Pesticide-induced epigenetic suppression of WNT signaling and NF-κB-driven inflammation impairs ovarian function in rats

The study examined the impact of chlorpyrifos, dimethoate, and their co-exposure on ovarian structure and function in female Wistar rats. The study involved 24 rats, divided into four groups: control, chlorpyrifos (3 mg/kg), dimethoate (30 mg/kg), and combination. Histopathology revealed degenerated...

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Bibliographic Details
Published in:	Food and chemical toxicology Vol. 205; p. 115706
Main Authors:	Jan, Jasmeena, Sheikh, Wajid Mohammad, Gul, Shazia, Mohidin, Rumaisa, Bhat, Owais Mohmad, Lone, Mohammad Nadeem, Shah, Showkat Ahmad, Dar, Abid Hamid, Zargar, Mohammad Afzal, Bashir, Showkeen Muzamil, Wani, Nissar Ahmad
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.11.2025
Subjects:	Animals Chlorpyrifos Chlorpyrifos - toxicity Dimethoate DNA methylation DNA Methylation - drug effects Epigenesis, Genetic - drug effects Female Hormonal imbalance Inflammation Inflammation - chemically induced Inflammation - genetics Inflammation - metabolism NF-kappa B - genetics NF-kappa B - metabolism Ovarian function Ovary - drug effects Ovary - metabolism Ovary - pathology Ovary - physiopathology Pesticides - toxicity Rats Rats, Wistar Wnt Signaling Pathway - drug effects Chlorpyrifos DNA methylation Inflammation Ovarian function Dimethoate Hormonal imbalance
ISSN:	0278-6915, 1873-6351, 1873-6351
Online Access:	Get full text
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