A protein corona sensor array detects breast and prostate cancers
Following exposure to human plasma (HP), nanoparticles (NPs) are coated with a biomolecular layer referred to as a protein corona. We recently revealed that characterizing the protein coronas of various NPs may provide a unique opportunity for cancer identification and discrimination. In other words...
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| Veröffentlicht in: | Nanoscale Jg. 12; H. 32; S. 16697 |
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| Sprache: | Englisch |
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20.08.2020
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| ISSN: | 2040-3372, 2040-3372 |
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| Abstract | Following exposure to human plasma (HP), nanoparticles (NPs) are coated with a biomolecular layer referred to as a protein corona. We recently revealed that characterizing the protein coronas of various NPs may provide a unique opportunity for cancer identification and discrimination. In other words, protein corona profiles of several NPs, when being analyzed using classifiers, would provide a unique "fingerprint" for each type of disease. Here, we probed the capacity of the protein corona for the identification and discrimination of breast and prostate cancer patients from healthy individuals. Using three lipid NP formulations with distinct physical-chemical properties as a cross-reactive sensor array and a supervised random forest classifier, we identified a set of proteins that showed a significant difference in cancer patients and control subjects. Our data show that many of the corona proteins with the highest discrimination ability between oncological patients and healthy individuals are related to cellular and molecular aspects of breast and prostate cancers. |
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| AbstractList | Following exposure to human plasma (HP), nanoparticles (NPs) are coated with a biomolecular layer referred to as a protein corona. We recently revealed that characterizing the protein coronas of various NPs may provide a unique opportunity for cancer identification and discrimination. In other words, protein corona profiles of several NPs, when being analyzed using classifiers, would provide a unique "fingerprint" for each type of disease. Here, we probed the capacity of the protein corona for the identification and discrimination of breast and prostate cancer patients from healthy individuals. Using three lipid NP formulations with distinct physical-chemical properties as a cross-reactive sensor array and a supervised random forest classifier, we identified a set of proteins that showed a significant difference in cancer patients and control subjects. Our data show that many of the corona proteins with the highest discrimination ability between oncological patients and healthy individuals are related to cellular and molecular aspects of breast and prostate cancers.Following exposure to human plasma (HP), nanoparticles (NPs) are coated with a biomolecular layer referred to as a protein corona. We recently revealed that characterizing the protein coronas of various NPs may provide a unique opportunity for cancer identification and discrimination. In other words, protein corona profiles of several NPs, when being analyzed using classifiers, would provide a unique "fingerprint" for each type of disease. Here, we probed the capacity of the protein corona for the identification and discrimination of breast and prostate cancer patients from healthy individuals. Using three lipid NP formulations with distinct physical-chemical properties as a cross-reactive sensor array and a supervised random forest classifier, we identified a set of proteins that showed a significant difference in cancer patients and control subjects. Our data show that many of the corona proteins with the highest discrimination ability between oncological patients and healthy individuals are related to cellular and molecular aspects of breast and prostate cancers. Following exposure to human plasma (HP), nanoparticles (NPs) are coated with a biomolecular layer referred to as a protein corona. We recently revealed that characterizing the protein coronas of various NPs may provide a unique opportunity for cancer identification and discrimination. In other words, protein corona profiles of several NPs, when being analyzed using classifiers, would provide a unique "fingerprint" for each type of disease. Here, we probed the capacity of the protein corona for the identification and discrimination of breast and prostate cancer patients from healthy individuals. Using three lipid NP formulations with distinct physical-chemical properties as a cross-reactive sensor array and a supervised random forest classifier, we identified a set of proteins that showed a significant difference in cancer patients and control subjects. Our data show that many of the corona proteins with the highest discrimination ability between oncological patients and healthy individuals are related to cellular and molecular aspects of breast and prostate cancers. |
