Reciprocal regulation of chromatin state and architecture by HOTAIRM1 contributes to temporal collinear HOXA gene activation

Thousands of long non-coding RNAs (lncRNAs) have been identified in mammals, many of which represent important regulators of gene expression. However, the mechanisms used by lncRNAs to control transcription remain largely uncharacterized. Here, we report on HOTAIRM1, a promising lncRNA biomarker in...

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Published in:	Nucleic acids research Vol. 45; no. 3; pp. gkw966 - 1104
Main Authors:	Wang, Xue Q. D., Dostie, Josée
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 17.02.2017
Subjects:	Cell Line, Tumor Chromatin - genetics Chromatin - metabolism Gene Expression Profiling Gene Knockdown Techniques Gene regulation, Chromatin and Epigenetics Genes, Homeobox Histone Demethylases - metabolism Histone-Lysine N-Methyltransferase - metabolism Homeodomain Proteins - genetics Humans MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Models, Genetic Myeloid-Lymphoid Leukemia Protein - metabolism Nuclear Proteins - metabolism Polycomb Repressive Complex 2 - metabolism RNA Interference Transcriptional Activation - drug effects Tretinoin - pharmacology
ISSN:	0305-1048, 1362-4962, 1362-4962
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Abstract	Thousands of long non-coding RNAs (lncRNAs) have been identified in mammals, many of which represent important regulators of gene expression. However, the mechanisms used by lncRNAs to control transcription remain largely uncharacterized. Here, we report on HOTAIRM1, a promising lncRNA biomarker in leukemia and solid tumors. We find that HOTAIRM1 contributes to three-dimensional chromatin organization changes required for the temporal collinear activation of HOXA genes. We show that distinct HOTAIRM1 variants preferentially associate with either UTX/MLL or PRC2 complexes to modulate the levels of activating and silencing marks at the bivalent domain. HOTAIRM1 contributes to physical dissociation of chromatin loops at the cluster proximal end, which delays recruitment of the histone demethylase UTX and transcription of central HOXA genes. Interestingly, we find overall proximal HOXA gene activation without chromatin conformation changes by HOTAIRM1 in a different cell type. Our results reveal a previously unappreciated relationship between chromatin structure, architecture and lncRNA function.
AbstractList	Thousands of long non-coding RNAs (lncRNAs) have been identified in mammals, many of which represent important regulators of gene expression. However, the mechanisms used by lncRNAs to control transcription remain largely uncharacterized. Here, we report on HOTAIRM1, a promising lncRNA biomarker in leukemia and solid tumors. We find that HOTAIRM1 contributes to three-dimensional chromatin organization changes required for the temporal collinear activation of HOXA genes. We show that distinct HOTAIRM1 variants preferentially associate with either UTX/MLL or PRC2 complexes to modulate the levels of activating and silencing marks at the bivalent domain. HOTAIRM1 contributes to physical dissociation of chromatin loops at the cluster proximal end, which delays recruitment of the histone demethylase UTX and transcription of central HOXA genes. Interestingly, we find overall proximal HOXA gene activation without chromatin conformation changes by HOTAIRM1 in a different cell type. Our results reveal a previously unappreciated relationship between chromatin structure, architecture and lncRNA function. Thousands of long non-coding RNAs (lncRNAs) have been identified in mammals, many of which represent important regulators of gene expression. However, the mechanisms used by lncRNAs to control transcription remain largely uncharacterized. Here, we report on HOTAIRM1, a promising lncRNA biomarker in leukemia and solid tumors. We find that HOTAIRM1 contributes to three-dimensional chromatin organization changes required for the temporal collinear activation of HOXA genes. We show that distinct HOTAIRM1 variants preferentially associate with either UTX/MLL or PRC2 complexes to modulate the levels of activating and silencing marks at the bivalent domain. HOTAIRM1 contributes to physical dissociation of chromatin loops at the cluster proximal end, which delays recruitment of the histone demethylase UTX and transcription of central HOXA genes. Interestingly, we find overall proximal HOXA gene activation without chromatin conformation changes by HOTAIRM1 in a different cell type. Our results reveal a previously unappreciated relationship between chromatin structure, architecture and lncRNA function.Thousands of long non-coding RNAs (lncRNAs) have been identified in mammals, many of which represent important regulators of gene expression. However, the mechanisms used by lncRNAs to control transcription remain largely uncharacterized. Here, we report on HOTAIRM1, a promising lncRNA biomarker in leukemia and solid tumors. We find that HOTAIRM1 contributes to three-dimensional chromatin organization changes required for the temporal collinear activation of HOXA genes. We show that distinct HOTAIRM1 variants preferentially associate with either UTX/MLL or PRC2 complexes to modulate the levels of activating and silencing marks at the bivalent domain. HOTAIRM1 contributes to physical dissociation of chromatin loops at the cluster proximal end, which delays recruitment of the histone demethylase UTX and transcription of central HOXA genes. Interestingly, we find overall proximal HOXA gene activation without chromatin conformation changes by HOTAIRM1 in a different cell type. Our results reveal a previously unappreciated relationship between chromatin structure, architecture and lncRNA function.
