Pesticide-induced epigenetic suppression of WNT signaling and NF-κB-driven inflammation impairs ovarian function in rats

The study examined the impact of chlorpyrifos, dimethoate, and their co-exposure on ovarian structure and function in female Wistar rats. The study involved 24 rats, divided into four groups: control, chlorpyrifos (3 mg/kg), dimethoate (30 mg/kg), and combination. Histopathology revealed degenerated...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Food and chemical toxicology Jg. 205; S. 115706
Hauptverfasser: Jan, Jasmeena, Sheikh, Wajid Mohammad, Gul, Shazia, Mohidin, Rumaisa, Bhat, Owais Mohmad, Lone, Mohammad Nadeem, Shah, Showkat Ahmad, Dar, Abid Hamid, Zargar, Mohammad Afzal, Bashir, Showkeen Muzamil, Wani, Nissar Ahmad
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 01.11.2025
Schlagworte:
Animals
Chlorpyrifos
Chlorpyrifos - toxicity
Dimethoate
DNA methylation
DNA Methylation - drug effects
Epigenesis, Genetic - drug effects
Female
Hormonal imbalance
Inflammation
Inflammation - chemically induced
Inflammation - genetics
Inflammation - metabolism
NF-kappa B - genetics
NF-kappa B - metabolism
Ovarian function
Ovary - drug effects
Ovary - metabolism
Ovary - pathology
Ovary - physiopathology
Pesticides - toxicity
Rats
Rats, Wistar
Wnt Signaling Pathway - drug effects
Chlorpyrifos
DNA methylation
Inflammation
Ovarian function
Dimethoate
Hormonal imbalance
ISSN:0278-6915, 1873-6351, 1873-6351
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Abstract The study examined the impact of chlorpyrifos, dimethoate, and their co-exposure on ovarian structure and function in female Wistar rats. The study involved 24 rats, divided into four groups: control, chlorpyrifos (3 mg/kg), dimethoate (30 mg/kg), and combination. Histopathology revealed degenerated and atretic follicles, disorganized granulosa cells and cystic follicles in pesticide exposed rats. Hormonal analysis showed decrease in FSH, LH, PG, T and AMH and increase in ED levels. Gene expression studies revealed significant upregulation of ESR2 (∼2, ∼1.8, and ∼1.85 fold respectively) in chlorpyrifos, dimethoate and combination groups. In contrast, RSPO2, WNT7A, WNT3A and WNT5A were downregulated (reduced by ∼1.73–1.8, 1.7–2.6, 1.45–2.13 and 1.3–1.75 fold, respectively). The changes correlated with reduced β-catenin activation. DNA methylation analysis revealed an inverse correlation between methylation and gene expression, alongside upregulation of DNMT3A and DNMT3B (∼4.5, ∼2.1, ∼4.9; ∼3.75, ∼2.2, ∼3.8 fold in chlorpyrifos, dimethoate and combination groups respectively), suggesting methylation-mediated repression. Furthermore, enhanced expression of inflammation-related genes and cytokines, coupled with NF-κB activation, indicated significant inflammatory responses. Overall, the findings highlight gene specific DNA methylation and inflammatory disruptions in pesticide-exposed ovaries. However, the lack of ChIP assay limits confirmation of DNMT recruitment, which should be addressed in future studies. [Display omitted]
AbstractList The study examined the impact of chlorpyrifos, dimethoate, and their co-exposure on ovarian structure and function in female Wistar rats. The study involved 24 rats, divided into four groups: control, chlorpyrifos (3 mg/kg), dimethoate (30 mg/kg), and combination. Histopathology revealed degenerated and atretic follicles, disorganized granulosa cells and cystic follicles in pesticide exposed rats. Hormonal analysis showed decrease in FSH, LH, PG, T and AMH and increase in ED levels. Gene expression studies revealed significant upregulation of ESR2 (∼2, ∼1.8, and ∼1.85 fold respectively) in chlorpyrifos, dimethoate and combination groups. In contrast, RSPO2, WNT7A, WNT3A and WNT5A were downregulated (reduced by ∼1.73-1.8, 1.7-2.6, 1.45-2.13 and 1.3-1.75 fold, respectively). The changes correlated with reduced β-catenin activation. DNA methylation analysis revealed an inverse correlation between methylation and gene expression, alongside upregulation of DNMT3A and DNMT3B (∼4.5, ∼2.1, ∼4.9; ∼3.75, ∼2.2, ∼3.8 fold in chlorpyrifos, dimethoate and combination groups respectively), suggesting methylation-mediated repression. Furthermore, enhanced expression of inflammation-related genes and cytokines, coupled with NF-κB activation, indicated significant inflammatory responses. Overall, the findings highlight gene specific DNA methylation and inflammatory disruptions in pesticide-exposed ovaries. However, the lack of ChIP assay limits confirmation of DNMT recruitment, which should be addressed in future studies.
The study examined the impact of chlorpyrifos, dimethoate, and their co-exposure on ovarian structure and function in female Wistar rats. The study involved 24 rats, divided into four groups: control, chlorpyrifos (3 mg/kg), dimethoate (30 mg/kg), and combination. Histopathology revealed degenerated and atretic follicles, disorganized granulosa cells and cystic follicles in pesticide exposed rats. Hormonal analysis showed decrease in FSH, LH, PG, T and AMH and increase in ED levels. Gene expression studies revealed significant upregulation of ESR2 (∼2, ∼1.8, and ∼1.85 fold respectively) in chlorpyrifos, dimethoate and combination groups. In contrast, RSPO2, WNT7A, WNT3A and WNT5A were downregulated (reduced by ∼1.73–1.8, 1.7–2.6, 1.45–2.13 and 1.3–1.75 fold, respectively). The changes correlated with reduced β-catenin activation. DNA methylation analysis revealed an inverse correlation between methylation and gene expression, alongside upregulation of DNMT3A and DNMT3B (∼4.5, ∼2.1, ∼4.9; ∼3.75, ∼2.2, ∼3.8 fold in chlorpyrifos, dimethoate and combination groups respectively), suggesting methylation-mediated repression. Furthermore, enhanced expression of inflammation-related genes and cytokines, coupled with NF-κB activation, indicated significant inflammatory responses. Overall, the findings highlight gene specific DNA methylation and inflammatory disruptions in pesticide-exposed ovaries. However, the lack of ChIP assay limits confirmation of DNMT recruitment, which should be addressed in future studies. [Display omitted]
The study examined the impact of chlorpyrifos, dimethoate, and their co-exposure on ovarian structure and function in female Wistar rats. The study involved 24 rats, divided into four groups: control, chlorpyrifos (3 mg/kg), dimethoate (30 mg/kg), and combination. Histopathology revealed degenerated and atretic follicles, disorganized granulosa cells and cystic follicles in pesticide exposed rats. Hormonal analysis showed decrease in FSH, LH, PG, T and AMH and increase in ED levels. Gene expression studies revealed significant upregulation of ESR2 (∼2, ∼1.8, and ∼1.85 fold respectively) in chlorpyrifos, dimethoate and combination groups. In contrast, RSPO2, WNT7A, WNT3A and WNT5A were downregulated (reduced by ∼1.73-1.8, 1.7-2.6, 1.45-2.13 and 1.3-1.75-fold, respectively). The changes correlated with reduced β-catenin activation. DNA methylation analysis revealed an inverse correlation between methylation and gene expression, alongside upregulation of DNMT3A and DNMT3B (∼4.5, ∼2.1, ∼4.9; ∼3.75, ∼2.2, ∼3.8 fold in chlorpyrifos, dimethoate and combination groups respectively), suggesting methylation-mediated repression. Furthermore, enhanced expression of inflammation-related genes and cytokines, coupled with NF-κB activation, indicated significant inflammatory responses. Overall, the findings highlight gene specific DNA methylation and inflammatory disruptions in pesticide-exposed ovaries. However, the lack of ChIP assay limits confirmation of DNMT recruitment, which should be addressed in future studies.The study examined the impact of chlorpyrifos, dimethoate, and their co-exposure on ovarian structure and function in female Wistar rats. The study involved 24 rats, divided into four groups: control, chlorpyrifos (3 mg/kg), dimethoate (30 mg/kg), and combination. Histopathology revealed degenerated and atretic follicles, disorganized granulosa cells and cystic follicles in pesticide exposed rats. Hormonal analysis showed decrease in FSH, LH, PG, T and AMH and increase in ED levels. Gene expression studies revealed significant upregulation of ESR2 (∼2, ∼1.8, and ∼1.85 fold respectively) in chlorpyrifos, dimethoate and combination groups. In contrast, RSPO2, WNT7A, WNT3A and WNT5A were downregulated (reduced by ∼1.73-1.8, 1.7-2.6, 1.45-2.13 and 1.3-1.75-fold, respectively). The changes correlated with reduced β-catenin activation. DNA methylation analysis revealed an inverse correlation between methylation and gene expression, alongside upregulation of DNMT3A and DNMT3B (∼4.5, ∼2.1, ∼4.9; ∼3.75, ∼2.2, ∼3.8 fold in chlorpyrifos, dimethoate and combination groups respectively), suggesting methylation-mediated repression. Furthermore, enhanced expression of inflammation-related genes and cytokines, coupled with NF-κB activation, indicated significant inflammatory responses. Overall, the findings highlight gene specific DNA methylation and inflammatory disruptions in pesticide-exposed ovaries. However, the lack of ChIP assay limits confirmation of DNMT recruitment, which should be addressed in future studies.
