Quantifying the coating yield by modeling heat and mass transfer in a Wurster fluidized bed coater
[Display omitted] •Full-physics CFD-DEM simulation of a pharmaceutical coating process.•Models for multicomponent spray evaporation and spray drying.•Possible reduction of coating losses from 28.2% to 6.1%•Evaluation of process robustness for various parameters. During the coating process of medicin...
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| Published in: | Chemical engineering science Vol. 252; p. 117505 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Ltd
28.04.2022
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| ISSN: | 0009-2509, 1873-4405 |
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| Abstract | [Display omitted]
•Full-physics CFD-DEM simulation of a pharmaceutical coating process.•Models for multicomponent spray evaporation and spray drying.•Possible reduction of coating losses from 28.2% to 6.1%•Evaluation of process robustness for various parameters.
During the coating process of medicines, premature drying of the spray droplets may cause losses, as the droplets do not stick to the product. This work addresses two mechanisms that are central to predicting the heat and mass transfer in coating processes: (i) the evaporation of multicomponent spray liquids and (ii) the quantification of losses due to spray drying. We modeled a Wurster coating process via CFD-DEM simulation and validated the results based on temperature and coating-yield measurements obtained in lab-scale experiments. We assessed the effects of the inlet air flow rate, inlet air temperature and spray rate on the drying performance in a set of virtual experiments. Our calculations show that spray-drying losses can be reduced from 28.2% to 6.1% by selecting appropriate values of the input parameters. Implementing these results in a real coating system will maximize the coating yield and can reduce the process time by up to 75%. |
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| AbstractList | [Display omitted]
•Full-physics CFD-DEM simulation of a pharmaceutical coating process.•Models for multicomponent spray evaporation and spray drying.•Possible reduction of coating losses from 28.2% to 6.1%•Evaluation of process robustness for various parameters.
During the coating process of medicines, premature drying of the spray droplets may cause losses, as the droplets do not stick to the product. This work addresses two mechanisms that are central to predicting the heat and mass transfer in coating processes: (i) the evaporation of multicomponent spray liquids and (ii) the quantification of losses due to spray drying. We modeled a Wurster coating process via CFD-DEM simulation and validated the results based on temperature and coating-yield measurements obtained in lab-scale experiments. We assessed the effects of the inlet air flow rate, inlet air temperature and spray rate on the drying performance in a set of virtual experiments. Our calculations show that spray-drying losses can be reduced from 28.2% to 6.1% by selecting appropriate values of the input parameters. Implementing these results in a real coating system will maximize the coating yield and can reduce the process time by up to 75%. |
| ArticleNumber | 117505 |
| Author | Liu, P. Trogrlic, M. Jajcevic, D. Carmody, A. Khinast, J.G. Forgber, T. Contreras, L. Davies, C. Sarkar, A. Kape, A. Madlmeir, S. |
| Author_xml | – sequence: 1 givenname: S. surname: Madlmeir fullname: Madlmeir, S. organization: Research Center Pharmaceutical Engineering, Graz, Austria – sequence: 2 givenname: T. surname: Forgber fullname: Forgber, T. organization: Research Center Pharmaceutical Engineering, Graz, Austria – sequence: 3 givenname: M. surname: Trogrlic fullname: Trogrlic, M. organization: Research Center Pharmaceutical Engineering, Graz, Austria – sequence: 4 givenname: D. surname: Jajcevic fullname: Jajcevic, D. organization: Research Center Pharmaceutical Engineering, Graz, Austria – sequence: 5 givenname: A. surname: Kape fullname: Kape, A. organization: Glatt, Integrated Process Solution, Binzen, Germany – sequence: 6 givenname: L. surname: Contreras fullname: Contreras, L. organization: Worldwide Research, Development and Medical, Pfizer Inc., Sandwich, UK – sequence: 7 givenname: A. surname: Carmody fullname: Carmody, A. organization: Worldwide Research, Development and Medical, Pfizer Inc., Sandwich, UK – sequence: 8 givenname: P. surname: Liu fullname: Liu, P. organization: Worldwide Research, Development and Medical, Pfizer Inc., Groton CT, USA – sequence: 9 givenname: C. surname: Davies fullname: Davies, C. organization: Worldwide Research, Development and Medical, Pfizer Inc., Groton CT, USA – sequence: 10 givenname: A. surname: Sarkar fullname: Sarkar, A. organization: Worldwide Research, Development and Medical, Pfizer Inc., Groton CT, USA – sequence: 11 givenname: J.G. surname: Khinast fullname: Khinast, J.G. email: khinast@tugraz.at organization: Research Center Pharmaceutical Engineering, Graz, Austria |
