Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

Prostaglandin E receptor EP4, a G-protein-coupled receptor, is involved in disorders such as cancer and autoimmune disease. Here, we report the crystal structure of human EP4 in complex with its antagonist ONO-AE3-208 and an inhibitory antibody at 3.2 Å resolution. The structure reveals that the ext...

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Veröffentlicht in:	Nature chemical biology Jg. 15; H. 1; S. 18 - 26
Hauptverfasser:	Toyoda, Yosuke, Morimoto, Kazushi, Suno, Ryoji, Horita, Shoichiro, Yamashita, Keitaro, Hirata, Kunio, Sekiguchi, Yusuke, Yasuda, Satoshi, Shiroishi, Mitsunori, Shimizu, Tomoko, Urushibata, Yuji, Kajiwara, Yuta, Inazumi, Tomoaki, Hotta, Yunhon, Asada, Hidetsugu, Nakane, Takanori, Shiimura, Yuki, Nakagita, Tomoya, Tsuge, Kyoshiro, Yoshida, Suguru, Kuribara, Tomoko, Hosoya, Takamitsu, Sugimoto, Yukihiko, Nomura, Norimichi, Sato, Miwa, Hirokawa, Takatsugu, Kinoshita, Masahiro, Murata, Takeshi, Takayama, Kiyoshi, Yamamoto, Masaki, Narumiya, Shuh, Iwata, So, Kobayashi, Takuya
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.01.2019 Nature Publishing Group
Schlagworte:	631/154/436 631/45/535 631/45/535/1266 631/92/287 Allosteric properties Binding Biochemical Engineering Biochemistry Bioorganic Chemistry Cancer Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Crystal structure Docking Drug delivery Drug development G protein-coupled receptors Ligands Lipid bilayers Lipids Prostaglandin E Prostaglandin E2 Proteins
ISSN:	1552-4450, 1552-4469, 1552-4469
Online-Zugang:	Volltext
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