Reciprocal regulation of chromatin state and architecture by HOTAIRM1 contributes to temporal collinear HOXA gene activation

Thousands of long non-coding RNAs (lncRNAs) have been identified in mammals, many of which represent important regulators of gene expression. However, the mechanisms used by lncRNAs to control transcription remain largely uncharacterized. Here, we report on HOTAIRM1, a promising lncRNA biomarker in...

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Bibliographic Details
Published in:	Nucleic acids research Vol. 45; no. 3; pp. gkw966 - 1104
Main Authors:	Wang, Xue Q. D., Dostie, Josée
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 17.02.2017
Subjects:	Cell Line, Tumor Chromatin - genetics Chromatin - metabolism Gene Expression Profiling Gene Knockdown Techniques Gene regulation, Chromatin and Epigenetics Genes, Homeobox Histone Demethylases - metabolism Histone-Lysine N-Methyltransferase - metabolism Homeodomain Proteins - genetics Humans MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Models, Genetic Myeloid-Lymphoid Leukemia Protein - metabolism Nuclear Proteins - metabolism Polycomb Repressive Complex 2 - metabolism RNA Interference Transcriptional Activation - drug effects Tretinoin - pharmacology
ISSN:	0305-1048, 1362-4962, 1362-4962
Online Access:	Get full text
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