A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability

The A118G SNP (single nucleotide polymorphism) of the hMOPR [human MOPR (μ opioid receptor)] gene OPRM1 results in an amino acid substitution (N40D). Subjects homozygous for the 118G allele have been reported to require higher morphine doses to achieve adequate analgesia, and the 118G allele is more...

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Bibliographic Details

Published in:	Biochemical journal Vol. 441; no. 1; p. 379
Main Authors:	Huang, Peng, Chen, Chongguang, Mague, Stephen D, Blendy, Julie A, Liu-Chen, Lee-Yuan
Format:	Journal Article
Language:	English
Published:	England 01.01.2012
Subjects:	Amino Acid Sequence Animals CHO Cells Cricetinae Gene Expression Regulation - physiology Glycosylation Humans Mice Mice, Knockout Polymorphism, Single Nucleotide Protein Stability Receptors, Opioid, mu - genetics Receptors, Opioid, mu - metabolism
ISSN:	1470-8728, 1470-8728
Online Access:	Get more information
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