Reliability of CKD-EPI predictive equation in estimating chronic kidney disease prevalence in the Croatian endemic nephropathy area

Chronic kidney disease (CKD) is a significant public health problem and it is not possible to precisely predict its progression to terminal renal failure. According to current guidelines, CKD stages are classified based on the estimated glomerular filtration rate (eGFR) and albuminuria. Aims of this...

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Vydané v:	Biochemia medica Ročník 28; číslo 1; s. 010701
Hlavní autori:	Fuček, Mirjana, Dika, Živka, Karanović, Sandra, Vuković Brinar, Ivana, Premužić, Vedran, Kos, Jelena, Cvitković, Ante, Mišić, Maja, Samardžić, Josip, Rogić, Dunja, Jelaković, Bojan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Croatia Croatian Society of Medical Biochemistry and Laboratory Medicine 15.02.2018
Predmet:	Adolescent Adult Aged Aged, 80 and over Algorithms Creatinine - blood Croatia - epidemiology Cross-Sectional Studies Female Glomerular Filtration Rate Humans Male Middle Aged Original Papers Prevalence Renal Insufficiency, Chronic - epidemiology Reproducibility of Results Young Adult Croatia predictive equation endemic nephropathy chronic kidney disease estimated glomerular filtration rate
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Abstract	Chronic kidney disease (CKD) is a significant public health problem and it is not possible to precisely predict its progression to terminal renal failure. According to current guidelines, CKD stages are classified based on the estimated glomerular filtration rate (eGFR) and albuminuria. Aims of this study were to determine the reliability of predictive equation in estimation of CKD prevalence in Croatian areas with endemic nephropathy (EN), compare the results with non-endemic areas, and to determine if the prevalence of CKD stages 3-5 was increased in subjects with EN. A total of 1573 inhabitants of the Croatian Posavina rural area from 6 endemic and 3 non-endemic villages were enrolled. Participants were classified according to the modified criteria of the World Health Organization for EN. Estimated GFR was calculated using Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI). The results showed a very high CKD prevalence in the Croatian rural area (19%). CKD prevalence was significantly higher in EN then in non EN villages with the lowest eGFR value in diseased subgroup. eGFR correlated significantly with the diagnosis of EN. Kidney function assessment using CKD-EPI predictive equation proved to be a good marker in differentiating the study subgroups, remained as one of the diagnostic criteria for EN.
AbstractList	Chronic kidney disease (CKD) is a significant public health problem and it is not possible to precisely predict its progression to terminal renal failure. According to current guidelines, CKD stages are classified based on the estimated glomerular filtration rate (eGFR) and albuminuria. Aims of this study were to determine the reliability of predictive equation in estimation of CKD prevalence in Croatian areas with endemic nephropathy (EN), compare the results with non-endemic areas, and to determine if the prevalence of CKD stages 3-5 was increased in subjects with EN.INTRODUCTIONChronic kidney disease (CKD) is a significant public health problem and it is not possible to precisely predict its progression to terminal renal failure. According to current guidelines, CKD stages are classified based on the estimated glomerular filtration rate (eGFR) and albuminuria. Aims of this study were to determine the reliability of predictive equation in estimation of CKD prevalence in Croatian areas with endemic nephropathy (EN), compare the results with non-endemic areas, and to determine if the prevalence of CKD stages 3-5 was increased in subjects with EN.A total of 1573 inhabitants of the Croatian Posavina rural area from 6 endemic and 3 non-endemic villages were enrolled. Participants were classified according to the modified criteria of the World Health Organization for EN. Estimated GFR was calculated using Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI).MATERIALS AND METHODSA total of 1573 inhabitants of the Croatian Posavina rural area from 6 endemic and 3 non-endemic villages were enrolled. Participants were classified according to the modified criteria of the World Health Organization for EN. Estimated GFR was calculated using Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI).The results showed a very high CKD prevalence in the Croatian rural area (19%). CKD prevalence was significantly higher in EN then in non EN villages with the lowest eGFR value in diseased subgroup.RESULTSThe results showed a very high CKD prevalence in the Croatian rural area (19%). CKD prevalence was significantly higher in EN then in non EN villages with the lowest eGFR value in diseased subgroup.eGFR correlated significantly with the diagnosis of EN. Kidney function assessment using CKD-EPI predictive equation proved to be a good marker in differentiating the study subgroups, remained as one of the diagnostic criteria for EN.CONCLUSIONSeGFR correlated significantly with the diagnosis of EN. Kidney function assessment using CKD-EPI predictive equation proved to be a good marker in differentiating the study subgroups, remained as one of the diagnostic criteria for EN. Chronic kidney disease (CKD) is a significant public health problem and it is not possible to precisely predict its progression to terminal renal failure. According to current guidelines, CKD stages are classified based on the estimated glomerular filtration rate (eGFR) and albuminuria. Aims of this study were to determine the reliability of predictive equation in estimation of CKD prevalence in Croatian areas with endemic nephropathy (EN), compare the results with non-endemic areas, and to determine if the prevalence of CKD stages 3-5 was increased in subjects with EN. A total of 1573 inhabitants of the Croatian Posavina rural area from 6 endemic and 3 non-endemic villages were enrolled. Participants were classified according to the modified criteria of the World Health Organization for EN. Estimated GFR was calculated using Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI). The results showed a very high CKD prevalence in the Croatian rural area (19%). CKD prevalence was significantly higher in EN then in non EN villages with the lowest eGFR value in diseased subgroup. eGFR correlated significantly with the diagnosis of EN. Kidney function assessment using CKD-EPI predictive equation proved to be a good marker in differentiating the study subgroups, remained as one of the diagnostic criteria for EN.
Author	Dika, Živka Kos, Jelena Cvitković, Ante Fuček, Mirjana Mišić, Maja Jelaković, Bojan Samardžić, Josip Rogić, Dunja Karanović, Sandra Vuković Brinar, Ivana Premužić, Vedran
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Cites_doi	10.1038/ki.2010.483 10.1007/s00508-005-0426-8 10.1016/S0140-6736(09)62004-3 10.7326/0003-4819-150-9-200905050-00006 10.1373/49.6.1011 10.1016/S0140-6736(10)60674-5 10.2337/dc08-S055 10.1093/ndt/gft384 10.1053/j.ajkd.2008.05.024 10.1016/j.ekir.2016.11.003 10.1093/ndt/gfl649 10.3390/ijms18020297
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Snippet	Chronic kidney disease (CKD) is a significant public health problem and it is not possible to precisely predict its progression to terminal renal failure....
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SubjectTerms	Adolescent Adult Aged Aged, 80 and over Algorithms Creatinine - blood Croatia - epidemiology Cross-Sectional Studies Female Glomerular Filtration Rate Humans Male Middle Aged Original Papers Prevalence Renal Insufficiency, Chronic - epidemiology Reproducibility of Results Young Adult
Title	Reliability of CKD-EPI predictive equation in estimating chronic kidney disease prevalence in the Croatian endemic nephropathy area
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