Prognostic significance of laminin, laminin receptor, and bone marrow micrometastases in breast cancer patients: are these markers of aggressive behavior and metastatic potential?

Laminin is a basement membrane glycoprotein implicated in a large number of biologic activities of cancer progression, many of which are mediated by the presence of the laminin receptor (67LR) on the cell membrane. We studied the correlations of laminin and its receptor with standardized and new pro...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Applied immunohistochemistry & molecular morphology Ročník 11; číslo 4; s. 311
Hlavní autoři: Molino, Annamaria, Pedersini, Rebecca, Micciolo, Rocco, Frisinghelli, Michela, Giovannini, Monica, Pavarana, Michele, Santo, Antonio, Colato, Chiara, Piubello, Quirino, Cetto, Gian Luigi
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.12.2003
Témata:
Adult
Age Factors
Antigens, Neoplasm - analysis
Bone Marrow Neoplasms - secondary
Breast Neoplasms - diagnosis
Breast Neoplasms - pathology
Disease-Free Survival
Female
Humans
Laminin - analysis
Lymph Nodes - pathology
Menopause
Middle Aged
Models, Statistical
Prognosis
Receptors, Laminin - analysis
Survival Rate
ISSN:1541-2016
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Laminin is a basement membrane glycoprotein implicated in a large number of biologic activities of cancer progression, many of which are mediated by the presence of the laminin receptor (67LR) on the cell membrane. We studied the correlations of laminin and its receptor with standardized and new prognostic factors (including bone marrow micrometastases) in a series of 112 patients with operable breast cancers. Laminin-positive cells were detected in 60% of the tumors and 67LR-positive cells in 55%; both were present in 35% of the cases. No association was found between laminin or 67LR positivity and pathologic tumor size, pathologic nodal status, grading, Ki-67, estrogen receptor status, progesterone receptor status, or bone marrow micrometastases. The only statistically significant association was with menopausal status and age, with a higher percentage of 67LR-positive tumors among premenopausal and younger patients. The median follow-up was approximately 7 years. The prognosis of disease-free survival was similar in the laminin-positive and laminin-negative subjects but was significantly better in 67LR-negative patients; there were no significant differences in overall survival. The prognostic role of laminin and 67LR in disease-free survival and overall survival varied according to nodal status. In the absence of nodal involvement, the risk of relapse (and death) was greater in the patients who were positive for laminin, 67LR, or both than in those who were negative for laminin, 67LR, or both; in the case of 4 or more involved nodes, the prognostic role of laminin and 67LR was reversed. These results did not change after adjustment for age, menopausal status, tumor status, nodal status, grading, or bone marrow micrometastases.
AbstractList Laminin is a basement membrane glycoprotein implicated in a large number of biologic activities of cancer progression, many of which are mediated by the presence of the laminin receptor (67LR) on the cell membrane. We studied the correlations of laminin and its receptor with standardized and new prognostic factors (including bone marrow micrometastases) in a series of 112 patients with operable breast cancers. Laminin-positive cells were detected in 60% of the tumors and 67LR-positive cells in 55%; both were present in 35% of the cases. No association was found between laminin or 67LR positivity and pathologic tumor size, pathologic nodal status, grading, Ki-67, estrogen receptor status, progesterone receptor status, or bone marrow micrometastases. The only statistically significant association was with menopausal status and age, with a higher percentage of 67LR-positive tumors among premenopausal and younger patients. The median follow-up was approximately 7 years. The prognosis of disease-free survival was similar in the laminin-positive and laminin-negative subjects but was significantly better in 67LR-negative patients; there were no significant differences in overall survival. The prognostic role of laminin and 67LR in disease-free survival and overall survival varied according to nodal status. In the absence of nodal involvement, the risk of relapse (and death) was greater in the patients who were positive for laminin, 67LR, or both than in those who were negative for laminin, 67LR, or both; in the case of 4 or more involved nodes, the prognostic role of laminin and 67LR was reversed. These results did not change after adjustment for age, menopausal status, tumor status, nodal status, grading, or bone marrow micrometastases.