ArticleNumber 115706
Author Wani, Nissar Ahmad
Mohidin, Rumaisa
Bhat, Owais Mohmad
Bashir, Showkeen Muzamil
Sheikh, Wajid Mohammad
Shah, Showkat Ahmad
Gul, Shazia
Lone, Mohammad Nadeem
Zargar, Mohammad Afzal
Jan, Jasmeena
Dar, Abid Hamid
Author_xml – sequence: 1
  givenname: Jasmeena
  surname: Jan
  fullname: Jan, Jasmeena
  organization: Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, India
– sequence: 2
  givenname: Wajid Mohammad
  surname: Sheikh
  fullname: Sheikh, Wajid Mohammad
  organization: Biochemistry & Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, Srinagar, 190006, Jammu & Kashmir, India
– sequence: 3
  givenname: Shazia
  surname: Gul
  fullname: Gul, Shazia
  organization: Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, India
– sequence: 4
  givenname: Rumaisa
  surname: Mohidin
  fullname: Mohidin, Rumaisa
  organization: Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, India
– sequence: 5
  givenname: Owais Mohmad
  surname: Bhat
  fullname: Bhat, Owais Mohmad
  organization: Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, India
– sequence: 6
  givenname: Mohammad Nadeem
  surname: Lone
  fullname: Lone, Mohammad Nadeem
  organization: Department of Chemistry, School of Physical & Chemical Sciences, Central University of Kashmir, Ganderbal, India
– sequence: 7
  givenname: Showkat Ahmad
  surname: Shah
  fullname: Shah, Showkat Ahmad
  organization: Division of Veterinary Pathology, Faculty of Veterinary Sciences & Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, Srinagar, Jammu & Kashmir, India
– sequence: 8
  givenname: Abid Hamid
  surname: Dar
  fullname: Dar, Abid Hamid
  organization: Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, India
– sequence: 9
  givenname: Mohammad Afzal
  surname: Zargar
  fullname: Zargar, Mohammad Afzal
  email: zargarma@gmail.com, zargarma@cukashmir.ac.in
  organization: Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, India
– sequence: 10
  givenname: Showkeen Muzamil
  surname: Bashir
  fullname: Bashir, Showkeen Muzamil
  email: showkeen.muzamil82@gmail.com, showkeen@skaustkashmir.ac.in
  organization: Biochemistry & Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, Srinagar, 190006, Jammu & Kashmir, India
– sequence: 11
  givenname: Nissar Ahmad
  orcidid: 0000-0002-9248-9039
  surname: Wani
  fullname: Wani, Nissar Ahmad
  email: waninh@yahoo.co.in, waninh@cukashmir.ac.in
  organization: Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, India
BackLink https://www.ncbi.nlm.nih.gov/pubmed/40825503$$D View this record in MEDLINE/PubMed
BookMark eNp9kc1u1TAQhS1URG8LD8AGeckmt_6JnUSsoKI_UlVYFLG0HHt8NVeJE-zkSn21PgTP1FylsOxqpJnvjHTOOSMncYhAyEfOtpxxfbHfBjdtBRNqy7mqmH5DNryuZKGl4idkw0RVF7rh6pSc5bxnjFW80u_IaclqoRSTG_L4E_KEDj0UGP3swFMYcQcRli3N8zgmyBmHSIdAf98_0Iy7aDuMO2qjp_dXxd-nb4VPeIBIMYbO9r2djjz2o8WU6XCwCW2kYY5uPUSa7JTfk7fBdhk-vMxz8uvq-8PlTXH34_r28utd4WTJpqJSUkvHWlnbUAdtQ1syH1rrSwilZWXrwIkagqy9sAFcoxvVNrZWFWgZlJbn5PP6d0zDn3lxa3rMDrrORhjmbKQoWcOFYHJBP72gc9uDN2PC3qZH8y-uBeAr4NKQc4LwH-HMHCsxe7NUYo6VmLWSRfNl1cBi8oCQTHYIcUkaEyysH_AV9TNmf5Ze
Cites_doi 10.1016/j.fct.2013.10.006
10.1016/j.steroids.2014.06.012
10.1515/JBCPP.2004.15.3-4.211
10.1093/molehr/gan082
10.1126/science.1108190
10.1371/journal.pone.0013100
10.1590/1413-81232018246.13142017
10.1007/s11356-020-09203-3
10.1016/j.pestbp.2012.06.011
10.1093/humupd/dmv016
10.1093/bioinformatics/18.11.1427
10.1158/1541-7786.MCR-11-0177
10.1186/1477-7827-4-30
10.1007/s11103-012-9885-2
10.1210/er.2009-0002
10.1371/journal.pone.0055387
10.1371/journal.pone.0046249
10.3390/ijerph18031112
10.1016/j.pestbp.2019.05.018
10.1016/j.fertnstert.2013.08.043
10.1111/jnc.14148
10.1007/s00414-019-02119-9
10.1177/1010428317694573
10.1038/s41418-020-0547-7
10.1073/pnas.1314239110
10.1034/j.1600-0412.2003.00108.x
10.1016/j.clinbiochem.2018.03.012
10.1002/tox.20360
10.1016/S0140-6736(24)00550-6
10.1016/j.cbi.2016.04.008
10.1016/j.reprotox.2012.08.010
10.1038/s41598-020-76638-6
10.1210/en.2009-0499
10.1016/S0950-3552(05)80464-X
10.2478/intox-2018-0009
10.1016/j.ydbio.2011.01.004
10.1016/S0140-6736(20)32667-2
10.1289/ehp.1204934
10.1530/JOE-17-0023
10.1038/nature02633
10.1038/nrendo.2010.217
10.1016/j.fct.2011.09.009
10.1186/1477-7827-11-66
10.1371/journal.pone.0022233
10.1016/j.fertnstert.2014.02.040
10.1038/nature12805
10.1007/s11356-023-27743-2
10.1016/j.tibs.2016.09.002
10.1016/j.envres.2005.03.012
10.1111/nyas.12458
10.1016/j.mce.2017.05.028
10.1016/j.fct.2021.112515
10.1016/j.reprotox.2024.108735
10.1093/toxsci/kft079
10.1007/s11356-022-23509-4
10.1016/S0955-2863(01)00160-7
10.1289/EHP8928
10.1093/humupd/dmn042
10.1016/j.etp.2015.01.005
10.1158/1535-7163.MCT-19-0135
10.18632/oncotarget.25543
10.1186/1477-7827-3-28
10.1542/peds.113.S3.1030
10.1210/me.2008-0213
10.1016/j.pestbp.2009.11.008
10.3389/fphar.2022.958443
10.1515/biol-2021-0069
10.1016/S2213-8587(19)30345-6
10.1016/j.pestbp.2014.09.004
10.1095/biolreprod66.1.77
ContentType Journal Article
Copyright 2025 Elsevier Ltd
Copyright © 2025 Elsevier Ltd. All rights reserved.
Copyright © 2025. Published by Elsevier Ltd.
Copyright_xml – notice: 2025 Elsevier Ltd
– notice: Copyright © 2025 Elsevier Ltd. All rights reserved.
– notice: Copyright © 2025. Published by Elsevier Ltd.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1016/j.fct.2025.115706
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Economics
Chemistry
Public Health
EISSN 1873-6351
ExternalDocumentID 40825503
10_1016_j_fct_2025_115706
S0278691525004740
Genre Journal Article
GroupedDBID ---
--K
--M
.55
.GJ
.~1
0R~
1B1
1RT
1~.
1~5
29H
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
9JM
AABNK
AAEDT
AAEDW
AAHBH
AAIKJ
AAKOC
AALCJ
AALRI
AAOAW
AAQFI
AAQXK
AATLK
AATTM
AAXKI
AAXUO
AAYWO
ABFNM
ABFRF
ABFYP
ABGRD
ABJNI
ABLST
ABMAC
ABWVN
ABXDB
ABZDS
ACDAQ
ACGFO
ACGFS
ACIUM
ACLOT
ACRLP
ACRPL
ACVFH
ADBBV
ADCNI
ADEZE
ADMUD
ADNMO
ADQTV
AEBSH
AEFWE
AEIPS
AEKER
AENEX
AEQOU
AEUPX
AFJKZ
AFPUW
AFTJW
AFXIZ
AGHFR
AGQPQ
AGUBO
AGYEJ
AHEUO
AHHHB
AI.
AIEXJ
AIGII
AIIUN
AIKHN
AITUG
AKBMS
AKIFW
AKRWK
AKYEP
ALCLG
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ANKPU
APXCP
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLECG
BLXMC
CS3
DU5
EBS
EFJIC
EFKBS
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HLV
HMT
HVGLF
HZ~
IHE
J1W
K-O
KCYFY
KOM
LW9
M34
M41
MO0
N9A
O-L
O9-
OAUVE
OGGZJ
OZT
P-8
P-9
P2P
PC.
