association between baseline brain volume (BV) measures and follow-up EDSS, that is, asking if baseline BV is a predictor of DP, or future EDSS score, did not find an association (4/15 observed an association).Around a 1% (range 0.4%-1.3%) decrease in global BV per year was associated with DP, but caution in comparing studies is recommended due to variations in the definition of DP.ConclusionAround a 1% (range 0.4%-1.3%) decrease in global BV per year was associated with DP, but caution in comparing studies is recommended due to variations in the definition of DP.
Background: Brain atrophy (BA) is a useful predictor of clinical outcomes in people with multiple sclerosis (PwMS). For this reason, MAGNIMS (Magnetic Resonance Imaging in Multiple Sclerosis), an expert consensus group, recommended that global brain volume loss (BVL) is included as a secondary outcome in therapeutic clinical trials. However, there has not been a recent review of the evidence of the association, or strength of association, between global BA and disability in PwMS. Objectives: Our aim is to review articles from 2013 onward measuring the associations between percentage of brain volume loss (PBVL), normalized brain volumes (NBV) or normalized brain parenchymal volume (NBPV), and the Expanded Disability Status Scale (EDSS), or disability progression (DP) measured by EDSS in PwMS. Design: Systematic review. Methods: We searched Medline, Embase, Cochrane Library, Cochrane Clinical Register of Controlled Trials, Cochrane Database of Systematic Reviews and Cumulative Index to Nursing and Allied Health Literature for observational studies, clinical trials and modelling studies measuring the association between global BVL, PBVL, NBV or NBPV, and EDSS score or DP in PwMS. We included people with clinically isolated syndrome and excluded studies with a population greater than 20% primary progressive multiple sclerosis patients. Results: We found 58 studies were eligible for the review. Most longitudinal studies (19/23) observed a significant association between global BVL and change in EDSS score or DP. Similarly the majority of cross-sectional studies (26/29) observed an association between baseline BV measures and EDSS. Most studies investigating the association between baseline brain volume (BV) measures and follow-up EDSS, that is, asking if baseline BV is a predictor of DP, or future EDSS score, did not find an association (4/15 observed an association). Conclusion: Around a 1% (range 0.4%–1.3%) decrease in global BV per year was associated with DP, but caution in comparing studies is recommended due to variations in the definition of DP.
Brain atrophy (BA) is a useful predictor of clinical outcomes in people with multiple sclerosis (PwMS). For this reason, MAGNIMS (Magnetic Resonance Imaging in Multiple Sclerosis), an expert consensus group, recommended that global brain volume loss (BVL) is included as a secondary outcome in therapeutic clinical trials. However, there has not been a recent review of the evidence of the association, or strength of association, between global BA and disability in PwMS. Our aim is to review articles from 2013 onward measuring the associations between percentage of brain volume loss (PBVL), normalized brain volumes (NBV) or normalized brain parenchymal volume (NBPV), and the Expanded Disability Status Scale (EDSS), or disability progression (DP) measured by EDSS in PwMS. Systematic review. We searched Medline, Embase, Cochrane Library, Cochrane Clinical Register of Controlled Trials, Cochrane Database of Systematic Reviews and Cumulative Index to Nursing and Allied Health Literature for observational studies, clinical trials and modelling studies measuring the association between global BVL, PBVL, NBV or NBPV, and EDSS score or DP in PwMS. We included people with clinically isolated syndrome and excluded studies with a population greater than 20% primary progressive multiple sclerosis patients. We found 58 studies were eligible for the review. Most longitudinal studies (19/23) observed a significant association between global BVL and change in EDSS score or DP. Similarly the majority of cross-sectional studies (26/29) observed an association between baseline BV measures and EDSS. Most studies investigating the association between baseline brain volume (BV) measures and follow-up EDSS, that is, asking if baseline BV is a predictor of DP, or future EDSS score, did not find an association (4/15 observed an association). Around a 1% (range 0.4%-1.3%) decrease in global BV per year was associated with DP, but caution in comparing studies is recommended due to variations in the definition of DP.
Author Zivadinov, Robert
Stocks, Susan Jill
Keenan, Alexander
Le, Hoa H.
