Induction by Phenobarbital of Phase I and II Xenobiotic-Metabolizing Enzymes in Bovine Liver: An Overall Catalytic and Immunochemical Characterization

In cattle, phenobarbital (PB) upregulates target drug-metabolizing enzyme (DME) mRNA levels. However, few data about PB’s post-transcriptional effects are actually available. This work provides the first, and an almost complete, characterization of PB-dependent changes in DME catalytic activities in...

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Vydáno v:International journal of molecular sciences Ročník 23; číslo 7; s. 3564
Hlavní autoři: Cantiello, Michela, Carletti, Monica, Giantin, Mery, Gardini, Giulia, Capolongo, Francesca, Cascio, Paolo, Pauletto, Marianna, Girolami, Flavia, Dacasto, Mauro, Nebbia, Carlo
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 24.03.2022
MDPI
Témata:
Animals
Cattle
Cytochrome
Cytochrome P-450 Enzyme System - metabolism
Enzyme Induction
Enzymes
Gene expression
Liver
Liver - metabolism
Metabolism
Microsomes, Liver - metabolism
Phenobarbital - pharmacology
Proteins
Xenobiotics - metabolism
hepatic drug metabolism
phenobarbital
induction
enzyme activity
species differences
cattle
drug-metabolizing enzymes
ISSN:1422-0067, 1661-6596, 1422-0067
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Abstract In cattle, phenobarbital (PB) upregulates target drug-metabolizing enzyme (DME) mRNA levels. However, few data about PB’s post-transcriptional effects are actually available. This work provides the first, and an almost complete, characterization of PB-dependent changes in DME catalytic activities in bovine liver using common probe substrates and confirmatory immunoblotting investigations. As expected, PB increased the total cytochrome P450 (CYP) content and the extent of metyrapone binding; moreover, an augmentation of protein amounts and related enzyme activities was observed for known PB targets such as CYP2B, 2C, and 3A, but also CYP2E1. However, contradictory results were obtained for CYP1A, while a decreased catalytic activity was observed for flavin-containing monooxygenases 1 and 3. The barbiturate had no effect on the chosen hydrolytic and conjugative DMEs. For the first time, we also measured the 26S proteasome activity, and the increase observed in PB-treated cattle would suggest this post-translational event might contribute to cattle DME regulation. Overall, this study increased the knowledge of cattle hepatic drug metabolism, and further confirmed the presence of species differences in DME expression and activity between cattle, humans, and rodents. This reinforced the need for an extensive characterization and understanding of comparative molecular mechanisms involved in expression, regulation, and function of DMEs.
AbstractList In cattle, phenobarbital (PB) upregulates target drug-metabolizing enzyme (DME) mRNA levels. However, few data about PB's post-transcriptional effects are actually available. This work provides the first, and an almost complete, characterization of PB-dependent changes in DME catalytic activities in bovine liver using common probe substrates and confirmatory immunoblotting investigations. As expected, PB increased the total cytochrome P450 (CYP) content and the extent of metyrapone binding; moreover, an augmentation of protein amounts and related enzyme activities was observed for known PB targets such as CYP2B, 2C, and 3A, but also CYP2E1. However, contradictory results were obtained for CYP1A, while a decreased catalytic activity was observed for flavin-containing monooxygenases 1 and 3. The barbiturate had no effect on the chosen hydrolytic and conjugative DMEs. For the first time, we also measured the 26S proteasome activity, and the increase observed in PB-treated cattle would suggest this post-translational event might contribute to cattle DME regulation. Overall, this study increased the knowledge of cattle hepatic drug metabolism, and further confirmed the presence of species differences in DME expression and activity between cattle, humans, and rodents. This reinforced the need for an extensive characterization and understanding of comparative molecular mechanisms involved in expression, regulation, and function of DMEs.In cattle, phenobarbital (PB) upregulates target drug-metabolizing enzyme (DME) mRNA levels. However, few data about PB's post-transcriptional effects are actually available. This work provides the first, and an almost complete, characterization of PB-dependent changes in DME catalytic activities in bovine liver using common probe substrates and confirmatory immunoblotting investigations. As expected, PB increased the total cytochrome P450 (CYP) content and the extent of metyrapone binding; moreover, an augmentation of protein amounts and related enzyme activities was observed for known PB targets such as CYP2B, 2C, and 3A, but also CYP2E1. However, contradictory results were obtained for CYP1A, while a decreased catalytic activity was observed for flavin-containing monooxygenases 1 and 3. The barbiturate had no effect on the chosen hydrolytic and conjugative DMEs. For the first time, we also measured the 26S proteasome activity, and the increase observed in PB-treated cattle would suggest this post-translational event might contribute to cattle DME regulation. Overall, this study increased the knowledge of cattle hepatic drug metabolism, and further confirmed the presence of species differences in DME expression and activity between cattle, humans, and rodents. This reinforced the need for an extensive characterization and understanding of comparative molecular mechanisms involved in expression, regulation, and function of DMEs.
In cattle, phenobarbital (PB) upregulates target drug-metabolizing enzyme (DME) mRNA levels. However, few data about PB’s post-transcriptional effects are actually available. This work provides the first, and an almost complete, characterization of PB-dependent changes in DME catalytic activities in bovine liver using common probe substrates and confirmatory immunoblotting investigations. As expected, PB increased the total cytochrome P450 (CYP) content and the extent of metyrapone binding; moreover, an augmentation of protein amounts and related enzyme activities was observed for known PB targets such as CYP2B, 2C, and 3A, but also CYP2E1. However, contradictory results were obtained for CYP1A, while a decreased catalytic activity was observed for flavin-containing monooxygenases 1 and 3. The barbiturate had no effect on the chosen hydrolytic and conjugative DMEs. For the first time, we also measured the 26S proteasome activity, and the increase observed in PB-treated cattle would suggest this post-translational event might contribute to cattle DME regulation. Overall, this study increased the knowledge of cattle hepatic drug metabolism, and further confirmed the presence of species differences in DME expression and activity between cattle, humans, and rodents. This reinforced the need for an extensive characterization and understanding of comparative molecular mechanisms involved in expression, regulation, and function of DMEs.
Author Carletti, Monica
Girolami, Flavia
Dacasto, Mauro
Capolongo, Francesca
Pauletto, Marianna
Cantiello, Michela
Cascio, Paolo
Giantin, Mery
Gardini, Giulia
Nebbia, Carlo
AuthorAffiliation 1 Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy; michela.cantiello@gmail.com (M.C.); monica.carletti@irta-ricerche.it (M.C.); giulia.gardini@unito.it (G.G.); paolo.cascio@unito.it (P.C.); flavia.girolami@unito.it (F.G.)
2 Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Agripolis Legnaro, Italy; mery.giantin@unipd.it (M.G.); francesca.capolongo@unipd.it (F.C.); marianna.pauletto@unipd.it (M.P.)
AuthorAffiliation_xml – name: 2 Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Agripolis Legnaro, Italy; mery.giantin@unipd.it (M.G.); francesca.capolongo@unipd.it (F.C.); marianna.pauletto@unipd.it (M.P.)
– name: 1 Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy; michela.cantiello@gmail.com (M.C.); monica.carletti@irta-ricerche.it (M.C.); giulia.gardini@unito.it (G.G.); paolo.cascio@unito.it (P.C.); flavia.girolami@unito.it (F.G.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35408925$$D View this record in MEDLINE/PubMed
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Cites_doi 10.3109/03602532.2011.567391
10.1016/0167-4838(89)90057-5
10.1097/00008571-199512001-00013
10.1016/0024-3205(96)00132-4
10.1042/BJ20130685
10.3109/10715761003610729
10.1016/0006-2952(93)90583-I
10.1016/0006-2952(78)90244-7
10.1111/j.2042-7158.1997.tb06791.x
10.3109/00498250903540875
10.1016/0041-008X(79)90041-3
10.1515/dmdi-2012-0001
10.1111/j.1600-0773.2001.890301.x
10.1042/bj2810577
10.1191/0960327102ht208oa
10.1016/j.tox.2020.152394
10.1016/j.dmpk.2014.12.001
10.1016/0003-9861(84)90600-3
10.1006/abbi.1999.1138
10.1016/S0076-6879(78)52026-0
10.1080/17425255.2016.1201069
10.2174/1389200219666180821094502
10.1146/annurev.pharmtox.45.120403.100030
10.1124/dmd.106.012492
10.1007/BF00324544
10.1111/j.1365-2885.2012.01427.x