Q38
R2-
ROL
RPZ
SAB
SCC
SDF
SDG
SDP
SES
SEW
SPCBC
SPT
SSA
SSJ
SSP
SSZ
T5K
VH1
WUQ
X7M
ZXP
~G-
~HD
~KM
9DU
AAYXX
CITATION
AGCQF
CGR
CUY
CVF
ECM
EIF
NPM
7X8
ID FETCH-LOGICAL-c340t-75363c0b38af8f6afb40dfbad4ef4a04bcec28ef38d2afec9695b9a857e63f563
ISICitedReferencesCount 0
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001562812900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0278-6915
1873-6351
IngestDate Thu Oct 02 21:54:02 EDT 2025
Thu Sep 18 02:03:25 EDT 2025
Sat Nov 29 06:52:10 EST 2025
Sat Oct 11 16:50:44 EDT 2025
IsPeerReviewed true
IsScholarly true
Keywords Chlorpyrifos
DNA methylation
Inflammation
Ovarian function
Dimethoate
Hormonal imbalance
Language English
License Copyright © 2025 Elsevier Ltd. All rights reserved.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c340t-75363c0b38af8f6afb40dfbad4ef4a04bcec28ef38d2afec9695b9a857e63f563
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-9248-9039
PMID 40825503
PQID 3240912203
PQPubID 23479
ParticipantIDs proquest_miscellaneous_3240912203
pubmed_primary_40825503
crossref_primary_10_1016_j_fct_2025_115706
elsevier_sciencedirect_doi_10_1016_j_fct_2025_115706
PublicationCentury 2000
PublicationDate 2025-11-01
PublicationDateYYYYMMDD 2025-11-01
PublicationDate_xml – month: 11
  year: 2025
  text: 2025-11-01
  day: 01
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Food and chemical toxicology
PublicationTitleAlternate Food Chem Toxicol
PublicationYear 2025
Publisher Elsevier Ltd
Publisher_xml – name: Elsevier Ltd
References Tudi, Daniel Ruan, Wang, Lyu, Sadler, Connell, Chu, Phung (bib72) 2021; 18
John, Kale, Rathore, Bhatnagar (bib27) 2001; 12
Kanbur, Liman, Eraslan, Altinordulu (bib28) 2008; 23
Milesi, Varayoud, Ramos, Luque (bib44) 2017; 454
Cheng, Weihua, Makinen, Makela, Saji, Warner, Gustafsson, Hovatta (bib10) 2002; 66
Soares, Rosado, Barroso, Vieira, Gallardo (bib66) 2019; 133
Kotil, Yon (bib32) 2015; 67
Diamanti-Kandarakis, Bourguignon, Giudice, Hauser, Prins, Soto, Zoeller, Gore (bib13) 2009; 30
Kumar, Mohapatra (bib33) 2024; 29
Fertility, Forecasting (bib18) 2024; 403
Paterni, Granchi, Katzenellenbogen, Minutolo (bib53) 2014; 90
Thong, Codner, Laven, Teede (bib71) 2020; 8
He, Hara, Nunez (bib22) 2016; 41
Ng, Leung, Shin, Wong, Ma, Jin, Chu, Kwong (bib47) 2011; 6
Manikkam, Tracey, Guerrero-Bosagna, Skinner (bib42) 2013; 8
Nishi, Hundal (bib48) 2013; 62
Jan, Bashir, Sheikh, Bhat, Rafeeqi, Shah, Dar, Zargar, Wani (bib25) 2024; 130
Yoshioka, Matsutani, Hara, Hirono, Hiwasa, Takiguchi, Iwadate (bib77) 2018; 9
Okoroiwu, Iwara (bib50) 2018; 11
Haney (bib21) 1993; 7
Basal, Ahmed, Mahmoud, Omar (bib5) 2020; 10
Duzguner, Erdogan (bib15) 2010; 97
Ramos Nieto, Lasagna, Cao, Alvarez, Santamaria, Rodriguez Girault, Bourguignon, DI Giorgio, Ventura, Mardirosian, Rodriguez, Lux-Llantos, Cocca, Nunez (bib55) 2021; 156
El-Din, Ghareeb, El-Garawani, El-Rahman (bib17) 2023; 30
Sultana, Karunamoorthy, Tumane, Venugopal, Ambikabathy, Beerappa (bib68) 2024
Kenigsberg, Bentov, Chalifa-Caspi, Potashnik, Ofir, Birk (bib31) 2009; 15
Goodarzi, Dumesic, Chazenbalk, Azziz (bib19) 2011; 7
Li, Fang, Pang, Zhang, Ren (bib34) 2019; 159
Sorelle, Ferdinand, Vemo Bertin Narcisse (bib67) 2019; 2
Ruiz-Arias, Medina-Diaz, Bernal-Hernandez, Agraz-Cibrian, Gonzalez-Arias, Barron-Vivanco, Herrera-Moreno, Verdin-Betancourt, Zambrano-Zaragoza, Rojas-Garcia (bib58) 2023; 30
Guerrero-Bosagna, Settles, Lucker, Skinner (bib20) 2010; 5
Yoshioka, King, Ran, Okuda, Maclean, Mcasey, Sugino, Brard, Watabe, Hayashi (bib78) 2012; 10
Xie, Xiao, Chen, Xu, Zhang (bib75) 2012
Li, Dahiya (bib35) 2002; 18
Mu, Hu, Gao, Pang (bib46) 2021; 16
Duzguner, Erdogan (bib16) 2012; 104
Manikkam, Tracey, Guerrero-Bosagna, Skinner (bib41) 2012; 34
Weiss, Amler, Amler (bib74) 2004; 113
Ouyang, Bernstein, Lummus, Ying, Boulet, Cartier, Gautrin, Ho (bib52) 2013; 133
Mehraj, Wani, Hamid, Alkhanani, Almilaibary, Mir (bib43) 2022; 13
Bretveld, Thomas, Scheepers, Zielhuis, Roeleveld (bib8) 2006; 4
Thapar, Sandhir, Kiran (bib70) 2002; 40
Agarwal, Baskaran, Parekh, Cho, Henkel, Vij, Arafa, Panner Selvam, Shah (bib1) 2021; 397
Kapoor, Srivastava, Srivastava (bib30) 2011; 49
Mokhtar, Abdel-Latif, Elmazoudy, Abdelwahab, Saad (bib45) 2013; 3
Smith, Velez, Dayan (bib65) 2021; 37
Roubroeks, Smith, VAN Den Hove, Lunnon (bib57) 2017; 143
Rattan, Zhou, Chiang, Mahalingam, Brehm, Flaws (bib56) 2017; 233
Vander Borght, Wyns (bib73) 2018; 62
Anway, Cupp, Uzumcu, Skinner (bib3) 2005; 308
Yamaguchi, Shen, Liu, Sendler, Zhang (bib76) 2013; 504
Hoang, Qi, Paul, Lee, White, Richards, Auerbach, Long, Shrestha, Wang (bib23) 2021; 129
Inhorn, Patrizio (bib24) 2015; 21
Sánchez-Rodríguez, Mendoza-Rodríguez, Romero-Arauz, Morán, Cerbón (bib60) 2010; 3
Barr, Allen, Olsson, Bravo, Caltabiano, Montesano, Nguyen, Udunka, Walden, Walker, Weerasekera, Whitehead, Schober, Needham (bib4) 2005; 99
Ombelet, Cooke, Dyer, Serour, Devroey (bib51) 2008; 14
Sharma, Biedenharn, Fedor, Agarwal (bib63) 2013; 11
Agarwal, Gupta, Sharma (bib2) 2005; 3
Cestonaro, Garcia, Nascimento, Gauer, Sauer, Goethel, Peruzzi, Nardi, Fao, Piton, Braga, Rocha, Saint'Pierre, Gioda, Arbo (bib9) 2020; 27
De Cian, Gregoire, LE Rolle, Lachambre, Mondin, Bell, Guigon, Chassot, Chaboissier (bib11) 2020; 27
Duran, Demirkoprulu, Guvenal, Arici, Tuncer, Cetin, Timuroglu (bib14) 2003; 82
Singh, Sandhir, Kiran (bib64) 2006; 44
Deroo, Rodriguez, Couse, Hamilton, Collins, Grissom, Korach (bib12) 2009; 23
Kaneda, Okano, Hata, Sado, Tsujimoto, Li, Sasaki (bib29) 2004; 429
Liu, Pan, Hsieh, Ng, Sun, Wang, Kasibhatla, Schuller, Li, Cheng, Li, Tompkins, Pferdekamper, Steffy, Cheng, Kowal, Phung, Guo, Wang, Graham, Flynn, Brenner, Li, Villarroel, Schultz, Wu, Mcnamara, Sellers, Petruzzelli, Boral, Seidel, Mclaughlin, Che, Carey, Vanasse, Harris (bib37) 2013; 110
Mahadevaswami, Kaliwal (bib39) 2004; 15
Manikkam, Tracey, Guerrero-Bosagna, Skinner (bib40) 2012; 7
Bhat, kabekkodu, varghese, chakrabarty, mallya, rotti, pandey, kushtagi, satyamoorthy (bib6) 2017; 39
Lin, Elkholy, Wani, Li, Hu, Barajas, Yu, Zhang, Jacob, Khan, Bai, Noonan, Ghoshal (bib36) 2020; 19
Sutterwala, Haasken, Cassel (bib69) 2014; 1319
No (bib49) 2013; 100
Sharma, Sangha, Khera (bib62) 2015; 117
Sakr, Mahran, Abdel-Maksoud (bib59) 2011; 46–54
Sanchez, Vigano, Quattrone, Pagliardini, Papaleo, Candiani, Panina-Bordignon (bib61) 2014; 101
Zama, Uzumcu (bib79) 2009; 150
Jin, Turcotte, Crocker, Han, Yoon (bib26) 2011; 352
Piccoli, Cremonese, Koifman, Koifman, Freire (bib54) 2019; 24
Lozano-Paniagua, Gómez-Martín, Gil, Parrón, Alarcón, Requena, Lacasaña, Hernández (bib38) 2016; 259
Boekelheide, Blumberg, Chapin, Cote, Graziano, Janesick, Lane, Lillycrop, Myatt, States, Thayer, Waalkes, Rogers (bib7) 2012; 120
Cheng (10.1016/j.fct.2025.115706_bib10) 2002; 66
Kapoor (10.1016/j.fct.2025.115706_bib30) 2011; 49
No (10.1016/j.fct.2025.115706_bib49) 2013; 100
Manikkam (10.1016/j.fct.2025.115706_bib41) 2012; 34
