Association between Testosterone/Estradiol Ratio and Risk of Cardiometabolic Diseases in Women at Menopause Transition Age

Background: Imbalance of testosterone/estradiol ratio are frequently reported to be associated with the risk of cardiometabolic diseases; however, studies have yet to report the testosterone/estradiol ratio and its relationship to cardiometabolic diseases in women at menopause transition. This study...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental obstetrics & gynecology Vol. 49; no. 12; p. 260
Main Authors: Awadji, Fabrice Boris, Huang, Bi, Sasmita, Bryan Richard, Obiegbusi, Samuel Chigbo, Czika, Armin, Xue, Yuzhou, Luo, Suxin, Sowanou, Alphonse, Liu, Gang
Format: Journal Article
Language:English
Published: IMR Press 01.12.2022
Subjects:
aging
cardiometabolic diseases
menopause transition
testosterone/estradiol ratio
ISSN:0390-6663, 2709-0094
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Background: Imbalance of testosterone/estradiol ratio are frequently reported to be associated with the risk of cardiometabolic diseases; however, studies have yet to report the testosterone/estradiol ratio and its relationship to cardiometabolic diseases in women at menopause transition. This study aimed to explore the association between testosterone/estradiol ratio with cardiometabolic diseases in women during their menopausal transition age. Methods: 551 women aged from 45 to 55 years old were involved in this study. Their baseline information, disease comorbidity, blood biochemical tests, echocardiography and serum sex hormones were collected. Women were categorized by tertile distribution of testosterone/estradiol ratio. We used binary logistic regression model (for odds ratio) and poissoon loglinear model (for prevalence ratio) to evaluate the association between testosterone/estradiol ratio with cardiometabolic diseases. Results: The mean age of the study population was 48.6 ± 3.5 years old. Taking testosterone/estradiol ratio <3.9 as reference, the odds ratio with 95% confidence interval across the tertile groups for obesity were: 1.0 (reference), 2.32 (0.96–5.64), 4.70 (1.75–12.67) (p for trend = 0.002); for hypertension were: 1.0 (reference), 2.37 (1.45–3.86), 2.02 (1.12–3.62) (p for trend = 0.013); for cardiometabolic diseases were: 1.0 (reference), 2.29 (1.47–3.56), 2.34 (1.37–3.99) (p for trend = 0.013), compared with the prevalence ratio of 1.0 (reference), 1.64 (1.26–2.15), 1.65 (1.21–2.23) (p for trend = 0.001), respectively. Conclusions: Higher testosterone/estradiol ratio was associated with elevated prevalence of cardiometabolic diseases in women at menopause transition period.
AbstractList Background: Imbalance of testosterone/estradiol ratio are frequently reported to be associated with the risk of cardiometabolic diseases; however, studies have yet to report the testosterone/estradiol ratio and its relationship to cardiometabolic diseases in women at menopause transition. This study aimed to explore the association between testosterone/estradiol ratio with cardiometabolic diseases in women during their menopausal transition age. Methods: 551 women aged from 45 to 55 years old were involved in this study. Their baseline information, disease comorbidity, blood biochemical tests, echocardiography and serum sex hormones were collected. Women were categorized by tertile distribution of testosterone/estradiol ratio. We used binary logistic regression model (for odds ratio) and poissoon loglinear model (for prevalence ratio) to evaluate the association between testosterone/estradiol ratio with cardiometabolic diseases. Results: The mean age of the study population was 48.6 ± 3.5 years old. Taking testosterone/estradiol ratio <3.9 as reference, the odds ratio with 95% confidence interval across the tertile groups for obesity were: 1.0 (reference), 2.32 (0.96–5.64), 4.70 (1.75–12.67) (p for trend = 0.002); for hypertension were: 1.0 (reference), 2.37 (1.45–3.86), 2.02 (1.12–3.62) (p for trend = 0.013); for cardiometabolic diseases were: 1.0 (reference), 2.29 (1.47–3.56), 2.34 (1.37–3.99) (p for trend = 0.013), compared with the prevalence ratio of 1.0 (reference), 1.64 (1.26–2.15), 1.65 (1.21–2.23) (p for trend = 0.001), respectively. Conclusions: Higher testosterone/estradiol ratio was associated with elevated prevalence of cardiometabolic diseases in women at menopause transition period.
