A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability

The A118G SNP (single nucleotide polymorphism) of the hMOPR [human MOPR (μ opioid receptor)] gene OPRM1 results in an amino acid substitution (N40D). Subjects homozygous for the 118G allele have been reported to require higher morphine doses to achieve adequate analgesia, and the 118G allele is more...

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Vydané v:	Biochemical journal Ročník 441; číslo 1; s. 379
Hlavní autori:	Huang, Peng, Chen, Chongguang, Mague, Stephen D, Blendy, Julie A, Liu-Chen, Lee-Yuan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.01.2012
Predmet:	Amino Acid Sequence Animals CHO Cells Cricetinae Gene Expression Regulation - physiology Glycosylation Humans Mice Mice, Knockout Polymorphism, Single Nucleotide Protein Stability Receptors, Opioid, mu - genetics Receptors, Opioid, mu - metabolism
ISSN:	1470-8728, 1470-8728
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