The study of apoptotic cells by flow cytometry

Programmed cell death (PCD) is of fundamental importance in the normal development of an animal. It also plays a key role in tumour and radiation biology. PCD produces a sequence of changes occurring in cells called apoptosis. The main elements of this apoptotic cascade are rapidly being elucidated....

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Vydáno v:Leukemia Ročník 12; číslo 7; s. 1013 - 1025
Hlavní autor: Ormerod, MG
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing 01.07.1998
Nature Publishing Group
Témata:
Ageing, cell death
Animals
Apoptosis
Apoptosis - physiology
Biological and medical sciences
Cascade flow
Cell culture
Cell death
Cell physiology
Flow cytometry
Flow Cytometry - methods
Fundamental and applied biological sciences. Psychology
Humans
Molecular and cellular biology
Radiation
Tumors
Human
Flow cytometry
Cell death
Cell biology
Cytopathology
Exploration
Malignant tumor
Apoptosis
ISSN:0887-6924, 1476-5551
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Popis
Shrnutí:Programmed cell death (PCD) is of fundamental importance in the normal development of an animal. It also plays a key role in tumour and radiation biology. PCD produces a sequence of changes occurring in cells called apoptosis. The main elements of this apoptotic cascade are rapidly being elucidated. Flow cytometry has been used to follow many of these changes. It has also been used to quantify the number of apoptotic cells in a culture and, more recently, in clinical samples. In this review, the properties of apoptotic cells and the main features of the apoptotic cascade are described. How flow cytometry can be used to follow changes during the apoptotic cascade is then discussed.
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ISSN:0887-6924
1476-5551
DOI:10.1038/sj.leu.2401061