10.1089/jmf.2021.K.0003
10.1016/j.bcp.2008.10.025
10.1515/dmdi-2014-0009
10.1016/S1090-0233(02)00174-0
10.1017/S1751731110001394
10.1080/00498254.2020.1867929
10.1016/j.jclinepi.2007.04.021
10.1006/abbi.1999.1351
10.2174/138920006776873544
10.1016/0300-483X(95)03221-Z
10.1016/j.lfs.2006.11.022
10.1080/00498250903098184
10.1139/y00-066
10.18388/abp.2000_3962
10.1016/0378-4274(88)90059-8
10.1046/j.1365-2885.2002.00385.x
10.3109/03602532.2014.973037
10.1074/jbc.M114.611525
10.2527/jas1987.641210x
10.1016/0003-9861(88)90273-1
10.1016/j.bbagen.2004.11.018
10.2460/ajvr.2003.64.1167
10.1016/j.lfs.2009.10.015
10.1053/tvjl.2000.0561
10.1139/y01-063
10.1016/S0887-2333(97)00051-9
10.1124/dmd.115.065201
10.3109/00498259409043279
10.1081/DMR-100101944
10.1016/j.yexcr.2017.09.011
10.11131/2015/101178
10.1016/j.ejphar.2008.03.013
10.1371/journal.pone.0196931
10.1124/jpet.106.112268
10.1046/j.1365-2885.2001.00362.x
10.1016/S0006-2952(97)00476-0
10.3109/00498259609050257
10.1074/jbc.M806104200
10.1089/ars.2019.7905
10.1002/jbt.20118
10.1111/bcpt.13004
10.1016/S0076-6879(78)52031-4
10.1016/j.toxrep.2020.12.019
10.1016/j.tox.2018.02.001
10.1515/hsz-2011-0285
10.1080/03602532.2016.1195403
10.1042/bj2630679
10.1124/dmd.116.070763
10.1016/S1532-0456(02)00224-7
10.1016/j.scitotenv.2015.06.001
10.1016/0006-2952(90)90008-9
10.1042/bj2520930
10.1016/0014-5793(82)80829-6
10.1016/S0887-2333(01)00076-5
10.1002/jbt.2570060206
10.1517/17425255.3.1.33
10.2174/1389200214666131211153307
10.1016/j.jsbmb.2004.12.015
10.1007/s12010-014-0931-1
10.1124/pr.55.4.2
10.1006/bbrc.1994.2189
10.2131/jts.34.647
10.1021/tx00022a013
10.3109/03602532.2011.597401
10.1038/cr.2016.86
10.1016/0009-2797(94)03584-U
10.1124/jpet.116.233635
10.1517/17425255.2013.754010
10.1111/j.1742-7843.2006.pto_261.x
10.1016/0006-2952(93)90195-3
10.1002/hep.510230432
10.1080/15287390500180549
10.1016/j.bbamcr.2014.05.005
10.1074/jbc.REV120.007933
10.1038/s41598-019-45212-0
10.2133/dmpk.DMPK-11-RG-146
10.1152/physrev.00058.2017
10.1016/j.crtox.2021.03.002
10.1016/j.ejphar.2006.09.006
10.1016/j.bcp.2012.04.002
10.3109/00498259309059405
10.1124/dmd.115.066316
10.1016/0887-2333(93)90052-7
10.1016/S1056-8719(97)00013-0
10.1016/j.vetimm.2015.04.005
10.1007/s43188-020-00056-z
10.2527/jas1984.582386x
10.1016/j.ejps.2015.07.006
10.1016/j.transproceed.2009.02.061
10.1016/j.pharmthera.2004.10.013
10.5507/bp.2010.017
10.1016/j.dmpk.2017.10.002
10.3109/00498254.2014.997325
10.1016/j.tox.2010.11.008
10.3390/ijms21134708
10.1124/dmd.106.012005
10.1016/S0034-5288(96)90127-7
10.1097/00008571-199906000-00004
10.1677/joe.0.1320083
10.1016/j.tvjl.2019.01.001
10.1016/0041-008X(76)90132-0
10.1074/jbc.275.12.8432
10.2527/jas1986.6341184x
10.1006/abbi.1999.1139
10.1124/dmd.106.010397
10.1517/17425255.2013.741589
10.1006/taap.2000.8994
10.1007/978-3-319-98788-0_2
10.1006/meth.2001.1262
10.1371/journal.pone.0214338
10.3109/01480549609002199
10.2460/ajvr.1994.55.11.1579
10.1016/j.taap.2008.11.008
10.1016/j.pharmthera.2012.12.007
10.1016/j.ijbiomac.2018.06.104
10.1016/S0006-2952(97)00679-5
10.1146/annurev-pharmtox-052220-105907
10.1124/dmd.107.019042
10.2460/ajvr.1991.52.10.1717
10.1021/tx034253s
10.1111/j.1365-2885.2009.01145.x
10.1002/hep.21234
10.1016/j.redox.2014.11.008
10.1080/03602532.2017.1343343
10.1002/jbt.10054
10.1002/(SICI)1099-081X(199704)18:3<213::AID-BDD15>3.0.CO;2-0
10.1111/j.1365-2885.2010.01173.x
10.1016/0300-483X(94)02918-K
10.1016/j.rvsc.2009.03.018
10.1016/j.ejphar.2008.03.014
10.1016/0300-483X(84)90077-5
10.1016/j.cca.2003.10.003
10.1016/j.toxlet.2011.07.014
10.1016/0006-2952(89)90192-5
10.1584/jpestics.30.75
10.1016/j.mam.2008.08.006
10.1016/j.tiv.2006.08.001
10.1016/0003-9861(85)90562-4
10.1016/j.yrtph.2011.02.006
10.1016/j.addr.2010.08.006
10.1111/j.1365-2885.2009.01137.x
10.1007/s00204-014-1371-y
10.1016/S0076-6879(05)00007-8
10.1074/jbc.M110.176685
10.1007/s11626-019-00408-6
10.1016/j.yexmp.2004.07.002
10.1080/00498254.2016.1246782
10.1371/journal.pone.0096092
10.18433/J31S53
10.1016/j.bcp.2009.08.008
10.1081/DMR-120005650
10.1007/BF02977789
10.1016/0006-2952(82)90408-7
10.1517/17425250903234709
10.2302/kjm.2012-0006-RE
10.1124/dmd.115.067439
10.2527/jas1987.651186x
10.1002/jbt.20103
10.1081/DMR-120023683
10.1016/j.bbrc.2018.12.124
10.1021/ja053809q
10.1016/j.lfs.2004.09.042
10.1111/jvp.12906
10.1080/17425255.2020.1746268
10.1186/1471-2164-11-9
10.1124/dmd.31.4.421
10.1016/j.tox.2008.09.002
10.1016/0742-8413(88)90053-9
10.1093/emboj/21.11.2636
10.1016/0006-2952(93)90326-R
10.1016/S0021-9258(19)52451-6
10.1016/j.tiv.2013.07.009
10.1016/j.tvjl.2008.08.006
10.1002/jat.2756
10.3109/03602530903205492
10.1016/j.scitotenv.2013.01.095
10.1016/j.tvjl.2014.07.028
10.1124/dmd.30.11.1206
10.1007/s11259-006-3247-y
10.1111/jpn.12416
10.1517/17425255.2.6.875
10.1016/S0034-5288(03)00143-7
10.1016/j.mrrev.2018.10.002
10.1038/s41389-017-0025-3
10.1016/j.fct.2008.05.018
10.1111/j.1530-0277.1992.tb01893.x
10.1016/S0006-2952(01)00710-9
10.3109/00498254.2015.1060374
10.1021/acs.biochem.8b01221
10.3390/ijms22010013
10.1016/j.apsb.2019.11.002
10.1006/taap.1998.8391
10.2174/138920009789375397
10.3109/00498254.2012.694493
10.3109/00498254.2010.489125
10.1111/j.1440-1681.1998.tb02135.x
10.3390/ijms22158062
10.1146/annurev.pharmtox.46.120604.141043
10.4142/jvs.2005.6.4.279
10.3109/00498254.2010.506562
10.3109/10408444.2013.835786
10.1016/j.gene.2015.07.071
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ISSN 1422-0067
1661-6596
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Issue 7
Keywords hepatic drug metabolism
phenobarbital
induction
enzyme activity
species differences
cattle
drug-metabolizing enzymes
Language English
License Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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These authors contributed equally to this work.
Current address: IRTA Ricerche s.r.l., 10093 Collegno, Italy.
Current address: Eurofins Biopharma Services, 33000 Bordeaux, France.
ORCID 0000-0001-9005-5301
0000-0003-0624-7787
0000-0002-3637-5643
0000-0003-0015-3800
0000-0002-2424-7484
OpenAccessLink https://www.proquest.com/docview/2649060419?pq-origsite=%requestingapplication%
PMID 35408925
PQID 2649060419
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ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8998613
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crossref_citationtrail_10_3390_ijms23073564
crossref_primary_10_3390_ijms23073564
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References Swales (ref_68) 1996; 24
Caron (ref_128) 2005; 19
Niwa (ref_121) 2016; 19
Jackson (ref_115) 2006; 34
Tuomi (ref_133) 1989; 38
Ejiri (ref_129) 2005; 78
Oladimeji (ref_59) 2016; 12
Xiao (ref_166) 2012; 84
Girolami (ref_7) 2013; 450–451
Raunio (ref_53) 2012; 27
Smith (ref_100) 1984; 58
Graham (ref_143) 2002; 30
Correia (ref_216) 2003; 35
Cerny (ref_161) 2016; 44
Nousiainen (ref_243) 1984; 32
Hakkola (ref_16) 2018; 123
Bjercke (ref_86) 1990; 18
Negishi (ref_25) 2020; 295
Cederbaum (ref_77) 2015; 4
Guengerich (ref_21) 2018; 1032
Chirulli (ref_27) 2005; 76
Cantiello (ref_229) 2008; 46
(ref_14) 2008; 585
Fukunaga (ref_37) 2009; 87
Zaher (ref_135) 1998; 55
Goettel (ref_113) 2020; 433–434
Zemaitis (ref_244) 1979; 48
Ribalta (ref_168) 2015; 532
Kim (ref_185) 2005; 68
Ramana (ref_74) 1996; 19
Carlson (ref_195) 1995; 96
Graham (ref_38) 2006; 20
Bell (ref_55) 2006; 44
Kaniuga (ref_80) 1974; 21
Roos (ref_93) 1993; 45
Koukouritaki (ref_149) 2007; 320
Ugazio (ref_237) 1991; 73
Nebbia (ref_2) 2001; 161
Lake (ref_9) 2009; 39
Zheng (ref_63) 2011; 60
Forman (ref_179) 2009; 30
(ref_169) 2014; 88
Briolotti (ref_60) 2021; 2
Kwon (ref_47) 2020; 10
ref_87
Raule (ref_211) 2015; 166
Nebbia (ref_10) 2003; 165
Chen (ref_223) 2014; 458
(ref_178) 2020; 33
Ahmad (ref_188) 1988; 266
Nomura (ref_122) 1997; 49
Chen (ref_146) 1996; 58
Dent (ref_233) 1976; 38
Henderson (ref_155) 2004; 17
Nebbia (ref_236) 1996; 60
Agrawal (ref_69) 1996; 49
Liu (ref_228) 1985; 241
Nebbia (ref_90) 1999; 27
Marini (ref_34) 2007; 80
Chatuphonprasert (ref_112) 2012; 32
Zhang (ref_46) 2016; 358
Ma (ref_219) 2000; 275
Werringloer (ref_231) 1978; 52
Hasegawa (ref_245) 1982; 31
Nebert (ref_235) 1978; 52
Shizu (ref_29) 2020; 16
Waxman (ref_127) 1992; 281
Jones (ref_180) 1995; 105
Goriya (ref_35) 2005; 6
Correia (ref_54) 2007; 3
Dogra (ref_19) 1998; 25
Cantiello (ref_64) 2009; 77
Zancanella (ref_43) 2014; 202
Gusson (ref_8) 2006; 30
Schelstraete (ref_138) 2019; 9
Kawalek (ref_111) 2003; 64
Plummer (ref_28) 2020; 8
Lee (ref_147) 2006; 552
Dennis (ref_221) 2005; 93
Hui (ref_156) 1988; 41
Elcombe (ref_23) 2014; 44
Chai (ref_57) 2013; 9
Fukami (ref_159) 2022; 62
Puccinelli (ref_30) 2010; 40
Korsmeyer (ref_214) 1999; 365
Meech (ref_199) 2019; 99
Rutten (ref_226) 1987; 61
Bock (ref_202) 2010; 42
Zancanella (ref_44) 2012; 42
Cascio (ref_248) 2002; 21
Hu (ref_205) 2014; 46
Nishibe (ref_131) 1993; 23
Callaerts (ref_132) 1997; 11
Reinke (ref_238) 1985; 13
Wang (ref_218) 2015; 290
Livak (ref_249) 2001; 25
(ref_84) 2002; 16
Park (ref_91) 2005; 127
Deng (ref_171) 2018; 778
Tien (ref_116) 2015; 43
Girolami (ref_6) 2011; 206
Somchit (ref_67) 2002; 21