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| Cites_doi | 10.1002/cite.201200148 10.1016/j.expthermflusci.2018.08.014 10.1016/j.powtec.2020.01.056 10.1016/j.ces.2013.05.014 10.1016/j.ces.2013.06.051 10.1016/j.powtec.2021.05.100 10.1016/j.powtec.2013.04.013 10.1016/j.cis.2010.06.003 10.1016/j.ejps.2021.105770 10.1021/ja01056a002 10.1021/i200021a019 10.1016/j.ces.2011.02.038 10.1016/j.ces.2013.05.051 10.1002/aic.15616 10.1016/j.ces.2013.05.057 10.1016/j.ces.2013.01.010 10.1002/aic.11065 10.1016/j.powtec.2015.04.031 10.1016/j.powtec.2017.01.088 10.1016/j.xphs.2018.10.016 10.1016/j.cej.2015.11.044 10.1208/s12249-020-01841-7 10.1016/j.ejps.2016.08.018 10.1002/9781119600800.ch67 10.1016/j.ces.2010.07.007 10.1021/jp0118322 10.1016/j.cej.2015.04.131 10.1016/j.ijheatmasstransfer.2017.04.040 10.1016/j.powtec.2004.11.021 10.1016/j.partic.2018.01.008 10.1016/S0032-5910(99)00265-X 10.1021/ci800253u 10.1016/j.ces.2014.07.011 10.1016/j.powtec.2006.05.001 10.1016/S0379-7112(96)00040-9 10.1016/j.powtec.2017.11.031 10.1016/j.powtec.2017.11.052 10.1201/b13576 10.1016/j.powtec.2006.12.006 10.1002/aic.11847 10.1016/j.icheatmasstransfer.2005.12.010 10.1016/j.ces.2019.115289 10.1016/S0924-2244(99)00041-2 10.1016/j.powtec.2016.12.046 10.1016/j.ejps.2015.12.022 10.1016/j.cherd.2018.01.013 10.1063/1.5000516 10.3109/03639049709148494 10.1081/PDT-35915 10.1021/ie50483a022 10.1002/aic.15237 10.1016/j.jclepro.2013.01.004 10.1016/j.ces.2011.04.015 10.1016/j.powtec.2012.04.014 10.1016/0017-9310(78)90080-7 10.1016/j.powtec.2019.11.008 10.1002/ceat.201100132 10.6028/NBS.IR.86-3384 10.1016/j.expthermflusci.2017.10.025 10.1016/j.cis.2013.08.006 10.1016/j.powtec.2016.10.007 |
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| Keywords | Spray drying CFD-DEM Coating yield Coating Multicomponent evaporation Wurster coater |
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| References | am Ende, Berchielli (b0005) 2005; 10 Tsory, Ben-Jacob, Brosh, Levy (b0300) 2013; 244 Bolleddula, Berchielli, Aliseda (b0050) 2010; 159 Patil, Peters, Kuipers (b0210) 2015; 277 Kariuki, Freireich, Smith, Rhodes, Hapgood (b0155) 2013; 92 Sutkar, Deen, Patil, Salikov, Antonyuk, Heinrich, Kuipers (b0275) 2016; 288 Tausendschön, Kolehmainen, Sundaresan, Radl (b0285) 2020; 364 Forgber, Toson, Madlmeir, Kureck, Khinast, Jajcevic (b0090) 2020; 361 Boehling, Toschkoff, Just, Knop, Kleinebudde, Funke, Rehbaum, Rajniak, Khinast (b0035) 2016; 93 Suzzi, Radl, Khinast (b0280) 2010; 65 Ozel, Gu, Milioli, Kolehmainen, Sundaresan (b0205) 2017; 29 Turton (b0305) 2008; 181 Di Marzo, M., Evans, D.D., 1986. Evaporation of a Water Droplet Deposited on a Hot High Thermal Conductivity Solid Surface. Radl, Sundaresan (b0230) 2014; 117 Fries, Antonyuk, Heinrich, Palzer (b0100) 2011; 66 Šibanc, Srčič, Dreu (b0270) 2013; 99 KuShaari, Pandey, Song, Turton (b0170) 2006; 166 Pietsch, Heinrich, Karpinski, Müller, Schönherr, Kleine Jäger (b0215) 2017; 316 Sandell (b0240) 1993 Wilson (b0335) 1964; 86 Pietsch, Kieckhefen, Heinrich, Müller, Schönherr, Kleine Jäger (b0220) 2018; 132 Boehling, Jacevic, Detobel, Holman, Wareham, Metzger, Khinast (b0030) 2021; 22 Beetstra, R., Hoef, M.A. Van Der, Kuipers, J.A.M., 2007. Drag Force of Intermediate Reynolds Number Flow Past Mono- and Bidisperse Arrays of Spheres. AIChE J. 53, 489–501. https://doi.org/10.1002/aic van Kampen, Kohlus (b0325) 2017; 305 Ansel, H.C., Popovich, N.G., 1990. Pharmaceutical Dosage Forms and Drug Delivery, 5th ed, Pharmaceutical Dosage Forms and Drug Delivery Systems. Lea and Febiger, Philadelphia, PA. https://doi.org/10.1201/b13576 Karlsson, Rasmuson, van Wachem, Björn (b0160) 2009; 55 Askarishahi, Salehi, Radl (b0020) 2017; 63 Chandra, di Marzo, Qiao, Tartarini (b0065) 1996; 27 Boltic, Ruzic, Jovanovic, Savic, Jovanovic, Petrovic (b0055) 2013; 44 Asai, Shioya, Hirasawa, Okazaki (b0015) 1993; 37 https://www.malvernpanalytical.com/en/products/product-range/spraytec [WWW Document], n.d. . Accessed 7th Sept. 2020. Böhling, Khinast, Jajcevic, Davies, Carmody, Doshi, Am Ende, Sarkar (b0045) 2019; 108 Mann (b0190) 1983; 22 Nguyen, Mitra, Sathe, Pareek, Joshi, Evans (b0200) 2018; 91 Sarkar, A., Shoemaker, B., Doshi, P., am Ende, M.T., Jajcevic, D., Böhling, P., Toson, P., Zadravec, M., Khinast, J.G., 2019. Multiscale Modeling of a Pharmaceutical Fluid Bed Coating Process using CFD/DEM and Population Balance Models to Predict Coating Uniformity, in: Chemical Engineering in the Pharmaceutical Industry, Wiley Online Books. pp. 419–450. https://doi.org/doi:10.1002/9781119600800.ch67 Volk, Ghia, Stoltz (b0330) 2017; 311 Christensen, Bertelsen (b0070) 1997; 23 Rieck, Bück, Tsotsas (b0235) 2016; 62 Turton, Cheng (b0310) 2005; 150 User Guide to MODDE, 12th ed, 2017. . Sartorius Stedim Data Analytics. Freireich, Li, Litster, Wassgren (b0095) 2011; 66 Gunn (b0115) 1978; 21 Heine, Antonyuk, Fries, Niederreiter, Heinrich, Palzer (b0120) 2013; 85 Lu, Morris, Li, Benyahia (b0180) 2017; 111 Börner, Peglow, Tsotsas (b0060) 2013; 238 Grodowska, Parczewski (b0110) 2010; 67 Madlmeir, Forgber, Trogrlic, Jajcevic, Kape, Contreras, Carmody, Liu, Davies, Sarkar, Khinast (b0185) 2021; 161 Boehling, Toschkoff, Knop, Kleinebudde, Just, Funke, Rehbaum, Khinast (b0040) 2016; 90 Fries, Dosta, Antonyuk, Heinrich, Palzer (b0105) 2011; 34 Semenov, Trybala, Rubio, Kovalchuk, Starov, Velarde (b0260) 2014; 206 Dewettinck, Huyghebaert (b0075) 1999; 10 Toschkoff, Just, Funke, Djuric, Knop, Kleinebudde, Scharrer, Khinast (b0290) 2013; 101 Schüürmann, Ebert, Chen, Wang, Kühne (b0250) 2008; 48 Hilton, Ying, Cleary (b0125) 2013; 99 Trogrlić, Madlmeir, Forgber, Salar-Behzadi, Sarkar, Liu, Contreras, Carmody, Kape, Khinast, Jajčević (b0295) 2021; 391 Kieckhefen, Lichtenegger, Pietsch, Pirker, Heinrich (b0165) 2019; 42 Nguyen, Mitra, Pareek, Joshi, Evans (b0195) 2018; 99 Jiang, Rieck, Bück, Tsotsas (b0145) 2020; 211 van Kampen, Kohlus (b0320) 2018; 325 Sefiane, Tadrist (b0255) 2006; 33 Jones, Godek (b0150) 2016 Pitt, Peña, Tew, Pal, Smith, Nagy, Litster (b0225) 2018; 326 Jajcevic, Siegmann, Radeke, Khinast (b0140) 2013; 98 Shelukar, Ho, Zega, Roland, Yeh, Quiram, Nole, Katdare, Reynolds (b0265) 2000; 110 Wurster, D.E., Lindlof, J.A., 1966. Particle coating apparatus. US Patent 3,241,520. Li, Remmelgas, van Wachem, von Corswant, Johansson, Folestad, Rasmuson (b0175) 2015; 280 Fairbanks, Wilke (b0085) 1950; 42 Hu, Larson (b0135) 2002; 106 Mann (10.1016/j.ces.2022.117505_b0190) 1983; 22 Kariuki (10.1016/j.ces.2022.117505_b0155) 2013; 92 Tsory (10.1016/j.ces.2022.117505_b0300) 2013; 244 10.1016/j.ces.2022.117505_b0025 Boehling (10.1016/j.ces.2022.117505_b0040) 2016; 90 Heine (10.1016/j.ces.2022.117505_b0120) 2013; 85 Toschkoff (10.1016/j.ces.2022.117505_b0290) 2013; 101 10.1016/j.ces.2022.117505_b0340 Ozel (10.1016/j.ces.2022.117505_b0205) 2017; 29 Pitt (10.1016/j.ces.2022.117505_b0225) 2018; 326 Boltic (10.1016/j.ces.2022.117505_b0055) 2013; 44 Bolleddula (10.1016/j.ces.2022.117505_b0050) 2010; 159 Pietsch (10.1016/j.ces.2022.117505_b0215) 2017; 316 Lu (10.1016/j.ces.2022.117505_b0180) 2017; 111 Madlmeir (10.1016/j.ces.2022.117505_b0185) 2021; 161 Dewettinck (10.1016/j.ces.2022.117505_b0075) 1999; 10 Schüürmann (10.1016/j.ces.2022.117505_b0250) 2008; 48 Sefiane (10.1016/j.ces.2022.117505_b0255) 2006; 33 van Kampen (10.1016/j.ces.2022.117505_b0320) 2018; 325 Semenov (10.1016/j.ces.2022.117505_b0260) 2014; 206 Sutkar (10.1016/j.ces.2022.117505_b0275) 2016; 288 KuShaari (10.1016/j.ces.2022.117505_b0170) 2006; 166 Rieck (10.1016/j.ces.2022.117505_b0235) 2016; 62 Suzzi (10.1016/j.ces.2022.117505_b0280) 2010; 65 Nguyen (10.1016/j.ces.2022.117505_b0200) 2018; 91 Börner (10.1016/j.ces.2022.117505_b0060) 2013; 238 Hilton (10.1016/j.ces.2022.117505_b0125) 2013; 99 Kieckhefen (10.1016/j.ces.2022.117505_b0165) 2019; 42 Fries (10.1016/j.ces.2022.117505_b0100) 2011; 66 Turton (10.1016/j.ces.2022.117505_b0305) 2008; 181 Freireich (10.1016/j.ces.2022.117505_b0095) 2011; 66 Tausendschön (10.1016/j.ces.2022.117505_b0285) 2020; 364 Christensen (10.1016/j.ces.2022.117505_b0070) 1997; 23 Patil (10.1016/j.ces.2022.117505_b0210) 2015; 277 10.1016/j.ces.2022.117505_b0080 10.1016/j.ces.2022.117505_b0245 Asai (10.1016/j.ces.2022.117505_b0015) 1993; 37 Nguyen (10.1016/j.ces.2022.117505_b0195) 2018; 99 Fries (10.1016/j.ces.2022.117505_b0105) 2011; 34 Karlsson (10.1016/j.ces.2022.117505_b0160) 2009; 55 Pietsch (10.1016/j.ces.2022.117505_b0220) 2018; 132 Sandell (10.1016/j.ces.2022.117505_b0240) 1993 am Ende (10.1016/j.ces.2022.117505_b0005) 2005; 10 Boehling (10.1016/j.ces.2022.117505_b0030) 2021; 22 Hu (10.1016/j.ces.2022.117505_b0135) 2002; 106 10.1016/j.ces.2022.117505_b0315 Chandra (10.1016/j.ces.2022.117505_b0065) 1996; 27 Boehling (10.1016/j.ces.2022.117505_b0035) 2016; 93 van Kampen (10.1016/j.ces.2022.117505_b0325) 2017; 305 Böhling (10.1016/j.ces.2022.117505_b0045) 2019; 108 Askarishahi (10.1016/j.ces.2022.117505_b0020) 2017; 63 Volk (10.1016/j.ces.2022.117505_b0330) 2017; 311 Grodowska (10.1016/j.ces.2022.117505_b0110) 2010; 67 10.1016/j.ces.2022.117505_b0130 Jiang (10.1016/j.ces.2022.117505_b0145) 2020; 211 Gunn (10.1016/j.ces.2022.117505_b0115) 1978; 21 Trogrlić (10.1016/j.ces.2022.117505_b0295) 2021; 391 Shelukar (10.1016/j.ces.2022.117505_b0265) 2000; 110 10.1016/j.ces.2022.117505_b0010 Forgber (10.1016/j.ces.2022.117505_b0090) 2020; 361 Turton (10.1016/j.ces.2022.117505_b0310) 2005; 150 Jajcevic (10.1016/j.ces.2022.117505_b0140) 2013; 98 Radl (10.1016/j.ces.2022.117505_b0230) 2014; 117 Šibanc (10.1016/j.ces.2022.117505_b0270) 2013; 99 Jones (10.1016/j.ces.2022.117505_b0150) 2016 Fairbanks (10.1016/j.ces.2022.117505_b0085) 1950; 42 Li (10.1016/j.ces.2022.117505_b0175) 2015; 280 Wilson (10.1016/j.ces.2022.117505_b0335) 1964; 86 |
| References_xml | – volume: 106 start-page: 1334 year: 2002 end-page: 1344 ident: b0135 article-title: Evaporation of a sessile droplet on a substrate publication-title: J. Phys. Chem. B – volume: 91 start-page: 329 year: 2018 end-page: 344 ident: b0200 article-title: Evaporation of a suspended binary mixture droplet in a heated flowing gas stream publication-title: Exp. Therm. Fluid Sci. – volume: 44 start-page: 123 year: 2013 end-page: 132 ident: b0055 article-title: Cleaner production aspects of tablet coating process in pharmaceutical industry: Problem of VOCs emission publication-title: J. Clean. Prod. – volume: 55 start-page: 2578 year: 2009 end-page: 2590 ident: b0160 article-title: CFD Modeling of the Wurster Bed Coater publication-title: AICHE J. – volume: 108 start-page: 538 year: 2019 end-page: 550 ident: b0045 article-title: Computational Fluid Dynamics-Discrete Element Method Modeling of an Industrial-Scale Wurster Coater publication-title: J. Pharm. Sci. – volume: 48 start-page: 2140 year: 2008 end-page: 2145 ident: b0250 article-title: External Validation and Prediction Employing the Predictive Squared Correlation Coefficient — Test Set Activity Mean vs Training Set Activity Mean publication-title: J. Chem. Inf. Model. – volume: 111 start-page: 723 year: 2017 end-page: 735 ident: b0180 article-title: Extension of a coarse grained particle method to simulate heat transfer in fluidized beds publication-title: Int. J. Heat Mass Transf. – volume: 98 start-page: 298 year: 2013 end-page: 310 ident: b0140 article-title: Large-scale