Author_xml – sequence: 1
  givenname: Robert
  orcidid: 0000-0002-7799-1485
  surname: Zivadinov
  fullname: Zivadinov, Robert
  organization: Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA, Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA
– sequence: 2
  givenname: Hoa H.
  surname: Le
  fullname: Le, Hoa H.
  organization: Real World Value & Evidence, Janssen Scientific Affairs, LLC, Titusville, NJ, USA
– sequence: 3
  givenname: Alexander
  orcidid: 0009-0006-4805-7606
  surname: Keenan
  fullname: Keenan, Alexander
  organization: Real World Value & Evidence, Janssen Scientific Affairs, LLC, 1125 Trenton-Harbourton Road, Titusville, NJ 08560, USA
– sequence: 4
  givenname: Susan Jill
  orcidid: 0000-0001-6034-476X
  surname: Stocks
  fullname: Stocks, Susan Jill
  organization: Open Health, The Weighbridge, Brewery Courtyard, Marlow, Buckinghamshire, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/40689156$$D View this record in MEDLINE/PubMed
BookMark eNplksFuEzEQhi1URNvAA3BBPnIJ2GvH3j2hqhSoVIlD4WyNvbOJK2e92E5DnoZXxUlK1YqTxzO_v9H8nnNyMsYRCXnL2QfOtf7I9UI1rZKN5IIJ1fIX5Gyfm--TJ0_iU3Ke8x1jqtGSvSKnkqm24wt1Rv5c0LzLBddQvKPBF0xQNglpwnuPWxoHWlZIIefofNXEkVosW8SRLkO0EKhN4EcKJcVptaMw9ocHV7-nGmJPP_sM1lfwjt6Wis701kFAml2sXerLCeNU71tfVnS9CcVPh2rAFLPPr8nLAULGNw_njPz8cvXj8tv85vvX68uLm7kTsi3z6sDQWInKSd1IUSftdadggYPTTnQt424ApZUD3lhtEWzrFlbB4LDru74RM3J95PYR7syU_BrSzkTw5pCIaWkgVYsCGoQBtQJwzFopXHWyE1oKtIueITpWWZ-OrGlj19g7HEuC8Az6vDL6lVnGe8ObRitZcTPy_oGQ4q8N5mLWPjsMAUaMm2xEI3hXh9SqSt89bfbY5d8XVwE_Clw1NCccHiWcmf0amf_WSPwFJ4G_Hg
Cites_doi 10.1016/j.nicl.2014.09.015
10.1016/j.jns.2015.07.014
10.1002/jmri.20550
10.1212/WNL.33.11.1444
10.1148/radiol.2021203414
10.1177/1352458516674567
10.1212/WNL.54.8.1689
10.1212/NXI.0000000000000979
10.1001/archneur.58.1.105
10.1007/s00415-019-09595-4
10.1177/1352458514562440
10.3389/fneur.2019.00459
10.1177/1352458513494958
10.1007/s11055-008-9086-2
10.1002/brb3.1068
10.7717/peerj.2442
10.3174/ajnr.A5166
10.1212/WNL.0000000000008198
10.1177/1352458514560928
10.1007/s002340000457
10.1001/archneur.63.9.1301
10.1007/s00330-020-06738-4
10.1155/2015/450341
10.1007/s40263-014-0140-z
10.1177/1352458516656808
10.7224/1537-2073.2012-053
10.1111/ene.13904
10.1136/jnnp.2008.148403
10.1186/s12974-018-1295-1
10.1212/WNL.0000000000000768
10.1016/j.bandl.2019.04.009
10.1016/j.jns.2005.03.016
10.3174/ajnr.A5876
10.1212/WNL.0000000000011494
10.1007/s00415-009-5108-4
10.1177/1756286418823462
10.1093/brain/awh126
10.1586/ern.11.196
10.1093/brain/119.6.2009
10.1177/1352458519855722
10.1002/jmri.25866
10.1016/j.msard.2018.02.003
10.3174/ajnr.A3262
10.1177/135245850000600601
10.1136/jnnp.25.4.315
10.1177/1352458517701313
10.1093/brain/awg038
10.1001/archneur.57.10.1485
10.1177/1352458520940548
10.1177/13524585211020296
10.1038/s41582-020-0314-x
10.1111/ene.13183
10.1212/WNL.0b013e3181a609f8