Kloss (ref_89) 1983; 23
Antoine (ref_246) 1988; 252
Rasmussen (ref_32) 2017; 360
Madan (ref_140) 2003; 31
ref_224
Gonzalez (ref_136) 1995; 5
ref_227
Giorgi (ref_72) 2000; 167
Longo (ref_96) 1991; 6
Fujiwara (ref_201) 2018; 33
Allocati (ref_186) 2018; 7
Ohtsuki (ref_48) 2019; 509
Heidari (ref_184) 2014; 4
Wang (ref_215) 2009; 284
Wheelock (ref_167) 2005; 30
Tanaka (ref_212) 2013; 62
Livneh (ref_209) 2016; 26
Capolongo (ref_104) 2010; 33
Dupuy (ref_33) 2001; 79
Haines (ref_110) 2018; 396–397
Truong (ref_176) 2021; 24
Smutny (ref_222) 2013; 14
Yoshioka (ref_42) 2020; 56
Handschin (ref_126) 2003; 55
Monostory (ref_148) 1994; 203
Darwish (ref_192) 2010; 4
Lopparelli (ref_193) 2010; 40
Pustylnyak (ref_58) 2009; 85
Graham (ref_196) 2008; 254
ref_11
Cashman (ref_157) 2006; 46
Petrilla (ref_36) 2016; 100
Ganem (ref_173) 1998; 150
Kojima (ref_61) 2011; 280
Zanger (ref_114) 2013; 138
Lamka (ref_101) 2004; 76
Giantin (ref_151) 2019; 245
Decker (ref_154) 1991; 4
Hayes (ref_190) 1989; 994
Coecke (ref_158) 1993; 7
Shaik (ref_75) 2010; 44
Court (ref_203) 2005; 400
Martignoni (ref_15) 2006; 2
Mitani (ref_92) 1982; 148
Morel (ref_197) 1996; 23
Watkins (ref_102) 1987; 65
Short (ref_99) 1988; 91
Fukami (ref_162) 2015; 78
Plewka (ref_82) 1988; 39
Nassi (ref_107) 2020; 43
Ziegler (ref_242) 2002; 34
Hughes (ref_170) 2015; 571
Giantin (ref_31) 2012; 27
Zancanella (ref_119) 2010; 33
Jensson (ref_247) 1989; 263
Nebbia (ref_145) 1996; 26
Court (ref_105) 1997; 18
Gao (ref_160) 2018; 118
Mohana (ref_181) 2017; 49
Raule (ref_210) 2014; 1843
Pegolo (ref_240) 2010; 40
Donato (ref_71) 1990; 39
Wang (ref_217) 2011; 286
Czernik (ref_207) 1999; 31
Merali (ref_165) 2014; 29
Grasso (ref_94) 2005; 1722
Yoshinari (ref_134) 2010; 79
Jancova (ref_175) 2010; 154
Yang (ref_130) 2003; 136
Henderson (ref_234) 1994; 24
Bastien (ref_120) 2000; 78
Baldini (ref_141) 2009; 41
Oda (ref_200) 2015; 30
Giantin (ref_189) 2008; 36
Hassett (ref_174) 1998; 55
Lee (ref_150) 1995; 96
Erzengin (ref_106) 2014; 173
Chu (ref_1) 2013; 9
Sevrioukova (ref_88) 2019; 58
Lucas (ref_144) 1992; 16
Tanaka (ref_213) 2012; 393
Zancanella (ref_66) 2016; 46
ref_172
Kawalek (ref_95) 1994; 55
Gonzalez (ref_20) 2007; 35
Catania (ref_142) 2007; 21
Choughule (ref_177) 2015; 45
ref_52
Prakash (ref_17) 2015; 2
Meikle (ref_191) 1992; 132
Saary (ref_51) 2008; 61
Kim (ref_208) 2016; 48
Sivapathasundaram (ref_98) 2003; 134
Gervot (ref_109) 1999; 9
Blaauboer (ref_41) 1993; 46
Corcos (ref_124) 2001; 89
Bullock (ref_70) 1995; 23
Wang (ref_49) 1999; 365
Wisniewski (ref_103) 1987; 64
Viviani (ref_152) 2017; 47
Virkel (ref_123) 2010; 33
Chen (ref_56) 2009; 10
Czekaj (ref_125) 2000; 47
Walker (ref_117) 2001; 15
ref_163
ref_65
Ioannides (ref_118) 2006; 7
Donato (ref_139) 2000; 28
Kaplan (ref_79) 1978; 27
Cantiello (ref_50) 2006; 26
Nebbia (ref_230) 2001; 24
Nebbia (ref_153) 1991; 52
Stefanski (ref_40) 2013; 27
Buters (ref_232) 1993; 46
Komura (ref_13) 2011; 43
Angelov (ref_83) 1993; 31
Thomford (ref_76) 1986; 63
Purdon (ref_239) 1997; 37
Schrickx (ref_3) 2008; 585
Hojo (ref_73) 2002; 25
Higgins (ref_187) 2011; 43
Waxman (ref_22) 1999; 369
Cui (ref_220) 2015; 43
Gillberg (ref_137) 2006; 98
Sivapathasundaram (ref_97) 2001; 62
Guengerich (ref_12) 2021; 37
Lowry (ref_225) 1951; 193
Liu (ref_45) 2021; 51
Shelby (ref_206) 2006; 34
Xu (ref_4) 2005; 28
Bhagwat (ref_194) 1998; 13
Zancanella (ref_24) 2013; 36
Pegolo (ref_108) 2010; 183
Huang (ref_182) 2018; 96
ref_183
Lambert (ref_62) 2009; 234
Di (ref_164) 2019; 20
Taira (ref_85) 1980; 18
Coon (ref_78) 2005; 45
Makino (ref_39) 2009; 34
Sakakibara (ref_204) 2016; 44
Dixit (ref_241) 1984; 233
Plewka (ref_81) 1992; 33
Kiang (ref_198) 2005; 106
ref_5
Tolson (ref_18) 2010; 62
Anderson (ref_26) 2009; 5
References_xml – volume: 43
  start-page: 92
  year: 2011
  ident: ref_187
  article-title: Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents
  publication-title: Drug Metab. Rev.
  doi: 10.3109/03602532.2011.567391
– volume: 994
  start-page: 21
  year: 1989
  ident: ref_190
  article-title: Expression of glyoxalase, glutathione peroxidase and glutathione S-transferase isoenzymes in different bovine tissues
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/0167-4838(89)90057-5
– volume: 5
  start-page: S123
  year: 1995
  ident: ref_136
  article-title: The CYP2A gene subfamily: Species differences, regulation, catalytic activities and role in chemical carcinogenesis
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199512001-00013
– volume: 58
  start-page: 1575
  year: 1996
  ident: ref_146
  article-title: Effects of cytochrome P450 2E1 modulators on the pharmacokinetics of chlorzoxazone and 6-hydroxychlorzoxazone in rats
  publication-title: Life Sci.
  doi: 10.1016/0024-3205(96)00132-4
– volume: 458
  start-page: 95
  year: 2014
  ident: ref_223
  article-title: Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor
  publication-title: Biochem. J.
  doi: 10.1042/BJ20130685
– volume: 44
  start-page: 441
  year: 2010
  ident: ref_75
  article-title: Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers
  publication-title: Free Radic. Res.
  doi: 10.3109/10715761003610729
– volume: 46
  start-page: 1781
  year: 1993
  ident: ref_41
  article-title: Cytochrome P450 induction and metabolism of alkoxyresorufins, ethylmorphine and testosterone in cultured hepatocytes from goats, sheep and cattle
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/0006-2952(93)90583-I
– volume: 27
  start-page: 367
  year: 1978
  ident: ref_79
  article-title: Phenobarbital-induced increase of NADH-cytochrome b5 reductase activity in rat liver microsomes
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/0006-2952(78)90244-7
– volume: 49
  start-page: 257
  year: 1997
  ident: ref_122
  article-title: Stereoselective N-demethylation of chlorpheniramine by rat-liver microsomes and the involvement of cytochrome P450 isozymes
  publication-title: J. Pharm. Pharmacol.
  doi: 10.1111/j.2042-7158.1997.tb06791.x
– volume: 40
  start-page: 255
  year: 2010
  ident: ref_240
  article-title: Testosterone hydroxylation in bovine liver: Enzyme kinetic and inhibition study
  publication-title: Xenobiotica
  doi: 10.3109/00498250903540875
– volume: 48
  start-page: 343
  year: 1979
  ident: ref_244
  article-title: In vivo and in vitro effects of thiuram disulfides and dithiocarbamates on hepatic microsomal drug metabolism in the rat
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/0041-008X(79)90041-3
– volume: 27
  start-page: 73
  year: 2012
  ident: ref_53
  article-title: CYP2A6: Genetics, structure, regulation, and function
  publication-title: Drug Metab. Drug Interact.
  doi: 10.1515/dmdi-2012-0001
– volume: 89
  start-page: 113
  year: 2001
  ident: ref_124
  article-title: Gene induction by phenobarbital: An update on an old question that receives key novel answers
  publication-title: Pharmacol. Toxicol.
  doi: 10.1111/j.1600-0773.2001.890301.x
– volume: 281
  start-page: 577
  year: 1992
  ident: ref_127
  article-title: Phenobarbital induction of cytochrome P-450 gene expression
  publication-title: Biochem. J.
  doi: 10.1042/bj2810577
– volume: 21
  start-page: 43
  year: 2002
  ident: ref_67
  article-title: Itraconazole- and fluconazole-induced toxicity in rat hepatocytes: A comparative in vitro study
  publication-title: Hum. Exp. Toxicol.
  doi: 10.1191/0960327102ht208oa
– volume: 433–434
  start-page: 152394
  year: 2020
  ident: ref_113
  article-title: Comparative studies on the effects of sodium phenobarbital and two other constitutive androstane receptor (CAR) activators on induction of cytochrome P450 enzymes and replicative DNA synthesis in cultured hepatocytes from wild type and CAR knockout rats
  publication-title: Toxicology
  doi: 10.1016/j.tox.2020.152394
– volume: 21
  start-page: 61
  year: 1974
  ident: ref_80
  article-title: The involvement of NADH-cytochrome b5 reductase and cytochrome b5 complex in microsomal NADH-cytochrome c reductase activity. Changes in NADH-cytochrome c reductase activity following phenobarbital treatment
  publication-title: Acta Biochim. Pol.
– volume: 30
  start-page: 30
  year: 2015
  ident: ref_200
  article-title: A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development
  publication-title: Drug Metab. Pharmacokinet.
  doi: 10.1016/j.dmpk.2014.12.001
– volume: 233
  start-page: 50
  year: 1984
  ident: ref_241
  article-title: Spectrophotometric assay of the flavin-containing monooxygenase and changes in its activity in female mouse liver with nutritional and diurnal conditions
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1016/0003-9861(84)90600-3
– volume: 24
  start-page: 1224
  year: 1996
  ident: ref_68
  article-title: Cryopreservation of rat and mouse hepatocytes. II. Assessment of metabolic capacity using testosterone metabolism
  publication-title: Drug Metab. Dispos.
– volume: 365
  start-page: 31
  year: 1999
  ident: ref_214
  article-title: Proteolytic degradation of heme-modified hepatic cytochromes P450: A role for phosphorylation, ubiquitination, and the 26S proteasome?