Author Liu, Gang
Huang, Bi
Awadji, Fabrice Boris
Sasmita, Bryan Richard
Czika, Armin
Sowanou, Alphonse
Luo, Suxin
Obiegbusi, Samuel Chigbo
Xue, Yuzhou
Author_xml – sequence: 1
  givenname: Fabrice Boris
  surname: Awadji
  fullname: Awadji, Fabrice Boris
– sequence: 2
  givenname: Bi
  surname: Huang
  fullname: Huang, Bi
– sequence: 3
  givenname: Bryan Richard
  surname: Sasmita
  fullname: Sasmita, Bryan Richard
– sequence: 4
  givenname: Samuel Chigbo
  surname: Obiegbusi
  fullname: Obiegbusi, Samuel Chigbo
– sequence: 5
  givenname: Armin
  surname: Czika
  fullname: Czika, Armin
– sequence: 6
  givenname: Yuzhou
  surname: Xue
  fullname: Xue, Yuzhou
– sequence: 7
  givenname: Suxin
  surname: Luo
  fullname: Luo, Suxin
– sequence: 8
  givenname: Alphonse
  surname: Sowanou
  fullname: Sowanou, Alphonse
– sequence: 9
  givenname: Gang
  surname: Liu
  fullname: Liu, Gang
BookMark eNp1UctqHDEQFMYGrx9Xn_UDs249VjNzXDZOYnAImA0-Di1Na9F6LBlJISRf78namBDwqaGqqwqqzthxTJEYuxKwVAI6db1fOko73QspDRyxhWyhbwB6fcwWoHpojDHqlJ2VsgfQujViwf6sS0kuYA0pckv1F1HkWyo1lUp5Dri-KTXjGNLE7_9-cYwjvw_lkSfPN5hn5okq2jQFxz-FQlio8BD5w4xHjpV_o5ie8Wchvs0YSzhErXd0wU48ToUu3-45-_H5Zrv52tx9_3K7Wd81TulVbZR1HnoEaQi0FLpvDXSGbC-lGjt03mhhpHUGjdRIGu1M69a3q047r4Q6Z7evvmPC_fCcwxPm30PCMByAlHcD5hrcRANZ047WopBaaQHSkumN8LAaW2ON72av5auXy6mUTP7dT8BwWGHYD_-sMAv0fwIX6qHtudUwfSR7ATlxkCA
CitedBy_id crossref_primary_10_1016_j_maturitas_2024_108029
crossref_primary_10_3389_fendo_2024_1384603
crossref_primary_10_1038_s41598_025_01910_6
crossref_primary_10_3390_cells12162077
crossref_primary_10_1186_s12902_024_01706_1
Cites_doi 10.1038/sj.jhh.1001095
10.1016/j.ogc.2018.07.002
10.1111/j.1365-2265.2011.04017.x
10.1161/ATVBAHA.114.304821
10.1210/jc.2006-1895
10.1210/jc.2015-2687
10.1161/01.CIR.0000091114.36254.F3
10.1210/jc.2004-2011
10.1016/j.arcmed.2015.11.003
10.1016/S0167-5273(02)00203-6
10.1161/01.CIR.0000157697.54255.CE
10.1210/jc.2009-1693
10.1007/s42000-018-0051-3
10.3390/ijerph18041821
10.1210/jcem.81.4.8636357
10.1016/j.amjcard.2016.03.035
10.1016/j.ogc.2018.07.006
10.1016/S0022-4804(03)00215-4
10.1152/physrev.00021.2015
10.1159/000508036
10.1158/1055-9965.EPI-05-0848
10.1016/j.jacc.2018.01.083
10.1016/j.ogc.2018.07.005
10.1016/j.mcna.2020.08.019
10.1210/jc.2011-3362
10.1210/jc.2004-0744
10.1016/j.maturitas.2015.08.009
10.1016/j.maturitas.2021.06.013
10.5301/JBM.2011.8883
10.1016/0378-5122(92)90003-M
10.1210/jc.84.11.4025
10.1530/EJE-10-0307
10.5665/sleep.1874
10.1016/j.cca.2019.09.010
10.1186/s13293-020-00294-8
10.1530/eje.1.02167
10.1161/01.ATV.17.4.695
10.1097/00006254-200007000-00020
10.1161/JAHA.112.001388
10.1161/CIR.0000000000000912
10.1097/gme.0b013e3182843aad
10.1210/jc.85.8.2832
10.3233/BME-2012-0705
10.1152/ajpheart.00396.2018
10.1016/S0140-6736(21)00684-X
10.1159/000337274
10.1016/S0140-6736(21)00798-4
ContentType Journal Article
DBID AAYXX
CITATION
DOA
DOI 10.31083/j.ceog4912260
DatabaseName CrossRef
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
DatabaseTitleList CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2709-0094