Laminin is a basement membrane glycoprotein implicated in a large number of biologic activities of cancer progression, many of which are mediated by the presence of the laminin receptor (67LR) on the cell membrane. We studied the correlations of laminin and its receptor with standardized and new prognostic factors (including bone marrow micrometastases) in a series of 112 patients with operable breast cancers. Laminin-positive cells were detected in 60% of the tumors and 67LR-positive cells in 55%; both were present in 35% of the cases. No association was found between laminin or 67LR positivity and pathologic tumor size, pathologic nodal status, grading, Ki-67, estrogen receptor status, progesterone receptor status, or bone marrow micrometastases. The only statistically significant association was with menopausal status and age, with a higher percentage of 67LR-positive tumors among premenopausal and younger patients. The median follow-up was approximately 7 years. The prognosis of disease-free survival was similar in the laminin-positive and laminin-negative subjects but was significantly better in 67LR-negative patients; there were no significant differences in overall survival. The prognostic role of laminin and 67LR in disease-free survival and overall survival varied according to nodal status. In the absence of nodal involvement, the risk of relapse (and death) was greater in the patients who were positive for laminin, 67LR, or both than in those who were negative for laminin, 67LR, or both; in the case of 4 or more involved nodes, the prognostic role of laminin and 67LR was reversed. These results did not change after adjustment for age, menopausal status, tumor status, nodal status, grading, or bone marrow micrometastases.Laminin is a basement membrane glycoprotein implicated in a large number of biologic activities of cancer progression, many of which are mediated by the presence of the laminin receptor (67LR) on the cell membrane. We studied the correlations of laminin and its receptor with standardized and new prognostic factors (including bone marrow micrometastases) in a series of 112 patients with operable breast cancers. Laminin-positive cells were detected in 60% of the tumors and 67LR-positive cells in 55%; both were present in 35% of the cases. No association was found between laminin or 67LR positivity and pathologic tumor size, pathologic nodal status, grading, Ki-67, estrogen receptor status, progesterone receptor status, or bone marrow micrometastases. The only statistically significant association was with menopausal status and age, with a higher percentage of 67LR-positive tumors among premenopausal and younger patients. The median follow-up was approximately 7 years. The prognosis of disease-free survival was similar in the laminin-positive and laminin-negative subjects but was significantly better in 67LR-negative patients; there were no significant differences in overall survival. The prognostic role of laminin and 67LR in disease-free survival and overall survival varied according to nodal status. In the absence of nodal involvement, the risk of relapse (and death) was greater in the patients who were positive for laminin, 67LR, or both than in those who were negative for laminin, 67LR, or both; in the case of 4 or more involved nodes, the prognostic role of laminin and 67LR was reversed. These results did not change after adjustment for age, menopausal status, tumor status, nodal status, grading, or bone marrow micrometastases.
