Inhibition of phosphodiesterase 4 and 7 regulates breast cancer cell proliferation

cAMP regulates key processes in mammary cell biology. Previous studies suggested reduced cAMP production in more malignant cells. This study investigates the role of cAMP in mammary biology using non-tumor (MCF-10A and HBL-100) and tumor (MCF-7 and MDA-MB-231) human breast cell lines. cAMP levels w...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1869; no. 11; p. 130850
Main Authors:	Mayora Justel, Carla, Valladares, Tamara, Gargiulo, Lucía, González-Pardo, Verónica, De Sousa, Maximiliano, Esandi, María del Carmen, Davio, Carlos, Lüthy, Isabel, Bruzzone, Ariana
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.10.2025
Subjects:	1-Methyl-3-isobutylxanthine - pharmacology Aminopyridines - pharmacology Benzamides - pharmacology Breast neoplasm Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell line Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Cyclic AMP Cyclic AMP - metabolism Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism Cyclic Nucleotide Phosphodiesterases, Type 7 - antagonists & inhibitors Cyclic Nucleotide Phosphodiesterases, Type 7 - metabolism Cyclopropanes - pharmacology Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Humans MCF-7 Cells Phosphodiesterase 4 inhibitor Phosphodiesterase 4 Inhibitors - pharmacology Phosphodiesterase Inhibitors - pharmacology Roflumilast Cyclic AMP Cell line Roflumilast Phosphodiesterase 4 inhibitor Gene expression Breast neoplasm
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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