The thyroid hormone-αvβ3 integrin axis in ovarian cancer: regulation of gene transcription and MAPK-dependent proliferation

Ovarian carcinoma is the fifth common cause of cancer death in women, despite advanced therapeutic approaches. αvβ3 integrin, a plasma membrane receptor, binds thyroid hormones (L-thyroxine, T4; 3,5,3’-triiodo-L-thyronine, T3) and is overexpressed in ovarian cancer. We have demonstrated selective bi...

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Veröffentlicht in:	Oncogene Jg. 35; H. 15; S. 1977 - 1987
Hauptverfasser:	Shinderman-Maman, E, Cohen, K, Weingarten, C, Nabriski, D, Twito, O, Baraf, L, Hercbergs, A, Davis, P J, Werner, H, Ellis, M, Ashur-Fabian, O
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 14.04.2016 Nature Publishing Group
Schlagworte:	13/31 13/95 14/19 14/63 38/77 631/67/1517/1709 82/80 Antibodies, Neutralizing - pharmacology Apoptosis Cell activation Cell Biology Cell cycle Cell Division - drug effects Cell growth Cell Line, Tumor Cell proliferation Cell survival Culture Media - pharmacology Development and progression Enzyme Activation Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Female Gene Expression Regulation, Neoplastic - drug effects Gene regulation Genetic aspects Genetic transcription Health aspects Hormones Human Genetics Humans Hypothyroidism Hypothyroidism - blood Insulin-like growth factor-binding protein 6 Integrin alphaV - genetics Integrin alphaV - metabolism Integrin alphaVbeta3 - biosynthesis Integrin alphaVbeta3 - genetics Integrin alphaVbeta3 - immunology Integrin alphaVbeta3 - physiology Integrin beta3 - genetics Integrin beta3 - metabolism Internal Medicine Kinases MAP kinase MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Medicine Medicine & Public Health Mitochondria mRNA Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - physiology Neoplasms, Hormone-Dependent - genetics Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Oligopeptides - pharmacology Oncology original-article Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Phosphorylation Properties Protein Processing, Post-Translational RNA, Messenger - biosynthesis RNA, Neoplasm - biosynthesis Thyroid gland Thyroid hormones Thyroxine Thyroxine - blood Thyroxine - pharmacology Thyroxine - physiology Transcription Transcription, Genetic - drug effects Transcription, Genetic - physiology Triiodothyronine Triiodothyronine - blood Triiodothyronine - pharmacology Triiodothyronine - physiology Tumor suppression Tumors Tyrosine
ISSN:	0950-9232, 1476-5594
Online-Zugang:	Volltext
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