10.1111/ene.14421
10.1007/s00415-020-09841-0
10.1136/jnnp.66.3.323
10.1111/jon.12358
10.1212/WNL.0000000000001281
10.1002/cne.24040
10.1111/jon.12271
10.1111/jon.12688
10.1007/s00415-018-9139-6
10.1590/0004-282X20160015
10.1177/13524585211031801
10.1212/WNL.53.8.1698
10.1093/brain/awg261
10.1007/s00415-020-09740-4
10.1006/nimg.2002.1040
10.3390/diagnostics11030578
10.1177/1352458514556300
10.3174/ajnr.A4952
10.1007/s00415-016-8368-9
10.1002/ana.25145
10.1007/s00415-010-5563-y
10.1002/jmri.26303
10.1177/2055217320902481
10.1191/1352458502ms788oa
10.1016/j.msard.2014.07.003
10.1371/journal.pone.0206939
10.3389/fneur.2020.00606
10.1016/j.tjem.2018.08.001
10.1177/1352458517690269
10.1093/brain/123.11.2256
10.1177/1352458515569099
10.1136/jnnp.70.6.773
10.1016/S1474-4422(06)70349-0
10.1177/1352458508093617
10.1136/jnnp-2020-325421
10.3310/hta6100
10.1016/S0140-6736(04)17271-1
10.1177/1352458516642314
10.1212/WNL.0000000000001756
10.1002/1531-8249(199909)46:3<296::AID-ANA4>3.0.CO;2-#
10.1007/s10072-015-2400-1
10.1093/brain/awab033
10.3389/fneur.2018.00718
10.1186/2046-4053-4-1
10.1007/s00415-015-7959-1
10.1136/jnnp-2013-306906
10.1191/1352458506ms1286oa
10.1016/j.nicl.2014.08.014
10.1186/s13317-019-0117-5
10.1001/jamaneurol.2018.1596
10.1111/jon.12237
10.1136/jnnp.73.2.141
10.1093/brain/awab132
10.1007/s00415-015-7853-x
10.1177/135245850000600602
10.1212/01.wnl.0000435551.90824.d0
10.1001/archneurol.2009.174
10.1016/j.jns.2004.11.046
10.1001/archneur.61.2.226
10.1186/1471-2377-14-58
10.1016/j.neuroimage.2007.07.056
10.3174/ajnr.A3503
10.1212/01.wnl.0000316810.01120.05
ContentType Journal Article
Copyright The Author(s), 2025.
The Author(s), 2025 2025 SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses
Copyright_xml – notice: The Author(s), 2025.
– notice: The Author(s), 2025 2025 SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses
DBID AAYXX
CITATION
NPM
7X8
5PM
DOA
DOI 10.1177/17562864241303681
DatabaseName CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
Open Access: DOAJ - Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

PubMed
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1756-2864
ExternalDocumentID oai_doaj_org_article_eafe76aac0bb43c68993743eb5d0eec0
PMC12276499
40689156
10_1177_17562864241303681
Genre Journal Article
Review
GrantInformation_xml – fundername: ;
GroupedDBID ---
-TM
01A
0R~
123
18M
29Q
4.4
53G
54M
5VS
7X7
8FI
8FJ
AABMB
AADUE
AAKDD
AAQDB
AARDL
AARIX
AAYXX
ABAWP
ABEIX
ABFWQ
ABJIS
ABKRH
ABNCE
ABQXT
ABRHV
ABUWG
ABVFX
ACARO
ACDSZ
ACDXX
ACGFS
ACHEB
ACOFE
ACROE
ACRPL
ADBBV
ADEBD
ADNMO
ADOGD
ADYCS
ADZZY
AENEX
AEQLS
AERKM
AEUHG
AEWDL
AEXNY
AFCOW
AFEET
AFFHD
AFKRA
AFKRG
AFRWT
AFUIA
AFWMB
AGNHF
AGQPQ
AHHFK
AJUZI
ALMA_UNASSIGNED_HOLDINGS
AOIJS
ARTOV
ASPBG
AUTPY
AUVAJ
AVWKF
AYAKG
AZFZN
B8M
BAWUL
BCNDV
BDDNI
BENPR
BKSCU
BPHCQ
BSEHC
BVXVI
CAG
CCPQU
CDWPY
CFDXU
CITATION
COF
CS3
DC-
DC.
