Adverse Drug Interaction Between Kratom and Amitriptyline With Gastrointestinal and Mild Hepatic Effects

Kratom ( ) is a tropical evergreen plant native to Southeast Asia, where it has been used historically for its various psychoactive and analgesic properties. In recent years, the popularity of kratom has surged in the United States as a supplement for treating opioid withdrawal/addiction, anxiety, d...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) Vol. 15; no. 1; p. e33809
Main Authors: Vanani, Naisarg B, Stevanovic, Stephen G, Stevanovic, Nebojsa
Format: Journal Article
Language:English
Published: United States Springer Nature B.V 15.01.2023
Cureus
Subjects:
Addictions
Back pain
Case reports
Chronic pain
Constipation
Delirium
Drug addiction
Drug dosages
Drug interactions
Drug withdrawal
Enzymes
Family/General Practice
Fatigue
Insomnia
Liver
Mental depression
Metabolism
Narcotics
Nausea
Pain Management
Substance Use and Addiction
Vitamin deficiency
United States > US
chronic and acute pain management
adverse side effect
stress and depression
kratom
kratom addiction
elevated liver enzyme
pharmacology
medication interaction
opioid use disorder (oud)
substance abuse program
ISSN:2168-8184, 2168-8184
Online Access:Get full text
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Summary:Kratom ( ) is a tropical evergreen plant native to Southeast Asia, where it has been used historically for its various psychoactive and analgesic properties. In recent years, the popularity of kratom has surged in the United States as a supplement for treating opioid withdrawal/addiction, anxiety, depression, and chronic pain, among others. However, much of Kratom processing and sales remain largely unregulated, with little clinical research to demonstrate the effects of kratom on physiologic processes such as potential drug interactions. Here, we present a case of Kratom interaction with Amitriptyline in a patient recovering from Opioid Use Disorder.
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.33809