HLA micropolymorphisms strongly affect peptide-MHC multimer-based monitoring of antigen-specific CD8+ T cell responses

Peptide-MHC (pMHC) multimers have become one of the most widely used tools to measure Ag-specific T cell responses in humans. With the aim of understanding the requirements for pMHC-based personalized immunomonitoring, in which individuals expressing subtypes of the commonly studied HLA alleles are...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 192; no. 2; p. 641
Main Authors:	van Buuren, Marit M, Dijkgraaf, Feline E, Linnemann, Carsten, Toebes, Mireille, Chang, Cynthia X L, Mok, Juk Yee, Nguyen, Melanie, van Esch, Wim J E, Kvistborg, Pia, Grotenbreg, Gijsbert M, Schumacher, Ton N M
Format:	Journal Article
Language:	English
Published:	United States 15.01.2014
Subjects:	Alleles Amino Acid Sequence Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology CD8-Positive T-Lymphocytes - immunology Clone Cells - immunology HLA-A2 Antigen - genetics HLA-A2 Antigen - immunology Humans Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Major Histocompatibility Complex - genetics Major Histocompatibility Complex - immunology Melanoma - genetics Melanoma - immunology Melanoma - metabolism Molecular Sequence Data Neoplasm Proteins - genetics Neoplasm Proteins - immunology Neoplasm Proteins - metabolism Peptides - genetics Peptides - immunology Peptides - metabolism Polymorphism, Genetic - genetics Polymorphism, Genetic - immunology Sequence Alignment
ISSN:	1550-6606, 1550-6606
Online Access:	Get more information
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