CFD–DEM simulations of fluidized granular systems publication-title: Chem. Eng. Sci. – volume: 85 start-page: 280 year: 2013 end-page: 289 ident: b0120 article-title: Modeling of the spray zone for particle wetting in a fluidized bed publication-title: Chemie-Ingenieur-Technik – volume: 159 start-page: 144 year: 2010 end-page: 159 ident: b0050 article-title: Impact of a heterogeneous liquid droplet on a dry surface: Application to the pharmaceutical industry publication-title: Adv. Colloid Interface Sci. – volume: 161 start-page: 105770 year: 2021 ident: b0185 article-title: Modeling the Coating Layer Thickness in a Pharmaceutical Coating Process publication-title: Eur. J. Pharm. Sci. – volume: 63 start-page: 2569 year: 2017 end-page: 2587 ident: b0020 article-title: Full-Physics Simulations of Spray-Particle Interaction in a Bubbling Fluidized Bed publication-title: AIChE J. – volume: 22 start-page: 288 year: 1983 end-page: 292 ident: b0190 article-title: Analysis of Spouted-Bed Coating and Granulation. 1. Batch Operation publication-title: Ind. Eng. Chem. Process Des. Dev. – volume: 42 start-page: 92 year: 2019 end-page: 103 ident: b0165 article-title: Simulation of Spray Coating in a Spouted Bed using Recurrence CFD publication-title: Particuology – reference: Ansel, H.C., Popovich, N.G., 1990. Pharmaceutical Dosage Forms and Drug Delivery, 5th ed, Pharmaceutical Dosage Forms and Drug Delivery Systems. Lea and Febiger, Philadelphia, PA. https://doi.org/10.1201/b13576 – volume: 132 start-page: 1105 year: 2018 end-page: 1116 ident: b0220 article-title: CFD-DEM modelling of circulation frequencies and residence times in a prismatic spouted bed publication-title: Chem. Eng. Res. Des. – volume: 93 start-page: 74 year: 2016 end-page: 83 ident: b0035 article-title: Simulation of a tablet coating process at different scales using DEM publication-title: Eur. J. Pharm. Sci. – volume: 280 start-page: 124 year: 2015 end-page: 134 ident: b0175 article-title: Residence time distributions of different size particles in the spray zone of a Wurster fluid bed studied using DEM-CFD publication-title: Powder Technol. – volume: 67 start-page: 3 year: 2010 end-page: 12 ident: b0110 article-title: Organic solvents in the pharmaceutical industry publication-title: Acta Pol. Pharm. - Drug Res. – volume: 27 start-page: 141 year: 1996 end-page: 158 ident: b0065 article-title: Effect of liquid-solid contact angle on droplet evaporation publication-title: Fire Saf. J. – volume: 166 start-page: 81 year: 2006 end-page: 90 ident: b0170 article-title: Monte Carlo simulations to determine coating uniformity in a Wurster fluidized bed coating process publication-title: Powder Technol. – volume: 364 start-page: 167 year: 2020 end-page: 182 ident: b0285 article-title: Coarse graining Euler-Lagrange simulations of cohesive particle fluidization publication-title: Powder Technol. – volume: 22 year: 2021 ident: b0030 article-title: Validating a Numerical Simulation of the ConsiGma(R) Coater publication-title: AAPS PharmSciTech – reference: Beetstra, R., Hoef, M.A. Van Der, Kuipers, J.A.M., 2007. Drag Force of Intermediate Reynolds Number Flow Past Mono- and Bidisperse Arrays of Spheres. AIChE J. 53, 489–501. https://doi.org/10.1002/aic – volume: 29 start-page: 103308 year: 2017 ident: b0205 article-title: Towards filtered drag force model for non-cohesive and cohesive particle-gas flows publication-title: Phys. Fluids – reference: Sarkar, A., Shoemaker, B., Doshi, P., am Ende, M.T., Jajcevic, D., Böhling, P., Toson, P., Zadravec, M., Khinast, J.G., 2019. Multiscale Modeling of a Pharmaceutical Fluid Bed Coating Process using CFD/DEM and Population Balance Models to Predict Coating Uniformity, in: Chemical Engineering in the Pharmaceutical Industry, Wiley Online Books. pp. 419–450. https://doi.org/doi:10.1002/9781119600800.ch67 – volume: 206 start-page: 382 year: 2014 end-page: 398 ident: b0260 article-title: Simultaneous spreading and evaporation: Recent developments publication-title: Adv. Colloid Interface Sci. – volume: 90 start-page: 14 year: 2016 end-page: 24 ident: b0040 article-title: Analysis of large-scale tablet coating: Modeling, simulation and experiments publication-title: Eur. J. Pharm. Sci. – year: 1993 ident: b0240 article-title: Industrial aspects of pharmaceutics – volume: 211 start-page: 115289 year: 2020 ident: b0145 article-title: Modeling of inter- and intra-particle coating uniformity in a Wurster fluidized bed by a coupled CFD-DEM-Monte Carlo approach publication-title: Chem. Eng. Sci. – volume: 10 start-page: 47 year: 2005 end-page: 58 ident: b0005 article-title: A Thermodynamic Model for Organic and Aqueous Tablet Film Coating publication-title: Pharm. Dev. Technol. – volume: 10 start-page: 163 year: 1999 end-page: 168 ident: b0075 article-title: Fluidized bed coating in food technology publication-title: Trends Food Sci. Technol. – volume: 244 start-page: 52 year: 2013 end-page: 60 ident: b0300 article-title: Thermal DEM-CFD modeling and simulation of heat transfer through packed bed publication-title: Powder Technol. – volume: 62 start-page: 2670 year: 2016 end-page: 2680 ident: b0235 article-title: Monte Carlo Modeling of Fluidized Bed Coating and Layering Processes publication-title: AIChE J. – volume: 92 start-page: 134 year: 2013 end-page: 145 ident: b0155 article-title: Distribution nucleation: Quantifying liquid distribution on the particle surface using