Author	Wang, Xue Q. D. Dostie, Josée
AuthorAffiliation	Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montréal, Québec H3G 1Y6, Canada
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Cites_doi	10.18632/oncotarget.5148 10.1126/science.1149042 10.1093/nar/gkq644 10.1074/jbc.M701574200 10.1111/j.1432-0436.1988.tb00798.x 10.1126/science.1192002 10.1261/rna.266707 10.1242/dev.02779 10.1038/nature09819 10.1016/0012-1606(84)90316-6 10.18632/oncotarget.5061 10.1016/j.gde.2015.04.002 10.1182/blood-2008-06-162164 10.1146/annurev-genom-091212-153530 10.1371/journal.pgen.1005615 10.1073/pnas.222671299 10.1126/science.1068597 10.1016/j.ymeth.2012.10.011 10.1016/j.cell.2006.02.041 10.1101/gr.132159.111 10.1016/j.molcel.2010.02.032 10.1016/B978-0-12-391938-0.00005-7 10.1101/gad.292104 10.1038/nature07672 10.1101/gr.073452.107 10.3892/ijo.2015.3292 10.1038/ng.3192 10.1182/blood.V77.5.1080.1080 10.1146/annurev-cellbio-101512-122415 10.1038/nsmb.2474 10.1016/j.cell.2005.01.001 10.1128/MCB.00839-14 10.1126/science.1112014 10.1101/gad.17446611 10.1016/S0301-472X(01)00757-3 10.1038/nm.3981 10.18632/oncotarget.2454 10.1016/j.cell.2007.05.022 10.1093/nar/gkt998 10.1016/0168-9525(91)90423-N 10.1038/ng.710 10.1101/gad.1035902 10.1101/gad.219626.113 10.2174/138920211796429772 10.1038/nsmb1128 10.1038/nature01266 10.1101/gad.381706 10.1038/nsmb1131 10.1126/science.1100576 10.1101/gr.191122.115 10.1128/JVI.05009-11 10.1128/MMBR.00006-15
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References	2016102717080532000_gkw966v1.35 2016102717080532000_gkw966v1.34 2016102717080532000_gkw966v1.33 2016102717080532000_gkw966v1.32 2016102717080532000_gkw966v1.31 2016102717080532000_gkw966v1.30 2016102717080532000_gkw966v1.39 2016102717080532000_gkw966v1.38 2016102717080532000_gkw966v1.37 2016102717080532000_gkw966v1.36 Zhou (2016102717080532000_gkw966v1.16) 2016; 48 2016102717080532000_gkw966v1.24 2016102717080532000_gkw966v1.23 2016102717080532000_gkw966v1.20 2016102717080532000_gkw966v1.29 2016102717080532000_gkw966v1.28 2016102717080532000_gkw966v1.27 2016102717080532000_gkw966v1.26 2016102717080532000_gkw966v1.25 Chen (2016102717080532000_gkw966v1.18) 2015; 8 2016102717080532000_gkw966v1.13 2016102717080532000_gkw966v1.12 2016102717080532000_gkw966v1.11 2016102717080532000_gkw966v1.10 2016102717080532000_gkw966v1.53 Lanotte (2016102717080532000_gkw966v1.22) 1991; 77 2016102717080532000_gkw966v1.52 2016102717080532000_gkw966v1.51 2016102717080532000_gkw966v1.50 2016102717080532000_gkw966v1.19 2016102717080532000_gkw966v1.15 2016102717080532000_gkw966v1.14 2016102717080532000_gkw966v1.4 2016102717080532000_gkw966v1.3 2016102717080532000_gkw966v1.2 2016102717080532000_gkw966v1.1 Diaz-Beya (2016102717080532000_gkw966v1.17) 2015; 6 2016102717080532000_gkw966v1.46 2016102717080532000_gkw966v1.45 2016102717080532000_gkw966v1.44 2016102717080532000_gkw966v1.43 2016102717080532000_gkw966v1.42 2016102717080532000_gkw966v1.41 2016102717080532000_gkw966v1.40 2016102717080532000_gkw966v1.9 2016102717080532000_gkw966v1.8 2016102717080532000_gkw966v1.7 2016102717080532000_gkw966v1.49 2016102717080532000_gkw966v1.6 Zagani (2016102717080532000_gkw966v1.21) 2015; 6 2016102717080532000_gkw966v1.48 2016102717080532000_gkw966v1.5 2016102717080532000_gkw966v1.47