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1006/abbi.1999.1138
– volume: 52
  start-page: 226
  year: 1978
  ident: ref_235
  article-title: Genetic differences in microsomal electron transport: The Ah locus
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(78)52026-0
– volume: 12
  start-page: 997
  year: 2016
  ident: ref_59
  article-title: Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk
  publication-title: Expert Opin. Drug Metab. Toxicol.
  doi: 10.1080/17425255.2016.1201069
– volume: 20
  start-page: 91
  year: 2019
  ident: ref_164
  article-title: The impact of carboxylesterases in drug metabolism and pharmacokinetics
  publication-title: Curr. Drug Metab.
  doi: 10.2174/1389200219666180821094502
– volume: 45
  start-page: 1
  year: 2005
  ident: ref_78
  article-title: Cytochrome P450: Nature’s most versatile biological catalyst
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev.pharmtox.45.120403.100030
– volume: 35
  start-page: 1
  year: 2007
  ident: ref_20
  article-title: The 2006 Bernard B. Brodie Award Lecture: CYP2E1
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.106.012492
– volume: 61
  start-page: 27
  year: 1987
  ident: ref_226
  article-title: Interlaboratory comparison of total cytochrome P-450 and protein determinations in rat liver microsomes
  publication-title: Arch. Toxicol.
  doi: 10.1007/BF00324544
– volume: 4
  start-page: 21
  year: 2014
  ident: ref_184
  article-title: Effects of enzyme induction and/or glutathione depletion on methimazole-induced hepatotoxicity in mice and the protective role of N-acetylcysteine
  publication-title: Adv. Pharm. Bull.
– volume: 36
  start-page: 358
  year: 2013
  ident: ref_24
  article-title: Tissue distribution and phenobarbital induction of target SLC- and ABC- transporters in cattle
  publication-title: J. Vet. Pharmacol. Ther.
  doi: 10.1111/j.1365-2885.2012.01427.x
– volume: 24
  start-page: 786
  year: 2021
  ident: ref_176
  article-title: Phytochemical and over-the-counter drug interactions: Involvement of phase I and II drug-metabolizing enzymes and phase III transporters
  publication-title: J. Med. Food
  doi: 10.1089/jmf.2021.K.0003
– volume: 77
  start-page: 451
  year: 2009
  ident: ref_64
  article-title: Effects of dexamethasone, administered for growth promoting purposes, upon the hepatic cytochrome P450 3A expression in the veal calf
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2008.10.025
– volume: 29
  start-page: 143
  year: 2014
  ident: ref_165
  article-title: The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect
  publication-title: Drug Metab. Drug Interact.
  doi: 10.1515/dmdi-2014-0009
– volume: 165
  start-page: 53
  year: 2003
  ident: ref_10
  article-title: Comparative expression of liver cytochrome P450-dependent monooxygenases in the horse and in other agricultural and laboratory species
  publication-title: Vet. J.
  doi: 10.1016/S1090-0233(02)00174-0
– volume: 4
  start-page: 2023
  year: 2010
  ident: ref_192
  article-title: High expression of the mRNA of cytochrome P450 and phase II enzymes in the lung and kidney tissues of cattle
  publication-title: Animal
  doi: 10.1017/S1751731110001394
– volume: 51
  start-page: 279
  year: 2021
  ident: ref_45
  article-title: Expression of cytochrome P450 isozyme transcripts and activities in human livers
  publication-title: Xenobiotica
  doi: 10.1080/00498254.2020.1867929
– volume: 61
  start-page: 311
  year: 2008
  ident: ref_51
  article-title: Radar plots: A useful way for presenting multivariate health care data
  publication-title: J. Clin. Epidemiol.
  doi: 10.1016/j.jclinepi.2007.04.021
– volume: 369
  start-page: 11
  year: 1999
  ident: ref_22
  article-title: P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1006/abbi.1999.1351
– volume: 7
  start-page: 335
  year: 2006
  ident: ref_118
  article-title: Cytochrome p450 expression in the liver of food-producing animals
  publication-title: Curr. Drug Metab.
  doi: 10.2174/138920006776873544
– volume: 105
  start-page: 267
  year: 1995
  ident: ref_180
  article-title: Variability in glutathione-dependent detoxication in vivo and its relevance to detoxication of chemical mixtures
  publication-title: Toxicology
  doi: 10.1016/0300-483X(95)03221-Z
– volume: 80
  start-page: 910
  year: 2007
  ident: ref_34
  article-title: Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2006.11.022
– volume: 39
  start-page: 582
  year: 2009
  ident: ref_9
  article-title: Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: Relationship to rodent liver tumour formation
  publication-title: Xenobiotica
  doi: 10.1080/00498250903098184
– volume: 78
  start-page: 912
  year: 2000
  ident: ref_120
  article-title: Differential alteration of cytochrome P450 isoenzymes in two experimental models of cirrhosis
  publication-title: Can. J. Physiol. Pharmacol.
  doi: 10.1139/y00-066
– volume: 47
  start-page: 1093
  year: 2000
  ident: ref_125
  article-title: Phenobarbital-induced expression of cytochrome P450 genes
  publication-title: Acta Biochim. Pol.
  doi: 10.18388/abp.2000_3962
– volume: 41
  start-page: 231
  year: 1988
  ident: ref_156
  article-title: Monooxygenase-mediated metabolism and binding of ethylene thiourea to mouse liver microsomal protein
  publication-title: Toxicol. Lett.
  doi: 10.1016/0378-4274(88)90059-8
– volume: 25
  start-page: 121
  year: 2002
  ident: ref_73
  article-title: Enzyme and plasma protein induction by multiple oral administrations of phenobarbital at a therapeutic dosage regimen in dogs
  publication-title: J. Vet. Pharmacol. Ther.
  doi: 10.1046/j.1365-2885.2002.00385.x
– volume: 46
  start-page: 421
  year: 2014
  ident: ref_205
  article-title: Transcriptional regulation of human UDP-glucuronosyltransferase genes
  publication-title: Drug Metab. Rev.
  doi: 10.3109/03602532.2014.973037
– volume: 290
  start-page: 3308
  year: 2015
  ident: ref_218
  article-title: Human liver cytochrome P450 3A4 ubiquitination: Molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M114.611525
– volume: 64
  start-page: 210
  year: 1987
  ident: ref_103
  article-title: Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep
  publication-title: J. Anim. Sci.
  doi: 10.2527/jas1987.641210x
– volume: 266
  start-page: 416
  year: 1988
  ident: ref_188
  article-title: Differential expression of alpha, mu and pi classes of isozymes of glutathione S-transferase in bovine lens, cornea, and retina
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1016/0003-9861(88)90273-1
– volume: 1722
  start-page: 116
  year: 2005
  ident: ref_94
  article-title: Cytochrome P450 expression and catalytic activity in coronary arteries and liver of cattle
  publication-title: Biochim. Biophys. Acta (BBA)-Gen. Subj.
  doi: 10.1016/j.bbagen.2004.11.018
– volume: 64
  start-page: 1167
  year: 2003
  ident: ref_111
  article-title: Effect of oral administration of low doses of pentobarbital on the induction of cytochrome P450 isoforms and cytochrome P450-mediated reactions in immature Beagles
  publication-title: Am. J. Vet. Res.
  doi: 10.2460/ajvr.2003.64.1167
– volume: 85
  start-page: 815
  year: 2009
  ident: ref_58
  article-title: Species-specific induction of CYP2B by 2,4,6-tryphenyldioxane-1,3 (TPD)
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2009.10.015
– volume: 96
  start-page: 5152
  year: 2018
  ident: ref_182
  article-title: Glutathione content and expression of proteins involved with glutathione metabolism differs in longissimus dorsi, subcutaneous adipose, and liver tissues of finished vs. growing beef steers
  publication-title: J. Anim. Sci.
– volume: 161
  start-page: 238
  year: 2001
  ident: ref_2
  article-title: Biotransformation enzymes as determinants of xenobiotic toxicity in domestic animals
  publication-title: Vet. J.
  doi: 10.1053/tvjl.2000.0561
– volume: 79
  start-page: 848
  year: 2001
  ident: ref_33
  article-title: Differential effects of phenobarbital on the constitutive and inducible expression of P450 2B and 3A subfamilies in sheep tissues
  publication-title: Can. J. Physiol. Pharmacol.
  doi: 10.1139/y01-063
– volume: 11
  start-page: 459
  year: 1997
  ident: ref_132
  article-title: Effect of phenobarbital on 7-ethoxycoumarin-O-deethylase and microsomal epoxide hydrase activities in collagen gel cultures of rat hepatocytes
  publication-title: Toxicol. In Vitro
  doi: 10.1016/S0887-2333(97)00051-9
– volume: 43
  start-page: 1316
  year: 2015
  ident: ref_220
  article-title: SUMOylation and ubiquitylation circuitry controls pregnane X receptor biology in hepatocytes
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.115.065201
– volume: 24
  start-page: 795
  year: 1994
  ident: ref_234
  article-title: Metabolism of [3-14C] coumarin by human liver microsomes
  publication-title: Xenobiotica
  doi: 10.3109/00498259409043279
– volume: 31
  start-page: 817
  year: 1999
  ident: ref_207
  article-title: Structural and functional studies of UDP-glucuronosyltransferases
  publication-title: Drug Metab. Rev.
  doi: 10.1081/DMR-100101944
– volume: 360
  start-page: 218
  year: 2017
  ident: ref_32
  article-title: Induction of cytochrome P450 mRNA in porcine primary hepatocytes cultured under serum free conditions: Comparison of freshly isolated cells and cryopreserved
  publication-title: Exp. Cell Res.
  doi: 10.1016/j.yexcr.2017.09.011
– volume: 2
  start-page: 101178
  year: 2015
  ident: ref_17
  article-title: Nuclear receptors in drug metabolism, drug response and drug interactions
  publication-title: Nucl. Recept. Res.
  doi: 10.11131/2015/101178
– volume: 585
  start-page: 502
  year: 2008
  ident: ref_14
  article-title: Implications of hepatic cytochrome P450-related biotransformation processes in veterinary sciences
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2008.03.013
– ident: ref_87
  doi: 10.1371/journal.pone.0196931
– volume: 320
  start-page: 266
  year: 2007
  ident: ref_149
  article-title: Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.106.112268
– volume: 24
  start-page: 399
  year: 2001
  ident: ref_230
  article-title: Oxidative monensin metabolism and cytochrome P450 3A content and functions in liver microsomes from horses, pigs, broiler chicks, cattle and rats
  publication-title: J. Vet. Pharmacol. Ther.
  doi: 10.1046/j.1365-2885.2001.00362.x
– volume: 55
  start-page: 235
  year: 1998
  ident: ref_135
  article-title: Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/S0006-2952(97)00476-0
– volume: 26
  start-page: 1121
  year: 1996
  ident: ref_145
  article-title: Gender differences in ethanol oxidation and cytochrome P4502E1 content and functions in hepatic microsomes from alcohol-preferring and non-preferring rats
  publication-title: Xenobiotica
  doi: 10.3109/00498259609050257
– volume: 284
  start-page: 5671
  year: 2009
  ident: ref_215
  article-title: A role for protein phosphorylation in cytochrome P450 3A4 ubiquitin-dependent proteasomal degradation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M806104200
– volume: 33
  start-page: 498
  year: 2020
  ident: ref_178
  article-title: Regulatory phenomena in the glutathione peroxidase superfamily
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2019.7905
– volume: 20
  start-page: 69
  year: 2006
  ident: ref_38
  article-title: Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes
  publication-title: J. Biochem. Mol. Toxicol.