Author Molino, Annamaria
Frisinghelli, Michela
Pedersini, Rebecca
Giovannini, Monica
Santo, Antonio
Micciolo, Rocco
Cetto, Gian Luigi
Pavarana, Michele
Piubello, Quirino
Colato, Chiara
Author_xml – sequence: 1
  givenname: Annamaria
  surname: Molino
  fullname: Molino, Annamaria
  email: annamaria.molino@univr.it
  organization: Department of Medical Oncology, University of Verona, Maggiore Hospital, Piazzale Stefani 1, 37126 Verona, Italy. annamaria.molino@univr.it
– sequence: 2
  givenname: Rebecca
  surname: Pedersini
  fullname: Pedersini, Rebecca
– sequence: 3
  givenname: Rocco
  surname: Micciolo
  fullname: Micciolo, Rocco
– sequence: 4
  givenname: Michela
  surname: Frisinghelli
  fullname: Frisinghelli, Michela
– sequence: 5
  givenname: Monica
  surname: Giovannini
  fullname: Giovannini, Monica
– sequence: 6
  givenname: Michele
  surname: Pavarana
  fullname: Pavarana, Michele
– sequence: 7
  givenname: Antonio
  surname: Santo
  fullname: Santo, Antonio
– sequence: 8
  givenname: Chiara
  surname: Colato
  fullname: Colato, Chiara
– sequence: 9
  givenname: Quirino
  surname: Piubello
  fullname: Piubello, Quirino
– sequence: 10
  givenname: Gian Luigi
  surname: Cetto
  fullname: Cetto, Gian Luigi
BackLink https://www.ncbi.nlm.nih.gov/pubmed/14663356$$D View this record in MEDLINE/PubMed
BookMark eNo1UE1PAyEQ5VBjtfoXDCdPXYUFdl0vxhi_kiZ60HMD7NCiu7ACrfF3-QeltSUzDDN5vPfgGI2cd4AQpuSCkqa-JISWDWFNURLCaN5IkZNUI3REBad5TKsxOo7xg5CyZJwfojHlVcWYqI7Q72vwC-djshpHu3DWWC2dBuwN7mRvnXXT_QEH0DAkH6ZYuhar7AP3MgT_jXurg-8hyZgDIs5gFSB3eMsW8CCTBZfiNZYBcFpC3N79hBA3UnKxCBCjXQNWsJRr68NWY0e5cTf4lAms7G5O0IGRXYTTXZ2g94f7t7unYvby-Hx3Oys042UqKpGXkVoTUbe0kSCUUFdCgzFMtUQJI1ge1g3URku44qppJW-blhHF28qUE3T-zzsE_7WCmOa9jRq6TjrwqzivKec1rXgGnu2AK9VDOx-CzW_7me-_ufwDiAKGyg
CitedBy_id crossref_primary_10_1158_0008_5472_CAN_06_2768
crossref_primary_10_2353_ajpath_2007_060709
crossref_primary_10_1111_j_1349_7006_2010_01592_x
crossref_primary_10_1016_j_critrevonc_2006_01_007
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1097/00129039-200312000-00006
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Medicine
ExternalDocumentID 14663356
Genre Journal Article
GroupedDBID ---
.Z2
0R~
4Q1
4Q2
4Q3
53G
5RE
5VS
6J9
71W
8L-
AAAAV
AAHPQ
AAIQE
AARTV
AASCR
AAYEP
ABASU
ABBUW
ABDIG
ABJNI
ABVCZ
ABXVJ
ABZAD
ACDDN
ACEWG
ACGFS
ACILI
ACNWC
ACWDW
ACWRI
ACXJB
ACXNZ
ADFPA
ADGGA
ADHPY
ADNKB
AE3
AEETU
AENEX
AFDTB
AFUWQ
AHQNM
AHRYX
AHVBC
AINUH
AJCLO
AJIOK
AJNWD
AJNYG
AJZMW
AKCTQ
ALKUP
ALMA_UNASSIGNED_HOLDINGS
ALMTX
AMJPA
AMKUR
AMNEI
AOHHW
AWKKM
BQLVK
BS7
C45
CGR
CUY
CVF
DIWNM
DUNZO
E.X
EBS
ECM
EEVPB
EIF
EJD
EX3
FCALG
FL-
GNXGY
GQDEL
H0~
HLJTE
HZ~
IKREB
IN~
IPNFZ
JF9
JG8
JK3
JK8
K8S
KD1
KD2
L-C
L7B
NPM
N~M
O9-
OAG
OAH
OCUKA
ODA
OJAPA
OLW
OPUJH
ORVUJ
OUVQU
OVD
OVDNE
OWU
OWV
OWW
OWX
OWY
OWZ
OXXIT
P-K
P2P
R58
RIG
RLZ
S4R
S4S
T8P
TEORI
TSPGW
V2I
VVN
W3M
WOQ
WOW
X3V
X3W
XXN
XYM
ZFV
ZZMQN
7X8
ADKSD
ID FETCH-LOGICAL-c342t-65555facc057d19ae5b5b85ceff3bd0b5f53ae579e7fcae84b9da4d9d30b4d6f2
IEDL.DBID 7X8
ISICitedReferencesCount 10
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000186848200004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1541-2016
