On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles
•The difficulty in the treatment of several diseases which affect the central nervous system (CNS) is related to the low permeation of therapeutic agents across the blood-brain barrier.•With unique anatomical features, the intranasal route allows direct entry to the CNS mainly through the sensory ne...
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| Published in: | Applied materials today Vol. 29; p. 101631 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Ltd
01.12.2022
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| ISSN: | 2352-9407 |
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| Abstract | •The difficulty in the treatment of several diseases which affect the central nervous system (CNS) is related to the low permeation of therapeutic agents across the blood-brain barrier.•With unique anatomical features, the intranasal route allows direct entry to the CNS mainly through the sensory neuronal pathway or indirectly by passage across the BBB from the systemic circulation.•Nanoparticles administered via this route can provide drug accumulation in the CNS.•This review focuses on the intranasal delivery of polymer, lipid, and inorganic nanoparticles and drug nanocrystals to treat diseases that affect millions of people globally.
The administration of drugs to the central nervous system (CNS) is primarily controlled by the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds from the blood to the brain's extracellular fluid. Although currently available treatments for brain diseases that affect millions of people globally are partially effective, they are associated with severe side effects of systemic drug distribution. On the other hand, the ability of certain drugs to permeate through the BBB is impeded by their physicochemical properties, achieving sub-therapeutic concentrations in their target tissues. In this sense, the intranasal route with its unique anatomical features provides a promising passage for the delivery of drugs to the brain. Nanoparticle-based systems, in particular, have demonstrated an outstanding capacity to overcome the challenges presented by the intranasal route and produce drug accumulation in the brain while avoiding systemic distribution. This review covers recent developments in the use of polymer, lipid, and inorganic nanoparticles, as well as drug nanocrystals, to deliver drugs to the brain via intranasal administration. A general discussion including favourable aspects and limitations of this approach is also provided.
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| AbstractList | •The difficulty in the treatment of several diseases which affect the central nervous system (CNS) is related to the low permeation of therapeutic agents across the blood-brain barrier.•With unique anatomical features, the intranasal route allows direct entry to the CNS mainly through the sensory neuronal pathway or indirectly by passage across the BBB from the systemic circulation.•Nanoparticles administered via this route can provide drug accumulation in the CNS.•This review focuses on the intranasal delivery of polymer, lipid, and inorganic nanoparticles and drug nanocrystals to treat diseases that affect millions of people globally.
The administration of drugs to the central nervous system (CNS) is primarily controlled by the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds from the blood to the brain's extracellular fluid. Although currently available treatments for brain diseases that affect millions of people globally are partially effective, they are associated with severe side effects of systemic drug distribution. On the other hand, the ability of certain drugs to permeate through the BBB is impeded by their physicochemical properties, achieving sub-therapeutic concentrations in their target tissues. In this sense, the intranasal route with its unique anatomical features provides a promising passage for the delivery of drugs to the brain. Nanoparticle-based systems, in particular, have demonstrated an outstanding capacity to overcome the challenges presented by the intranasal route and produce drug accumulation in the brain while avoiding systemic distribution. This review covers recent developments in the use of polymer, lipid, and inorganic nanoparticles, as well as drug nanocrystals, to deliver drugs to the brain via intranasal administration. A general discussion including favourable aspects and limitations of this approach is also provided.
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| ArticleNumber | 101631 |
| Author | Picchio, Matías L. Donnelly, Ryan F. Catlin, Elise Real, Daniel A. Formica, María L. Paredes, Alejandro J. |
| Author_xml | – sequence: 1 givenname: María L. surname: Formica fullname: Formica, María L. organization: CONICET and Departamento de Farmacia, Facultad de Ciencias Químicas, Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba 5000, Argentina – sequence: 2 givenname: Daniel A. orcidid: 0000-0002-5189-680X surname: Real fullname: Real, Daniel A. organization: Advanced Center for Chronic Diseases (ACCDIS) and Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santos Dumont 964, Independencia, Santiago 8380494, Chile – sequence: 3 givenname: Matías L. orcidid: 0000-0003-3454-5992 surname: Picchio fullname: Picchio, Matías L. organization: Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, IPQA, CONICET-UNC, Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba 5000, Argentina – sequence: 4 givenname: Elise surname: Catlin fullname: Catlin, Elise organization: School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK – sequence: 5 givenname: Ryan F. surname: Donnelly fullname: Donnelly, Ryan F. organization: School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK – sequence: 6 givenname: Alejandro J. orcidid: 0000-0002-0414-8972 surname: Paredes fullname: Paredes, Alejandro J. email: a.paredes@qub.ac.uk organization: School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK |
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