Entry of antivirally active T lymphocytes into the thymus of virus-infected mice

The thymus has long been regarded as an immunologically "privileged site" by being shielded against the entry of exogenous Ag as well as protective elements of the immune system. After i.p. infection of mice, the lymphocytic choriomeningitis virus multiplied in this organ. Viral Ag was fou...

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Vydáno v:The Journal of immunology (1950) Ročník 146; číslo 1; s. 293
Hlavní autoři: Gossmann, J, Löhler, J, Lehmann-Grube, F
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.01.1991
Témata:
Animals
Antigens, Differentiation, T-Lymphocyte - analysis
Antigens, Viral - metabolism
CD8 Antigens
Cell Movement
Female
Fluorescent Antibody Technique
Immunity, Cellular
Immunization, Passive
Lymphocytic Choriomeningitis - immunology
Lymphocytic choriomeningitis virus - immunology
Mice
Mice, Inbred Strains
T-Lymphocytes, Cytotoxic - cytology
T-Lymphocytes, Cytotoxic - immunology
Thymus Gland - cytology
Thymus Gland - immunology
Thymus Gland - microbiology
Virus Replication
ISSN:0022-1767
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Popis
Shrnutí:The thymus has long been regarded as an immunologically "privileged site" by being shielded against the entry of exogenous Ag as well as protective elements of the immune system. After i.p. infection of mice, the lymphocytic choriomeningitis virus multiplied in this organ. Viral Ag was found predominantly in the epithelial-reticular cells of the medulla and to a lesser extent in such cells of the cortex. Beginning on day 7 after infection, the virus disappeared, a process that could be blocked by depleting the mice of peripheral T lymphocytes or of CD8+ cytotoxic T lymphocytes. Viral clearance was accelerated by i.v. injection of splenocytes from mice, which themselves were just eliminating the virus. CD8+ cells from CD8-congenic donor mice, most with blast morphology, were detected immunocytochemically in the thymus, predominantly in the medulla. A few CD8+ T lymphocytes from donors not previously infected were also demonstrated in the thymic tissue of infected mice. Our findings indicate that the lymphocytic choriomeningitis virus has access to the thymus and suggest that it is cleared by the antiviral activity of circulating cytotoxic T lymphocytes. Thus, just as other organs, the thymus appears to be subject to immune surveillance by mature T lymphocytes that have their origin in secondary lymphoid tissues.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-1767
DOI:10.4049/jimmunol.146.1.293