References_xml	– volume: 6 start-page: 31613 year: 2015 ident: 2016102717080532000_gkw966v1.17 article-title: The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature publication-title: Oncotarget doi: 10.18632/oncotarget.5148 – ident: 2016102717080532000_gkw966v1.41 doi: 10.1126/science.1149042 – ident: 2016102717080532000_gkw966v1.20 doi: 10.1093/nar/gkq644 – ident: 2016102717080532000_gkw966v1.43 doi: 10.1074/jbc.M701574200 – ident: 2016102717080532000_gkw966v1.34 doi: 10.1111/j.1432-0436.1988.tb00798.x – ident: 2016102717080532000_gkw966v1.11 doi: 10.1126/science.1192002 – ident: 2016102717080532000_gkw966v1.30 doi: 10.1261/rna.266707 – ident: 2016102717080532000_gkw966v1.37 doi: 10.1242/dev.02779 – ident: 2016102717080532000_gkw966v1.13 doi: 10.1038/nature09819 – ident: 2016102717080532000_gkw966v1.31 doi: 10.1016/0012-1606(84)90316-6 – volume: 6 start-page: 28282 year: 2015 ident: 2016102717080532000_gkw966v1.21 article-title: Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells publication-title: Oncotarget doi: 10.18632/oncotarget.5061 – ident: 2016102717080532000_gkw966v1.9 doi: 10.1016/j.gde.2015.04.002 – ident: 2016102717080532000_gkw966v1.15 doi: 10.1182/blood-2008-06-162164 – ident: 2016102717080532000_gkw966v1.8 doi: 10.1146/annurev-genom-091212-153530 – ident: 2016102717080532000_gkw966v1.12 doi: 10.1371/journal.pgen.1005615 – ident: 2016102717080532000_gkw966v1.28 doi: 10.1073/pnas.222671299 – ident: 2016102717080532000_gkw966v1.1 doi: 10.1126/science.1068597 – ident: 2016102717080532000_gkw966v1.25 doi: 10.1016/j.ymeth.2012.10.011 – ident: 2016102717080532000_gkw966v1.38 doi: 10.1016/j.cell.2006.02.041 – ident: 2016102717080532000_gkw966v1.6 doi: 10.1101/gr.132159.111 – ident: 2016102717080532000_gkw966v1.50 doi: 10.1016/j.molcel.2010.02.032 – ident: 2016102717080532000_gkw966v1.26 doi: 10.1016/B978-0-12-391938-0.00005-7 – ident: 2016102717080532000_gkw966v1.36 doi: 10.1101/gad.292104 – ident: 2016102717080532000_gkw966v1.4 doi: 10.1038/nature07672 – ident: 2016102717080532000_gkw966v1.49 doi: 10.1101/gr.073452.107 – volume: 48 start-page: 670 year: 2016 ident: 2016102717080532000_gkw966v1.16 article-title: Microarray expression profile analysis of long non-coding RNAs in pancreatic ductal adenocarcinoma publication-title: Int. J. Oncol. doi: 10.3892/ijo.2015.3292 – volume: 8 start-page: 5033 year: 2015 ident: 2016102717080532000_gkw966v1.18 article-title: Differential lncRNA expression