He (10.1016/j.fct.2025.115706_bib22) 2016; 41
Li (10.1016/j.fct.2025.115706_bib35) 2002; 18
Boekelheide (10.1016/j.fct.2025.115706_bib7) 2012; 120
Duran (10.1016/j.fct.2025.115706_bib14) 2003; 82
Inhorn (10.1016/j.fct.2025.115706_bib24) 2015; 21
Jan (10.1016/j.fct.2025.115706_bib25) 2024; 130
Jin (10.1016/j.fct.2025.115706_bib26) 2011; 352
Manikkam (10.1016/j.fct.2025.115706_bib42) 2013; 8
Yoshioka (10.1016/j.fct.2025.115706_bib77) 2018; 9
Milesi (10.1016/j.fct.2025.115706_bib44) 2017; 454
Bhat (10.1016/j.fct.2025.115706_bib6) 2017; 39
Duzguner (10.1016/j.fct.2025.115706_bib15) 2010; 97
Kotil (10.1016/j.fct.2025.115706_bib32) 2015; 67
Okoroiwu (10.1016/j.fct.2025.115706_bib50) 2018; 11
John (10.1016/j.fct.2025.115706_bib27) 2001; 12
Cestonaro (10.1016/j.fct.2025.115706_bib9) 2020; 27
Mehraj (10.1016/j.fct.2025.115706_bib43) 2022; 13
Yoshioka (10.1016/j.fct.2025.115706_bib78) 2012; 10
Manikkam (10.1016/j.fct.2025.115706_bib40) 2012; 7
Singh (10.1016/j.fct.2025.115706_bib64) 2006; 44
Lin (10.1016/j.fct.2025.115706_bib36) 2020; 19
Kanbur (10.1016/j.fct.2025.115706_bib28) 2008; 23
Thong (10.1016/j.fct.2025.115706_bib71) 2020; 8
Haney (10.1016/j.fct.2025.115706_bib21) 1993; 7
Sutterwala (10.1016/j.fct.2025.115706_bib69) 2014; 1319
Ouyang (10.1016/j.fct.2025.115706_bib52) 2013; 133
Fertility (10.1016/j.fct.2025.115706_bib18) 2024; 403
Hoang (10.1016/j.fct.2025.115706_bib23) 2021; 129
Deroo (10.1016/j.fct.2025.115706_bib12) 2009; 23
Diamanti-Kandarakis (10.1016/j.fct.2025.115706_bib13) 2009; 30
Goodarzi (10.1016/j.fct.2025.115706_bib19) 2011; 7
Guerrero-Bosagna (10.1016/j.fct.2025.115706_bib20) 2010; 5
Soares (10.1016/j.fct.2025.115706_bib66) 2019; 133
Tudi (10.1016/j.fct.2025.115706_bib72) 2021; 18
Zama (10.1016/j.fct.2025.115706_bib79) 2009; 150
Yamaguchi (10.1016/j.fct.2025.115706_bib76) 2013; 504
Basal (10.1016/j.fct.2025.115706_bib5) 2020; 10
Anway (10.1016/j.fct.2025.115706_bib3) 2005; 308
Nishi (10.1016/j.fct.2025.115706_bib48) 2013; 62
Liu (10.1016/j.fct.2025.115706_bib37) 2013; 110
Piccoli (10.1016/j.fct.2025.115706_bib54) 2019; 24
Agarwal (10.1016/j.fct.2025.115706_bib2) 2005; 3
Sorelle (10.1016/j.fct.2025.115706_bib67) 2019; 2
Kumar (10.1016/j.fct.2025.115706_bib33) 2024; 29
Mahadevaswami (10.1016/j.fct.2025.115706_bib39) 2004; 15
Xie (10.1016/j.fct.2025.115706_bib75) 2012
Weiss (10.1016/j.fct.2025.115706_bib74) 2004; 113
El-Din (10.1016/j.fct.2025.115706_bib17) 2023; 30
Thapar (10.1016/j.fct.2025.115706_bib70) 2002; 40
Ramos Nieto (10.1016/j.fct.2025.115706_bib55) 2021; 156
Smith (10.1016/j.fct.2025.115706_bib65) 2021; 37
Ombelet (10.1016/j.fct.2025.115706_bib51) 2008; 14
Lozano-Paniagua (10.1016/j.fct.2025.115706_bib38) 2016; 259
Kenigsberg (10.1016/j.fct.2025.115706_bib31) 2009; 15
Paterni (10.1016/j.fct.2025.115706_bib53) 2014; 90
Sánchez-Rodríguez (10.1016/j.fct.2025.115706_bib60) 2010; 3
Agarwal (10.1016/j.fct.2025.115706_bib1) 2021; 397
Ng (10.1016/j.fct.2025.115706_bib47) 2011; 6
Sharma (10.1016/j.fct.2025.115706_bib63) 2013; 11
Barr (10.1016/j.fct.2025.115706_bib4) 2005; 99
Mu (10.1016/j.fct.2025.115706_bib46) 2021; 16
Sultana (10.1016/j.fct.2025.115706_bib68) 2024
Ruiz-Arias (10.1016/j.fct.2025.115706_bib58) 2023; 30
De Cian (10.1016/j.fct.2025.115706_bib11) 2020; 27
Sanchez (10.1016/j.fct.2025.115706_bib61) 2014; 101
Mokhtar (10.1016/j.fct.2025.115706_bib45) 2013; 3
Vander Borght (10.1016/j.fct.2025.115706_bib73) 2018; 62
Duzguner (10.1016/j.fct.2025.115706_bib16) 2012; 104
Sharma (10.1016/j.fct.2025.115706_bib62) 2015; 117
Roubroeks (10.1016/j.fct.2025.115706_bib57) 2017; 143
Kaneda (10.1016/j.fct.2025.115706_bib29) 2004; 429
Sakr (10.1016/j.fct.2025.115706_bib59) 2011; 46–54
Li (10.1016/j.fct.2025.115706_bib34) 2019; 159
Rattan (10.1016/j.fct.2025.115706_bib56) 2017; 233
Bretveld (10.1016/j.fct.2025.115706_bib8) 2006; 4
References_xml – year: 2012
  ident: bib75
  article-title: miRDeepFinder: a miRNA analysis tool for deep sequencing of plant small RNAs
  publication-title: Plant Mol. Biol.
– volume: 454
  start-page: 1
  year: 2017
  end-page: 11
  ident: bib44
  article-title: Uterine ERα epigenetic modifications are induced by the endocrine disruptor endosulfan in female rats with impaired fertility
  publication-title: Mol. Cell. Endocrinol.
– volume: 30
  start-page: 77917
  year: 2023
  end-page: 77930
  ident: bib17
  article-title: Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats
  publication-title: Environ. Sci. Pollut. Res. Int.
– volume: 46–54
  year: 2011
  ident: bib59
  article-title: Suppressive effect of Ginkgo biloba extract (EGb 761) on topsin induced ovarian toxicity and oxidative stress in albino rats
  publication-title: J. Appl. Pharmaceut. Sci.
– volume: 41
  start-page: 1012
  year: 2016
  end-page: 1021
  ident: bib22
  article-title: Mechanism and regulation of NLRP3 inflammasome activation
  publication-title: Trends Biochem. Sci.
– volume: 62
  start-page: 2
  year: 2018
  end-page: 10
  ident: bib73
  article-title: Fertility and infertility: definition and epidemiology
  publication-title: Clin. Biochem.
– volume: 133
  start-page: 218
  year: 2013
  end-page: 224
  ident: bib52
  article-title: Interferon-gamma promoter is hypermethylated in blood DNA from workers with confirmed diisocyanate asthma
  publication-title: Toxicol. Sci.
– volume: 24
  start-page: 2325
  year: 2019
  end-page: 2340
  ident: bib54
  article-title: Occupational exposure to pesticides and hematological alterations: a survey of farm residents in the south of Brazil
  publication-title: Ciência Saúde Coletiva
– volume: 8
  year: 2013
  ident: bib42
  article-title: Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations
  publication-title: PLoS One
– volume: 104
  start-page: 58
  year: 2012
  end-page: 64
  ident: bib16
  article-title: Chronic exposure to imidacloprid induces inflammation and oxidative stress in the liver & central nervous system of rats
  publication-title: Pestic. Biochem. Physiol.
– volume: 44
  start-page: 580
  year: 2006
  end-page: 583
  ident: bib64
  article-title: Erythrocyte antioxidant enzymes in toxicological evaluation of commonly used organophosphate pesticides
  publication-title: Indian J. Exp. Biol.
– volume: 29
  start-page: 126
  year: 2024
  ident: bib33
  article-title: Epigenetic modifications in genome help remembering the stress tolerance strategy adopted by the plant
– volume: 11
  start-page: 66
  year: 2013
  ident: bib63
  article-title: Lifestyle factors and reproductive health: taking control of your fertility
  publication-title: Reprod. Biol. Endocrinol.
– volume: 100
  start-page: 931
  year: 2013
  end-page: 934
  ident: bib49
  article-title: Exposure to toxic environmental agents
  publication-title: Fertil. Steril.
– volume: 117
  start-page: 9
  year: 2015
  end-page: 18
  ident: bib62
  article-title: Triazophos-induced oxidative stress and histomorphological changes in ovary of female wistar rats
  publication-title: Pestic. Biochem. Physiol.
