Methoxychalcones as potential anticancer agents for colon cancer: Is membrane perturbing potency relevant?

Chalcones are naturally produced by many plants, and constitute precursors for the synthesis of flavons and flavanons. They were shown to possess antibacterial, antifungal, anti-cancer, and anti- inflammatory properties. The goal of the study was to assess the suitability of three synthetic methoxyc...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1868; no. 4; p. 130581
Main Authors:	Palko-Łabuz, Anna, Wesołowska, Olga, Błaszczyk, Maria, Uryga, Anna, Sobieszczańska, Beata, Skonieczna, Magdalena, Kostrzewa-Susłow, Edyta, Janeczko, Tomasz, Środa-Pomianek, Kamila
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.04.2024
Subjects:	antineoplastic activity Antineoplastic Agents - chemistry Apoptosis calorimetry cell cycle checkpoints Cell Line chalcones Chalcones - chemistry Chalcones - pharmacology colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology colorectal neoplasms cytotoxicity Humans lipid composition Lipid rafts Membrane interaction metastasis Methoxychalcones neoplasm cells Phosphatidylcholines reactive oxygen species receptor protein-tyrosine kinase therapeutics Lipid rafts Membrane interaction colon cancer Methoxychalcones Apoptosis
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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