the dimensionless particle coating number publication-title: Chem. Eng. Sci. – reference: https://www.malvernpanalytical.com/en/products/product-range/spraytec [WWW Document], n.d. . Accessed 7th Sept. 2020. – volume: 181 start-page: 186 year: 2008 end-page: 194 ident: b0305 article-title: Challenges in the modeling and prediction of coating of pharmaceutical dosage forms publication-title: Powder Technol. – volume: 66 start-page: 3592 year: 2011 end-page: 3604 ident: b0095 article-title: Incorporating particle flow information from discrete element simulations in population balance models of mixer-coaters publication-title: Chem. Eng. Sci. – volume: 305 start-page: 426 year: 2017 end-page: 432 ident: b0325 article-title: Systematic process optimisation of fluid bed coating publication-title: Powder Technol. – volume: 150 start-page: 78 year: 2005 end-page: 85 ident: b0310 article-title: The scale-up of spray coating processes for granular solids and tablets publication-title: Powder Technol. – volume: 21 start-page: 467 year: 1978 end-page: 476 ident: b0115 article-title: Transfer of heat or mass to particles in fixed and fluidised beds publication-title: Int. J. Heat Mass Transf. – volume: 110 start-page: 29 year: 2000 end-page: 36 ident: b0265 article-title: Identification and characterization of factors controlling tablet coating uniformity in a Wurster coating process publication-title: Powder Technol. – volume: 238 start-page: 122 year: 2013 end-page: 131 ident: b0060 article-title: Derivation of parameters for a two compartment population balance model of Wurster fluidised bed granulation publication-title: Powder Technol. – start-page: 997 year: 2016 end-page: 1014 ident: b0150 article-title: Development, optimization, and scale-up of process parameters: Wurster coating publication-title: Developing Solid Oral Dosage Forms – volume: 117 start-page: 416 year: 2014 end-page: 425 ident: b0230 article-title: A drag model for filtered Euler-Lagrange simulations of clustered gas-particle suspensions publication-title: Chem. Eng. Sci. – volume: 33 start-page: 482 year: 2006 end-page: 490 ident: b0255 article-title: Experimental investigation of the de-pinning phenomenon on rough surfaces of volatile drops publication-title: Int. Commun. Heat Mass Transf. – volume: 86 start-page: 127 year: 1964 end-page: 130 ident: b0335 article-title: Vapor-Liquid Equilibrium. XI. A New Expression for the Excess Free Energy of Mixing publication-title: J. Am. Chem. Soc. – volume: 37 start-page: 205 year: 1993 end-page: 207 ident: b0015 article-title: Impact of an Ink Drop on Paper publication-title: J. Imaging Sci. Technol. – volume: 42 start-page: 471 year: 1950 end-page: 475 ident: b0085 article-title: Diffusion Coefficients in Multicomponent Gas Mixtures publication-title: Ind. Eng. Chem. – volume: 66 start-page: 2340 year: 2011 end-page: 2355 ident: b0100 article-title: DEM-CFD modeling of a fluidized bed spray granulator publication-title: Chem. Eng. Sci. – volume: 101 start-page: 603 year: 2013 end-page: 614 ident: b0290 article-title: Spray models for discrete element simulations of particle coating processes publication-title: Chem. Eng. Sci. – reference: User Guide to MODDE, 12th ed, 2017. . Sartorius Stedim Data Analytics. – volume: 326 start-page: 327 year: 2018 end-page: 343 ident: b0225 article-title: Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling publication-title: Powder Technol. – volume: 23 start-page: 451 year: 1997 end-page: 463 ident: b0070 article-title: Qualitative Description of the Wurster-Based Fluid-Bed Coating Process publication-title: Drug Dev. Ind. Pharm. – volume: 65 start-page: 5699 year: 2010 end-page: 5715 ident: b0280 article-title: Local analysis of the tablet coating process: Impact of operation conditions on film quality publication-title: Chem. Eng. Sci. – volume: 311 start-page: 137 year: 2017 end-page: 146 ident: b0330 article-title: Effect of grid type and refinement method on CFD-DEM solution trend with grid size publication-title: Powder Technol. – volume: 99 start-page: 141 year: 2013 end-page: 160 ident: b0125 article-title: Modelling spray coating using a combined CFD-DEM and spherical harmonic formulation publication-title: Chem. Eng. Sci. – reference: Di Marzo, M., Evans, D.D., 1986. Evaporation of a Water Droplet Deposited on a Hot High Thermal Conductivity Solid Surface. – volume: 361 start-page: 880 year: 2020 end-page: 893 ident: b0090 article-title: Extended validation and verification of XPS/AVL-Fire publication-title: Powder Technol. – volume: 277 start-page: 388 year: 2015 end-page: 401 ident: b0210 article-title: Comparison of CFD-DEM heat transfer simulations with infrared/visual measurements publication-title: Chem. Eng. J. – volume: 99 start-page: 558 year: 2018 end-page: 571 ident: b0195 article-title: Evaporation of a sessile binary droplet on a heated spherical particle publication-title: Exp. Therm. Fluid Sci. – volume: 316 start-page: 245 year: 2017 end-page: 255 ident: b0215 article-title: CFD-DEM modeling of a three-dimensional prismatic spouted bed publication-title: Powder Technol. – volume: 34 start-page: 1076 year: 2011 end-page: 1084 ident: b0105 article-title: Moisture distribution in fluidized beds with liquid injection publication-title: Chem. Eng. Technol. – volume: 325 start-page: 557 year: 2018 end-page: 567 ident: b0320 article-title: Statistical modelling of coating layer thickness