  doi: 10.1002/jbt.20118
– volume: 123
  start-page: 42
  year: 2018
  ident: ref_16
  article-title: Cytochrome P450 induction and xeno-sensing receptors pregnane X receptor, constitutive androstane receptor, aryl hydrocarbon receptor and peroxisome proliferator-activated receptor α at the crossroads of toxicokinetics and toxicodynamics
  publication-title: Basic Clin. Pharmacol. Toxicol.
  doi: 10.1111/bcpt.13004
– volume: 52
  start-page: 297
  year: 1978
  ident: ref_231
  article-title: Assay of formaldehyde generated during microsomal oxidation reactions
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(78)52031-4
– volume: 8
  start-page: 155
  year: 2020
  ident: ref_28
  article-title: Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues
  publication-title: Toxicol. Rep.
  doi: 10.1016/j.toxrep.2020.12.019
– volume: 396–397
  start-page: 23
  year: 2018
  ident: ref_110
  article-title: Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes
  publication-title: Toxicology
  doi: 10.1016/j.tox.2018.02.001
– volume: 393
  start-page: 217
  year: 2012
  ident: ref_213
  article-title: The proteasome: Molecular machinery and pathophysiological roles
  publication-title: Biol. Chem.
  doi: 10.1515/hsz-2011-0285
– volume: 48
  start-page: 405
  year: 2016
  ident: ref_208
  article-title: Hepatic cytochromes P450: Structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame
  publication-title: Drug Metab. Rev.
  doi: 10.1080/03602532.2016.1195403
– volume: 263
  start-page: 679
  year: 1989
  ident: ref_247
  article-title: Effects of inducers of drug metabolism on basic hepatic forms of mouse glutathione transferase
  publication-title: Biochem. J.
  doi: 10.1042/bj2630679
– volume: 44
  start-page: 1246
  year: 2016
  ident: ref_161
  article-title: Prevalence of non-cytochrome P450-mediated metabolism in food and drug administration-approved oral and intravenous drugs: 2006–2015
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.116.070763
– volume: 134
  start-page: 169
  year: 2003
  ident: ref_98
  article-title: Xenobiotic conjugation systems in deer compared with cattle and rat
  publication-title: Comp. Biochem. Physiol. C Toxicol. Pharmacol.
  doi: 10.1016/S1532-0456(02)00224-7
– volume: 532
  start-page: 176
  year: 2015
  ident: ref_168
  article-title: Hepatic biotransformation and antioxidant enzyme activities in Mediterranean fish from different habitat depths
  publication-title: Sci. Total Environ.
  doi: 10.1016/j.scitotenv.2015.06.001
– volume: 39
  start-page: 1321
  year: 1990
  ident: ref_71
  article-title: Effect of xenobiotics on monooxygenase activities in cultured human hepatocytes
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/0006-2952(90)90008-9
– volume: 252
  start-page: 930
  year: 1988
  ident: ref_246
  article-title: Further validation of the Mulder and van Doorn kinetic procedure for the measurement of microsomal UDP-glucuronosyltransferase activities
  publication-title: Biochem. J.
  doi: 10.1042/bj2520930
– volume: 148
  start-page: 302
  year: 1982
  ident: ref_92
  article-title: Complexes of cytochrome P450 with metyrapone. A convenient method for the quantitative analysis of phenobarbital-inducible cytochrome P450 in rat liver microsomes
  publication-title: FEBS Lett.
  doi: 10.1016/0014-5793(82)80829-6
– volume: 15
  start-page: 713
  year: 2001
  ident: ref_117
  article-title: Cytochrome P450 activity in control and induced long-term cultures of rat hepatocyte spheroids
  publication-title: Toxicol. In Vitro
  doi: 10.1016/S0887-2333(01)00076-5
– volume: 6
  start-page: 123
  year: 1991
  ident: ref_96
  article-title: Drug-metabolizing enzymes in liver, olfactory, and respiratory epithelium of cattle
  publication-title: J. Biochem. Toxicol.
  doi: 10.1002/jbt.2570060206
– volume: 3
  start-page: 33
  year: 2007
  ident: ref_54
  article-title: Cellular proteolytic systems in P450 degradation: Evolutionary conservation from Saccharomyces cerevisiae to mammalian liver
  publication-title: Expert Opin. Drug Metab. Toxicol.
  doi: 10.1517/17425255.3.1.33
– volume: 14
  start-page: 1059
  year: 2013
  ident: ref_222
  article-title: Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily
  publication-title: Curr. Drug Metab.
  doi: 10.2174/1389200214666131211153307
– volume: 93
  start-page: 139
  year: 2005
  ident: ref_221
  article-title: Rush hour at the promoter: How the ubiquitin-proteasome pathway polices the traffic flow of nuclear receptor-dependent transcription
  publication-title: J. Steroid Biochem. Mol. Biol.
  doi: 10.1016/j.jsbmb.2004.12.015
– volume: 173
  start-page: 1597
  year: 2014
  ident: ref_106
  article-title: Purification and characterization of paraoxonase 1 (PON1) from Swiss Black, Holstein, and Montofon bovines
  publication-title: Appl. Biochem. Biotechnol.
  doi: 10.1007/s12010-014-0931-1
– ident: ref_227
– volume: 55
  start-page: 649
  year: 2003
  ident: ref_126
  article-title: Induction of drug metabolism: The role of nuclear receptors
  publication-title: Pharmacol. Rev.
  doi: 10.1124/pr.55.4.2
– volume: 203
  start-page: 351
  year: 1994
  ident: ref_148
  article-title: The effect of phenobarbital and dexamethasone coadministration on the activity of rat liver P450 system
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.1994.2189
– volume: 34
  start-page: 647
  year: 2009
  ident: ref_39
  article-title: Comprehensive analysis of hepatic gene and protein expression profiles on phenobarbital- or clofibrate-induced hepatic hypertrophy in dogs
  publication-title: J. Toxicol. Sci.
  doi: 10.2131/jts.34.647
– volume: 4
  start-page: 482
  year: 1991
  ident: ref_154
  article-title: Rat hepatic microsomal metabolism of ethylenethiourea. Contributions of the flavin-containing monooxygenase and cytochrome P-450 isozymes
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/tx00022a013
– volume: 43
  start-page: 476
  year: 2011
  ident: ref_13
  article-title: In vitro and in vivo small intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: Species differences
  publication-title: Drug Metab. Rev.
  doi: 10.3109/03602532.2011.597401
– volume: 26
  start-page: 869
  year: 2016
  ident: ref_209
  article-title: The life cycle of the 26S proteasome: From birth, through regulation and function, and onto its death
  publication-title: Cell Res.
  doi: 10.1038/cr.2016.86
– volume: 26
  start-page: 109
  year: 2006
  ident: ref_50
  article-title: Catalytic, immunochemical and molecular characterization of xenobiotic metabolising enzyme modulation by phenobarbital in the bovine liver
  publication-title: J. Vet. Pharmacol. Ther.
– volume: 96
  start-page: 75
  year: 1995
  ident: ref_150
  article-title: Developmental regulation of flavin-containing monooxygenase (FMO) isoforms 1 and 2 in pregnant rabbit
  publication-title: Chem. Biol. Interact.
  doi: 10.1016/0009-2797(94)03584-U
– volume: 358
  start-page: 83
  year: 2016
  ident: ref_46
  article-title: Physiological content and intrinsic activities of 10 cytochrome P450 isoforms in human normal liver microsomes
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.116.233635
– volume: 9
  start-page: 253
  year: 2013
  ident: ref_57
  article-title: Nuclear receptors PXR and CAR: Implications for drug metabolism regulation, pharmacogenomics and beyond
  publication-title: Expert Opin. Drug Metab. Toxicol.
  doi: 10.1517/17425255.2013.754010
– volume: 98
  start-page: 480
  year: 2006
  ident: ref_137
  article-title: Regulation of gender-dependent CYP2A expression in pigs: Involvement of androgens and CAR
  publication-title: Basic Clin. Pharmacol. Toxicol.
  doi: 10.1111/j.1742-7843.2006.pto_261.x
– volume: 45
  start-page: 2239
  year: 1993
  ident: ref_93
  article-title: Formation of ligand and metabolite complexes as a means for selective quantitation of cytochrome P450 isozymes
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/0006-2952(93)90195-3
– volume: 23
  start-page: 881
  year: 1996
  ident: ref_197
  article-title: A comparison of the effect of inducers on the expression of glutathione-S-transferases in the liver of the intact rat and in hepatocytes in primary culture
  publication-title: Hepatology
  doi: 10.1002/hep.510230432
– volume: 68
  start-page: 2187
  year: 2005
  ident: ref_185
  article-title: Role of metabolism in parathion-induced hepatotoxicity and immunotoxicity
  publication-title: J. Toxicol. Environ. Health Part A
  doi: 10.1080/15287390500180549
– volume: 1843
  start-page: 1942
  year: 2014
  ident: ref_210
  article-title: Enhanced rate of degradation of basic proteins by 26S immunoproteasomes
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamcr.2014.05.005
– volume: 295
  start-page: 15210
  year: 2020
  ident: ref_25
  article-title: Nuclear receptor phosphorylation in xenobiotic signal transduction
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.REV120.007933
– volume: 23
  start-page: 736
  year: 1995
  ident: ref_70
  article-title: Induction of liver microsomal cytochrome P450 in cynomolgus monkeys
  publication-title: Drug Metab. Dispos.
