Use of Composite End Points in Early and Intermediate Age-Related Macular Degeneration Clinical Trials: State-of-the-Art and Future Directions

The slow progression of early age-related macular degeneration (AMD) stages to advanced AMD requires the use of surrogate end points in clinical trials. The use of combined end points may allow for shorter and smaller trials due to increased precision. We performed a literature search for the use of...

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Bibliographic Details
Published in:	Ophthalmologica (Basel) Vol. 244; no. 5; pp. 387 - 395
Main Authors:	Terheyden, Jan Henrik, Schmitz-Valckenberg, Steffen, Crabb, David P., Dunbar, Hannah, Luhmann, Ulrich F.O., Behning, Charlotte, Schmid, Matthias, Silva, Rufino, Cunha-Vaz, José, Tufail, Adnan, Weissgerber, Georges, Leal, Sergio, Holz, Frank G., Finger, Robert P.
Format:	Journal Article
Language:	English
Published:	Basel, Switzerland 01.11.2021
Subjects:	Review Article Age-related macular degeneration Trial outcomes Composite end points
ISBN:	9783318070378, 3318070378
ISSN:	0030-3755, 1423-0267, 1423-0267
Online Access:	Get full text
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