– volume: 82
  start-page: 220
  year: 2003
  end-page: 224
  ident: bib14
  article-title: Histopathological changes in ovary and endometrium after tubal ligation: a rat model
  publication-title: Acta Obstet. Gynecol. Scand.
– volume: 129
  year: 2021
  ident: bib23
  article-title: Epigenome-wide DNA methylation and pesticide use in the agricultural lung health study
  publication-title: Environ. Health Perspect.
– volume: 233
  start-page: R109
  year: 2017
  end-page: R129
  ident: bib56
  article-title: Exposure to endocrine disruptors during adulthood: consequences for female fertility
  publication-title: J. Endocrinol.
– volume: 19
  start-page: 384
  year: 2020
  end-page: 396
  ident: bib36
  article-title: Ibrutinib potentiates antihepatocarcinogenic efficacy of sorafenib by targeting EGFR in tumor cells and BTK in immune cells in the stroma
  publication-title: Mol. Cancer Therapeut.
– volume: 15
  start-page: 89
  year: 2009
  end-page: 103
  ident: bib31
  article-title: Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients
  publication-title: Mol. Hum. Reprod.
– volume: 7
  start-page: 219
  year: 2011
  end-page: 231
  ident: bib19
  article-title: Polycystic ovary syndrome: etiology, pathogenesis and diagnosis
  publication-title: Nat. Rev. Endocrinol.
– volume: 40
  start-page: 963
  year: 2002
  end-page: 966
  ident: bib70
  article-title: Acephate induced oxidative damage in erythrocytes
  publication-title: Indian J. Exp. Biol.
– volume: 5
  year: 2010
  ident: bib20
  article-title: Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome
  publication-title: PLoS One
– volume: 4
  start-page: 30
  year: 2006
  ident: bib8
  article-title: Pesticide exposure: the hormonal function of the female reproductive system disrupted?
  publication-title: Reprod. Biol. Endocrinol.
– volume: 27
  start-page: 29291
  year: 2020
  end-page: 29302
  ident: bib9
  article-title: Biochemical, hematological and immunological parameters and relationship with occupational exposure to pesticides and metals
  publication-title: Environ. Sci. Pollut. Res. Int.
– volume: 37
  start-page: 1959
  year: 2021
  end-page: 1968
  ident: bib65
  article-title: Infertility, infertility treatment, and cardiovascular disease: an overview
  publication-title: Can. J. Cardiol.
– volume: 120
  start-page: 1353
  year: 2012
  end-page: 1361
  ident: bib7
  article-title: Predicting later-life outcomes of early-life exposures
  publication-title: Environ. Health Perspect.
– volume: 18
  start-page: 1427
  year: 2002
  end-page: 1431
  ident: bib35
  article-title: MethPrimer: designing primers for methylation PCRs
  publication-title: Bioinformatics
– volume: 6
  year: 2011
  ident: bib47
  article-title: Quantitative analysis and diagnostic significance of methylated SLC19A3 DNA in the plasma of breast and gastric cancer patients
  publication-title: PLoS One
– volume: 49
  start-page: 3086
  year: 2011
  end-page: 3089
  ident: bib30
  article-title: Toxicological impact of technical imidacloprid on ovarian morphology, hormones and antioxidant enzymes in female rats
  publication-title: Food Chem. Toxicol.
– volume: 1319
  start-page: 82
  year: 2014
  end-page: 95
  ident: bib69
  article-title: Mechanism of NLRP3 inflammasome activation
  publication-title: Ann. N. Y. Acad. Sci.
– volume: 8
  start-page: 134
  year: 2020
  end-page: 149
  ident: bib71
  article-title: Diabetes: a metabolic and reproductive disorder in women
  publication-title: Lancet Diabetes Endocrinol.
– year: 2024
  ident: bib68
  article-title: Occupational Exposures to Pesticide Mixtures and Its Epigenomic Effects Among Agriculture Farmers
– volume: 18
  year: 2021
  ident: bib72
  article-title: Agriculture development, pesticide application and its impact on the environment
  publication-title: Int. J. Environ. Res. Publ. Health
– volume: 504
  start-page: 460
  year: 2013
  end-page: 464
  ident: bib76
  article-title: Role of Tet1 in erasure of genomic imprinting
  publication-title: Nature
– volume: 403
  start-page: 2057
  year: 2024
  end-page: 2099
  ident: bib18
  article-title: Global fertility in 204 countries and territories, 1950-2021, with forecasts to 2100: a comprehensive demographic analysis for the global burden of disease study 2021
  publication-title: Lancet
– volume: 97
  start-page: 13
  year: 2010
  end-page: 18
  ident: bib15
  article-title: Acute oxidant and inflammatory effects of imidacloprid on the Mammalian central nervous system and liver in rats
  publication-title: Pestic. Biochem. Physiol.
– volume: 130
  year: 2024
  ident: bib25
  article-title: Chlorpyrifos and dimethoate exposure impairs female fertility by deregulating WNT signaling pathway & uterine receptivity
  publication-title: Reprod. Toxicol.
– volume: 159
  start-page: 68
  year: 2019
  end-page: 79
  ident: bib34
  article-title: Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats
  publication-title: Pestic. Biochem. Physiol.
– volume: 397
  start-page: 319
  year: 2021
  end-page: 333
  ident: bib1
  article-title: Male infertility
  publication-title: Lancet
– volume: 308
  start-page: 1466
  year: 2005
  end-page: 1469
  ident: bib3
  article-title: Epigenetic transgenerational actions of endocrine disruptors and Male fertility
  publication-title: Science
– volume: 66
  start-page: 77
  year: 2002
  end-page: 84
  ident: bib10
  article-title: A role for the androgen receptor in follicular atresia of estrogen receptor beta knockout mouse ovary
  publication-title: Biol. Reprod.
– volume: 10
  year: 2020
  ident: bib5
  article-title: Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses
  publication-title: Sci. Rep.
– volume: 7
  start-page: 791
  year: 1993
  end-page: 812
  ident: bib21
  article-title: Endometriosis-associated infertility
  publication-title: Baillieres Clin Obstet Gynaecol
– volume: 67
  start-page: 279
  year: 2015
  end-page: 285
  ident: bib32
  article-title: The effects of permethrin on rat ovarian tissue morphology
  publication-title: Exp. Toxicol. Pathol.
– volume: 30
  start-page: 293
  year: 2009
  end-page: 342
  ident: bib13
  article-title: Endocrine-disrupting chemicals: an endocrine society scientific statement
  publication-title: Endocr. Rev.
– volume: 110
  start-page: 20224
  year: 2013
  end-page: 20229
  ident: bib37
  article-title: Targeting Wnt-driven cancer through the inhibition of porcupine by LGK974
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 3
  start-page: 109
  year: 2013
  end-page: 119
  ident: bib45
  article-title: Effect of methomyl on fertility, embryotoxicity and physiological parameters in female rats
  publication-title: J. Appl. Pharmaceut. Sci.
– volume: 16
  start-page: 703
  year: 2021
  end-page: 710
  ident: bib46
  article-title: Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning
  publication-title: Open Life Sci.
– volume: 2
  start-page: 58
  year: 2019
  end-page: 73
  ident: bib67
  article-title: Medicinal plants and female reproduction disorders due to oxidative stress
  publication-title: Archives of Veterinary Science and Medicine
– volume: 39
  year: 2017
  ident: bib6
  article-title: aberrant gene-specific dna methylation signature analysis in cervical cancer
  publication-title: tumour biol
– volume: 21
  start-page: 411
  year: 2015
  end-page: 426
  ident: bib24
  article-title: Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century
  publication-title: Hum. Reprod. Update
– volume: 156
  year: 2021
  ident: bib55
  article-title: Chronic exposure to low concentrations of chlorpyrifos affects normal cyclicity and histology of the uterus in female rats
  publication-title: Food Chem. Toxicol.
– volume: 13
  year: 2022
  ident: bib43
  article-title: Adapalene inhibits the growth of triple-negative breast cancer cells by S-phase arrest and potentiates the antitumor efficacy of GDC-0941
  publication-title: Front. Pharmacol.
– volume: 143
  start-page: 158
  year: 2017
  end-page: 170
  ident: bib57
  article-title: Epigenetics and DNA methylomic profiling in alzheimer's disease and other neurodegenerative diseases
  publication-title: J. Neurochem.
– volume: 62
  start-page: 732
  year: 2013
  end-page: 738
  ident: bib48
  article-title: Chlorpyrifos induced toxicity in reproductive organs of female wistar rats
  publication-title: Food Chem. Toxicol.
– volume: 150
  start-page: 4681
  year: 2009
  end-page: 4691
  ident: bib79
  article-title: Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes
  publication-title: Endocrinology
– volume: 352
  start-page: 1
  year: 2011
  end-page: 13
  ident: bib26
  article-title: The canonical wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction
  publication-title: Dev. Biol.
– volume: 90
  start-page: 13
  year: 2014
  end-page: 29
  ident: bib53
  article-title: Estrogen receptors alpha (ERalpha) and beta (ERbeta): subtype-selective ligands and clinical potential
  publication-title: Steroids
– volume: 3
  start-page: 28
  year: 2005
  ident: bib2
  article-title: Role of oxidative stress in female reproduction
  publication-title: Reprod. Biol. Endocrinol.
– volume: 99
  start-page: 314
  year: 2005
  end-page: 326
  ident: bib4
  article-title: Concentrations of selective metabolites of organophosphorus pesticides in the United States population
  publication-title: Environ. Res.
