Zirconium-catalysed N-acylation of lactams using unactivated carboxylic acids

[Display omitted] •New method for the catalytic N-acylation of lactams with carboxylic acids.•Screening of Lewis acid catalysts for N-acylation of pyroglutamic acid methyl ester.•Yields up to 97% were reached with 10 mol% Zr(propoxide)4.•Substrate scope was investigated; with 57–97% yield achieved.•...

Full description

Saved in:

Bibliographic Details
Published in:	Tetrahedron letters Vol. 59; no. 17; pp. 1646 - 1650
Main Authors:	Hulsbosch, Joris, Claes, Laurens, De Vos, Dirk E.
Format:	Journal Article
Language:	English
Published:	OXFORD Elsevier Ltd 25.04.2018 Elsevier
Subjects:	Aniracetam Catalysis catalysts chemical reactions Chemistry Chemistry, Organic drugs Lactam lactams Lewis acids moieties N-Acylation palmitic acid pesticides Physical Sciences Science & Technology surfactants temperature zirconium Zirconyl chloride Zirconyl chloride Catalysis Aniracetam Lactam N-Acylation CHEMISTRY DISORDERS CHLORIDE
ISSN:	0040-4039, 1873-3581
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!