Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects

Immunization of humans with whole sporozoites confers complete, sterilizing immunity against malaria infection. However, achieving consistent safety while maintaining immunogenicity of whole parasite vaccines remains a formidable challenge. We generated a genetically attenuated Plasmodium falciparum...

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Veröffentlicht in:	Science translational medicine Jg. 9; H. 371
Hauptverfasser:	Kublin, James G, Mikolajczak, Sebastian A, Sack, Brandon K, Fishbaugher, Matt E, Seilie, Annette, Shelton, Lisa, VonGoedert, Tracie, Firat, Melike, Magee, Sara, Fritzen, Emma, Betz, Will, Kain, Heather S, Dankwa, Dorender A, Steel, Ryan W J, Vaughan, Ashley M, Noah Sather, D, Murphy, Sean C, Kappe, Stefan H I
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 04.01.2017
Schlagworte:	Adult Animals Antibodies, Protozoan - blood Female Gene Deletion Genetic Engineering Humans Immunoglobulin G - blood Malaria Vaccines - genetics Malaria Vaccines - immunology Malaria, Falciparum - prevention & control Male Mice Mice, Inbred BALB C Middle Aged Plasmodium falciparum - genetics Plasmodium falciparum - immunology Protozoan Proteins - genetics Sporozoites - genetics Sporozoites - immunology Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Young Adult
ISSN:	1946-6242
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