DIK
DOPDO
E3Z
EBS
EJD
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION
GX1
H13
HMCUK
HVGLF
HYE
HZ~
J8X
K.F
N9A
O9-
OK1
P.B
PHGZM
PHGZT
PIMPY
PQQKQ
PSYQQ
ROL
RPM
S01
SAUOL
SCDPB
SCNPE
SFC
UKHRP
ZONMY
ZPPRI
ZRKOI
ZSSAH
AASGM
ALIPV
NPM
7X8
PUEGO
5PM
ID FETCH-LOGICAL-c348t-241f2b4e6c47243006d796a5efc7c39801cfa676ca12b7beab8c5b6afce9d9d23
IEDL.DBID DOA
ISICitedReferencesCount 1
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001531133100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1756-2864
1756-2856
IngestDate Fri Oct 03 12:43:46 EDT 2025
Tue Nov 04 02:03:12 EST 2025
Fri Sep 05 15:38:24 EDT 2025
Thu Jul 24 02:12:41 EDT 2025
Sat Nov 29 07:38:31 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords brain atrophy
brain volume loss
disability
multiple sclerosis
Language English
License The Author(s), 2025.
This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c348t-241f2b4e6c47243006d796a5efc7c39801cfa676ca12b7beab8c5b6afce9d9d23
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ORCID 0000-0002-7799-1485
0009-0006-4805-7606
0000-0001-6034-476X
OpenAccessLink https://doaj.org/article/eafe76aac0bb43c68993743eb5d0eec0
PMID 40689156
PQID 3231900676
PQPubID 23479
ParticipantIDs doaj_primary_oai_doaj_org_article_eafe76aac0bb43c68993743eb5d0eec0
pubmedcentral_primary_oai_pubmedcentral_nih_gov_12276499
proquest_miscellaneous_3231900676
pubmed_primary_40689156
crossref_primary_10_1177_17562864241303681
PublicationCentury 2000
PublicationDate 2025-01-01
PublicationDateYYYYMMDD 2025-01-01
PublicationDate_xml – month: 01
  year: 2025
  text: 2025-01-01
  day: 01
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: Sage UK: London, England
PublicationTitle Therapeutic advances in neurological disorders
PublicationTitleAlternate Ther Adv Neurol Disord
PublicationYear 2025
Publisher SAGE Publications
SAGE Publishing
Publisher_xml – name: SAGE Publications
– name: SAGE Publishing
References e_1_3_5_100_2
e_1_3_5_123_2
e_1_3_5_27_2
e_1_3_5_23_2
e_1_3_5_108_2
e_1_3_5_65_2
e_1_3_5_46_2
e_1_3_5_88_2
Rao SM (e_1_3_5_48_2) 2014; 2014
e_1_3_5_104_2
e_1_3_5_69_2
e_1_3_5_80_2
e_1_3_5_61_2
e_1_3_5_42_2
e_1_3_5_84_2
e_1_3_5_5_2
e_1_3_5_39_2
e_1_3_5_112_2
e_1_3_5_16_2
e_1_3_5_12_2
e_1_3_5_35_2
e_1_3_5_54_2
e_1_3_5_77_2
e_1_3_5_58_2
e_1_3_5_116_2
Filippi P (e_1_3_5_91_2) 2020; 41
e_1_3_5_92_2
e_1_3_5_50_2
e_1_3_5_73_2
e_1_3_5_96_2
e_1_3_5_31_2
e_1_3_5_28_2
e_1_3_5_101_2
e_1_3_5_120_2
e_1_3_5_24_2
e_1_3_5_43_2
e_1_3_5_66_2
e_1_3_5_89_2
e_1_3_5_109_2
e_1_3_5_47_2
e_1_3_5_105_2
Ghione E (e_1_3_5_68_2) 2020; 41
e_1_3_5_124_2
e_1_3_5_81_2
e_1_3_5_62_2
e_1_3_5_85_2
e_1_3_5_8_2
e_1_3_5_20_2
e_1_3_5_4_2
e_1_3_5_17_2
e_1_3_5_36_2
e_1_3_5_13_2
e_1_3_5_32_2
e_1_3_5_55_2
e_1_3_5_78_2
e_1_3_5_117_2
e_1_3_5_59_2
e_1_3_5_113_2
e_1_3_5_93_2
e_1_3_5_70_2
Giovannoni G (e_1_3_5_9_2) 2016; 9
e_1_3_5_51_2
e_1_3_5_97_2
De Stefano N (e_1_3_5_71_2) 2016; 87
e_1_3_5_74_2
e_1_3_5_121_2
e_1_3_5_25_2
e_1_3_5_21_2