– volume: 9
  start-page: 9233
  year: 2019
  ident: ref_138
  article-title: Characterization of porcine hepatic and intestinal drug metabolizing CYP450: Comparison with human orthologues from a quantitative, activity and selectivity perspective
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-45212-0
– volume: 27
  start-page: 495
  year: 2012
  ident: ref_31
  article-title: Effects of time culture and prototypical cytochrome P450 3A (CYP3A) inducers on CYP2B22, CYP2C, CYP3A and nuclear receptor (NR) mRNAs in long-term cryopreserved pig hepatocytes (CPHs)
  publication-title: Drug Metab. Pharmacokinet.
  doi: 10.2133/dmpk.DMPK-11-RG-146
– volume: 99
  start-page: 1153
  year: 2019
  ident: ref_199
  article-title: The UDP-glycosyltransferase (UGT) Superfamily: New members, new functions, and novel paradigms
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00058.2017
– volume: 2
  start-page: 149
  year: 2021
  ident: ref_60
  article-title: Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome P450 expression following exposure to prototypical activators of AhR, CAR and PXR
  publication-title: Curr. Res. Toxicol.
  doi: 10.1016/j.crtox.2021.03.002
– volume: 552
  start-page: 151
  year: 2006
  ident: ref_147
  article-title: Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2006.09.006
– volume: 84
  start-page: 232
  year: 2012
  ident: ref_166
  article-title: Age-related inducibility of carboxylesterases by the antiepileptic agent phenobarbital and implications in drug metabolism and lipid accumulation
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2012.04.002
– volume: 23
  start-page: 681
  year: 1993
  ident: ref_131
  article-title: Effect of phenobarbital and other model inducers on cytochrome P450 isoenzymes in primary culture of dog hepatocytes
  publication-title: Xenobiotica
  doi: 10.3109/00498259309059405
– volume: 43
  start-page: 1938
  year: 2015
  ident: ref_116
  article-title: Dose of phenobarbital and age of treatment at early life are two key factors for the persistent induction of cytochrome P450 enzymes in adult mouse liver
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.115.066316
– volume: 7
  start-page: 487
  year: 1993
  ident: ref_158
  article-title: Expression of flavin-containing monooxygenase activity in adult rat hepatocytes under various culture conditions
  publication-title: Toxicol. In Vitro
  doi: 10.1016/0887-2333(93)90052-7
– volume: 37
  start-page: 67
  year: 1997
  ident: ref_239
  article-title: Improved high-performance liquid chromatographic procedure for the separation and quantification of hydroxytestosterone metabolites
  publication-title: J. Pharmacol. Toxicol. Methods
  doi: 10.1016/S1056-8719(97)00013-0
– volume: 166
  start-page: 43
  year: 2015
  ident: ref_211
  article-title: Comparative study of the biochemical properties of proteasomes in domestic animals
  publication-title: Vet. Immunol. Immunopathol.
  doi: 10.1016/j.vetimm.2015.04.005
– volume: 13
  start-page: 548
  year: 1985
  ident: ref_238
  article-title: p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol
  publication-title: Drug Metab. Dispos.
– volume: 37
  start-page: 1
  year: 2021
  ident: ref_12
  article-title: A history of the roles of cytochrome P450 enzymes in the toxicity of drugs
  publication-title: Toxicol. Res.
  doi: 10.1007/s43188-020-00056-z
– volume: 58
  start-page: 386
  year: 1984
  ident: ref_100
  article-title: Oxidative and conjugative metabolism of xenobiotics by livers of cattle, sheep, swine and rats
  publication-title: J. Anim. Sci.
  doi: 10.2527/jas1984.582386x
– volume: 78
  start-page: 47
  year: 2015
  ident: ref_162
  article-title: Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2015.07.006
– volume: 41
  start-page: 1367
  year: 2009
  ident: ref_141
  article-title: Cryopreserved porcine hepatocytes: Expression and induction of cytochrome P450, isoform CYP2E1
  publication-title: Transplant. Proc.
  doi: 10.1016/j.transproceed.2009.02.061
– volume: 106
  start-page: 97
  year: 2005
  ident: ref_198
  article-title: UDP-glucuronosyltransferases and clinical drug-drug interactions
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2004.10.013
– volume: 154
  start-page: 103
  year: 2010
  ident: ref_175
  article-title: Phase II drug metabolizing enzymes
  publication-title: Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub.
  doi: 10.5507/bp.2010.017
– volume: 33
  start-page: 9
  year: 2018
  ident: ref_201
  article-title: Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans
  publication-title: Drug Metab. Pharmacokinet.
  doi: 10.1016/j.dmpk.2017.10.002
– volume: 45
  start-page: 495
  year: 2015
  ident: ref_177
  article-title: Characterization of bovine phenol sulfotransferases: Evidence of a major role for SULT1B1 in the liver
  publication-title: Xenobiotica
  doi: 10.3109/00498254.2014.997325
– volume: 280
  start-page: 77
  year: 2011
  ident: ref_61
  article-title: Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays
  publication-title: Toxicology
  doi: 10.1016/j.tox.2010.11.008
– ident: ref_52
  doi: 10.3390/ijms21134708
– volume: 34
  start-page: 2003
  year: 2006
  ident: ref_115
  article-title: Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.106.012005
– volume: 60
  start-page: 33
  year: 1996
  ident: ref_236
  article-title: Changes in the activities of hepatic xenobiotic metabolising enzymes after the administration of clenbuterol to female broilers
  publication-title: Res. Vet. Sci.
  doi: 10.1016/S0034-5288(96)90127-7
– volume: 9
  start-page: 295
  year: 1999
  ident: ref_109
  article-title: Human CYP2B6: Expression, inducibility and catalytic activities
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199906000-00004
– volume: 132
  start-page: 83
  year: 1992
  ident: ref_191
  article-title: Expression of an abundant alpha-class glutathione S-transferase in bovine and human adrenal cortex tissues
  publication-title: J. Endocrinol.
  doi: 10.1677/joe.0.1320083
– volume: 245
  start-page: 61
  year: 2019
  ident: ref_151
  article-title: Effects of fenbendazole and triclabendazole on the expression of cytochrome P450 1A and flavin-monooxygenase isozymes in bovine precision-cut liver slices
  publication-title: Vet. J.
  doi: 10.1016/j.tvjl.2019.01.001
– volume: 38
  start-page: 237
  year: 1976
  ident: ref_233
  article-title: The induction of hepatic microsomal metabolism in rats following acute administration of a mixture of polybrominated biphenyls
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/0041-008X(76)90132-0
– volume: 275
  start-page: 8432
  year: 2000
  ident: ref_219
  article-title: 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced degradation of aryl hydrocarbon receptor (AhR) by the ubiquitin-proteasome pathway. Role of the transcription activaton and DNA binding of AhR
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.275.12.8432
– volume: 63
  start-page: 1184
  year: 1986
  ident: ref_76
  article-title: The influence of dose of phenobarbital and interval to measurement on concentration of liver enzymes in barrows and gilts
  publication-title: J. Anim. Sci.
  doi: 10.2527/jas1986.6341184x
– volume: 365
  start-page: 45
  year: 1999
  ident: ref_49
  article-title: Cytochrome P450 3A degradation in isolated rat hepatocytes: 26S proteasome inhibitors as probes
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1006/abbi.1999.1139
– volume: 34
  start-page: 1772
  year: 2006
  ident: ref_206
  article-title: Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.106.010397
– volume: 9
  start-page: 237
  year: 2013
  ident: ref_1
  article-title: Species differences in drug transporters and implications for translating preclinical findings to humans
  publication-title: Expert Opin. Drug Metab. Toxicol.
  doi: 10.1517/17425255.2013.741589
– volume: 167
  start-page: 237
  year: 2000
  ident: ref_72
  article-title: Cytochrome P450-dependent monooxygenase activities and their inducibility by classic P450 inducers in the liver, kidney, and nasal mucosa of male adult ring-necked pheasants
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1006/taap.2000.8994
– volume: 1032
  start-page: 15
  year: 2018
  ident: ref_21
  article-title: Roles of cytochrome P450 in metabolism of ethanol and carcinogens
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-3-319-98788-0_2
– volume: 31
  start-page: 1
  year: 1993
  ident: ref_83
  article-title: A selective decrease in cytochrome P450 in the liver microsomes of male rats following phenobarbital and 3-methylcholanthrene induction and acute tetrachloromethane poisoning
  publication-title: Eksp. Med. Morfol.
– volume: 25
  start-page: 402
  year: 2001
  ident: ref_249
  article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
  publication-title: Methods
  doi: 10.1006/meth.2001.1262
– ident: ref_65
  doi: 10.1371/journal.pone.0214338
– volume: 13
  start-page: 281
  year: 1998
  ident: ref_194
  article-title: Differential response of cytosolic, microsomal, and mitochondrial glutathione S-transferases to xenobiotic inducers
  publication-title: Int. J. Oncol.
– volume: 27
  start-page: 1039
  year: 1999
  ident: ref_90
  article-title: Oxidative metabolism of monensin in rat liver microsomes and interactions with tiamulin and other chemotherapeutic agents: Evidence for the involvement of cytochrome P-450 3A subfamily
  publication-title: Drug Metab. Dispos.
– volume: 19
  start-page: 97
  year: 1996
  ident: ref_74
  article-title: Induction of hepatic cytochrome P450 by phenobarbitone in rhesus monkey (Macaca mulatta)
  publication-title: Drug Chem. Toxicol.
  doi: 10.3109/01480549609002199
– volume: 55
  start-page: 1579
  year: 1994
  ident: ref_95
  article-title: Comparison of maturation of drug-metabolizing enzymes in calves with functioning or nonfunctioning rumen
  publication-title: Am. J. Vet. Res.
  doi: 10.2460/ajvr.1994.55.11.1579
– volume: 234
  start-page: 345
  year: 2009
  ident: ref_62
  article-title: Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/j.taap.2008.11.008
– volume: 138
  start-page: 103
  year: 2013
  ident: ref_114
  article-title: Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2012.12.007
– volume: 118
  start-page: 460
  year: 2018
  ident: ref_160
  article-title: Binding of methimazole and NADP(H) to human FMO3: In vitro and in silico
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2018.06.104
– volume: 55
  start-page: 1059
  year: 1998
  ident: ref_174
  article-title: Effects of chemical inducers on human microsomal epoxide hydrolase in primary hepatocyte cultures
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/S0006-2952(97)00679-5
– volume: 62
  start-page: 405
  year: 2022
  ident: ref_159
  article-title: Non-P450 drug-metabolizing enzymes: Contribution to drug disposition, toxicity, and development
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev-pharmtox-052220-105907
– volume: 36
  start-page: 885
  year: 2008
  ident: ref_189
  article-title: Effect of breed upon cytochromes P450 and phase II enzyme expression in cattle liver
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.107.019042
– volume: 52
  start-page: 1717
  year: 1991
  ident: ref_153
  article-title: Pathologic changes, tissue distribution, and extent of conversion to ethylenethiourea after subacute administration of zinc ethylene-bis-dithiocarbamate (zineb) to calves with immature rumen function
  publication-title: Am. J. Vet. Res.
  doi: 10.2460/ajvr.1991.52.10.1717
– volume: 17
  start-page: 633
  year: 2004
  ident: ref_155
  article-title: Human flavin-containing monooxygenase form 2 S-oxygenation: Sulfenic acid formation from thioureas and oxidation of glutathione
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/tx034253s
– volume: 33
  start-page: 341
  year: 2010
  ident: ref_104
  article-title: Benzydamine as a useful substrate of hepatic flavin-containing monooxygenase activity in veterinary species
  publication-title: J. Vet. Pharmacol. Ther.
  doi: 10.1111/j.1365-2885.2009.01145.x
– volume: 44
  start-page: 186
  year: 2006
  ident: ref_55
  article-title: Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR
  publication-title: Hepatology
  doi: 10.1002/hep.21234
– volume: 4
  start-page: 60
  year: 2015
  ident: ref_77
  article-title: Molecular mechanisms of the microsomal mixed function oxidases and biological and pathological implications
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2014.11.008
– volume: 49
  start-page: 318
  year: 2017
  ident: ref_181
  article-title: Human cytosolic glutathione-S-transferases: Quantitative analysis of expression, comparative analysis of structures and inhibition strategies of isozymes involved in drug resistance
  publication-title: Drug Metab. Rev.
