An intact immune system is required for the anticancer activities of histone deacetylase inhibitors

Cell-intrinsic effects such as induction of apoptosis and/or inhibition of cell proliferation have been proposed as the major antitumor responses to histone deacetylase inhibitors (HDACi). These compounds can also mediate immune-modulatory effects that may contribute to their anticancer effects. How...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 73; no. 24; p. 7265
Main Authors:	West, Alison C, Mattarollo, Stephen R, Shortt, Jake, Cluse, Leonie A, Christiansen, Ailsa J, Smyth, Mark J, Johnstone, Ricky W
Format:	Journal Article
Language:	English
Published:	United States 15.12.2013
Subjects:	Adenocarcinoma - drug therapy Adenocarcinoma - immunology Animals Apoptosis - drug effects Apoptosis - immunology Cell Growth Processes - drug effects Cell Growth Processes - immunology Cell Line, Tumor Colonic Neoplasms - drug therapy Colonic Neoplasms - immunology Histone Deacetylase Inhibitors - pharmacology Immune System - drug effects Immune System - physiology Immunotherapy Interferon gamma Receptor Leukemia, Lymphoid - drug therapy Leukemia, Lymphoid - immunology Male Mice Mice, Inbred C57BL Mice, Transgenic Neoplasms, Experimental - drug therapy Neoplasms, Experimental - immunology Receptors, Interferon - metabolism
ISSN:	1538-7445, 1538-7445
Online Access:	Get more information
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