e_1_3_5_44_2
e_1_3_5_106_2
e_1_3_5_67_2
e_1_3_5_102_2
e_1_3_5_29_2
e_1_3_5_82_2
e_1_3_5_40_2
e_1_3_5_86_2
e_1_3_5_63_2
e_1_3_5_7_2
e_1_3_5_3_2
e_1_3_5_37_2
e_1_3_5_110_2
e_1_3_5_14_2
e_1_3_5_10_2
e_1_3_5_33_2
e_1_3_5_56_2
e_1_3_5_79_2
e_1_3_5_98_2
e_1_3_5_118_2
e_1_3_5_18_2
e_1_3_5_90_2
LaMontagne PJ (e_1_3_5_114_2) 2019
e_1_3_5_52_2
e_1_3_5_94_2
Zivadinov R (e_1_3_5_75_2) 2019; 40
e_1_3_5_122_2
e_1_3_5_26_2
e_1_3_5_22_2
e_1_3_5_45_2
e_1_3_5_87_2
e_1_3_5_107_2
e_1_3_5_49_2
e_1_3_5_103_2
e_1_3_5_2_2
e_1_3_5_60_2
e_1_3_5_41_2
e_1_3_5_64_2
e_1_3_5_83_2
e_1_3_5_6_2
e_1_3_5_38_2
e_1_3_5_111_2
e_1_3_5_15_2
e_1_3_5_34_2
e_1_3_5_11_2
e_1_3_5_76_2
e_1_3_5_119_2
e_1_3_5_57_2
e_1_3_5_99_2
e_1_3_5_115_2
e_1_3_5_19_2
e_1_3_5_72_2
e_1_3_5_53_2
e_1_3_5_95_2
e_1_3_5_30_2
References_xml – ident: e_1_3_5_66_2
  doi: 10.1016/j.nicl.2014.09.015
– ident: e_1_3_5_8_2
  doi: 10.1016/j.jns.2015.07.014
– ident: e_1_3_5_25_2
  doi: 10.1002/jmri.20550
– ident: e_1_3_5_53_2
  doi: 10.1212/WNL.33.11.1444
– ident: e_1_3_5_81_2
  doi: 10.1148/radiol.2021203414
– ident: e_1_3_5_83_2
  doi: 10.1177/1352458516674567
– ident: e_1_3_5_14_2
  doi: 10.1212/WNL.54.8.1689
– year: 2019
  ident: e_1_3_5_114_2
  article-title: OASIS-3: longitudinal neuroimaging, clinical, and cognitive dataset for normal aging and Alzheimer disease
  publication-title: Radiol Imaging
– ident: e_1_3_5_70_2
  doi: 10.1212/NXI.0000000000000979
– ident: e_1_3_5_119_2
  doi: 10.1001/archneur.58.1.105
– ident: e_1_3_5_116_2
  doi: 10.1007/s00415-019-09595-4
– ident: e_1_3_5_122_2
  doi: 10.1177/1352458514562440
– ident: e_1_3_5_95_2
  doi: 10.3389/fneur.2019.00459
– ident: e_1_3_5_111_2
  doi: 10.1177/1352458513494958
– ident: e_1_3_5_42_2
  doi: 10.1007/s11055-008-9086-2
– ident: e_1_3_5_57_2
  doi: 10.1002/brb3.1068
– ident: e_1_3_5_65_2
  doi: 10.7717/peerj.2442
– ident: e_1_3_5_101_2
  doi: 10.3174/ajnr.A5166
– ident: e_1_3_5_34_2
  doi: 10.1212/WNL.0000000000008198
– ident: e_1_3_5_110_2
  doi: 10.1177/1352458514560928
– ident: e_1_3_5_117_2
  doi: 10.1007/s002340000457
– ident: e_1_3_5_31_2
  doi: 10.1001/archneur.63.9.1301
– ident: e_1_3_5_74_2
  doi: 10.1007/s00330-020-06738-4
– ident: e_1_3_5_56_2
  doi: 10.1155/2015/450341
– ident: e_1_3_5_50_2
  doi: 10.1007/s40263-014-0140-z
– ident: e_1_3_5_67_2
  doi: 10.1177/1352458516656808
– ident: e_1_3_5_4_2
  doi: 10.7224/1537-2073.2012-053
– volume: 2014
  start-page: 975803
  year: 2014
  ident: e_1_3_5_48_2
  article-title: Correlations between MRI and information processing speed in MS: a meta-analysis
  publication-title: Mult Scler Int
– ident: e_1_3_5_69_2
  doi: 10.1111/ene.13904
– ident: e_1_3_5_32_2
  doi: 10.1136/jnnp.2008.148403
– ident: e_1_3_5_98_2
  doi: 10.1186/s12974-018-1295-1
– ident: e_1_3_5_2_2
  doi: 10.1212/WNL.0000000000000768
– ident: e_1_3_5_97_2
  doi: 10.1016/j.bandl.2019.04.009
– ident: e_1_3_5_10_2
  doi: 10.1016/j.jns.2005.03.016
– ident: e_1_3_5_12_2