– volume: 12
  start-page: 500
  year: 2001
  end-page: 504
  ident: bib27
  article-title: Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes
  publication-title: J. Nutr. Biochem.
– volume: 11
  start-page: 129
  year: 2018
  end-page: 137
  ident: bib50
  article-title: Dichlorvos toxicity: a public health perspective
  publication-title: Interdiscip. Toxicol.
– volume: 34
  start-page: 708
  year: 2012
  end-page: 719
  ident: bib41
  article-title: Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations
  publication-title: Reprod. Toxicol.
– volume: 7
  year: 2012
  ident: bib40
  article-title: Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations
  publication-title: PLoS One
– volume: 101
  start-page: 1688
  year: 2014
  end-page: 1696
  ident: bib61
  article-title: The WNT/beta-catenin signaling pathway and expression of survival promoting genes in luteinized granulosa cells: endometriosis as a paradigm for a dysregulated apoptosis pathway
  publication-title: Fertil. Steril.
– volume: 30
  start-page: 19466
  year: 2023
  end-page: 19476
  ident: bib58
  article-title: Hematological indices as indicators of inflammation induced by exposure to pesticides
  publication-title: Environ. Sci. Pollut. Res. Int.
– volume: 14
  start-page: 605
  year: 2008
  end-page: 621
  ident: bib51
  article-title: Infertility and the provision of infertility medical services in developing countries
  publication-title: Hum. Reprod. Update
– volume: 15
  start-page: 211
  year: 2004
  end-page: 221
  ident: bib39
  article-title: Evaluation of dimethoate toxicity on pregnancy in albino mice
  publication-title: J. Basic Clin. Physiol. Pharmacol.
– volume: 259
  start-page: 160
  year: 2016
  end-page: 167
  ident: bib38
  article-title: Activity and determinants of cholinesterases and paraoxonase-1 in blood of workers exposed to non-cholinesterase inhibiting pesticides
  publication-title: Chem. Biol. Interact.
– volume: 113
  start-page: 1030
  year: 2004
  end-page: 1036
  ident: bib74
  article-title: Pesticides
  publication-title: Pediatrics
– volume: 10
  start-page: 469
  year: 2012
  end-page: 482
  ident: bib78
  article-title: WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/beta-catenin pathway
  publication-title: Mol. Cancer Res.
– volume: 23
  start-page: 473
  year: 2008
  end-page: 479
  ident: bib28
  article-title: Effects of cypermethrin, propetamphos, and combination involving cypermethrin and propetamphos on lipid peroxidation in mice
  publication-title: Environ. Toxicol.
– volume: 23
  start-page: 955
  year: 2009
  end-page: 965
  ident: bib12
  article-title: Estrogen receptor beta is required for optimal cAMP production in mouse granulosa cells
  publication-title: Mol. Endocrinol.
– volume: 3
  start-page: 143
  year: 2010
  end-page: 151
  ident: bib60
  article-title: Immune-endocrine alterations during preeclampsia
  publication-title: Open Neuroendocrinol. J.
– volume: 9
  start-page: 27728
  year: 2018
  end-page: 27735
  ident: bib77
  article-title: Real-time methylation-specific PCR for the evaluation of methylation status of MGMT gene in glioblastoma
  publication-title: Oncotarget
– volume: 27
  start-page: 2856
  year: 2020
  end-page: 2871
  ident: bib11
  article-title: R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth
  publication-title: Cell Death Differ.
– volume: 133
  start-page: 1763
  year: 2019
  end-page: 1784
  ident: bib66
  article-title: Organophosphorus pesticide determination in biological specimens: bioanalytical and toxicological aspects
  publication-title: Int. J. Leg. Med.
– volume: 429
  start-page: 900
  year: 2004
  end-page: 903
  ident: bib29
  article-title: Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
  publication-title: Nature
– volume: 62
  start-page: 732
  year: 2013
  ident: 10.1016/j.fct.2025.115706_bib48
  article-title: Chlorpyrifos induced toxicity in reproductive organs of female wistar rats
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2013.10.006
– volume: 90
  start-page: 13
  year: 2014
  ident: 10.1016/j.fct.2025.115706_bib53
  article-title: Estrogen receptors alpha (ERalpha) and beta (ERbeta): subtype-selective ligands and clinical potential
  publication-title: Steroids
  doi: 10.1016/j.steroids.2014.06.012
– volume: 15
  start-page: 211
  year: 2004
  ident: 10.1016/j.fct.2025.115706_bib39
  article-title: Evaluation of dimethoate toxicity on pregnancy in albino mice
  publication-title: J. Basic Clin. Physiol. Pharmacol.
  doi: 10.1515/JBCPP.2004.15.3-4.211
– volume: 15
  start-page: 89
  year: 2009
  ident: 10.1016/j.fct.2025.115706_bib31
  article-title: Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients
  publication-title: Mol. Hum. Reprod.
  doi: 10.1093/molehr/gan082
– volume: 3
  start-page: 143
  year: 2010
  ident: 10.1016/j.fct.2025.115706_bib60
  article-title: Immune-endocrine alterations during preeclampsia
  publication-title: Open Neuroendocrinol. J.
– volume: 308
  start-page: 1466
  year: 2005
  ident: 10.1016/j.fct.2025.115706_bib3
  article-title: Epigenetic transgenerational actions of endocrine disruptors and Male fertility
  publication-title: Science
  doi: 10.1126/science.1108190
– volume: 5
  year: 2010
  ident: 10.1016/j.fct.2025.115706_bib20
  article-title: Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0013100
– volume: 24
  start-page: 2325
  year: 2019
  ident: 10.1016/j.fct.2025.115706_bib54
  article-title: Occupational exposure to pesticides and hematological alterations: a survey of farm residents in the south of Brazil
  publication-title: Ciência Saúde Coletiva
  doi: 10.1590/1413-81232018246.13142017
– volume: 27
  start-page: 29291
  year: 2020
  ident: 10.1016/j.fct.2025.115706_bib9
  article-title: Biochemical, hematological and immunological parameters and relationship with occupational exposure to pesticides and metals
  publication-title: Environ. Sci. Pollut. Res. Int.
  doi: 10.1007/s11356-020-09203-3
– volume: 104
  start-page: 58
  year: 2012
  ident: 10.1016/j.fct.2025.115706_bib16
  article-title: Chronic exposure to imidacloprid induces inflammation and oxidative stress in the liver & central nervous system of rats
  publication-title: Pestic. Biochem. Physiol.
  doi: 10.1016/j.pestbp.2012.06.011
– volume: 21
  start-page: 411
  year: 2015
  ident: 10.1016/j.fct.2025.115706_bib24
  article-title: Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century
  publication-title: Hum. Reprod. Update
  doi: 10.1093/humupd/dmv016
– volume: 29
  start-page: 126
  year: 2024
  ident: 10.1016/j.fct.2025.115706_bib33
  article-title: Epigenetic modifications in genome help remembering the stress tolerance strategy adopted by the plant
– volume: 18
  start-page: 1427
  year: 2002
  ident: 10.1016/j.fct.2025.115706_bib35
  article-title: MethPrimer: designing primers for methylation PCRs
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/18.11.1427
– volume: 10
  start-page: 469
  year: 2012
  ident: 10.1016/j.fct.2025.115706_bib78
  article-title: WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/beta-catenin pathway
  publication-title: Mol. Cancer Res.
  doi: 10.1158/1541-7786.MCR-11-0177
– volume: 4
  start-page: 30
  year: 2006
  ident: 10.1016/j.fct.2025.115706_bib8
  article-title: Pesticide exposure: the hormonal function of the female reproductive system disrupted?
  publication-title: Reprod. Biol. Endocrinol.
  doi: 10.1186/1477-7827-4-30
– year: 2012
  ident: 10.1016/j.fct.2025.115706_bib75
  article-title: miRDeepFinder: a miRNA analysis tool for deep sequencing of plant small RNAs
  publication-title: Plant Mol. Biol.
  doi: 10.1007/s11103-012-9885-2
– volume: 37
  start-page: 1959
  year: 2021
  ident: 10.1016/j.fct.2025.115706_bib65
  article-title: Infertility, infertility treatment, and cardiovascular disease: an overview
  publication-title: Can. J. Cardiol.
