Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects

Immunization of humans with whole sporozoites confers complete, sterilizing immunity against malaria infection. However, achieving consistent safety while maintaining immunogenicity of whole parasite vaccines remains a formidable challenge. We generated a genetically attenuated Plasmodium falciparum...

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Vydané v:	Science translational medicine Ročník 9; číslo 371
Hlavní autori:	Kublin, James G, Mikolajczak, Sebastian A, Sack, Brandon K, Fishbaugher, Matt E, Seilie, Annette, Shelton, Lisa, VonGoedert, Tracie, Firat, Melike, Magee, Sara, Fritzen, Emma, Betz, Will, Kain, Heather S, Dankwa, Dorender A, Steel, Ryan W J, Vaughan, Ashley M, Noah Sather, D, Murphy, Sean C, Kappe, Stefan H I
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 04.01.2017
Predmet:	Adult Animals Antibodies, Protozoan - blood Female Gene Deletion Genetic Engineering Humans Immunoglobulin G - blood Malaria Vaccines - genetics Malaria Vaccines - immunology Malaria, Falciparum - prevention & control Male Mice Mice, Inbred BALB C Middle Aged Plasmodium falciparum - genetics Plasmodium falciparum - immunology Protozoan Proteins - genetics Sporozoites - genetics Sporozoites - immunology Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Young Adult
ISSN:	1946-6242
On-line prístup:	Zistit podrobnosti o prístupe
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