  doi: 10.3174/ajnr.A5876
– ident: e_1_3_5_72_2
  doi: 10.1212/WNL.0000000000011494
– ident: e_1_3_5_51_2
  doi: 10.1007/s00415-009-5108-4
– ident: e_1_3_5_60_2
  doi: 10.1177/1756286418823462
– ident: e_1_3_5_16_2
  doi: 10.1093/brain/awh126
– ident: e_1_3_5_13_2
  doi: 10.1586/ern.11.196
– ident: e_1_3_5_6_2
  doi: 10.1093/brain/119.6.2009
– ident: e_1_3_5_61_2
  doi: 10.1177/1352458519855722
– ident: e_1_3_5_82_2
  doi: 10.1002/jmri.25866
– ident: e_1_3_5_29_2
  doi: 10.1016/j.msard.2018.02.003
– ident: e_1_3_5_113_2
  doi: 10.3174/ajnr.A3262
– volume: 41
  start-page: 17
  issue: 1
  year: 2020
  ident: e_1_3_5_91_2
  article-title: Neurofilament light chain and MRI volume parameters as markers of neurodegeneration in multiple sclerosis
  publication-title: Neuro Endocrinol Lett
– ident: e_1_3_5_35_2
  doi: 10.1177/135245850000600601
– ident: e_1_3_5_5_2
  doi: 10.1136/jnnp.25.4.315
– ident: e_1_3_5_100_2
  doi: 10.1177/1352458517701313
– ident: e_1_3_5_26_2
  doi: 10.1093/brain/awg038
– ident: e_1_3_5_44_2
  doi: 10.1001/archneur.57.10.1485
– ident: e_1_3_5_85_2
  doi: 10.1177/1352458520940548
– ident: e_1_3_5_86_2
  doi: 10.1177/13524585211020296
– ident: e_1_3_5_52_2
  doi: 10.1038/s41582-020-0314-x
– ident: e_1_3_5_105_2
  doi: 10.1111/ene.13183
– ident: e_1_3_5_43_2
  doi: 10.1212/WNL.0b013e3181a609f8
– ident: e_1_3_5_93_2
  doi: 10.1111/ene.14421
– ident: e_1_3_5_36_2
  doi: 10.1007/s00415-020-09841-0
– ident: e_1_3_5_118_2
  doi: 10.1136/jnnp.66.3.323
– ident: e_1_3_5_104_2
  doi: 10.1111/jon.12358
– ident: e_1_3_5_59_2
  doi: 10.1212/WNL.0000000000001281
– ident: e_1_3_5_121_2
  doi: 10.1002/cne.24040
– ident: e_1_3_5_107_2
  doi: 10.1111/jon.12271
– ident: e_1_3_5_90_2
  doi: 10.1111/jon.12688
– ident: e_1_3_5_96_2
  doi: 10.1007/s00415-018-9139-6
– ident: e_1_3_5_49_2
  doi: 10.1590/0004-282X20160015
– ident: e_1_3_5_73_2
  doi: 10.1177/13524585211031801
– ident: e_1_3_5_7_2
  doi: 10.1212/WNL.53.8.1698
– ident: e_1_3_5_18_2
  doi: 10.1093/brain/awg261
– ident: e_1_3_5_41_2
  doi: 10.1007/s00415-020-09740-4
– ident: e_1_3_5_55_2
  doi: 10.1006/nimg.2002.1040
– ident: e_1_3_5_87_2
  doi: 10.3390/diagnostics11030578
– ident: e_1_3_5_64_2
  doi: 10.1177/1352458514556300
– ident: e_1_3_5_102_2
  doi: 10.3174/ajnr.A4952
– ident: e_1_3_5_103_2
  doi: 10.1007/s00415-016-8368-9
– ident: e_1_3_5_28_2
  doi: 10.1002/ana.25145
– volume: 40
  start-page: 446
  issue: 3
  year: 2019
  ident: e_1_3_5_75_2
  article-title: A serial 10-year follow-up study of atrophied brain lesion volume and disability progression in patients with relapsing-remitting MS
  publication-title: AJNR Am J Neuroradiol
– ident: e_1_3_5_37_2
  doi: 10.1007/s00415-010-5563-y
– ident: e_1_3_5_94_2
  doi: 10.1002/jmri.26303
– ident: e_1_3_5_47_2
  doi: 10.1177/2055217320902481
– volume: 9
  year: 2016
  ident: e_1_3_5_9_2
  article-title: Brain health: time matters in multiple sclerosis
  publication-title: Mult Scler Relat Disord