  doi: 10.1080/03602532.2017.1343343
– ident: ref_11
– volume: 16
  start-page: 286
  year: 2002
  ident: ref_84
  article-title: Biochemical characteristics of purified beef liver NADPH-cytochrome P450 reductase
  publication-title: J. Biochem. Mol. Toxicol.
  doi: 10.1002/jbt.10054
– volume: 18
  start-page: 213
  year: 1997
  ident: ref_105
  article-title: Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species
  publication-title: Biopharm. Drug Dispos.
  doi: 10.1002/(SICI)1099-081X(199704)18:3<213::AID-BDD15>3.0.CO;2-0
– volume: 33
  start-page: 528
  year: 2010
  ident: ref_119
  article-title: Proposed new nomenclature for Bos taurus cytochromes P450 involved in xenobiotic drug metabolism
  publication-title: J. Vet. Pharmacol. Ther.
  doi: 10.1111/j.1365-2885.2010.01173.x
– volume: 96
  start-page: 127
  year: 1995
  ident: ref_195
  article-title: Comparison of the induction of rat glutathione S-transferase and fatty acid ethyl ester synthase activities
  publication-title: Toxicology
  doi: 10.1016/0300-483X(94)02918-K
– volume: 87
  start-page: 455
  year: 2009
  ident: ref_37
  article-title: Long-lasting enhancement of CYP activity after discontinuation of repeated administration of phenobarbital in dogs
  publication-title: Res. Vet. Sci.
  doi: 10.1016/j.rvsc.2009.03.018
– volume: 585
  start-page: 510
  year: 2008
  ident: ref_3
  article-title: Implications of ABC transporters on the disposition of typical veterinary medicinal products
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2008.03.014
– volume: 32
  start-page: 243
  year: 1984
  ident: ref_243
  article-title: Differential induction of various carboxylesterases by certain polycyclic aromatic hydrocarbons in the rat
  publication-title: Toxicology
  doi: 10.1016/0300-483X(84)90077-5
– volume: 136
  start-page: 297
  year: 2003
  ident: ref_130
  article-title: Cytochrome P450 expression and activities in rat, rabbit and bovine tongue
  publication-title: Comp. Biochem. Physiol. C Toxicol. Pharmacol.
  doi: 10.1016/j.cca.2003.10.003
– volume: 206
  start-page: 204
  year: 2011
  ident: ref_6
  article-title: Gene expression and inducibility of the aryl hydrocarbon receptor-dependent pathway in cultured bovine blood lymphocytes
  publication-title: Toxicol. Lett.
  doi: 10.1016/j.toxlet.2011.07.014
– volume: 38
  start-page: 1517
  year: 1989
  ident: ref_133
  article-title: Induction of cytochrome P450IA1 in mouse hepatoma cells by several chemicals. Phenobarbital and TCDD induce the same form of cytochrome P450
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/0006-2952(89)90192-5
– volume: 30
  start-page: 75
  year: 2005
  ident: ref_167
  article-title: Overview of carboxylesterases and their role in the metabolism of insecticides
  publication-title: J. Pestic. Sci.
  doi: 10.1584/jpestics.30.75
– volume: 30
  start-page: 1
  year: 2009
  ident: ref_179
  article-title: Glutathione: Overview of its protective roles, measurement, and biosynthesis
  publication-title: Mol. Asp. Med.
  doi: 10.1016/j.mam.2008.08.006
– volume: 73
  start-page: 231
  year: 1991
  ident: ref_237
  article-title: Age- and sex-related effects on hepatic drug metabolism in rats chronically exposed to dietary atrazine
  publication-title: Res. Commun. Chem. Pathol. Pharmacol.
– volume: 21
  start-page: 109
  year: 2007
  ident: ref_142
  article-title: Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium
  publication-title: Toxicol. In Vitro
  doi: 10.1016/j.tiv.2006.08.001
– volume: 241
  start-page: 397
  year: 1985
  ident: ref_228
  article-title: Cytochrome P-450 ligands: Metyrapone revisited
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1016/0003-9861(85)90562-4
– volume: 60
  start-page: 54
  year: 2011
  ident: ref_63
  article-title: Assessment of subclinical, toxicant-induced hepatic gene expression profiles after low-dose, short-term exposures in mice
  publication-title: Regul. Toxicol. Pharmacol.
  doi: 10.1016/j.yrtph.2011.02.006
– volume: 62
  start-page: 1238
  year: 2010
  ident: ref_18
  article-title: Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2010.08.006
– volume: 33
  start-page: 295
  year: 2010
  ident: ref_123
  article-title: Characterization of xenobiotic metabolizing enzymes in bovine small intestinal mucosa
  publication-title: J. Vet. Pharmacol. Ther.
  doi: 10.1111/j.1365-2885.2009.01137.x
– volume: 88
  start-page: 2013
  year: 2014
  ident: ref_169
  article-title: The role of epoxide hydrolases in health and disease
  publication-title: Arch. Toxicol.
  doi: 10.1007/s00204-014-1371-y
– volume: 400
  start-page: 104
  year: 2005
  ident: ref_203
  article-title: Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(05)00007-8
– volume: 286
  start-page: 9443
  year: 2011
  ident: ref_217
  article-title: Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: Identification of sites targeted for phosphorylation and ubiquitination
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.176685
– volume: 18
  start-page: 759
  year: 1990
  ident: ref_86
  article-title: Interaction of cotinine with rat hepatic microsomal P-450. Comparison with metyrapone and immunomodulation of cotinine and metyrapone binding by monoclonal anti-cotinine antibodies
  publication-title: Drug Metab. Dispos.
– volume: 56
  start-page: 2
  year: 2020
  ident: ref_42
  article-title: Synergistic induction of drug-metabolizing enzymes in co-cultures of bovine hepatocytic and sinusoidal cell lines
  publication-title: In Vitro Cell. Dev. Biol. Anim.
  doi: 10.1007/s11626-019-00408-6
– volume: 78
  start-page: 150
  year: 2005
  ident: ref_129
  article-title: Induction of cytochrome P450 isozymes by phenobarbital in pregnant rat and fetal livers and placenta
  publication-title: Exp. Mol. Pathol.
  doi: 10.1016/j.yexmp.2004.07.002
– ident: ref_5
– volume: 47
  start-page: 933
  year: 2017
  ident: ref_152
  article-title: Assessment of liver slices for research on metabolic drug–drug interactions in cattle
  publication-title: Xenobiotica
  doi: 10.1080/00498254.2016.1246782
– ident: ref_224
  doi: 10.1371/journal.pone.0096092
– volume: 19
  start-page: 423
  year: 2016
  ident: ref_121
  article-title: Substrate specificity of human cytochrome P450 (CYP) 2C subfamily and effect of azole antifungal agents on CYP2C8
  publication-title: J. Pharm. Pharm. Sci.
  doi: 10.18433/J31S53
– volume: 79
  start-page: 261
  year: 2010
  ident: ref_134
  article-title: Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5’-flanking region
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2009.08.008
– volume: 34
  start-page: 503
  year: 2002
  ident: ref_242
  article-title: An overview of the mechanism, substrate specificities, and structure of FMOs
  publication-title: Drug Metab. Rev.
  doi: 10.1081/DMR-120005650
– volume: 28
  start-page: 249
  year: 2005
  ident: ref_4
  article-title: Induction of phase I, II and III drug metabolism/transport by xenobiotics
  publication-title: Arch. Pharm. Res.
  doi: 10.1007/BF02977789
– volume: 31
  start-page: 1979
  year: 1982
  ident: ref_245
  article-title: Spectrophotometric assay for mammalian cytosolic epoxide hydrolase using trans-stilbene oxide as the substrate
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/0006-2952(82)90408-7
– volume: 5
  start-page: 1501
  year: 2009
  ident: ref_26
  article-title: Glucocorticoids and phenobarbital induce murine CYP2B genes by independent mechanisms
  publication-title: Expert Opin. Drug Metab. Toxicol.
  doi: 10.1517/17425250903234709
– volume: 62
  start-page: 1
  year: 2013
  ident: ref_212
  article-title: The proteasome: From basic mechanisms to emerging roles
  publication-title: Keio J. Med.
  doi: 10.2302/kjm.2012-0006-RE
– volume: 44
  start-page: 370
  year: 2016
  ident: ref_204
  article-title: Effects of phenobarbital on expression of UDP-glucuronosyltransferase 1a6 and 1a7 in rat brain
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.115.067439
– volume: 65
  start-page: 186
  year: 1987
  ident: ref_102
  article-title: Characterization of xenobiotic biotransformation in hepatic, renal and gut tissues of cattle and sheep
  publication-title: J. Anim. Sci.
  doi: 10.2527/jas1987.651186x
– volume: 19
  start-page: 368
  year: 2005
  ident: ref_128
  article-title: Quantification of the expression and inducibility of 12 rat cytochrome P450 isoforms by quantitative RT-PCR
  publication-title: J. Biochem. Mol. Toxicol.
  doi: 10.1002/jbt.20103
– volume: 35
  start-page: 107
  year: 2003
  ident: ref_216
  article-title: Hepatic cytochrome P450 degradation: Mechanistic diversity of the cellular sanitation brigade
  publication-title: Drug Metab. Rev.
  doi: 10.1081/DMR-120023683
– volume: 509
  start-page: 287
  year: 2019
  ident: ref_48
  article-title: Inhibition of cytochrome P450 3A protein degradation and subsequent increase in enzymatic activity through p38 MAPK activation by acetaminophen and salicylate derivatives
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2018.12.124
– volume: 127
  start-page: 13634
  year: 2005
  ident: ref_91
  article-title: Structural and dynamical basis of broad substrate specificity, catalytic mechanism, and inhibition of cytochrome P450 3A4
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja053809q
– volume: 76
  start-page: 2535
  year: 2005
  ident: ref_27
  article-title: CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2004.09.042
– volume: 43
  start-page: 608
  year: 2020
  ident: ref_107
  article-title: Midazolam oxidation in cattle liver microsomes: The role of cytochrome P450 3A
  publication-title: J. Vet. Pharmacol. Ther.
  doi: 10.1111/jvp.12906
– volume: 16
  start-page: 343
  year: 2020
  ident: ref_29
  article-title: Nuclear receptor CAR-mediated liver cancer and its species differences
  publication-title: Expert Opin. Drug Metab. Toxicol.
  doi: 10.1080/17425255.2020.1746268
– ident: ref_183
  doi: 10.1186/1471-2164-11-9
– volume: 31
  start-page: 421
  year: 2003
  ident: ref_140
  article-title: Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.31.4.421
– volume: 254
  start-page: 184
  year: 2008
  ident: ref_196
  article-title: Induction of drug metabolism: Species differences and toxicological relevance
  publication-title: Toxicology
  doi: 10.1016/j.tox.2008.09.002
– volume: 33
  start-page: 141
  year: 1992
  ident: ref_81
  article-title: Effect of age and phenobarbital on liver activity of mixed function oxidase
  publication-title: Folia Med. Cracov.
