Zygophyllum album leaves extract prevented hepatic fibrosis in rats, by reducing liver injury and suppressing oxidative stress, inflammation, apoptosis and the TGF-β1/Smads signaling pathways. Exploring of bioactive compounds using HPLC–DAD–ESI–QTOF-MS/MS
Zygophyllum album is traditionally used against many illnesses, such as liver disease. The present study investigated the bioactive compounds in methanol extract of Z. album (MEZA) using HPLC–DAD–ESI–QTOF-MS/MS and explored its possible antioxidative, anti-inflammatory, anti-apoptotic, and hepatopro...
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| Vydáno v: | Inflammopharmacology Ročník 28; číslo 6; s. 1735 - 1750 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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Cham
Springer International Publishing
01.12.2020
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| ISSN: | 0925-4692, 1568-5608, 1568-5608 |
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| Abstract | Zygophyllum album
is traditionally used against many illnesses, such as liver disease. The present study investigated the bioactive compounds in methanol extract of
Z. album
(MEZA) using HPLC–DAD–ESI–QTOF-MS/MS and explored its possible antioxidative, anti-inflammatory, anti-apoptotic, and hepatoprotective effect. Twelve phenolic compounds were identified; isorhamnetin-3-
O
-rutinoside being the main one was the main composite (144.6 mg/100 g dm). Results showed that MEZA reduced significantly the biochemical markers (AST, ALT, LDH and ALP), and the hepatic oxidative stress indicators (MDA, PC, SOD, CAT, and GPx) in deltamethrin (DLM)-treated rats. Moreover, MEZA limited the inflammatory responses through downregulation of NF-κB gene, which suppressed the production of proinflammatory cytokines (TNF-α, IL-1β, IL-6). Furthermore,
Z. album
reduced DLM-induced apoptosis by attenuating caspase 3 and p53 mRNA activation. MEZA treatment also alleviated upregulation of α-SMA, type I collagen, and TGF-β1 mRNA in the liver. The possible antifibrotic effect of MEZA was clearly demonstrated by the histopathology examination, using Masson’s Trichrome and Sirius Red stainings. Therefore, the current study suggested that the bioactive compounds of
Z. album
possessed antifibrotic effect against DLM-induced hepatic fibrosis, by protecting liver tissue, and inhibiting oxidative stress, inflammation, apoptosis and the TGF-β1/Smads signaling pathways. |
|---|---|
| AbstractList | Zygophyllum album
is traditionally used against many illnesses, such as liver disease. The present study investigated the bioactive compounds in methanol extract of
Z. album
(MEZA) using HPLC–DAD–ESI–QTOF-MS/MS and explored its possible antioxidative, anti-inflammatory, anti-apoptotic, and hepatoprotective effect. Twelve phenolic compounds were identified; isorhamnetin-3-
O
-rutinoside being the main one was the main composite (144.6 mg/100 g dm). Results showed that MEZA reduced significantly the biochemical markers (AST, ALT, LDH and ALP), and the hepatic oxidative stress indicators (MDA, PC, SOD, CAT, and GPx) in deltamethrin (DLM)-treated rats. Moreover, MEZA limited the inflammatory responses through downregulation of NF-κB gene, which suppressed the production of proinflammatory cytokines (TNF-α, IL-1β, IL-6). Furthermore,
Z. album
reduced DLM-induced apoptosis by attenuating caspase 3 and p53 mRNA activation. MEZA treatment also alleviated upregulation of α-SMA, type I collagen, and TGF-β1 mRNA in the liver. The possible antifibrotic effect of MEZA was clearly demonstrated by the histopathology examination, using Masson’s Trichrome and Sirius Red stainings. Therefore, the current study suggested that the bioactive compounds of
Z. album
