On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles

•The difficulty in the treatment of several diseases which affect the central nervous system (CNS) is related to the low permeation of therapeutic agents across the blood-brain barrier.•With unique anatomical features, the intranasal route allows direct entry to the CNS mainly through the sensory ne...

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Bibliographic Details
Published in:	Applied materials today Vol. 29; p. 101631
Main Authors:	Formica, María L., Real, Daniel A., Picchio, Matías L., Catlin, Elise, Donnelly, Ryan F., Paredes, Alejandro J.
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01.12.2022
Subjects:	Brain targeting Functional nanoparticles Intranasal administration Nanocrystals Nose-to-brain delivery LNC BBB TAT FUSIN AUC BSA CD-CS QD SLN AuNC GNS-D1 HSA Functional nanoparticles Lf PSA IN Intranasal administration IV DTE NC LCN Tmax PCL DTP NP NLC PLA MRI NS QTPP GNP CNS Brain targeting Mw GNS PCL_SCH us-GO OB Lf-TMC CSF OL PCL_P80 Cmax GNPr-D1 PEG-PLGA GNPr GO MSN PolyGION Nose-to-brain delivery WGA Nanocrystals PEG PLGA NAP
ISSN:	2352-9407
Online Access:	Get full text
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