– volume: 2
  start-page: 58
  year: 2019
  ident: 10.1016/j.fct.2025.115706_bib67
  article-title: Medicinal plants and female reproduction disorders due to oxidative stress
  publication-title: Archives of Veterinary Science and Medicine
– volume: 30
  start-page: 293
  year: 2009
  ident: 10.1016/j.fct.2025.115706_bib13
  article-title: Endocrine-disrupting chemicals: an endocrine society scientific statement
  publication-title: Endocr. Rev.
  doi: 10.1210/er.2009-0002
– volume: 8
  year: 2013
  ident: 10.1016/j.fct.2025.115706_bib42
  article-title: Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0055387
– volume: 7
  year: 2012
  ident: 10.1016/j.fct.2025.115706_bib40
  article-title: Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0046249
– volume: 18
  year: 2021
  ident: 10.1016/j.fct.2025.115706_bib72
  article-title: Agriculture development, pesticide application and its impact on the environment
  publication-title: Int. J. Environ. Res. Publ. Health
  doi: 10.3390/ijerph18031112
– volume: 159
  start-page: 68
  year: 2019
  ident: 10.1016/j.fct.2025.115706_bib34
  article-title: Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats
  publication-title: Pestic. Biochem. Physiol.
  doi: 10.1016/j.pestbp.2019.05.018
– volume: 100
  start-page: 931
  year: 2013
  ident: 10.1016/j.fct.2025.115706_bib49
  article-title: Exposure to toxic environmental agents
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2013.08.043
– year: 2024
  ident: 10.1016/j.fct.2025.115706_bib68
– volume: 143
  start-page: 158
  year: 2017
  ident: 10.1016/j.fct.2025.115706_bib57
  article-title: Epigenetics and DNA methylomic profiling in alzheimer's disease and other neurodegenerative diseases
  publication-title: J. Neurochem.
  doi: 10.1111/jnc.14148
– volume: 133
  start-page: 1763
  year: 2019
  ident: 10.1016/j.fct.2025.115706_bib66
  article-title: Organophosphorus pesticide determination in biological specimens: bioanalytical and toxicological aspects
  publication-title: Int. J. Leg. Med.
  doi: 10.1007/s00414-019-02119-9
– volume: 39
  year: 2017
  ident: 10.1016/j.fct.2025.115706_bib6
  article-title: aberrant gene-specific dna methylation signature analysis in cervical cancer
  publication-title: tumour biol
  doi: 10.1177/1010428317694573
– volume: 27
  start-page: 2856
  year: 2020
  ident: 10.1016/j.fct.2025.115706_bib11
  article-title: R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-020-0547-7
– volume: 110
  start-page: 20224
  year: 2013
  ident: 10.1016/j.fct.2025.115706_bib37
  article-title: Targeting Wnt-driven cancer through the inhibition of porcupine by LGK974
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1314239110
– volume: 82
  start-page: 220
  year: 2003
  ident: 10.1016/j.fct.2025.115706_bib14
  article-title: Histopathological changes in ovary and endometrium after tubal ligation: a rat model
  publication-title: Acta Obstet. Gynecol. Scand.
  doi: 10.1034/j.1600-0412.2003.00108.x
– volume: 62
  start-page: 2
  year: 2018
  ident: 10.1016/j.fct.2025.115706_bib73
  article-title: Fertility and infertility: definition and epidemiology
  publication-title: Clin. Biochem.
  doi: 10.1016/j.clinbiochem.2018.03.012
– volume: 23
  start-page: 473
  year: 2008
  ident: 10.1016/j.fct.2025.115706_bib28
  article-title: Effects of cypermethrin, propetamphos, and combination involving cypermethrin and propetamphos on lipid peroxidation in mice
  publication-title: Environ. Toxicol.
  doi: 10.1002/tox.20360
– volume: 403
  start-page: 2057
  year: 2024
  ident: 10.1016/j.fct.2025.115706_bib18
  article-title: Global fertility in 204 countries and territories, 1950-2021, with forecasts to 2100: a comprehensive demographic analysis for the global burden of disease study 2021
  publication-title: Lancet
  doi: 10.1016/S0140-6736(24)00550-6
– volume: 259
  start-page: 160
  year: 2016
  ident: 10.1016/j.fct.2025.115706_bib38
  article-title: Activity and determinants of cholinesterases and paraoxonase-1 in blood of workers exposed to non-cholinesterase inhibiting pesticides
  publication-title: Chem. Biol. Interact.
  doi: 10.1016/j.cbi.2016.04.008
– volume: 46–54
  year: 2011
  ident: 10.1016/j.fct.2025.115706_bib59
  article-title: Suppressive effect of Ginkgo biloba extract (EGb 761) on topsin induced ovarian toxicity and oxidative stress in albino rats
  publication-title: J. Appl. Pharmaceut. Sci.
– volume: 40
  start-page: 963
  year: 2002
  ident: 10.1016/j.fct.2025.115706_bib70
  article-title: Acephate induced oxidative damage in erythrocytes
  publication-title: Indian J. Exp. Biol.
– volume: 34
  start-page: 708
  year: 2012
  ident: 10.1016/j.fct.2025.115706_bib41
  article-title: Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations
  publication-title: Reprod. Toxicol.
  doi: 10.1016/j.reprotox.2012.08.010
– volume: 10
  year: 2020
  ident: 10.1016/j.fct.2025.115706_bib5
  article-title: Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-76638-6
– volume: 150
  start-page: 4681
  year: 2009
  ident: 10.1016/j.fct.2025.115706_bib79
  article-title: Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes
  publication-title: Endocrinology
  doi: 10.1210/en.2009-0499
– volume: 7
  start-page: 791
  year: 1993
  ident: 10.1016/j.fct.2025.115706_bib21
  article-title: Endometriosis-associated infertility
  publication-title: Baillieres Clin Obstet Gynaecol
  doi: 10.1016/S0950-3552(05)80464-X
– volume: 11
  start-page: 129
  year: 2018
  ident: 10.1016/j.fct.2025.115706_bib50
  article-title: Dichlorvos toxicity: a public health perspective
  publication-title: Interdiscip. Toxicol.
  doi: 10.2478/intox-2018-0009
– volume: 352
  start-page: 1
  year: 2011
  ident: 10.1016/j.fct.2025.115706_bib26
  article-title: The canonical wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2011.01.004
– volume: 397
  start-page: 319
  year: 2021
  ident: 10.1016/j.fct.2025.115706_bib1
  article-title: Male infertility
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)32667-2
– volume: 120
  start-page: 1353
  year: 2012
  ident: 10.1016/j.fct.2025.115706_bib7
  article-title: Predicting later-life outcomes of early-life exposures
  publication-title: Environ. Health Perspect.
  doi: 10.1289/ehp.1204934
– volume: 233
  start-page: R109
  year: 2017
  ident: 10.1016/j.fct.2025.115706_bib56
  article-title: Exposure to endocrine disruptors during adulthood: consequences for female fertility
  publication-title: J. Endocrinol.
  doi: 10.1530/JOE-17-0023
– volume: 429
  start-page: 900
  year: 2004
  ident: 10.1016/j.fct.2025.115706_bib29
  article-title: Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
  publication-title: Nature
  doi: 10.1038/nature02633
– volume: 44
  start-page: 580
  year: 2006
  ident: 10.1016/j.fct.2025.115706_bib64
  article-title: Erythrocyte antioxidant enzymes in toxicological evaluation of commonly used organophosphate pesticides
  publication-title: Indian J. Exp. Biol.
– volume: 7
  start-page: 219
  year: 2011
  ident: 10.1016/j.fct.2025.115706_bib19
  article-title: Polycystic ovary syndrome: etiology, pathogenesis and diagnosis
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2010.217
– volume: 49
  start-page: 3086
  year: 2011
  ident: 10.1016/j.fct.2025.115706_bib30
  article-title: Toxicological impact of technical imidacloprid on ovarian morphology, hormones and antioxidant enzymes in female rats
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2011.09.009
– volume: 11
  start-page: 66
  year: 2013
  ident: 10.1016/j.fct.2025.115706_bib63
  article-title: Lifestyle factors and reproductive health: taking control of your fertility
  publication-title: Reprod. Biol. Endocrinol.
  doi: 10.1186/1477-7827-11-66
– volume: 6
  year: 2011
  ident: 10.1016/j.fct.2025.115706_bib47
  article-title: Quantitative analysis and diagnostic significance of methylated SLC19A3 DNA in the plasma of breast and gastric cancer patients
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0022233
– volume: 101
  start-page: 1688
  year: 2014
  ident: 10.1016/j.fct.2025.115706_bib61
  article-title: The WNT/beta-catenin signaling pathway and expression of survival promoting genes in luteinized granulosa cells: endometriosis as a paradigm for a dysregulated apoptosis pathway
  publication-title: Fertil. Steril.
  doi: 10.1016/j.fertnstert.2014.02.040
– volume: 504
  start-page: 460
  year: 2013
  ident: 10.1016/j.fct.2025.115706_bib76
  article-title: Role of Tet1 in erasure of genomic imprinting
  publication-title: Nature
  doi: 10.1038/nature12805
– volume: 30
  start-page: 77917
  year: 2023
  ident: 10.1016/j.fct.2025.115706_bib17
  article-title: Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats
  publication-title: Environ. Sci. Pollut. Res. Int.
  doi: 10.1007/s11356-023-27743-2
– volume: 41
  start-page: 1012
  year: 2016
  ident: 10.1016/j.fct.2025.115706_bib22
  article-title: Mechanism and regulation of NLRP3 inflammasome activation
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2016.09.002
– volume: 99
  start-page: 314
  year: 2005
  ident: 10.1016/j.fct.2025.115706_bib4
  article-title: Concentrations of selective metabolites of organophosphorus pesticides in the United States population
  publication-title: Environ. Res.
  doi: 10.1016/j.envres.2005.03.012
– volume: 1319
  start-page: 82
  year: 2014
  ident: 10.1016/j.fct.2025.115706_bib69
  article-title: Mechanism of NLRP3 inflammasome activation
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/nyas.12458
– volume: 454
  start-page: 1
  year: 2017
  ident: 10.1016/j.fct.2025.115706_bib44
  article-title: Uterine ERα epigenetic modifications are induced by the endocrine disruptor endosulfan in female rats with impaired fertility
  publication-title: Mol. Cell. Endocrinol.
  doi: 10.1016/j.mce.2017.05.028
– volume: 156
  year: 2021
  ident: 10.1016/j.fct.2025.115706_bib55
  article-title: Chronic exposure to low concentrations of chlorpyrifos affects normal cyclicity and histology of the uterus in female rats
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2021.112515
– volume: 130
  year: 2024
  ident: 10.1016/j.fct.2025.115706_bib25
  article-title: Chlorpyrifos and dimethoate exposure impairs female fertility by deregulating WNT signaling pathway & uterine receptivity
  publication-title: Reprod. Toxicol.