possessed antifibrotic effect against DLM-induced hepatic fibrosis, by protecting liver tissue, and inhibiting oxidative stress, inflammation, apoptosis and the TGF-β1/Smads signaling pathways. Zygophyllum album is traditionally used against many illnesses, such as liver disease. The present study investigated the bioactive compounds in methanol extract of Z. album (MEZA) using HPLC-DAD-ESI-QTOF-MS/MS and explored its possible antioxidative, anti-inflammatory, anti-apoptotic, and hepatoprotective effect. Twelve phenolic compounds were identified; isorhamnetin-3-O-rutinoside being the main one was the main composite (144.6 mg/100 g dm). Results showed that MEZA reduced significantly the biochemical markers (AST, ALT, LDH and ALP), and the hepatic oxidative stress indicators (MDA, PC, SOD, CAT, and GPx) in deltamethrin (DLM)-treated rats. Moreover, MEZA limited the inflammatory responses through downregulation of NF-κB gene, which suppressed the production of proinflammatory cytokines (TNF-α, IL-1β, IL-6). Furthermore, Z. album reduced DLM-induced apoptosis by attenuating caspase 3 and p53 mRNA activation. MEZA treatment also alleviated upregulation of α-SMA, type I collagen, and TGF-β1 mRNA in the liver. The possible antifibrotic effect of MEZA was clearly demonstrated by the histopathology examination, using Masson's Trichrome and Sirius Red stainings. Therefore, the current study suggested that the bioactive compounds of Z. album possessed antifibrotic effect against DLM-induced hepatic fibrosis, by protecting liver tissue, and inhibiting oxidative stress, inflammation, apoptosis and the TGF-β1/Smads signaling pathways. Zygophyllum album is traditionally used against many illnesses, such as liver disease. The present study investigated the bioactive compounds in methanol extract of Z. album (MEZA) using HPLC-DAD-ESI-QTOF-MS/MS and explored its possible antioxidative, anti-inflammatory, anti-apoptotic, and hepatoprotective effect. Twelve phenolic compounds were identified; isorhamnetin-3-O-rutinoside being the main one was the main composite (144.6 mg/100 g dm). Results showed that MEZA reduced significantly the biochemical markers (AST, ALT, LDH and ALP), and the hepatic oxidative stress indicators (MDA, PC, SOD, CAT, and GPx) in deltamethrin (DLM)-treated rats. Moreover, MEZA limited the inflammatory responses through downregulation of NF-κB gene, which suppressed the production of proinflammatory cytokines (TNF-α, IL-1β, IL-6). Furthermore, Z. album reduced DLM-induced apoptosis by attenuating caspase 3 and p53 mRNA activation. MEZA treatment also alleviated upregulation of α-SMA, type I collagen, and TGF-β1 mRNA in the liver. The possible antifibrotic effect of MEZA was clearly demonstrated by the histopathology examination, using Masson's Trichrome and Sirius Red stainings. Therefore, the current study suggested that the bioactive compounds of Z. album possessed antifibrotic effect against DLM-induced hepatic fibrosis, by protecting liver tissue, and inhibiting oxidative stress, inflammation, apoptosis and the TGF-β1/Smads signaling pathways.Zygophyllum album is traditionally used against many illnesses, such as liver disease. The present study investigated the bioactive compounds in methanol extract of Z. album (MEZA) using HPLC-DAD-ESI-QTOF-MS/MS and explored its possible antioxidative, anti-inflammatory, anti-apoptotic, and hepatoprotective effect. Twelve phenolic compounds were identified; isorhamnetin-3-O-rutinoside being the main one was the main composite (144.6 mg/100 g dm). Results showed that MEZA reduced significantly the biochemical markers (AST, ALT, LDH and ALP), and the hepatic oxidative stress indicators (MDA, PC, SOD, CAT, and GPx) in deltamethrin (DLM)-treated rats. Moreover, MEZA limited the inflammatory responses through downregulation of NF-κB gene, which suppressed the production of proinflammatory cytokines (TNF-α, IL-1β, IL-6). Furthermore, Z. album reduced DLM-induced apoptosis by attenuating caspase 3 and p53 mRNA activation. MEZA treatment also alleviated upregulation of α-SMA, type I collagen, and TGF-β1 mRNA in the liver. The possible antifibrotic effect of MEZA was clearly demonstrated by the histopathology examination, using Masson's Trichrome and Sirius Red stainings. Therefore, the current study suggested that the bioactive compounds of Z. album possessed antifibrotic effect against DLM-induced hepatic fibrosis, by protecting liver tissue, and inhibiting oxidative stress, inflammation, apoptosis and the TGF-β1/Smads signaling pathways. |