ExternalDocumentID oai_doaj_org_article_eb67dbba12434102be6961f05d76b6f8
10_31083_j_ceog4912260
GroupedDBID ---
29B
53G
5GY
5RE
AAFWJ
AAYXX
AENEX
AFPKN
ALMA_UNASSIGNED_HOLDINGS
CITATION
EBS
EJD
F5P
GROUPED_DOAJ
OK1
SJN
ID FETCH-LOGICAL-c345t-3bcf09a026e04214976086eb9223d8acf64162bc6a624ae4ab08647f7584cf313
IEDL.DBID DOA
ISICitedReferencesCount 5
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000906778300021&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0390-6663
IngestDate Fri Oct 03 12:51:35 EDT 2025
Tue Nov 18 22:32:57 EST 2025
Sat Nov 29 06:39:54 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 12
Language English
License https://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c345t-3bcf09a026e04214976086eb9223d8acf64162bc6a624ae4ab08647f7584cf313
OpenAccessLink https://doaj.org/article/eb67dbba12434102be6961f05d76b6f8
ParticipantIDs doaj_primary_oai_doaj_org_article_eb67dbba12434102be6961f05d76b6f8
crossref_primary_10_31083_j_ceog4912260
crossref_citationtrail_10_31083_j_ceog4912260
PublicationCentury 2000
PublicationDate 2022-12-01
PublicationDateYYYYMMDD 2022-12-01
PublicationDate_xml – month: 12
  year: 2022
  text: 2022-12-01
  day: 01
PublicationDecade 2020
PublicationTitle Clinical and experimental obstetrics & gynecology
PublicationYear 2022
Publisher IMR Press
Publisher_xml – name: IMR Press
References ref13
ref35
ref12
ref34
ref15
ref37
ref14
ref36
ref31
ref30
ref11
ref33
ref10
ref32
ref2
ref1
ref17
ref39
ref16
ref38
ref19
ref18
ref24
ref46
ref23
ref45
ref26
ref48
ref25
ref47
ref20
ref42
ref41
ref22
ref44
ref21
ref43
ref28
ref27
ref29
ref8
ref7
ref9
ref4
ref3
ref6
ref5
ref40
References_xml – ident: ref3
  doi: 10.1038/sj.jhh.1001095
– ident: ref1
– ident: ref24
  doi: 10.1016/j.ogc.2018.07.002
– ident: ref47
  doi: 10.1111/j.1365-2265.2011.04017.x
– ident: ref7
  doi: 10.1161/ATVBAHA.114.304821
– ident: ref39
  doi: 10.1210/jc.2006-1895
– ident: ref9
  doi: 10.1210/jc.2015-2687
– ident: ref41
  doi: 10.1161/01.CIR.0000091114.36254.F3
– ident: ref34
  doi: 10.1210/jc.2004-2011
– ident: ref48
  doi: 10.1016/j.arcmed.2015.11.003
– ident: ref4
  doi: 10.1016/S0167-5273(02)00203-6
– ident: ref38
  doi: 10.1161/01.CIR.0000157697.54255.CE
– ident: ref40
  doi: 10.1210/jc.2009-1693
– ident: ref27
  doi: 10.1007/s42000-018-0051-3
– ident: ref28
  doi: 10.3390/ijerph18041821
– ident: ref30
  doi: 10.1210/jcem.81.4.8636357
– ident: ref15
  doi: 10.1016/j.amjcard.2016.03.035
– ident: ref43
  doi: 10.1016/j.ogc.2018.07.006
– ident: ref42
  doi: 10.1016/S0022-4804(03)00215-4
– ident: ref10
  doi: 10.1152/physrev.00021.2015
– ident: ref44
  doi: 10.1159/000508036
– ident: ref23
  doi: 10.1158/1055-9965.EPI-05-0848
– ident: ref6
  doi: 10.1016/j.jacc.2018.01.083
– ident: ref17
  doi: 10.1016/j.ogc.2018.07.005
– ident: ref19
  doi: 10.1016/j.mcna.2020.08.019
– ident: ref29
  doi: 10.1210/jc.2011-3362
– ident: ref36
  doi: 10.1210/jc.2004-0744
– ident: ref8
  doi: 10.1016/j.maturitas.2015.08.009
– ident: ref13
  doi: 10.1016/j.maturitas.2021.06.013
– ident: ref20
  doi: 10.5301/JBM.2011.8883