– ident: e_1_3_5_17_2
  doi: 10.1191/1352458502ms788oa
– ident: e_1_3_5_62_2
  doi: 10.1016/j.msard.2014.07.003
– ident: e_1_3_5_63_2
  doi: 10.1371/journal.pone.0206939
– ident: e_1_3_5_92_2
  doi: 10.3389/fneur.2020.00606
– ident: e_1_3_5_84_2
  doi: 10.1016/j.tjem.2018.08.001
– ident: e_1_3_5_76_2
  doi: 10.1177/1352458517690269
– ident: e_1_3_5_19_2
  doi: 10.1093/brain/123.11.2256
– ident: e_1_3_5_78_2
  doi: 10.1177/1352458515569099
– ident: e_1_3_5_21_2
  doi: 10.1136/jnnp.70.6.773
– ident: e_1_3_5_11_2
  doi: 10.1016/S1474-4422(06)70349-0
– ident: e_1_3_5_38_2
  doi: 10.1177/1352458508093617
– ident: e_1_3_5_88_2
  doi: 10.1136/jnnp-2020-325421
– ident: e_1_3_5_3_2
  doi: 10.3310/hta6100
– ident: e_1_3_5_27_2
  doi: 10.1016/S0140-6736(04)17271-1
– ident: e_1_3_5_106_2
  doi: 10.1177/1352458516642314
– ident: e_1_3_5_108_2
  doi: 10.1212/WNL.0000000000001756
– ident: e_1_3_5_20_2
  doi: 10.1002/1531-8249(199909)46:3<296::AID-ANA4>3.0.CO;2-#
– ident: e_1_3_5_24_2
  doi: 10.1007/s10072-015-2400-1
– volume: 87
  start-page: 93
  issue: 1
  year: 2016
  ident: e_1_3_5_71_2
  article-title: Establishing pathological cut-offs of brain atrophy rates in multiple sclerosis
  publication-title: J Neurol Neurosurg Psychiatry
– ident: e_1_3_5_89_2
  doi: 10.1093/brain/awab033
– ident: e_1_3_5_99_2
  doi: 10.3389/fneur.2018.00718
– ident: e_1_3_5_58_2
  doi: 10.1186/2046-4053-4-1
– volume: 41
  start-page: 1577
  issue: 9
  year: 2020
  ident: e_1_3_5_68_2
  article-title: Disability improvement is associated with less brain atrophy development in multiple sclerosis
  publication-title: AJNR Am J Neuroradiol
– ident: e_1_3_5_77_2
  doi: 10.1007/s00415-015-7959-1
– ident: e_1_3_5_79_2
  doi: 10.1136/jnnp-2013-306906
– ident: e_1_3_5_39_2
  doi: 10.1191/1352458506ms1286oa
– ident: e_1_3_5_124_2
  doi: 10.1016/j.nicl.2014.08.014
– ident: e_1_3_5_23_2
  doi: 10.1186/s13317-019-0117-5
– ident: e_1_3_5_115_2
  doi: 10.1001/jamaneurol.2018.1596
– ident: e_1_3_5_109_2
  doi: 10.1111/jon.12237
– ident: e_1_3_5_15_2
  doi: 10.1136/jnnp.73.2.141
– ident: e_1_3_5_120_2
  doi: 10.1093/brain/awab132
– ident: e_1_3_5_46_2
  doi: 10.1007/s00415-015-7853-x
– ident: e_1_3_5_22_2
  doi: 10.1177/135245850000600602
– ident: e_1_3_5_112_2
  doi: 10.1212/01.wnl.0000435551.90824.d0
– ident: e_1_3_5_33_2
  doi: 10.1001/archneurol.2009.174
– ident: e_1_3_5_45_2
  doi: 10.1016/j.jns.2004.11.046
– ident: e_1_3_5_30_2
  doi: 10.1001/archneur.61.2.226
– ident: e_1_3_5_54_2
  doi: 10.1186/1471-2377-14-58
– ident: e_1_3_5_40_2
  doi: 10.1016/j.neuroimage.2007.07.056
– ident: e_1_3_5_80_2
  doi: 10.3174/ajnr.A3503
– ident: e_1_3_5_123_2
  doi: 10.1212/01.wnl.0000316810.01120.05
SSID ssj0062740
Score 2.353385
SecondaryResourceType review_article
Snippet Brain atrophy (BA) is a useful predictor of clinical outcomes in people with multiple sclerosis (PwMS). For this reason, MAGNIMS (Magnetic Resonance Imaging in...