– volume: 91
  start-page: 419
  year: 1988
  ident: ref_99
  article-title: Comparison of hepatic drug metabolizing enzyme activities in several agricultural species
  publication-title: Comp. Biochem. Physiol. C Comp. Pharmacol. Toxicol.
  doi: 10.1016/0742-8413(88)90053-9
– volume: 21
  start-page: 2636
  year: 2002
  ident: ref_248
  article-title: Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes
  publication-title: EMBO J.
  doi: 10.1093/emboj/21.11.2636
– volume: 39
  start-page: 381
  year: 1988
  ident: ref_82
  article-title: Effect of age on the activity of hepatic mixed function oxidases in female rats after phenobarbital induction
  publication-title: Med. Pr.
– volume: 46
  start-page: 1577
  year: 1993
  ident: ref_232
  article-title: A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man. Direct fluorescence monitoring of the deethylation of 7-ethoxy-4-trifluoromethylcoumarin
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/0006-2952(93)90326-R
– volume: 193
  start-page: 265
  year: 1951
  ident: ref_225
  article-title: Protein measurement with the Folin phenol reagent
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)52451-6
– volume: 27
  start-page: 2023
  year: 2013
  ident: ref_40
  article-title: Induction of cytochrome P450 enzymes in primary equine hepatocyte culture
  publication-title: Toxicol. In Vitro
  doi: 10.1016/j.tiv.2013.07.009
– volume: 49
  start-page: 523
  year: 1996
  ident: ref_69
  article-title: Phenobarbital induction of hepatic CYP2B1 and CYP2B2: Pretranscriptional and post-transcriptional effects of gender, adult age, and phenobarbital dose
  publication-title: Mol. Pharmacol.
– volume: 183
  start-page: 81
  year: 2010
  ident: ref_108
  article-title: High performance liquid chromatography determination of cytochrome P450 1A and 2C activities in bovine liver microsomes
  publication-title: Vet. J.
  doi: 10.1016/j.tvjl.2008.08.006
– volume: 32
  start-page: 1002
  year: 2012
  ident: ref_112
  article-title: Different profiles of hepatic alkoxyresorufin O-dealkylase activities in small rodents
  publication-title: J. Appl. Toxicol.
  doi: 10.1002/jat.2756
– volume: 42
  start-page: 6
  year: 2010
  ident: ref_202
  article-title: UDP-glucuronosyltransferases (UGTs): From purification of Ah-receptor–inducible UGT1A6 to coordinate regulation of subsets of CYPs, UGTs, and ABC transporters by nuclear receptors
  publication-title: Drug Metab. Rev.
  doi: 10.3109/03602530903205492
– volume: 450–451
  start-page: 7
  year: 2013
  ident: ref_7
  article-title: Modulation of aryl hydrocarbon receptor target genes in circulating lymphocytes from dairy cows bred in a dioxin-like PCB contaminated area
  publication-title: Sci. Total Environ.
  doi: 10.1016/j.scitotenv.2013.01.095
– volume: 202
  start-page: 106
  year: 2014
  ident: ref_43
  article-title: Absolute quantification and modulation of cytochrome P450 3A isoforms in cattle liver
  publication-title: Vet. J.
  doi: 10.1016/j.tvjl.2014.07.028
– volume: 30
  start-page: 1206
  year: 2002
  ident: ref_143
  article-title: In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.30.11.1206
– volume: 30
  start-page: 271
  year: 2006
  ident: ref_8
  article-title: Comparison of hydrolytic and conjugative biotransformation pathways in horse, cattle, pig, broiler chick, rabbit and rat liver subcellullar fractions
  publication-title: Vet. Res. Commun.
  doi: 10.1007/s11259-006-3247-y
– volume: 100
  start-page: 637
  year: 2016
  ident: ref_36
  article-title: Feed-drug interaction of orally applied butyrate and phenobarbital on hepatic cytochrome P450 activity in chickens
  publication-title: J. Anim. Physiol. Anim. Nutr.
  doi: 10.1111/jpn.12416
– volume: 2
  start-page: 875
  year: 2006
  ident: ref_15
  article-title: Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction
  publication-title: Expert Opin. Drug Metab. Toxicol.
  doi: 10.1517/17425255.2.6.875
– volume: 18
  start-page: 304
  year: 1980
  ident: ref_85
  article-title: Effects of phenobarbital, pregnenolone-16 alpha-carbonitrile, and 3-methylcholanthrene pretreatments on the distribution of NADPH-cytochrome c (P-450) reductase within the liver lobule
  publication-title: Mol. Pharmacol.
– volume: 76
  start-page: 43
  year: 2004
  ident: ref_101
  article-title: Comparison of in vitro activities of biotransformation enzymes in pig, cattle, goat and sheep
  publication-title: Res. Vet. Sci.
  doi: 10.1016/S0034-5288(03)00143-7
– volume: 778
  start-page: 79
  year: 2018
  ident: ref_171
  article-title: Aflatoxin B1 metabolism: Regulation by phase I and II metabolizing enzymes and chemoprotective agents
  publication-title: Mutat. Res. Rev. Mutat. Res.
  doi: 10.1016/j.mrrev.2018.10.002
– volume: 7
  start-page: 8
  year: 2018
  ident: ref_186
  article-title: Glutathione transferases: Substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases
  publication-title: Oncogenesis
  doi: 10.1038/s41389-017-0025-3
– volume: 46
  start-page: 2849
  year: 2008
  ident: ref_229
  article-title: Cytochrome P450 inhibition profile in liver of veal calves administered a combination of 17beta-estradiol, clenbuterol, and dexamethasone for growth-promoting purposes
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2008.05.018
– volume: 23
  start-page: 482
  year: 1983
  ident: ref_89
  article-title: N-demethylation of cocaine to norcocaine. Evidence for participation by cytochrome P-450 and FAD-containing monooxygenase
  publication-title: Mol. Pharmacol.
– volume: 16
  start-page: 916
  year: 1992
  ident: ref_144
  article-title: Differences in hepatic microsomal cytochrome P-450 isoenzyme induction by pyrazole, chronic ethanol, 3-methylcholanthrene, and phenobarbital in high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats
  publication-title: Alcohol Clin. Exp. Res.
  doi: 10.1111/j.1530-0277.1992.tb01893.x
– volume: 62
  start-page: 635
  year: 2001
  ident: ref_97
  article-title: A Study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/S0006-2952(01)00710-9
– volume: 46
  start-page: 200
  year: 2016
  ident: ref_66
  article-title: Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons
  publication-title: Xenobiotica
  doi: 10.3109/00498254.2015.1060374
– volume: 58
  start-page: 930
  year: 2019
  ident: ref_88
  article-title: Interaction of human drug-metabolizing CYP3A4 with small inhibitory molecules
  publication-title: Biochemistry
  doi: 10.1021/acs.biochem.8b01221
– ident: ref_163
  doi: 10.3390/ijms22010013
– volume: 28
  start-page: 1321
  year: 2000
  ident: ref_139
  article-title: CYP2A5/CYP2A6 expression in mouse and human hepatocytes treated with various in vivo inducers
  publication-title: Drug Metab. Dispos.
– volume: 10
  start-page: 42
  year: 2020
  ident: ref_47
  article-title: Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): Therapeutic and pathophysiological implications
  publication-title: Acta Pharm. Sin. B
  doi: 10.1016/j.apsb.2019.11.002
– volume: 150
  start-page: 68
  year: 1998
  ident: ref_173
  article-title: Endocrine factors modulate the phenobarbital-mediated induction of cytochromes P450 and phase II enzymes in a similar strain-dependent manner
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1006/taap.1998.8391
– volume: 10
  start-page: 567
  year: 2009
  ident: ref_56
  article-title: The transcriptional regulation of the human CYP2C genes
  publication-title: Curr. Drug Metab.
  doi: 10.2174/138920009789375397
– volume: 42
  start-page: 1096
  year: 2012
  ident: ref_44
  article-title: Constitutive expression and phenobarbital modulation of drug metabolizing enzymes and related nuclear receptors in cattle liver and extra-hepatic tissues
  publication-title: Xenobiotica
  doi: 10.3109/00498254.2012.694493
– volume: 40
  start-page: 525
  year: 2010
  ident: ref_30
  article-title: Expression and inducibility by phenobarbital of CYP2C33, CYP2C42, CYP2C49, CYP2B22, and CYP3As in porcine liver, kidney, small intestine, and nasal tissues
  publication-title: Xenobiotica
  doi: 10.3109/00498254.2010.489125
– volume: 25
  start-page: 1
  year: 1998
  ident: ref_19
  article-title: Transcriptional activation of cytochrome P450 genes by different classes of chemical inducers
  publication-title: Clin. Exp. Pharmacol. Physiol.
  doi: 10.1111/j.1440-1681.1998.tb02135.x
– ident: ref_172
  doi: 10.3390/ijms22158062
– volume: 46
  start-page: 65
  year: 2006
  ident: ref_157
  article-title: Human flavin-containing monooxygenases
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev.pharmtox.46.120604.141043
– volume: 6
  start-page: 279
  year: 2005
  ident: ref_35
  article-title: Comparative evaluation of phenobarbital-induced CYP3A and CYP2H1 gene expression by quantitative RT-PCR in Bantam, Bantamized White Leghorn and White Leghorn chicks
  publication-title: J. Vet. Sci.
  doi: 10.4142/jvs.2005.6.4.279
– volume: 40
  start-page: 670
  year: 2010
  ident: ref_193
  article-title: Constitutive expression of drug metabolizing enzymes and related transcription factors in cattle testis and their modulation by illicit steroids
  publication-title: Xenobiotica
  doi: 10.3109/00498254.2010.506562
– volume: 44
  start-page: 64
  year: 2014
  ident: ref_23
  article-title: Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator
  publication-title: Crit. Rev. Toxicol.
  doi: 10.3109/10408444.2013.835786
– volume: 571
  start-page: 1
  year: 2015
  ident: ref_170
  article-title: Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease
  publication-title: Gene
  doi: 10.1016/j.gene.2015.07.071
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Snippet In cattle, phenobarbital (PB) upregulates target drug-metabolizing enzyme (DME) mRNA levels. However, few data about PB’s post-transcriptional effects are...
In cattle, phenobarbital (PB) upregulates target drug-metabolizing enzyme (DME) mRNA levels. However, few data about PB's post-transcriptional effects are...
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StartPage 3564
SubjectTerms Animals
Cattle
Cytochrome
Cytochrome P-450 Enzyme System - metabolism
Enzyme Induction
Enzymes
Gene expression
Liver
Liver - metabolism
Metabolism
Microsomes, Liver - metabolism
Phenobarbital - pharmacology
Proteins
Xenobiotics - metabolism
Title Induction by Phenobarbital of Phase I and II Xenobiotic-Metabolizing Enzymes in Bovine Liver: An Overall Catalytic and Immunochemical Characterization
URI https://www.ncbi.nlm.nih.gov/pubmed/35408925
https://www.proquest.com/docview/2649060419
https://www.proquest.com/docview/2649589732
https://pubmed.ncbi.nlm.nih.gov/PMC8998613
Volume 23
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