Induction by Phenobarbital of Phase I and II Xenobiotic-Metabolizing Enzymes in Bovine Liver: An Overall Catalytic and Immunochemical Characterization

In cattle, phenobarbital (PB) upregulates target drug-metabolizing enzyme (DME) mRNA levels. However, few data about PB’s post-transcriptional effects are actually available. This work provides the first, and an almost complete, characterization of PB-dependent changes in DME catalytic activities in...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 23; no. 7; p. 3564
Main Authors:	Cantiello, Michela, Carletti, Monica, Giantin, Mery, Gardini, Giulia, Capolongo, Francesca, Cascio, Paolo, Pauletto, Marianna, Girolami, Flavia, Dacasto, Mauro, Nebbia, Carlo
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 24.03.2022 MDPI
Subjects:	Animals Cattle Cytochrome Cytochrome P-450 Enzyme System - metabolism Enzyme Induction Enzymes Gene expression Liver Liver - metabolism Metabolism Microsomes, Liver - metabolism Phenobarbital - pharmacology Proteins Xenobiotics - metabolism hepatic drug metabolism phenobarbital induction enzyme activity species differences cattle drug-metabolizing enzymes
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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