– ident: ref14
  doi: 10.1016/0378-5122(92)90003-M
– ident: ref18
  doi: 10.1210/jc.84.11.4025
– ident: ref5
  doi: 10.1530/EJE-10-0307
– ident: ref16
  doi: 10.5665/sleep.1874
– ident: ref21
  doi: 10.1016/j.cca.2019.09.010
– ident: ref33
  doi: 10.1186/s13293-020-00294-8
– ident: ref35
  doi: 10.1530/eje.1.02167
– ident: ref37
  doi: 10.1161/01.ATV.17.4.695
– ident: ref22
  doi: 10.1097/00006254-200007000-00020
– ident: ref45
  doi: 10.1161/JAHA.112.001388
– ident: ref25
  doi: 10.1161/CIR.0000000000000912
– ident: ref46
  doi: 10.1097/gme.0b013e3182843aad
– ident: ref32
  doi: 10.1210/jc.85.8.2832
– ident: ref11
  doi: 10.3233/BME-2012-0705
– ident: ref31
  doi: 10.1152/ajpheart.00396.2018
– ident: ref2
  doi: 10.1016/S0140-6736(21)00684-X
– ident: ref12
  doi: 10.1159/000337274
– ident: ref26
  doi: 10.1016/S0140-6736(21)00798-4
SSID ssj0044761
Score 2.303946
Snippet Background: Imbalance of testosterone/estradiol ratio are frequently reported to be associated with the risk of cardiometabolic diseases; however, studies have...
SourceID doaj
crossref
SourceType Open Website
Enrichment Source
Index Database
StartPage 260
SubjectTerms aging
cardiometabolic diseases
menopause transition
testosterone/estradiol ratio
Title Association between Testosterone/Estradiol Ratio and Risk of Cardiometabolic Diseases in Women at Menopause Transition Age
URI https://doaj.org/article/eb67dbba12434102be6961f05d76b6f8
Volume 49
WOSCitedRecordID wos000906778300021&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2709-0094
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0044761
  issn: 0390-6663
  databaseCode: DOA
  dateStart: 20210101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV07T8MwELZQhRAL4inKSx6QmELT2LWTsZRWDLRCVUHdKtuxq0BJUJMy8Os5O2kVBsTCGp8i6-7iuy93_g6haxOYmMCiRwxXHiW2SGjAIDriijEexNxVdF8e-WgUTqfRU23Ul-0JK-mBS8W1tGQ8llJAHIID1w-kZhFrG78TcyaZcdd8IetZg6nyDKaUO6ZUHxC9Bwk6KekaIZUJSev1VulsTqM2ZB7-j3BUY-134WWwj_aqvBB3y_0coC2dHqKdYVX5PkJfNT3iqrkKT-xYGMt0kKW61bc_LeIkW-CxlcIijfE4yd9wZnDPdZ2-6wJMvkgUvi_LMjlOUuxmWGJR4KFOAUGvco1dAHO9XLg718foedCf9B68am6CpwjtFB6RyviRAHSl4ZMECMQZABctI0gF4lAowyALC6RiggVUaCokLFNuADpQZUibnKBGChs_RViFyueREB1NNWU0CmVA7ZyhOFSCEKWayFurb6YqUnE722IxA3Dh1A3ooqbuJrrZyH-UdBq_St5Za2ykLA22ewDOMaucY_aXc5z9x0vO0W5g7zy4HpYL1CiWK32JttVnkeTLK-d330RP3Oo
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+between+Testosterone%2FEstradiol+Ratio+and+Risk+of+Cardiometabolic+Diseases+in+Women+at+Menopause+Transition+Age&rft.jtitle=Clinical+and+experimental+obstetrics+%26+gynecology&rft.au=Awadji%2C+Fabrice+Boris&rft.au=Huang%2C+Bi&rft.au=Sasmita%2C+Bryan+Richard&rft.au=Obiegbusi%2C+Samuel+Chigbo&rft.date=2022-12-01&rft.issn=0390-6663&rft.eissn=2709-0094&rft.volume=49&rft.issue=12&rft_id=info:doi/10.31083%2Fj.ceog4912260&rft.externalDBID=n%2Fa&rft.externalDocID=10_31083_j_ceog4912260
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0390-6663&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0390-6663&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0390-6663&client=summon