  doi: 10.1016/j.reprotox.2024.108735
– volume: 133
  start-page: 218
  year: 2013
  ident: 10.1016/j.fct.2025.115706_bib52
  article-title: Interferon-gamma promoter is hypermethylated in blood DNA from workers with confirmed diisocyanate asthma
  publication-title: Toxicol. Sci.
  doi: 10.1093/toxsci/kft079
– volume: 30
  start-page: 19466
  year: 2023
  ident: 10.1016/j.fct.2025.115706_bib58
  article-title: Hematological indices as indicators of inflammation induced by exposure to pesticides
  publication-title: Environ. Sci. Pollut. Res. Int.
  doi: 10.1007/s11356-022-23509-4
– volume: 12
  start-page: 500
  year: 2001
  ident: 10.1016/j.fct.2025.115706_bib27
  article-title: Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/S0955-2863(01)00160-7
– volume: 129
  year: 2021
  ident: 10.1016/j.fct.2025.115706_bib23
  article-title: Epigenome-wide DNA methylation and pesticide use in the agricultural lung health study
  publication-title: Environ. Health Perspect.
  doi: 10.1289/EHP8928
– volume: 14
  start-page: 605
  year: 2008
  ident: 10.1016/j.fct.2025.115706_bib51
  article-title: Infertility and the provision of infertility medical services in developing countries
  publication-title: Hum. Reprod. Update
  doi: 10.1093/humupd/dmn042
– volume: 67
  start-page: 279
  year: 2015
  ident: 10.1016/j.fct.2025.115706_bib32
  article-title: The effects of permethrin on rat ovarian tissue morphology
  publication-title: Exp. Toxicol. Pathol.
  doi: 10.1016/j.etp.2015.01.005
– volume: 19
  start-page: 384
  year: 2020
  ident: 10.1016/j.fct.2025.115706_bib36
  article-title: Ibrutinib potentiates antihepatocarcinogenic efficacy of sorafenib by targeting EGFR in tumor cells and BTK in immune cells in the stroma
  publication-title: Mol. Cancer Therapeut.
  doi: 10.1158/1535-7163.MCT-19-0135
– volume: 9
  start-page: 27728
  year: 2018
  ident: 10.1016/j.fct.2025.115706_bib77
  article-title: Real-time methylation-specific PCR for the evaluation of methylation status of MGMT gene in glioblastoma
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.25543
– volume: 3
  start-page: 28
  year: 2005
  ident: 10.1016/j.fct.2025.115706_bib2
  article-title: Role of oxidative stress in female reproduction
  publication-title: Reprod. Biol. Endocrinol.
  doi: 10.1186/1477-7827-3-28
– volume: 113
  start-page: 1030
  year: 2004
  ident: 10.1016/j.fct.2025.115706_bib74
  article-title: Pesticides
  publication-title: Pediatrics
  doi: 10.1542/peds.113.S3.1030
– volume: 23
  start-page: 955
  year: 2009
  ident: 10.1016/j.fct.2025.115706_bib12
  article-title: Estrogen receptor beta is required for optimal cAMP production in mouse granulosa cells
  publication-title: Mol. Endocrinol.
  doi: 10.1210/me.2008-0213
– volume: 3
  start-page: 109
  year: 2013
  ident: 10.1016/j.fct.2025.115706_bib45
  article-title: Effect of methomyl on fertility, embryotoxicity and physiological parameters in female rats
  publication-title: J. Appl. Pharmaceut. Sci.
– volume: 97
  start-page: 13
  year: 2010
  ident: 10.1016/j.fct.2025.115706_bib15
  article-title: Acute oxidant and inflammatory effects of imidacloprid on the Mammalian central nervous system and liver in rats
  publication-title: Pestic. Biochem. Physiol.
  doi: 10.1016/j.pestbp.2009.11.008
– volume: 13
  year: 2022
  ident: 10.1016/j.fct.2025.115706_bib43
  article-title: Adapalene inhibits the growth of triple-negative breast cancer cells by S-phase arrest and potentiates the antitumor efficacy of GDC-0941
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2022.958443
– volume: 16
  start-page: 703
  year: 2021
  ident: 10.1016/j.fct.2025.115706_bib46
  article-title: Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning
  publication-title: Open Life Sci.
  doi: 10.1515/biol-2021-0069
– volume: 8
  start-page: 134
  year: 2020
  ident: 10.1016/j.fct.2025.115706_bib71
  article-title: Diabetes: a metabolic and reproductive disorder in women
  publication-title: Lancet Diabetes Endocrinol.
  doi: 10.1016/S2213-8587(19)30345-6
– volume: 117
  start-page: 9
  year: 2015
  ident: 10.1016/j.fct.2025.115706_bib62
  article-title: Triazophos-induced oxidative stress and histomorphological changes in ovary of female wistar rats
  publication-title: Pestic. Biochem. Physiol.
  doi: 10.1016/j.pestbp.2014.09.004
– volume: 66
  start-page: 77
  year: 2002
  ident: 10.1016/j.fct.2025.115706_bib10
  article-title: A role for the androgen receptor in follicular atresia of estrogen receptor beta knockout mouse ovary
  publication-title: Biol. Reprod.
  doi: 10.1095/biolreprod66.1.77
SSID ssj0007176
Score 2.476576
Snippet The study examined the impact of chlorpyrifos, dimethoate, and their co-exposure on ovarian structure and function in female Wistar rats. The study involved 24...
SourceID proquest
pubmed
crossref
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 115706
SubjectTerms Animals
Chlorpyrifos
Chlorpyrifos - toxicity
Dimethoate
DNA methylation
DNA Methylation - drug effects
Epigenesis, Genetic - drug effects
Female
Hormonal imbalance
Inflammation
Inflammation - chemically induced
Inflammation - genetics
Inflammation - metabolism
NF-kappa B - genetics
NF-kappa B - metabolism
Ovarian function
Ovary - drug effects
Ovary - metabolism
Ovary - pathology
Ovary - physiopathology
Pesticides - toxicity
Rats
Rats, Wistar
Wnt Signaling Pathway - drug effects
Title Pesticide-induced epigenetic suppression of WNT signaling and NF-κB-driven inflammation impairs ovarian function in rats
URI https://dx.doi.org/10.1016/j.fct.2025.115706
https://www.ncbi.nlm.nih.gov/pubmed/40825503
https://www.proquest.com/docview/3240912203
Volume 205
WOSCitedRecordID wos001562812900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVESC
  databaseName: ScienceDirect database
  customDbUrl:
  eissn: 1873-6351
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0007176
  issn: 0278-6915
  databaseCode: AIEXJ
  dateStart: 19950101
  isFulltext: true
  titleUrlDefault: https://www.sciencedirect.com
  providerName: Elsevier
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1fb9MwELe6DQkkhGAwKH8mI7EXpkwhiVPnsataQYWqiRWtb5HjP2rKllZNUxW-D1-CD8Fn4hzHabepiD3wEkWpY51yv57vznc_I_SOssQlhLuOZjdzAoh7HKYrAYIw9FwZhknAS57Zz63BgI5G0Vmj8dP2wiwvW1lGV6to9l9VDc9A2bp19g7qrieFB3APSocrqB2u_6T4M82bwVMhHQi3C729L2eaclN3Kx7nxayqfC3dxIvB8FhXcLBL26s46DlHne7RafvUEXNtCXW5FqDGdDiWTZXpPD-eLiHG1vkRWBZtuSRgKd_0dXuaMLlsm7OkBIvpKuXX8vh9k3_ts_wKAup6iTgfy_RbmfC5YJNUgOUZaxFEXS1UlJnr8zH7kdYvwaBUGEqEL8UVS3O2mdLwSNXbt7Z8HoS2YWT6PK2Z9lyyYWg1R1BJVXB7DTDpiMmJ4rpW1iMn67HX-bZvrIN1daItfJvEMEWsp4jNFDtoz2uRCIznXvtTd9Svl3yIictNcSu33T4vCwlvyLHNAdoW4JSOzvAxelRFKLhtkPUENWS2j-537MGAcG-b2fN99NCkfbHpZnuKvt9CH16jD2-gD08VBvThGn0YkIIBfb9_WeThTeThCnm4Qh62yINRWCPvGfra6w47H53qdA-H-4G7cCBODn3uJj5liqqQqSRwhUqYCKQKmBskXHKPSuVT4TEleRRGJIkYJS0Z-oqE_gHazaaZfIFwpLjiHlfwg9CnqVPOI-EKFpBIKCpEE723nzyeGRKXeKuSmyiwSokrL9R4lzEA7G-vvbUKjEEfetuNZXJa5LGmvIw-eJ7rN9Fzo9laCn3cOyGu__IuEr5CD9b_mtdodzEv5Bt0jy8XaT4_RDutET2sEPoHqY7BGA
linkProvider Elsevier
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pesticide-induced+epigenetic+suppression+of+WNT+signaling+and+NF-%CE%BAB-driven+inflammation+impairs+ovarian+function+in+rats&rft.jtitle=Food+and+chemical+toxicology&rft.au=Jan%2C+Jasmeena&rft.au=Sheikh%2C+Wajid+Mohammad&rft.au=Gul%2C+Shazia&rft.au=Mohidin%2C+Rumaisa&rft.date=2025-11-01&rft.issn=0278-6915&rft.volume=205&rft.spage=115706&rft_id=info:doi/10.1016%2Fj.fct.2025.115706&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_fct_2025_115706
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0278-6915&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0278-6915&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0278-6915&client=summon