IMATAC imputes single-cell ATAC-seq data by deep hierarchical network with denoising autoencoder

Abstract Single-cell ATAC-seq (scATAC-seq) technology allows the interrogation of chromatin accessibility of individual cells. Dropout events occur while the sequencing data signals at some bona fide chromatin sites of individuals are not captured, and the curse of these dropouts in scATAC-seq data...

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Bibliographic Details
Published in:	Briefings in bioinformatics Vol. 26; no. 5
Main Authors:	Li, Yao, Lyu, Hongqiang, Li, Kexin, Liu, Yuan, Zhang, Xinman, Liu, Ze, Jing, Pengcheng, Han, Peng
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.09.2025 Oxford Publishing Limited (England)
Subjects:	Algorithms Autoencoder Chromatin Chromatin Immunoprecipitation Sequencing - methods Clustering Comparative analysis Computational Biology - methods Humans Interrogation Noise reduction Single-Cell Analysis - methods Software hierarchical network denoising autoencoder single-cell ATAC-seq imputation
ISSN:	1467-5463, 1477-4054, 1477-4054
Online Access:	Get full text
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