Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity

The unfolded protein response (UPR) is a signal transduction pathway that coordinates cellular adaptation to microenvironmental stresses that include hypoxia, nutrient deprivation, and change in redox status. These stress stimuli are common in many tumors and thus targeting components of the UPR sig...

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Bibliographic Details

Published in:	Cancer research (Chicago, Ill.) Vol. 73; no. 6; p. 1993
Main Authors:	Atkins, Charity, Liu, Qi, Minthorn, Elisabeth, Zhang, Shu-Yun, Figueroa, David J, Moss, Katherine, Stanley, Thomas B, Sanders, Brent, Goetz, Aaron, Gaul, Nathan, Choudhry, Anthony E, Alsaid, Hasan, Jucker, Beat M, Axten, Jeffrey M, Kumar, Rakesh
Format:	Journal Article
Language:	English
Published:	United States 15.03.2013
Subjects:	Adenine - analogs & derivatives Adenine - pharmacology Angiogenesis Inhibitors - pharmacology Animals Antineoplastic Agents - pharmacology eIF-2 Kinase - antagonists & inhibitors Female Gene Expression Profiling Indoles - pharmacology Mice Protein Kinase Inhibitors - pharmacology
ISSN:	1538-7445, 1538-7445
Online Access:	Get more information
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