distributions: Influence of overspray on coating quality publication-title: Powder Technol. – volume: 288 start-page: 185 year: 2016 end-page: 197 ident: b0275 article-title: CFD-DEM model for coupled heat and mass transfer in a spout fluidized bed with liquid injection publication-title: Chem. Eng. J. – volume: 391 start-page: 97 year: 2021 end-page: 113 ident: b0295 article-title: Numerical and experimental validation of a detailed non-isothermal CFD-DEM model of a pilot-scale Wurster coater publication-title: Powder Technol. – volume: 99 start-page: 225 year: 2013 end-page: 237 ident: b0270 article-title: Numerical simulation of two-phase flow in a Wurster coating chamber and comparison with experimental results publication-title: Chem. Eng. Sci. – reference: Wurster, D.E., Lindlof, J.A., 1966. Particle coating apparatus. US Patent 3,241,520. – volume: 85 start-page: 280 issue: 3 year: 2013 ident: 10.1016/j.ces.2022.117505_b0120 article-title: Modeling of the spray zone for particle wetting in a fluidized bed publication-title: Chemie-Ingenieur-Technik doi: 10.1002/cite.201200148 – volume: 99 start-page: 558 year: 2018 ident: 10.1016/j.ces.2022.117505_b0195 article-title: Evaporation of a sessile binary droplet on a heated spherical particle publication-title: Exp. Therm. Fluid Sci. doi: 10.1016/j.expthermflusci.2018.08.014 – volume: 364 start-page: 167 year: 2020 ident: 10.1016/j.ces.2022.117505_b0285 article-title: Coarse graining Euler-Lagrange simulations of cohesive particle fluidization publication-title: Powder Technol. doi: 10.1016/j.powtec.2020.01.056 – volume: 98 start-page: 298 year: 2013 ident: 10.1016/j.ces.2022.117505_b0140 article-title: Large-scale CFD–DEM simulations of fluidized granular systems publication-title: Chem. Eng. Sci. doi: 10.1016/j.ces.2013.05.014 – volume: 101 start-page: 603 year: 2013 ident: 10.1016/j.ces.2022.117505_b0290 article-title: Spray models for discrete element simulations of particle coating processes publication-title: Chem. Eng. Sci. doi: 10.1016/j.ces.2013.06.051 – volume: 391 start-page: 97 year: 2021 ident: 10.1016/j.ces.2022.117505_b0295 article-title: Numerical and experimental validation of a detailed non-isothermal CFD-DEM model of a pilot-scale Wurster coater publication-title: Powder Technol. doi: 10.1016/j.powtec.2021.05.100 – volume: 244 start-page: 52 year: 2013 ident: 10.1016/j.ces.2022.117505_b0300 article-title: Thermal DEM-CFD modeling and simulation of heat transfer through packed bed publication-title: Powder Technol. doi: 10.1016/j.powtec.2013.04.013 – volume: 159 start-page: 144 issue: 2 year: 2010 ident: 10.1016/j.ces.2022.117505_b0050 article-title: Impact of a heterogeneous liquid droplet on a dry surface: Application to the pharmaceutical industry publication-title: Adv. Colloid Interface Sci. doi: 10.1016/j.cis.2010.06.003 – volume: 161 start-page: 105770 year: 2021 ident: 10.1016/j.ces.2022.117505_b0185 article-title: Modeling the Coating Layer Thickness in a Pharmaceutical Coating Process publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2021.105770 – volume: 86 start-page: 127 issue: 2 year: 1964 ident: 10.1016/j.ces.2022.117505_b0335 article-title: Vapor-Liquid Equilibrium. XI. A New Expression for the Excess Free Energy of Mixing publication-title: J. Am. Chem. Soc. doi: 10.1021/ja01056a002 – volume: 22 start-page: 288 issue: 2 year: 1983 ident: 10.1016/j.ces.2022.117505_b0190 article-title: Analysis of Spouted-Bed Coating and Granulation. 1. Batch Operation publication-title: Ind. Eng. Chem. Process Des. Dev. doi: 10.1021/i200021a019 – volume: 66 start-page: 2340 issue: 11 year: 2011 ident: 10.1016/j.ces.2022.117505_b0100 article-title: DEM-CFD modeling of a fluidized bed spray granulator publication-title: Chem. Eng. Sci. doi: 10.1016/j.ces.2011.02.038 – volume: 37 start-page: 205 year: 1993 ident: 10.1016/j.ces.2022.117505_b0015 article-title: Impact of an Ink Drop on Paper publication-title: J. Imaging Sci. Technol. – volume: 99 start-page: 141 year: 2013 ident: 10.1016/j.ces.2022.117505_b0125 article-title: Modelling spray coating using a combined CFD-DEM and spherical harmonic formulation publication-title: Chem. Eng. Sci. doi: 10.1016/j.ces.2013.05.051 – ident: 10.1016/j.ces.2022.117505_b0315 – ident: 10.1016/j.ces.2022.117505_b0340 – volume: 63 start-page: 2569 issue: 7 year: 2017 ident: 10.1016/j.ces.2022.117505_b0020 article-title: Full-Physics Simulations of Spray-Particle Interaction in a Bubbling Fluidized Bed publication-title: AIChE J. doi: 10.1002/aic.15616 – volume: 99 start-page: 225 year: 2013 ident: 10.1016/j.ces.2022.117505_b0270 article-title: Numerical simulation of two-phase flow in a Wurster coating chamber and comparison with experimental results publication-title: Chem. Eng. Sci. doi: 10.1016/j.ces.2013.05.057 – volume: 92 start-page: 134 year: 2013 ident: 10.1016/j.ces.2022.117505_b0155 article-title: Distribution nucleation: Quantifying liquid distribution on the particle surface using the dimensionless particle coating number publication-title: Chem. Eng. Sci. doi: 10.1016/j.ces.2013.01.010 – ident: 10.1016/j.ces.2022.117505_b0025 doi: 10.1002/aic.11065 – volume: 280 start-page: 124 year: 2015 ident: 10.1016/j.ces.2022.117505_b0175 article-title: Residence time distributions of different size particles in the spray zone of a Wurster fluid bed studied using DEM-CFD publication-title: Powder Technol. doi: 10.1016/j.powtec.2015.04.031 – volume: 311 start-page: 137 year: 2017 ident: 10.1016/j.ces.2022.117505_b0330 article-title: Effect of grid type and refinement method on CFD-DEM solution trend with grid size publication-title: Powder Technol. doi: 10.1016/j.powtec.2017.01.088 – volume: 108 start-page: 538 issue: 1 year: 2019 ident: 10.1016/j.ces.2022.117505_b0045 article-title: Computational Fluid Dynamics-Discrete Element Method Modeling of an Industrial-Scale Wurster Coater publication-title: J. Pharm. Sci. doi: 10.1016/j.xphs.2018.10.016 – volume: 288 start-page: 185 year: 2016 ident: 10.1016/j.ces.2022.117505_b0275 article-title: CFD-DEM model for coupled heat and mass transfer in a spout fluidized bed with liquid injection publication-title: Chem. Eng. J. doi: 10.1016/j.cej.2015.11.044 – volume: 22 issue: 1 year: 2021 ident: 10.1016/j.ces.2022.117505_b0030 article-title: Validating a Numerical Simulation of the ConsiGma(R) Coater publication-title: AAPS PharmSciTech doi: 10.1208/s12249-020-01841-7 – volume: 93 start-page: 74 year: 2016 ident: 10.1016/j.ces.2022.117505_b0035 article-title: Simulation of a tablet coating process at different scales using DEM publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2016.08.018 – ident: 10.1016/j.ces.2022.117505_b0245 doi: 10.1002/9781119600800.ch67 – volume: 65 start-page: 5699 issue: 21 year: 2010 ident: 10.1016/j.ces.2022.117505_b0280 article-title: Local analysis of the tablet coating process: Impact of operation conditions on film quality publication-title: Chem. Eng. Sci. doi: 10.1016/j.ces.2010.07.007 – volume: 106 start-page: 1334 issue: 6 year: 2002 ident: 10.1016/j.ces.2022.117505_b0135 article-title: Evaporation of a sessile droplet on a substrate publication-title: J. Phys. Chem. B doi: 10.1021/jp0118322 – volume: 277 start-page: 388 year: 2015 ident: 10.1016/j.ces.2022.117505_b0210 article-title: Comparison of CFD-DEM heat transfer simulations with infrared/visual measurements publication-title: Chem. Eng. J. doi: 10.1016/j.cej.2015.04.131 – start-page: 997 year: 2016 ident: 10.1016/j.ces.2022.117505_b0150 article-title: Development, optimization, and scale-up of process parameters: Wurster coating – volume: 111 start-page: 723 year: 2017 ident: 10.1016/j.ces.2022.117505_b0180 article-title: Extension of a coarse grained particle method to simulate heat transfer in fluidized beds publication-title: Int. J. Heat Mass Transf. doi: 10.1016/j.ijheatmasstransfer.2017.04.040 – volume: 150 start-page: 78 issue: 2 year: 2005 ident: 10.1016/j.ces.2022.117505_b0310 article-title: The scale-up of spray coating processes for granular solids and tablets publication-title: Powder Technol. doi: 10.1016/j.powtec.2004.11.021 – volume: 42 start-page: 92 year: 2019 ident: 10.1016/j.ces.2022.117505_b0165 article-title: Simulation of Spray Coating in a Spouted Bed using Recurrence CFD publication-title: Particuology doi: 10.1016/j.partic.2018.01.008 – volume: 110 start-page: 29 issue: 1-2 year: 2000 ident: 10.1016/j.ces.2022.117505_b0265 article-title: Identification and characterization of factors controlling tablet coating uniformity in a Wurster coating process publication-title: Powder Technol. doi: 10.1016/S0032-5910(99)00265-X – volume: 48 start-page: 2140 issue: 11 year: 2008 ident: 10.1016/j.ces.2022.117505_b0250 article-title: External Validation and Prediction Employing the Predictive Squared Correlation Coefficient — Test Set Activity Mean vs Training Set Activity Mean publication-title: J. Chem. Inf. Model. doi: 10.1021/ci800253u – volume: 117 start-page: 416 year: 2014 ident: 10.1016/j.ces.2022.117505_b0230 article-title: A drag model for filtered Euler-Lagrange simulations of clustered gas-particle suspensions publication-title: Chem. Eng. Sci. doi: 10.1016/j.ces.2014.07.011 – volume: 166 start-page: 81 issue: 2 year: 2006 ident: 10.1016/j.ces.2022.117505_b0170 article-title: Monte Carlo simulations to determine coating uniformity in a Wurster fluidized bed coating process publication-title: Powder Technol. doi: 10.1016/j.powtec.2006.05.001 – volume: 27 start-page: 141 issue: 2 year: 1996 ident: 10.1016/j.ces.2022.117505_b0065 article-title: Effect of liquid-solid contact angle on droplet evaporation publication-title: Fire Saf. J. doi: 10.1016/S0379-7112(96)00040-9 – volume: 325 start-page: 557 year: 2018 ident: 10.1016/j.ces.2022.117505_b0320 article-title: Statistical modelling of coating layer thickness distributions: Influence of overspray on coating quality publication-title: Powder Technol. doi: 10.1016/j.powtec.2017.11.031 – volume: 326 start-page: 327 year: 2018 ident: 10.1016/j.ces.2022.117505_b0225 article-title: Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling publication-title: Powder Technol. doi: 10.1016/j.powtec.2017.11.052 – ident: 10.1016/j.ces.2022.117505_b0010 doi: 10.1201/b13576 – ident: 10.1016/j.ces.2022.117505_b0130 – volume: 181 start-page: 186 issue: 2 year: 2008 ident: 10.1016/j.ces.2022.117505_b0305 article-title: Challenges in the modeling and prediction of coating of pharmaceutical dosage forms publication-title: Powder Technol. doi: 10.1016/j.powtec.2006.12.006 – volume: 55 start-page: 2578 issue: 10 year: 2009 ident: 10.1016/j.ces.2022.117505_b0160 article-title: CFD Modeling of the Wurster Bed Coater publication-title: AICHE J. doi: 10.1002/aic.11847 – volume: 33 start-page: 482 issue: 4 year: 2006 ident: 10.1016/j.ces.2022.117505_b0255 article-title: Experimental investigation of the