β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

Catecholamines released by sympathetic nerves can activate adrenergic receptors present on nearly every cell type, including myeloid-derived suppressor cells (MDSCs). Using in vitro systems, murine tumor models in wild-type and genetically modified (β2-AR-/-) mice, and adoptive transfer approaches,...

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Vydáno v:	The Journal of clinical investigation Ročník 129; číslo 12; s. 5537 - 5552
Hlavní autoři:	Mohammadpour, Hemn, MacDonald, Cameron R., Qiao, Guanxi, Chen, Minhui, Dong, Bowen, Hylander, Bonnie L., McCarthy, Philip L., Abrams, Scott I., Repasky, Elizabeth A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States American Society for Clinical Investigation 02.12.2019
Témata:	Animals Immune Tolerance Mice Mice, Inbred BALB C Mice, Inbred C57BL Myeloid-Derived Suppressor Cells - immunology Myeloid-Derived Suppressor Cells - physiology Neoplasms - blood supply Phosphorylation Receptors, Adrenergic, beta-2 - immunology Signal Transduction - physiology STAT3 Transcription Factor - metabolism Oncology Immunology G-protein coupled receptors Cancer immunotherapy Cellular immune response
ISSN:	0021-9738, 1558-8238, 1558-8238
On-line přístup:	Získat plný text
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