Antarease-like Zn-metalloproteases are ubiquitous in the venom of different scorpion genera

The venoms of several scorpion species have long been associated with pancreatitis in animal models and humans. Antarease, a Zn-metalloprotease from Tityus serrulatus, is able to penetrate intact pancreatic tissue and disrupts the normal vesicular traffic necessary for secretion, so it could play a...

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Veröffentlicht in:	Biochimica et biophysica acta Jg. 1840; H. 6; S. 1738 - 1746
Hauptverfasser:	Ortiz, Ernesto, Rendón-Anaya, Martha, Rego, Solange Cristina, Schwartz, Elisabeth Ferroni, Possani, Lourival Domingos
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands 01.06.2014
Schlagworte:	Amino Acid Sequence animal models antivenoms Base Sequence cDNA libraries complementary DNA humans Metalloproteases - chemistry Metalloproteases - genetics Metalloproteases - physiology metalloproteinases Models, Molecular molecular cloning Molecular Dynamics Simulation Molecular Sequence Data pancreatitis phylogeny Phylogeography physiological transport polymerase chain reaction Scorpion Venoms - enzymology secretion sequence analysis Tityus serrulatus venoms Zn-metalloprotease Scorpion Antarease Pancreatitis cDNA library
ISSN:	0304-4165, 0006-3002
Online-Zugang:	Volltext
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