Electrochemical Determination of Ampicillin Based on an Electropolymerized Poly(o-Phenylenediamine)/Gold Nanoparticle/Single-Walled Carbon Nanotube Modified Glassy Carbon Electrode

A sensitive and selective molecular-imprinted electrochemical sensor was developed for the determination of ampicillin. The molecularly imprinted film was electropolymerized on the surface of a glassy carbon electrode modified with gold nanoparticles (AuNPs) and single walled carbon nanotubes (SWCNT...

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Bibliographic Details
Published in:Analytical letters Vol. 53; no. 18; pp. 2854 - 2867
Main Authors: Shi, Xiaohong, Ren, Xuehong, Jing, Ning, Zhang, Jialin
Format: Journal Article
Language:English
Published: Abingdon Taylor & Francis 11.12.2020
Taylor & Francis Ltd
Subjects:
Ampicillin
Antibiotics
Carbon
Chemical sensors
Electrodes
Glassy carbon
Gold
gold nanoparticle/single-walled carbon nanotube modified electrode
Milk
molecularly imprinted electrochemical sensor
Nanoparticles
Phenylenediamine
Sensors
Single wall carbon nanotubes
ISSN:0003-2719, 1532-236X
Online Access:Get full text
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Summary:A sensitive and selective molecular-imprinted electrochemical sensor was developed for the determination of ampicillin. The molecularly imprinted film was electropolymerized on the surface of a glassy carbon electrode modified with gold nanoparticles (AuNPs) and single walled carbon nanotubes (SWCNTs) using ampicillin as the template molecule and o-phenylendiamine as the functional monomer. Under the optimized conditions, the current change of this electrode showed a linear relationship with the ampicillin concentration from 5.0 × 10 −8  mol/L to 1.0 × 10 −5  mol/L and a detection limit of 1.0 × 10 −9  mol/L. Due to the increased specific surface areas and conductivity of the AuNPs and SWCNTs, this sensor exhibited excellent sensitivity for ampicillin. The recovery values for ampicillin detection in milk using the developed sensor were from 95.0% to 98.1%.
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ISSN:0003-2719
1532-236X
DOI:10.1080/00032719.2020.1759619