| Author | Laganà, Aldo Mahmoudi, Morteza Grasso, Antonella Coppola, Roberto Caracciolo, Giulio Jafari-Khouzani, Kourosh Caputo, Damiano Cascone, Chiara Capriotti, Anna Laura Flammia, Gerardo Zenezini Chiozzi, Riccardo Palchetti, Sara Digiacomo, Luca Pozzi, Daniela Altomare, Vittorio |
| Author_xml | – sequence: 1 givenname: Luca surname: Digiacomo fullname: Digiacomo, Luca email: giulio.caracciolo@uniroma1.it organization: Department of Molecular Medicine, "Sapienza" University of Rome, Viale Regina Elena 291, 00161 Rome, Italy. giulio.caracciolo@uniroma1.it – sequence: 2 givenname: Kourosh surname: Jafari-Khouzani fullname: Jafari-Khouzani, Kourosh organization: IBM Watson Health, Cambridge, MA, USA – sequence: 3 givenname: Sara surname: Palchetti fullname: Palchetti, Sara email: giulio.caracciolo@uniroma1.it organization: Department of Molecular Medicine, "Sapienza" University of Rome, Viale Regina Elena 291, 00161 Rome, Italy. giulio.caracciolo@uniroma1.it – sequence: 4 givenname: Daniela orcidid: 0000-0001-6158-5880 surname: Pozzi fullname: Pozzi, Daniela email: giulio.caracciolo@uniroma1.it organization: Department of Molecular Medicine, "Sapienza" University of Rome, Viale Regina Elena 291, 00161 Rome, Italy. giulio.caracciolo@uniroma1.it – sequence: 5 givenname: Anna Laura surname: Capriotti fullname: Capriotti, Anna Laura organization: Department of Chemistry, "Sapienza" University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy – sequence: 6 givenname: Aldo surname: Laganà fullname: Laganà, Aldo organization: Department of Chemistry, "Sapienza" University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy – sequence: 7 givenname: Riccardo surname: Zenezini Chiozzi fullname: Zenezini Chiozzi, Riccardo organization: Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands and Netherlands Proteomics Centre, Utrecht, the Netherlands – sequence: 8 givenname: Damiano surname: Caputo fullname: Caputo, Damiano organization: Department of General Surgery, University Campus-Biomedico di Roma, Via Alvaro del Portillo 200, 00128 Rome, Italy – sequence: 9 givenname: Chiara surname: Cascone fullname: Cascone, Chiara organization: Department of General Surgery, University Campus-Biomedico di Roma, Via Alvaro del Portillo 200, 00128 Rome, Italy – sequence: 10 givenname: Roberto orcidid: 0000-0001-5798-0714 surname: Coppola fullname: Coppola, Roberto organization: Department of General Surgery, University Campus-Biomedico di Roma, Via Alvaro del Portillo 200, 00128 Rome, Italy – sequence: 11 givenname: Gerardo surname: Flammia fullname: Flammia, Gerardo organization: Department of Urology, University Campus Bio-Medico di Roma, Via Alvaro del Portillo, 200, 00128 Rome, Italy – sequence: 12 givenname: Vittorio surname: Altomare fullname: Altomare, Vittorio organization: Breast Unit, University Campus Bio-Medico di Roma, Via Alvaro del Portillo, 200, 00128 Rome, Italy – sequence: 13 givenname: Antonella surname: Grasso fullname: Grasso, Antonella organization: Breast Unit, University Campus Bio-Medico di Roma, Via Alvaro del Portillo, 200, 00128 Rome, Italy – sequence: 14 givenname: Morteza orcidid: 0000-0002-2575-9684 surname: Mahmoudi fullname: Mahmoudi, Morteza email: mahmou22@msu.ed organization: Precision Health Medicine, Department of Radiology Michigan State University, MI, USA. mahmou22@msu.ed – sequence: 15 givenname: Giulio orcidid: 0000-0002-8636-4475 surname: Caracciolo fullname: Caracciolo, Giulio email: giulio.caracciolo@uniroma1.it organization: Department of Molecular Medicine, "Sapienza" University of Rome, Viale Regina Elena 291, 00161 Rome, Italy. giulio.caracciolo@uniroma1.it |
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| Title | A protein corona sensor array detects breast and prostate cancers |
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