Background: Brain atrophy (BA) is a useful predictor of clinical outcomes in people with multiple sclerosis (PwMS). For this reason, MAGNIMS (Magnetic...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 17562864241303681
SubjectTerms Systematic Review
Title A systematic literature review of the association between global brain atrophy and the Expanded Disability Status Scale score in people with multiple sclerosis
URI https://www.ncbi.nlm.nih.gov/pubmed/40689156
https://www.proquest.com/docview/3231900676
https://pubmed.ncbi.nlm.nih.gov/PMC12276499
https://doaj.org/article/eafe76aac0bb43c68993743eb5d0eec0
Volume 18
WOSCitedRecordID wos001531133100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1756-2864
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0062740
  issn: 1756-2864
  databaseCode: DOA
  dateStart: 20170101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1756-2864
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0062740
  issn: 1756-2864
  databaseCode: BENPR
  dateStart: 20160101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Health & Medical Collection
  customDbUrl:
  eissn: 1756-2864
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0062740
  issn: 1756-2864
  databaseCode: 7X7
  dateStart: 20160101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Publicly Available Content
  customDbUrl:
  eissn: 1756-2864
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0062740
  issn: 1756-2864
  databaseCode: PIMPY
  dateStart: 20160101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEB7atJReSvp2H8sUeiqYrmWtZB-TdkN7yLL0AduTkeQRWQjeEO-W9tfkr2Zk2ZtsWuilF4MtC8szI81Do28A3urMGioEpQHqJZXOUmqlm6TaZrVmf8QqL7tiE3o2KxaLcn6t1FfICYvwwJFw78l40soYN7ZW5k4VQaHKnOykHhO5zltnq2dwpuIaHArKDHuYAV6JdWQ4gilFXLKLbEcLdWD9f7MwbyZKXtM8R_vwoDcZ8SAO9SHcouYR3DvuN8Ufw8UBXuEx4-kWJxnjsRRceWQrD80VI7DPzsIIB4I21InAEBVnoqNp6q7D9NdZiDDX-LHH4V3_xmCbblr8ypwlbAMEJnLPmIaOIaaLQ4Yit54S__yyfQLfj6bfPnxK-7oLqctlsU6ZSl5YScpJLWTO5Kx1qcyEvNMuL1mnOW-UVs5kwmpLxhZuYpXxjsq6rEX-FPaaVUPPAcsxlVZo74WsJVsKxhofEME0s05blyfwbuBDdRbhNaqsRyD_g2kJHAZObV8MyNjdA5aXqpeX6l_yksCbgc8Vz6SwPWIaWm3aKmdTtwzaWyXwLPJ9-yk2e4qSXd0Eih2J2BnLbkuzPOnQujMhtGK_8sX_GP1LuC9CAeIuBvQK9tbnG3oNd93P9bI9H8FtvdDdtRjBncPpbP5l1M0Lvpt_Pp7_uARHuBd5
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+systematic+literature+review+of+the+association+between+global+brain+atrophy+and+the+Expanded+Disability+Status+Scale+score+in+people+with+multiple+sclerosis&rft.jtitle=Therapeutic+advances+in+neurological+disorders&rft.au=Zivadinov%2C+Robert&rft.au=Le%2C+Hoa+H.&rft.au=Keenan%2C+Alexander&rft.au=Stocks%2C+Susan+Jill&rft.date=2025-01-01&rft.issn=1756-2864&rft.eissn=1756-2864&rft.volume=18&rft_id=info:doi/10.1177%2F17562864241303681&rft.externalDBID=n%2Fa&rft.externalDocID=10_1177_17562864241303681
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1756-2864&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1756-2864&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1756-2864&client=summon