Impact of RAS, BRAF mutations and microsatellite status in peritoneal metastases from colorectal cancer treated with cytoreduction + HIPEC: scoping review

Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has shown survival benefits in select patients with peritoneal metastases (PM) from colorectal cancer (CRC). Molecular alterations, particularly RAS/BRAF mutations and Microsatellite Instability (MSI), play c...

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Bibliographic Details
Published in:	International journal of hyperthermia Vol. 42; no. 1; p. 2479527
Main Authors:	Zucchini, Valentina, D’Acapito, Fabrizio, Rapposelli, Ilario Giovanni, Framarini, Massimo, Di Pietrantonio, Daniela, Turrini, Riccardo, Pozzi, Eleonora, Ercolani, Giorgio
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis Group 01.12.2025
Subjects:	Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Cytoreduction Surgical Procedures - methods cytoreductive surgery HIPEC Humans Hyperthermic Intraperitoneal Chemotherapy - methods Microsatellite Instability Mutation peritoneal metastasis Peritoneal Neoplasms - genetics Peritoneal Neoplasms - secondary Peritoneal Neoplasms - therapy Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics ras Proteins - genetics RAS/BRAF mutations microsatellite instability RAS/BRAF mutations HIPEC peritoneal metastasis Colorectal cancer cytoreductive surgery
ISSN:	0265-6736, 1464-5157, 1464-5157
Online Access:	Get full text
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