profiles in recurrent gliomas compared with primary gliomas identified by microarray analysis publication-title: Int. J. Clin. Exp. Med. – ident: 2016102717080532000_gkw966v1.53 doi: 10.1038/ng.3192 – volume: 77 start-page: 1080 year: 1991 ident: 2016102717080532000_gkw966v1.22 article-title: NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3) publication-title: Blood doi: 10.1182/blood.V77.5.1080.1080 – ident: 2016102717080532000_gkw966v1.47 doi: 10.1146/annurev-cellbio-101512-122415 – ident: 2016102717080532000_gkw966v1.52 doi: 10.1038/nsmb.2474 – ident: 2016102717080532000_gkw966v1.29 doi: 10.1016/j.cell.2005.01.001 – ident: 2016102717080532000_gkw966v1.42 doi: 10.1128/MCB.00839-14 – ident: 2016102717080532000_gkw966v1.3 doi: 10.1126/science.1112014 – ident: 2016102717080532000_gkw966v1.5 doi: 10.1101/gad.17446611 – ident: 2016102717080532000_gkw966v1.27 doi: 10.1016/S0301-472X(01)00757-3 – ident: 2016102717080532000_gkw966v1.14 doi: 10.1038/nm.3981 – ident: 2016102717080532000_gkw966v1.19 doi: 10.18632/oncotarget.2454 – ident: 2016102717080532000_gkw966v1.10 doi: 10.1016/j.cell.2007.05.022 – ident: 2016102717080532000_gkw966v1.24 doi: 10.1093/nar/gkt998 – ident: 2016102717080532000_gkw966v1.33 doi: 10.1016/0168-9525(91)90423-N – ident: 2016102717080532000_gkw966v1.46 doi: 10.1038/ng.710 – ident: 2016102717080532000_gkw966v1.40 doi: 10.1101/gad.1035902 – ident: 2016102717080532000_gkw966v1.39 doi: 10.1101/gad.219626.113 – ident: 2016102717080532000_gkw966v1.7 doi: 10.2174/138920211796429772 – ident: 2016102717080532000_gkw966v1.44 doi: 10.1038/nsmb1128 – ident: 2016102717080532000_gkw966v1.2 doi: 10.1038/nature01266 – ident: 2016102717080532000_gkw966v1.32 doi: 10.1101/gad.381706 – ident: 2016102717080532000_gkw966v1.45 doi: 10.1038/nsmb1131 – ident: 2016102717080532000_gkw966v1.51 doi: 10.1126/science.1100576 – ident: 2016102717080532000_gkw966v1.48 doi: 10.1101/gr.191122.115 – ident: 2016102717080532000_gkw966v1.23 doi: 10.1128/JVI.05009-11 – ident: 2016102717080532000_gkw966v1.35 doi: 10.1128/MMBR.00006-15
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SubjectTerms	Cell Line, Tumor Chromatin - genetics Chromatin - metabolism Gene Expression Profiling Gene Knockdown Techniques Gene regulation, Chromatin and Epigenetics Genes, Homeobox Histone Demethylases - metabolism Histone-Lysine N-Methyltransferase - metabolism Homeodomain Proteins - genetics Humans MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Models, Genetic Myeloid-Lymphoid Leukemia Protein - metabolism Nuclear Proteins - metabolism Polycomb Repressive Complex 2 - metabolism RNA Interference Transcriptional Activation - drug effects Tretinoin - pharmacology
Title	Reciprocal regulation of chromatin state and architecture by HOTAIRM1 contributes to temporal collinear HOXA gene activation
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