The contribution of voxel-based morphometry in staging patients with mild cognitive impairment

To assess whether different patterns of regional gray matter loss in patients with mild cognitive impairment (MCI) are associated with different risks of conversion to Alzheimer disease (AD), using MRI and voxel-based morphometry (VBM). The authors recruited 22 patients with MCI, 22 patients with pr...

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Vydáno v:Neurology Ročník 67; číslo 3; s. 453
Hlavní autoři: Bozzali, M, Filippi, M, Magnani, G, Cercignani, M, Franceschi, M, Schiatti, E, Castiglioni, S, Mossini, R, Falautano, M, Scotti, G, Comi, G, Falini, A
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 08.08.2006
Témata:
Aged
Alzheimer Disease - complications
Brain Mapping
Cognition Disorders - complications
Cognition Disorders - pathology
Disease Progression
Female
Humans
Magnetic Resonance Imaging
Male
ISSN:1526-632X, 1526-632X
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Abstract To assess whether different patterns of regional gray matter loss in patients with mild cognitive impairment (MCI) are associated with different risks of conversion to Alzheimer disease (AD), using MRI and voxel-based morphometry (VBM). The authors recruited 22 patients with MCI, 22 patients with probable AD, and 20 healthy subjects (HS). T1 volumes from each subject were postprocessed according to an optimized VBM protocol. All patients were clinically followed up (mean [SD] time = 28.7 [5.7] months), and patients with MCI were reclassified into two groups (converters and nonconverters to AD). When comparing patients with AD to HS, widespread areas of reduced gray matter density were found predominantly in temporal, frontal, and parietal lobes and in the insula. Comparing MCI converters and nonconverters with HS, the converters showed more widespread areas of reduced gray matter density than nonconverters, with a pattern of abnormalities similar to that seen in patients with AD. Conversely, when comparing the same groups with patients with AD, MCI nonconverters showed a pattern of gray matter density similar to that of HS. Areas of decreased gray matter density were also found in MCI converters compared with nonconverters. Different patterns of gray matter density distribution in patients with mild cognitive impairment may be associated to different rates of conversion to Alzheimer disease.
AbstractList To assess whether different patterns of regional gray matter loss in patients with mild cognitive impairment (MCI) are associated with different risks of conversion to Alzheimer disease (AD), using MRI and voxel-based morphometry (VBM).OBJECTIVETo assess whether different patterns of regional gray matter loss in patients with mild cognitive impairment (MCI) are associated with different risks of conversion to Alzheimer disease (AD), using MRI and voxel-based morphometry (VBM).The authors recruited 22 patients with MCI, 22 patients with probable AD, and 20 healthy subjects (HS). T1 volumes from each subject were postprocessed according to an optimized VBM protocol. All patients were clinically followed up (mean [SD] time = 28.7 [5.7] months), and patients with MCI were reclassified into two groups (converters and nonconverters to AD).METHODSThe authors recruited 22 patients with MCI, 22 patients with probable AD, and 20 healthy subjects (HS). T1 volumes from each subject were postprocessed according to an optimized VBM protocol. All patients were clinically followed up (mean [SD] time = 28.7 [5.7] months), and patients with MCI were reclassified into two groups (converters and nonconverters to AD).When comparing patients with AD to HS, widespread areas of reduced gray matter density were found predominantly in temporal, frontal, and parietal lobes and in the insula. Comparing MCI converters and nonconverters with HS, the converters showed more widespread areas of reduced gray matter density than nonconverters, with a pattern of abnormalities similar to that seen in patients with AD. Conversely, when comparing the same groups with patients with AD, MCI nonconverters showed a pattern of gray matter density similar to that of HS. Areas of decreased gray matter density were also found in MCI converters compared with nonconverters.RESULTSWhen comparing patients with AD to HS, widespread areas of reduced gray matter density were found predominantly in temporal, frontal, and parietal lobes and in the insula. Comparing MCI converters and nonconverters with HS, the converters showed more widespread areas of reduced gray matter density than nonconverters, with a pattern of abnormalities similar to that seen in patients with AD. Conversely, when comparing the same groups with patients with AD, MCI nonconverters showed a pattern of gray matter density similar to that of HS. Areas of decreased gray matter density were also found in MCI converters compared with nonconverters.Different patterns of gray matter density distribution in patients with mild cognitive impairment may be associated to different rates of conversion to Alzheimer disease.CONCLUSIONSDifferent patterns of gray matter density distribution in patients with mild cognitive impairment may be associated to different rates of conversion to Alzheimer disease.
To assess whether different patterns of regional gray matter loss in patients with mild cognitive impairment (MCI) are associated with different risks of conversion to Alzheimer disease (AD), using MRI and voxel-based morphometry (VBM). The authors recruited 22 patients with MCI, 22 patients with probable AD, and 20 healthy subjects (HS). T1 volumes from each subject were postprocessed according to an optimized VBM protocol. All patients were clinically followed up (mean [SD] time = 28.7 [5.7] months), and patients with MCI were reclassified into two groups (converters and nonconverters to AD). When comparing patients with AD to HS, widespread areas of reduced gray matter density were found predominantly in temporal, frontal, and parietal lobes and in the insula. Comparing MCI converters and nonconverters with HS, the converters showed more widespread areas of reduced gray matter density than nonconverters, with a pattern of abnormalities similar to that seen in patients with AD. Conversely, when comparing the same groups with patients with AD, MCI nonconverters showed a pattern of gray matter density similar to that of HS. Areas of decreased gray matter density were also found in MCI converters compared with nonconverters. Different patterns of gray matter density distribution in patients with mild cognitive impairment may be associated to different rates of conversion to Alzheimer disease.
Author Comi, G
Cercignani, M
Magnani, G
Castiglioni, S
Bozzali, M
Franceschi, M
Scotti, G
Filippi, M
Schiatti, E
Mossini, R
Falautano, M
Falini, A
Author_xml – sequence: 1
  givenname: M
  surname: Bozzali
  fullname: Bozzali, M
  email: m.bozzali@fil.ion.ucl.ac.uk
  organization: Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy. m.bozzali@fil.ion.ucl.ac.uk
– sequence: 2
  givenname: M
  surname: Filippi
  fullname: Filippi, M
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  surname: Magnani
  fullname: Magnani, G
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  surname: Cercignani
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  surname: Franceschi
  fullname: Franceschi, M
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  surname: Falini
  fullname: Falini, A
BackLink https://www.ncbi.nlm.nih.gov/pubmed/16894107$$D View this record in MEDLINE/PubMed
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Snippet To assess whether different patterns of regional gray matter loss in patients with mild cognitive impairment (MCI) are associated with different risks of...
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SubjectTerms Aged
Alzheimer Disease - complications
Brain Mapping
Cognition Disorders - complications
Cognition Disorders - pathology
Disease Progression
Female
Humans
Magnetic Resonance Imaging
Male
Title The contribution of voxel-based morphometry in staging patients with mild cognitive impairment
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