The Involvement of Cell Adhesion Molecules, Tight Junctions, and Gap Junctions in Human Placentation

Placentation is a major determinant of the success of pregnancy. It is regulated by several factors such as cell adhesion molecules, tight junctions, and gap junctions. The cell adhesion molecules are integrins, cadherins, immunoglobulins, nectins, and selectins. The tight junctions are composed of...

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Vydáno v:Reproductive sciences (Thousand Oaks, Calif.) Ročník 28; číslo 2; s. 305 - 320
Hlavní autoři: Adu-Gyamfi, Enoch Appiah, Czika, Armin, Gorleku, Philip Narteh, Ullah, Amin, Panhwar, Zulqarnain, Ruan, Ling-Ling, Ding, Yu-Bin, Wang, Ying-Xiong
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cham Springer International Publishing 01.02.2021
Témata:
Embryology
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Reproductive Medicine
Review
Selectin
Connexin
Integrin
Nectin
Claudin
Preeclampsia
Trophoblast
Immunoglobulin
Cadherin
Occludin
ISSN:1933-7191, 1933-7205, 1933-7205
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Shrnutí:Placentation is a major determinant of the success of pregnancy. It is regulated by several factors such as cell adhesion molecules, tight junctions, and gap junctions. The cell adhesion molecules are integrins, cadherins, immunoglobulins, nectins, and selectins. The tight junctions are composed of claudins, occludin, and junction adhesion molecule proteins while the gap junctions are composed of connexins of varying molecular weights. During placentation, some of these molecules regulate trophoblast proliferation, trophoblast fusion, trophoblast migration, trophoblast invasion, trophoblast-endothelium adhesion, glandular remodeling, and spiral artery remodeling. There is a dysregulated placental expression of some of these molecules during obstetric complications. We have, hereby, indicated the expression patterns of the subunits of each of these molecules in the various trophoblast subtypes and in the decidua, and have highlighted their involvement in physiological and pathological placentation. The available evidence points to the relevance of these molecules as distinguishing markers of the various trophoblast lineages and as potential therapeutic targets in the management of malplacentation-mediated diseases.
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ISSN:1933-7191
1933-7205
1933-7205
DOI:10.1007/s43032-020-00364-7