IngestDate Mon Sep 08 17:48:37 EDT 2025
Wed Feb 19 01:52:34 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 4
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c342t-65555facc057d19ae5b5b85ceff3bd0b5f53ae579e7fcae84b9da4d9d30b4d6f2
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 14663356
PQID 71447164
PQPubID 23479
ParticipantIDs proquest_miscellaneous_71447164
pubmed_primary_14663356
PublicationCentury 2000
PublicationDate 2003-12-01
PublicationDateYYYYMMDD 2003-12-01
PublicationDate_xml – month: 12
  year: 2003
  text: 2003-12-01
  day: 01
PublicationDecade 2000
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Applied immunohistochemistry & molecular morphology
PublicationTitleAlternate Appl Immunohistochem Mol Morphol
PublicationYear 2003
SSID ssj0022344
Score 1.6904156
Snippet Laminin is a basement membrane glycoprotein implicated in a large number of biologic activities of cancer progression, many of which are mediated by the...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 311
SubjectTerms Adult
Age Factors
Antigens, Neoplasm - analysis
Bone Marrow Neoplasms - secondary
Breast Neoplasms - diagnosis
Breast Neoplasms - pathology
Disease-Free Survival
Female
Humans
Laminin - analysis
Lymph Nodes - pathology
Menopause
Middle Aged
Models, Statistical
Prognosis
Receptors, Laminin - analysis
Survival Rate
Title Prognostic significance of laminin, laminin receptor, and bone marrow micrometastases in breast cancer patients: are these markers of aggressive behavior and metastatic potential?
URI https://www.ncbi.nlm.nih.gov/pubmed/14663356
https://www.proquest.com/docview/71447164
Volume 11
WOSCitedRecordID wos000186848200004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT4QwEG5W1xgvvh_rswePSwTKq8bEGOPGg7vZgyZ727SlNUYXENA_5h90poA340EOhAB9kBmmXztfZwg5F7GONCY0AXDgOgFojCOMUI7LYbg3jAuP243CD_FkksxmfNojV91eGKRVdjbRGuo0V7hGfhED8kdsf128O5gzCn2rbQKNJdJnAGSQ0BXPfnwIMO7ZVK6AETzQBS9qeTxNyEZcfmEcdYR53e5qN_odZtrhZrTxv45ukvUWZtKbRi-2SE9n22R13DrSd8jXtMyRYgePKVI4kDCE8qe5oaAjmDVi2F1QMIq6gLn5kIospTLPNF3Y2I10Yel8uhaAMStdUXhZIsu9pra2krZhW6tLKkpNAWxWtuwrgE5sSjzb6T5YXNrFC7BttFVi74q8RkKTeLveJU-ju8fbe6fN3-AoFvi1E4VwgOAVYMLU40KHMpRJqLQxTKauDE3I4GbMdWyU0EkgeSqClKfMlUEaGX-PLGfwTQeE-tKPdCjiRGkeYNBBJUF-MBtLTCyFJwbkrBPGHP4PdHqITOcf1bwTx4DsN_KcF00YD5z0RIyF0eGfZY_IWsPhQxbLMekbsAz6hKyoz_qlKk-t2sF5Mh1_AwaB5fQ
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prognostic+significance+of+laminin%2C+laminin+receptor%2C+and+bone+marrow+micrometastases+in+breast+cancer+patients%3A+are+these+markers+of+aggressive+behavior+and+metastatic+potential%3F&rft.jtitle=Applied+immunohistochemistry+%26+molecular+morphology&rft.au=Molino%2C+Annamaria&rft.au=Pedersini%2C+Rebecca&rft.au=Micciolo%2C+Rocco&rft.au=Frisinghelli%2C+Michela&rft.date=2003-12-01&rft.issn=1541-2016&rft.volume=11&rft.issue=4&rft.spage=311&rft_id=info:doi/10.1097%2F00129039-200312000-00006&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1541-2016&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1541-2016&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1541-2016&client=summon