| Author | Segura-Carretero, Antonio Tir, Meriam Harrath, Abdel Halim Tlili, Nizar Taamalli, Amani Ghazouani, Lakhdar Mufti, Afoua Feriani, Anouar Gómez-Caravaca, Ana María El Feki, Abdelfattah Allagui, Mohamed Salah del Mar Contreras, María |
| Author_xml | – sequence: 1 givenname: Anouar surname: Feriani fullname: Feriani, Anouar organization: Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa – sequence: 2 givenname: Meriam surname: Tir fullname: Tir, Meriam email: tirmeriam@yahoo.fr organization: Laboratoire D’Ecologie, de Biologie Et de Physiologie Des Organismes Aquatiques, LR18ES41, Faculté Des Sciences de Tunis, Université Tunis EL Manar – sequence: 3 givenname: Ana María surname: Gómez-Caravaca fullname: Gómez-Caravaca, Ana María organization: Department of Analytical Chemistry, University of Granada – sequence: 4 givenname: María surname: del Mar Contreras fullname: del Mar Contreras, María organization: Department of Analytical Chemistry, University of Granada, Department of Chemical, Environmental and Material Engineering, University of Jaén – sequence: 5 givenname: Amani surname: Taamalli fullname: Taamalli, Amani organization: Laboratory of Olive Biotechnology, Center of Biotechnology of Borj-Cédria – sequence: 6 givenname: Antonio surname: Segura-Carretero fullname: Segura-Carretero, Antonio organization: Department of Analytical Chemistry, University of Granada – sequence: 7 givenname: Lakhdar surname: Ghazouani fullname: Ghazouani, Lakhdar organization: Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa – sequence: 8 givenname: Afoua surname: Mufti fullname: Mufti, Afoua organization: Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa – sequence: 9 givenname: Nizar surname: Tlili fullname: Tlili, Nizar organization: Institut Supérieur des Sciences et Technologies de l’Environnement, ISSTE de Borj Cédria, Université de Carthage, Faculté Des Sciences de Tunis (UR13/ES25), Université Tunis El-Manar – sequence: 10 givenname: Abdelfattah surname: El Feki fullname: El Feki, Abdelfattah organization: Laboratory of Animal Ecophysiology, Faculty of Science of Sfax – sequence: 11 givenname: Abdel Halim surname: Harrath fullname: Harrath, Abdel Halim organization: Department of Zoology, College of Science, King Saud University – sequence: 12 givenname: Mohamed Salah surname: Allagui fullname: Allagui, Mohamed Salah organization: Laboratory of Animal Ecophysiology, Faculty of Science of Sfax |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32206981$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_metabo14060316 crossref_primary_10_1080_00032719_2020_1803348 crossref_primary_10_3389_fphar_2024_1408459 crossref_primary_10_3390_w16020214 crossref_primary_10_1038_s41598_024_77860_2 crossref_primary_10_1007_s11356_020_11745_5 crossref_primary_10_3389_fphar_2023_1320062 crossref_primary_10_3390_foods9060804 crossref_primary_10_1016_j_fbio_2025_106820 crossref_primary_10_3390_biology12020162 crossref_primary_10_1039_D2FO00888B crossref_primary_10_1080_15376516_2023_2301667 |
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| Keywords | Oxidative stress Inflammation HPLC–DAD–ESI–QTOF-MS Fibrosis Apoptosis Zygophyllum album |
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is traditionally used against many illnesses, such as liver disease. The present study investigated the bioactive compounds in methanol... Zygophyllum album is traditionally used against many illnesses, such as liver disease. The present study investigated the bioactive compounds in methanol... |
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| SubjectTerms | Allergology Biomedical and Life Sciences Biomedicine Dermatology Gastroenterology Immunology Original Article Pharmacology/Toxicology Rheumatology |
| Title | Zygophyllum album leaves extract prevented hepatic fibrosis in rats, by reducing liver injury and suppressing oxidative stress, inflammation, apoptosis and the TGF-β1/Smads signaling pathways. Exploring of bioactive compounds using HPLC–DAD–ESI–QTOF-MS/MS |
| URI | https://link.springer.com/article/10.1007/s10787-020-00700-y https://www.ncbi.nlm.nih.gov/pubmed/32206981 https://www.proquest.com/docview/2382662289 |
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