The effects of a dentifrice containing zinc citrate and 2,4,4' trichloro-2'-hydroxydiphenyl ether

The effects of a dentifrice which contained 1% zinc citrate and 0.5% of a nonionic antimicrobial agent, 2,4,4' trichloro-2'-hydroxydiphenyl ether on plaque and gingival health have been investigated. In a 4-day nonbrushing study in which dentifrices were used as slurries, this dentifrice i...

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Bibliographic Details
Published in:Journal of periodontology (1970) Vol. 57; no. 9; p. 555
Main Author: Saxton, C A
Format: Journal Article
Language:English
Published: United States 01.09.1986
Subjects:
Adult
Citrates - administration & dosage
Citrates - pharmacology
Citric Acid
Dental Plaque - etiology
Dental Plaque - prevention & control
Dentifrices - administration & dosage
Dentifrices - pharmacology
Double-Blind Method
Drug Combinations
Female
Gingivitis - etiology
Gingivitis - prevention & control
Humans
Male
Middle Aged
Phenyl Ethers - pharmacology
Placebos
Time Factors
Triclosan - administration & dosage
Triclosan - pharmacology
ISSN:0022-3492
Online Access:Get more information
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Summary:The effects of a dentifrice which contained 1% zinc citrate and 0.5% of a nonionic antimicrobial agent, 2,4,4' trichloro-2'-hydroxydiphenyl ether on plaque and gingival health have been investigated. In a 4-day nonbrushing study in which dentifrices were used as slurries, this dentifrice inhibited plaque accumulation significantly more than dentifrices which contained either zinc citrate or Triclosan separately. In a 28-day double-blind cross-over study, a significant reduction in plaque accumulation and improvement in gingival health was demonstrated for the test dentifrice compared to the placebo. The effect was demonstrated with a group of well motivated volunteers who had a good standard of oral health. Analysis of the data suggested that the benefit might be extended to a less motivated population.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0022-3492
DOI:10.1902/jop.1986.57.9.555