Neutrophil extracellular traps in COVID-19

In severe cases of coronavirus disease 2019 (COVID-19), viral pneumonia progresses to respiratory failure. Neutrophil extracellular traps (NETs) are extracellular webs of chromatin, microbicidal proteins, and oxidant enzymes that are released by neutrophils to contain infections. However, when not p...

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Bibliographic Details
Published in:	JCI insight Vol. 5; no. 11
Main Authors:	Zuo, Yu, Yalavarthi, Srilakshmi, Shi, Hui, Gockman, Kelsey, Zuo, Melanie, Madison, Jacqueline A., Blair, Christopher N., Weber, Andrew, Barnes, Betsy J., Egeblad, Mikala, Woods, Robert J., Kanthi, Yogendra, Knight, Jason S.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 04.06.2020
Subjects:	Adult Aged Aged, 80 and over Biomarkers Blood platelets C-reactive protein C-Reactive Protein - metabolism Case-Control Studies Cell-Free Nucleic Acids - metabolism Chromatin Citrullination Citrulline Coronavirus Infections - blood Coronavirus Infections - metabolism Coronavirus Infections - therapy Coronaviruses COVID-19 Cytokines Dehydrogenases Deoxyribonucleic acid Disease DNA Enzymes Extracellular Traps - metabolism Female Fibrin Fibrinogen Degradation Products - metabolism Histone H3 Histones Histones - metabolism Hospitalization Humans In Vitro Techniques Infections Influenza L-Lactate dehydrogenase L-Lactate Dehydrogenase - metabolism Leukocytes (neutrophilic) Lymphocyte Count Male Mann-Whitney U test Mechanical ventilation Medical laboratories Microbicides Microvasculature Middle Aged Neutrophils Neutrophils - metabolism Oxidants Pandemics Patients Peroxidase Peroxidase - metabolism Platelet Count Pneumonia Pneumonia, Viral - blood Pneumonia, Viral - metabolism Pneumonia, Viral - therapy Respiration, Artificial Respiratory distress syndrome Respiratory failure Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Therapeutic targets Thrombosis Ventilators Infectious disease Inflammation Neutrophils
ISSN:	2379-3708, 2379-3708
Online Access:	Get full text
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