de-pinning phenomenon on rough surfaces of volatile drops publication-title: Int. Commun. Heat Mass Transf. doi: 10.1016/j.icheatmasstransfer.2005.12.010 – volume: 67 start-page: 3 year: 2010 ident: 10.1016/j.ces.2022.117505_b0110 article-title: Organic solvents in the pharmaceutical industry publication-title: Acta Pol. Pharm. - Drug Res. – volume: 211 start-page: 115289 year: 2020 ident: 10.1016/j.ces.2022.117505_b0145 article-title: Modeling of inter- and intra-particle coating uniformity in a Wurster fluidized bed by a coupled CFD-DEM-Monte Carlo approach publication-title: Chem. Eng. Sci. doi: 10.1016/j.ces.2019.115289 – volume: 10 start-page: 163 issue: 4-5 year: 1999 ident: 10.1016/j.ces.2022.117505_b0075 article-title: Fluidized bed coating in food technology publication-title: Trends Food Sci. Technol. doi: 10.1016/S0924-2244(99)00041-2 – volume: 316 start-page: 245 year: 2017 ident: 10.1016/j.ces.2022.117505_b0215 article-title: CFD-DEM modeling of a three-dimensional prismatic spouted bed publication-title: Powder Technol. doi: 10.1016/j.powtec.2016.12.046 – volume: 90 start-page: 14 year: 2016 ident: 10.1016/j.ces.2022.117505_b0040 article-title: Analysis of large-scale tablet coating: Modeling, simulation and experiments publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2015.12.022 – volume: 132 start-page: 1105 year: 2018 ident: 10.1016/j.ces.2022.117505_b0220 article-title: CFD-DEM modelling of circulation frequencies and residence times in a prismatic spouted bed publication-title: Chem. Eng. Res. Des. doi: 10.1016/j.cherd.2018.01.013 – volume: 29 start-page: 103308 issue: 10 year: 2017 ident: 10.1016/j.ces.2022.117505_b0205 article-title: Towards filtered drag force model for non-cohesive and cohesive particle-gas flows publication-title: Phys. Fluids doi: 10.1063/1.5000516 – volume: 23 start-page: 451 issue: 5 year: 1997 ident: 10.1016/j.ces.2022.117505_b0070 article-title: Qualitative Description of the Wurster-Based Fluid-Bed Coating Process publication-title: Drug Dev. Ind. Pharm. doi: 10.3109/03639049709148494 – volume: 10 start-page: 47 issue: 1 year: 2005 ident: 10.1016/j.ces.2022.117505_b0005 article-title: A Thermodynamic Model for Organic and Aqueous Tablet Film Coating publication-title: Pharm. Dev. Technol. doi: 10.1081/PDT-35915 – volume: 42 start-page: 471 issue: 3 year: 1950 ident: 10.1016/j.ces.2022.117505_b0085 article-title: Diffusion Coefficients in Multicomponent Gas Mixtures publication-title: Ind. Eng. Chem. doi: 10.1021/ie50483a022 – volume: 62 start-page: 2670 year: 2016 ident: 10.1016/j.ces.2022.117505_b0235 article-title: Monte Carlo Modeling of Fluidized Bed Coating and Layering Processes publication-title: AIChE J. doi: 10.1002/aic.15237 – volume: 44 start-page: 123 year: 2013 ident: 10.1016/j.ces.2022.117505_b0055 article-title: Cleaner production aspects of tablet coating process in pharmaceutical industry: Problem of VOCs emission publication-title: J. Clean. Prod. doi: 10.1016/j.jclepro.2013.01.004 – year: 1993 ident: 10.1016/j.ces.2022.117505_b0240 – volume: 66 start-page: 3592 issue: 16 year: 2011 ident: 10.1016/j.ces.2022.117505_b0095 article-title: Incorporating particle flow information from discrete element simulations in population balance models of mixer-coaters publication-title: Chem. Eng. Sci. doi: 10.1016/j.ces.2011.04.015 – volume: 238 start-page: 122 year: 2013 ident: 10.1016/j.ces.2022.117505_b0060 article-title: Derivation of parameters for a two compartment population balance model of Wurster fluidised bed granulation publication-title: Powder Technol. doi: 10.1016/j.powtec.2012.04.014 – volume: 21 start-page: 467 issue: 4 year: 1978 ident: 10.1016/j.ces.2022.117505_b0115 article-title: Transfer of heat or mass to particles in fixed and fluidised beds publication-title: Int. J. Heat Mass Transf. doi: 10.1016/0017-9310(78)90080-7 – volume: 361 start-page: 880 year: 2020 ident: 10.1016/j.ces.2022.117505_b0090 article-title: Extended validation and verification of XPS/AVL-FireTM, a computational CFD-DEM software platform publication-title: Powder Technol. doi: 10.1016/j.powtec.2019.11.008 – volume: 34 start-page: 1076 year: 2011 ident: 10.1016/j.ces.2022.117505_b0105 article-title: Moisture distribution in fluidized beds with liquid injection publication-title: Chem. Eng. Technol. doi: 10.1002/ceat.201100132 – ident: 10.1016/j.ces.2022.117505_b0080 doi: 10.6028/NBS.IR.86-3384 – volume: 91 start-page: 329 year: 2018 ident: 10.1016/j.ces.2022.117505_b0200 article-title: Evaporation of a suspended binary mixture droplet in a heated flowing gas stream publication-title: Exp. Therm. Fluid Sci. doi: 10.1016/j.expthermflusci.2017.10.025 – volume: 206 start-page: 382 year: 2014 ident: 10.1016/j.ces.2022.117505_b0260 article-title: Simultaneous spreading and evaporation: Recent developments publication-title: Adv. Colloid Interface Sci. doi: 10.1016/j.cis.2013.08.006 – volume: 305 start-page: 426 year: 2017 ident: 10.1016/j.ces.2022.117505_b0325 article-title: Systematic process optimisation of fluid bed coating publication-title: Powder Technol. doi: 10.1016/j.powtec.2016.10.007 |
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| SubjectTerms | CFD-DEM Coating Coating yield Multicomponent evaporation Spray drying Wurster coater |
| Title | Quantifying the coating yield by modeling heat and mass transfer in a Wurster fluidized bed coater |
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